Duloxetine
Generic name: Pronounced as (doo lox' e teen)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 03/15/2022
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants (''mood elevators'') such as duloxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take duloxetine, but in some cases, a doctor may decide that duloxetine is the best medication to treat a child's condition.
You should know that your mental health may change in unexpected ways when you take duloxetine or other antidepressants even if you are an adult over 24 years of age. These changes may occur even if you do not have a mental illness and you are taking duloxetine to treat a different type of condition. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive or hostile behavior; irritability; acting without thinking; severe restlessness; frenzied abnormal excitement; or any other unusual changes in behavior. Be sure that your family or caregiver checks on you daily and knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
Your healthcare provider will want to see you often while you are taking duloxetine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.
The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with duloxetine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.
No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood), depression, or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.
Why is this medication prescribed?
Duloxetine is used to treat depression in adults and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults and children 7 years of age and older. Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes) in adults and fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep) in adults and children 13 years of age and older. It is also used to treat ongoing bone or muscle pain such as lower back pain or osteoarthritis (joint pain or stiffness that may worsen over time) in adults. Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
How should this medicine be used?
Duloxetine comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule to take by mouth. When duloxetine is used to treat depression, it is usually taken once or twice a day with or without food. When duloxetine is used to treat generalized anxiety disorder, the pain of diabetic neuropathy, fibromyalgia, or ongoing bone or muscle pain, it is usually taken once a day with or without food. Take duloxetine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take duloxetine exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.
Swallow the delayed-release capsules whole; do not split, chew, or crush them. Do not open the delayed-release capsules and mix the contents with liquids or sprinkle the contents on food.
Your doctor may start you on a low dose of medication and increase your dose after one week.
Duloxetine may help control your symptoms but will not cure your condition. It may take 1 to 4 weeks or longer before you feel the full benefit of duloxetine. Continue to take duloxetine even if you feel well. Do not stop taking duloxetine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking duloxetine, you may experience withdrawal symptoms such as nausea; vomiting; diarrhea; anxiety; dizziness; tiredness; headache; pain, burning, numbness, or tingling in the hands or feet; irritability; difficulty falling asleep or staying asleep; sweating; and nightmares. Tell your doctor if you experience any of these symptoms when your dose of duloxetine is decreased.
Other uses for this medicine
Duloxetine is also sometimes used to treat stress urinary incontinence (leakage of urine during physical activity such as coughing, sneezing, laughing, and exercise) in women. Talk to your doctor about using this medication to treat your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking duloxetine,
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tell your doctor and pharmacist if you are allergic to duloxetine, any other medications, or any of the ingredients in duloxetine delayed-release capsules. Ask your doctor or pharmacist for a list of the ingredients.
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tell your doctor if you are taking thioridazine or a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid (Zyvox); methylene blue; phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take duloxetine. If you stop taking duloxetine, you should wait at least 5 days before you start to take an MAO inhibitor.
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tell your doctor and pharmacist what other prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: amphetamines such as amphetamine (in Adderall, others), dextroamphetamine (Dexedrine, in Adderall), and methamphetamine (Desoxyn); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; cimetidine (Tagamet); ciprofloxacin (Cipro); diuretics ('water pills'); fentanyl (Abstral, Actiq, Fentora, Onsolis, others); medications for irregular heartbeat such as amiodarone (Cordarone), flecainide (Tambocor), moricizine (Ethmozine), propafenone (Rythmol), and quinidine (in Nuedexta); medications for anxiety, high blood pressure, mental illness, pain, and nausea; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, Onzetra, Tosmyra, in Treximet), and zolmitriptan (Zomig); lithium (Lithobid); proton pump inhibitors such as lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (Aciphex); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), and paroxetine (Paxil); sleeping pills; theophylline (Theo-24, Theochron); tramadol (Ultram); and tranquilizers. Many other medications may interact with duloxetine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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tell your doctor what nutritional supplements and herbal products you are taking, especially products containing St. John's wort or tryptophan.
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tell your doctor if you drink or have ever drunk large amounts of alcohol or if you use or have ever used street drugs or have ever overused prescription medications. Also tell your doctor if you have a low level of sodium in your blood; glaucoma (increased pressure in the eye that may cause loss of sight); if you have recently had a heart attack; or if you have or have ever had high blood pressure; seizures; coronary artery disease (blockage or narrowing of the blood vessels that lead to the heart); bleeding problems; any type of stomach problem such as slow stomach emptying; or heart, liver, or kidney disease. If you have diabetes, be sure to talk to your doctor about how serious your condition is so your doctor can decide if duloxetine is right for you.
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tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking duloxetine, call your doctor. Duloxetine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
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if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking duloxetine.
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you should know that duloxetine may make you drowsy, dizzy, or may affect your judgment, thinking or coordination. Do not drive a car or operate machinery until you know how this medication affects you.
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ask your doctor about the safe use of alcoholic beverages while you are taking duloxetine. Alcohol can increase the risk of serious side effects from duloxetine.
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you should know that duloxetine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking duloxetine or with an increase in dose. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
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you should know that duloxetine may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.
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you should know that duloxetine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Duloxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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nausea
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vomiting
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constipation
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diarrhea
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weight changes
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heartburn
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stomach pain
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decreased appetite
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dry mouth
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increased urination
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sweating or night sweats
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dizziness
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headache
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weight changes
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tiredness
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drowsiness
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muscle pain or cramps
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sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation
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sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm
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uncontrollable shaking of a part of the body
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Some side effects can be serious. If you experience any of the following side effects, or those mentioned in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:
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unusual bruising or bleeding
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pain in the upper right part of the stomach
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swelling of the abdomen
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itching
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yellowing of the skin or eyes
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dark colored urine
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loss of appetite
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extreme tiredness or weakness
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confusion
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unsteady walking that may cause falling
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flu-like symptoms
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agitation, fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea
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seizures
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hallucinations (seeing things or hearing voices that do not exist)
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fever
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blisters or peeling skin
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rash
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hives
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difficulty breathing or swallowing
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swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
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hoarseness
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difficulty urinating
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Duloxetine may decrease appetite and cause weight loss in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Talk to your child's doctor about the risks of giving duloxetine to your child.
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Duloxetine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
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agitation
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hallucinating (seeing things or hearing voices that do not exist)
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fast heartbeat
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fever
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loss of coordination
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nausea
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vomiting
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diarrhea
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drowsiness
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seizures
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dizziness
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lightheadedness
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fainting
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unresponsiveness
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Moxifloxacin | Moxifloxacin The metabolism of Duloxetine can be decreased when combined with Moxifloxacin. |
Repaglinide | Repaglinide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Repaglinide. |
Montelukast | Montelukast The metabolism of Duloxetine can be decreased when combined with Montelukast. |
Insulin Glargine (rDNA origin) Injection | Insulin Glargine (rDNA origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin glargine. |
Leflunomide | Leflunomide The serum concentration of Duloxetine can be decreased when it is combined with Leflunomide. |
Delavirdine | Delavirdine The metabolism of Duloxetine can be decreased when combined with Delavirdine. |
Nevirapine | Nevirapine The metabolism of Duloxetine can be decreased when combined with Nevirapine. |
Atorvastatin | Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Duloxetine. |
Dolasetron | Dolasetron The metabolism of Duloxetine can be decreased when combined with Dolasetron. |
Aminophylline | Aminophylline The metabolism of Aminophylline can be decreased when combined with Duloxetine. |
Anagrelide | Anagrelide The risk or severity of hemorrhage can be increased when Duloxetine is combined with Anagrelide. |
Candesartan | Candesartan The metabolism of Candesartan can be decreased when combined with Duloxetine. |
Cilostazol | Cilostazol The metabolism of Cilostazol can be decreased when combined with Duloxetine. |
Clopidogrel | Clopidogrel The risk or severity of hemorrhage can be increased when Duloxetine is combined with Clopidogrel. |
Diphenoxylate | Diphenoxylate The risk or severity of serotonin syndrome can be increased when Diphenoxylate is combined with Duloxetine. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The metabolism of Duloxetine can be decreased when combined with Erythromycin. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) The metabolism of Duloxetine can be decreased when combined with Conjugated estrogens. |
Fenofibrate | Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Duloxetine. |
Guanfacine | Guanfacine The risk or severity of orthostatic hypotension and syncope can be increased when Guanfacine is combined with Duloxetine. |
Magnesium Hydroxide | Magnesium Hydroxide Duloxetine may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. |
Methylergonovine | Methylergonovine The metabolism of Duloxetine can be decreased when combined with Methylergometrine. |
Miglitol | Miglitol The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Miglitol. |
Mycophenolate | Mycophenolate Duloxetine may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level. |
Naratriptan | Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Duloxetine. |
Olsalazine | Olsalazine The risk or severity of gastrointestinal bleeding can be increased when Olsalazine is combined with Duloxetine. |
Paregoric | Paregoric The risk or severity of orthostatic hypotension and syncope can be increased when Morphine is combined with Duloxetine. |
Penbutolol | Penbutolol The risk or severity of orthostatic hypotension and syncope can be increased when Acebutolol is combined with Duloxetine. |
Pentazocine | Pentazocine The risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Duloxetine. |
Potassium | Potassium Potassium may increase the excretion rate of Duloxetine which could result in a lower serum level and potentially a reduction in efficacy. |
Prednisone | Prednisone Duloxetine may decrease the excretion rate of Prednisone which could result in a higher serum level. |
Ranitidine | Ranitidine The metabolism of Ranitidine can be decreased when combined with Duloxetine. |
Reserpine | Reserpine The risk or severity of orthostatic hypotension and syncope can be increased when Reserpine is combined with Duloxetine. |
Rizatriptan | Rizatriptan The risk or severity of adverse effects can be increased when Duloxetine is combined with Rizatriptan. |
Sumatriptan | Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Duloxetine. |
Tacrolimus | Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Duloxetine. |
Tizanidine | Tizanidine The risk or severity of orthostatic hypotension and syncope can be increased when Tizanidine is combined with Duloxetine. |
Triamcinolone | Triamcinolone The metabolism of Duloxetine can be increased when combined with Triamcinolone. |
Zolmitriptan | Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Duloxetine. |
Ampicillin Injection | Ampicillin Injection Ampicillin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Doxycycline Injection | Doxycycline Injection The metabolism of Duloxetine can be decreased when combined with Doxycycline. |
Famotidine Injection | Famotidine Injection The metabolism of Duloxetine can be decreased when combined with Famotidine. |
Fluconazole Injection | Fluconazole Injection The metabolism of Duloxetine can be decreased when combined with Fluconazole. |
Foscarnet Injection | Foscarnet Injection Foscarnet may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Hydromorphone Injection | Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Duloxetine. |
Interferon Beta-1b Injection | Interferon Beta-1b Injection The metabolism of Duloxetine can be decreased when combined with Interferon beta-1b. |
Interferon Gamma-1b Injection | Interferon Gamma-1b Injection The metabolism of Duloxetine can be decreased when combined with Interferon gamma-1b. |
Levofloxacin Injection | Levofloxacin Injection The metabolism of Duloxetine can be decreased when combined with Levofloxacin. |
Meperidine Injection | Meperidine Injection The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Meperidine. |
Methylprednisolone Injection | Methylprednisolone Injection The metabolism of Duloxetine can be increased when combined with Methylprednisolone. |
Metoclopramide Injection | Metoclopramide Injection The risk or severity of adverse effects can be increased when Metoclopramide is combined with Duloxetine. |
Metronidazole Injection | Metronidazole Injection The metabolism of Duloxetine can be decreased when combined with Metronidazole. |
Morphine Injection | Morphine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Morphine is combined with Duloxetine. |
Pamidronate Injection | Pamidronate Injection Pamidronic acid may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Vancomycin Injection | Vancomycin Injection Duloxetine may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
Zidovudine Injection | Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Duloxetine. |
Altretamine | Altretamine Amphetamine may increase the serotonergic activities of Duloxetine. |
Cefuroxime | Cefuroxime Cefuroxime may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Cyclosporine | Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Duloxetine. |
Ondansetron | Ondansetron The metabolism of Ondansetron can be decreased when combined with Duloxetine. |
Enoxaparin Injection | Enoxaparin Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Enoxaparin. |
Granisetron | Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Duloxetine. |
Torsemide | Torsemide The risk or severity of orthostatic hypotension and syncope can be increased when Torasemide is combined with Duloxetine. |
Olanzapine | Olanzapine The risk or severity of orthostatic hypotension and syncope can be increased when Olanzapine is combined with Duloxetine. |
Alosetron | Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Duloxetine. |
Dofetilide | Dofetilide The metabolism of Dofetilide can be decreased when combined with Duloxetine. |
Entacapone | Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Duloxetine. |
Eprosartan | Eprosartan The risk or severity of orthostatic hypotension and syncope can be increased when Eprosartan is combined with Duloxetine. |
Hydroxychloroquine | Hydroxychloroquine The metabolism of Duloxetine can be decreased when combined with Hydroxychloroquine. |
Meloxicam | Meloxicam The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Meloxicam. |
Orlistat | Orlistat The metabolism of Duloxetine can be increased when combined with Orlistat. |
Oxcarbazepine | Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Duloxetine. |
Pantoprazole | Pantoprazole Pantoprazole may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Telmisartan | Telmisartan The risk or severity of orthostatic hypotension and syncope can be increased when Telmisartan is combined with Duloxetine. |
Temozolomide | Temozolomide Duloxetine may decrease the excretion rate of Temozolomide which could result in a higher serum level. |
Zaleplon | Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Duloxetine. |
Anakinra | Anakinra The metabolism of Duloxetine can be increased when combined with Anakinra. |
Desloratadine | Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Duloxetine. |
Linezolid | Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Duloxetine. |
Pentosan Polysulfate | Pentosan Polysulfate The risk or severity of hemorrhage can be increased when Duloxetine is combined with Pentosan polysulfate. |
Trimipramine | Trimipramine The metabolism of Trimipramine can be decreased when combined with Duloxetine. |
Etanercept Injection | Etanercept Injection The metabolism of Duloxetine can be increased when combined with Etanercept. |
Glycopyrrolate | Glycopyrrolate Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium. |
Modafinil | Modafinil The metabolism of Duloxetine can be increased when combined with Modafinil. |
Perindopril | Perindopril The risk or severity of orthostatic hypotension and syncope can be increased when Perindopril is combined with Duloxetine. |
Tenofovir | Tenofovir Tenofovir may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Choline magnesium trisalicylate. |
Sirolimus | Sirolimus The metabolism of Sirolimus can be decreased when combined with Duloxetine. |
Epinephrine Injection | Epinephrine Injection Duloxetine may increase the tachycardic activities of Epinephrine. |
Eplerenone | Eplerenone The risk or severity of orthostatic hypotension and syncope can be increased when Eplerenone is combined with Duloxetine. |
Escitalopram | Escitalopram The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Escitalopram. |
Olmesartan | Olmesartan The risk or severity of orthostatic hypotension and syncope can be increased when Olmesartan is combined with Duloxetine. |
Zonisamide | Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine. |
Adalimumab Injection | Adalimumab Injection The metabolism of Duloxetine can be increased when combined with Adalimumab. |
Aripiprazole | Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Duloxetine. |
Atomoxetine | Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Duloxetine. |
Dexmethylphenidate | Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Duloxetine. |
Teriparatide Injection | Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Duloxetine. |
Atazanavir | Atazanavir The metabolism of Duloxetine can be decreased when combined with Atazanavir. |
Almotriptan | Almotriptan The metabolism of Duloxetine can be decreased when combined with Almotriptan. |
Eletriptan | Eletriptan The metabolism of Eletriptan can be decreased when combined with Duloxetine. |
Mefloquine | Mefloquine The metabolism of Duloxetine can be decreased when combined with Mefloquine. |
Rosuvastatin | Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Duloxetine. |
Vardenafil | Vardenafil The metabolism of Vardenafil can be decreased when combined with Duloxetine. |
Alfuzosin | Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Duloxetine. |
Aprepitant | Aprepitant The metabolism of Duloxetine can be decreased when combined with Aprepitant. |
Emtricitabine | Emtricitabine Duloxetine may decrease the excretion rate of Emtricitabine which could result in a higher serum level. |
Interferon Beta-1a Subcutaneous Injection | Interferon Beta-1a Subcutaneous Injection The metabolism of Duloxetine can be decreased when combined with Interferon beta-1a. |
Memantine | Memantine Duloxetine may decrease the excretion rate of Memantine which could result in a higher serum level. |
Tegaserod | Tegaserod The metabolism of Tegaserod can be decreased when combined with Duloxetine. |
Tadalafil | Tadalafil Duloxetine may decrease the excretion rate of Tadalafil which could result in a higher serum level. |
Frovatriptan | Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Duloxetine. |
Gemifloxacin | Gemifloxacin The metabolism of Duloxetine can be decreased when combined with Gemifloxacin. |
Progesterone | Progesterone The metabolism of Progesterone can be decreased when combined with Duloxetine. |
Apomorphine Injection | Apomorphine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Apomorphine is combined with Duloxetine. |
Infliximab Injection | Infliximab Injection The metabolism of Duloxetine can be increased when combined with Infliximab. |
Oxandrolone | Oxandrolone The metabolism of Duloxetine can be decreased when combined with Oxandrolone. |
Protriptyline | Protriptyline The metabolism of Duloxetine can be decreased when combined with Protriptyline. |
Rifaximin | Rifaximin The metabolism of Duloxetine can be increased when combined with Rifaximin. |
Norethindrone | Norethindrone The metabolism of Norethisterone can be decreased when combined with Duloxetine. |
Tinidazole | Tinidazole Duloxetine may decrease the excretion rate of Tinidazole which could result in a higher serum level. |
Trospium | Trospium Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium. |
Bosentan | Bosentan The metabolism of Duloxetine can be increased when combined with Bosentan. |
Cefditoren | Cefditoren Duloxetine may decrease the excretion rate of Cefdinir which could result in a higher serum level. |
Cinacalcet | Cinacalcet The metabolism of Duloxetine can be decreased when combined with Cinacalcet. |
Cyanocobalamin Injection | Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Erlotinib | Erlotinib The metabolism of Erlotinib can be decreased when combined with Duloxetine. |
Eszopiclone | Eszopiclone The risk or severity of CNS depression can be increased when Duloxetine is combined with Eszopiclone. |
Ganciclovir | Ganciclovir Duloxetine may decrease the excretion rate of Ganciclovir which could result in a higher serum level. |
Insulin Aspart (rDNA Origin) Injection | Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Insulin aspart. |
Ribavirin | Ribavirin Duloxetine may decrease the excretion rate of Ribavirin which could result in a higher serum level. |
Solifenacin | Solifenacin The metabolism of Solifenacin can be decreased when combined with Duloxetine. |
Valganciclovir | Valganciclovir Duloxetine may decrease the excretion rate of Valganciclovir which could result in a higher serum level. |
Voriconazole | Voriconazole The metabolism of Duloxetine can be decreased when combined with Voriconazole. |
Adefovir | Adefovir Adefovir may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Dextroamphetamine | Dextroamphetamine Amphetamine may increase the serotonergic activities of Duloxetine. |
Entecavir | Entecavir The metabolism of Duloxetine can be decreased when combined with Entecavir. |
Peginterferon Alfa-2a Injection | Peginterferon Alfa-2a Injection The metabolism of Duloxetine can be decreased when combined with Peginterferon alfa-2a. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Duloxetine can be increased when it is combined with Peginterferon alfa-2b. |
Pramlintide Injection | Pramlintide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Pramlintide. |
Sodium Oxybate | Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Duloxetine. |
Exenatide Injection | Exenatide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Exenatide. |
Isocarboxazid | Isocarboxazid The risk or severity of orthostatic hypotension and syncope can be increased when Isocarboxazid is combined with Duloxetine. |
Ramelteon | Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Duloxetine. |
Darifenacin | Darifenacin The metabolism of Darifenacin can be decreased when combined with Duloxetine. |
Fentanyl | Fentanyl The metabolism of Fentanyl can be decreased when combined with Duloxetine. |
Pregabalin | Pregabalin The therapeutic efficacy of Duloxetine can be increased when used in combination with Pregabalin. |
Deferasirox | Deferasirox The serum concentration of Duloxetine can be increased when it is combined with Deferasirox. |
Phenylephrine | Phenylephrine Duloxetine may increase the tachycardic activities of Phenylephrine. |
Tipranavir | Tipranavir The metabolism of Tipranavir can be decreased when combined with Duloxetine. |
Felbamate | Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Duloxetine. |
Insulin Detemir (rDNA Origin) Injection | Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Insulin detemir. |
Ranolazine | Ranolazine The serum concentration of Duloxetine can be increased when it is combined with Ranolazine. |
Abatacept Injection | Abatacept Injection The metabolism of Duloxetine can be increased when combined with Abatacept. |
Rasagiline | Rasagiline The risk or severity of orthostatic hypotension and syncope can be increased when Rasagiline is combined with Duloxetine. |
Imatinib | Imatinib The metabolism of Duloxetine can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Sitagliptin. |
Varenicline | Varenicline Duloxetine may decrease the excretion rate of Varenicline which could result in a higher serum level. |
Gefitinib | Gefitinib The metabolism of Gefitinib can be decreased when combined with Duloxetine. |
Albuterol | Albuterol Duloxetine may increase the tachycardic activities of Salbutamol. |
Paliperidone | Paliperidone The metabolism of Paliperidone can be decreased when combined with Duloxetine. |
Bortezomib | Bortezomib The metabolism of Bortezomib can be decreased when combined with Duloxetine. |
Clofarabine Injection | Clofarabine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Clofarabine is combined with Duloxetine. |
Insulin Glulisine (rDNA origin) Injection | Insulin Glulisine (rDNA origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin glulisine. |
Lubiprostone | Lubiprostone Duloxetine may decrease the excretion rate of Lubiprostone which could result in a higher serum level. |
Posaconazole | Posaconazole The metabolism of Duloxetine can be decreased when combined with Posaconazole. |
Primaquine | Primaquine The metabolism of Duloxetine can be decreased when combined with Primaquine. |
Aliskiren | Aliskiren The risk or severity of orthostatic hypotension and syncope can be increased when Aliskiren is combined with Duloxetine. |
Darunavir | Darunavir The metabolism of Duloxetine can be decreased when combined with Darunavir. |
Pemetrexed Injection | Pemetrexed Injection Duloxetine may decrease the excretion rate of Pemetrexed which could result in a higher serum level. |
Dimenhydrinate | Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Duloxetine. |
Lisdexamfetamine | Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Duloxetine. |
Nabilone | Nabilone The risk or severity of orthostatic hypotension and syncope can be increased when Nabilone is combined with Duloxetine. |
Retapamulin | Retapamulin The metabolism of Retapamulin can be decreased when combined with Duloxetine. |
Sorafenib | Sorafenib The metabolism of Duloxetine can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Duloxetine can be decreased when combined with Sunitinib. |
Dronabinol | Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Duloxetine. |
Lapatinib | Lapatinib The metabolism of Lapatinib can be decreased when combined with Duloxetine. |
Levocetirizine | Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Duloxetine. |
Pegaptanib Injection | Pegaptanib Injection Duloxetine may decrease the excretion rate of Pegaptanib which could result in a higher serum level. |
Dasatinib | Dasatinib The metabolism of Dasatinib can be decreased when combined with Duloxetine. |
Mexiletine | Mexiletine The metabolism of Duloxetine can be decreased when combined with Mexiletine. |
Armodafinil | Armodafinil The metabolism of Duloxetine can be decreased when combined with Armodafinil. |
Azacitidine Injection | Azacitidine Injection Duloxetine may decrease the excretion rate of Azacitidine which could result in a higher serum level. |
Ivermectin | Ivermectin The metabolism of Duloxetine can be increased when combined with Ivermectin. |
Temsirolimus | Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Duloxetine. |
Lenalidomide | Lenalidomide Duloxetine may decrease the excretion rate of Lenalidomide which could result in a higher serum level. |
Nilotinib | Nilotinib The metabolism of Duloxetine can be decreased when combined with Nilotinib. |
Bexarotene | Bexarotene The metabolism of Duloxetine can be increased when combined with Bexarotene. |
Budesonide | Budesonide The metabolism of Duloxetine can be increased when combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Duloxetine can be decreased when combined with Chloramphenicol. |
Desmopressin | Desmopressin The risk or severity of hyponatremia can be increased when Duloxetine is combined with Desmopressin. |
OnabotulinumtoxinA Injection | OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine. |
RimabotulinumtoxinB Injection | RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Duloxetine. |
Doripenem Injection | Doripenem Injection Duloxetine may decrease the excretion rate of Doripenem which could result in a higher serum level. |
Etravirine | Etravirine The metabolism of Duloxetine can be increased when combined with Etravirine. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of orthostatic hypotension and syncope can be increased when Arsenic trioxide is combined with Duloxetine. |
Mitoxantrone Injection | Mitoxantrone Injection The metabolism of Duloxetine can be decreased when combined with Mitoxantrone. |
Desvenlafaxine | Desvenlafaxine The risk or severity of adverse effects can be increased when Duloxetine is combined with Desvenlafaxine. |
Cevimeline | Cevimeline The metabolism of Duloxetine can be decreased when combined with Cevimeline. |
Nebivolol | Nebivolol The risk or severity of orthostatic hypotension and syncope can be increased when Nebivolol is combined with Duloxetine. |
Tretinoin | Tretinoin The risk or severity of orthostatic hypotension and syncope can be increased when Tretinoin is combined with Duloxetine. |
Bendamustine Injection | Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Duloxetine. |
Pilocarpine | Pilocarpine The metabolism of Duloxetine can be decreased when combined with Pilocarpine. |
Flecainide | Flecainide The metabolism of Flecainide can be decreased when combined with Duloxetine. |
Certolizumab Injection | Certolizumab Injection The metabolism of Duloxetine can be increased when combined with Certolizumab pegol. |
Ixabepilone Injection | Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Duloxetine. |
Irinotecan Injection | Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Duloxetine. |
Daptomycin Injection | Daptomycin Injection Daptomycin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Praziquantel | Praziquantel The metabolism of Praziquantel can be decreased when combined with Duloxetine. |
Mitotane | Mitotane The metabolism of Duloxetine can be increased when combined with Mitotane. |
Methylnaltrexone Injection | Methylnaltrexone Injection Duloxetine may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. |
Rufinamide | Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Duloxetine. |
Midazolam | Midazolam The serum concentration of Midazolam can be increased when it is combined with Duloxetine. |
Naltrexone Injection | Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Naltrexone. |
Dexrazoxane Injection | Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Eltrombopag | Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Duloxetine. |
Milnacipran | Milnacipran The risk or severity of adverse effects can be increased when Duloxetine is combined with Milnacipran. |
Plerixafor Injection | Plerixafor Injection Duloxetine may decrease the excretion rate of Plerixafor which could result in a higher serum level. |
Fesoterodine | Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Duloxetine. |
Betaxolol | Betaxolol The risk or severity of orthostatic hypotension and syncope can be increased when Betaxolol is combined with Duloxetine. |
Iloperidone | Iloperidone The metabolism of Iloperidone can be decreased when combined with Duloxetine. |
Prasugrel | Prasugrel The risk or severity of hemorrhage can be increased when Duloxetine is combined with Prasugrel. |
Lacosamide | Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Duloxetine. |
Everolimus | Everolimus The metabolism of Everolimus can be decreased when combined with Duloxetine. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The metabolism of Duloxetine can be decreased when combined with Tolvaptan. |
Dronedarone | Dronedarone The metabolism of Dronedarone can be decreased when combined with Duloxetine. |
AbobotulinumtoxinA Injection | AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine. |
Pralatrexate Injection | Pralatrexate Injection Duloxetine may decrease the excretion rate of Pralatrexate which could result in a higher serum level. |
Palonosetron Injection | Palonosetron Injection The metabolism of Duloxetine can be decreased when combined with Palonosetron. |
Saxagliptin | Saxagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Saxagliptin. |
Telavancin Injection | Telavancin Injection Duloxetine may decrease the excretion rate of Telavancin which could result in a higher serum level. |
Romidepsin Injection | Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Duloxetine. |
Tapentadol | Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Duloxetine. |
Topotecan | Topotecan The metabolism of Duloxetine can be decreased when combined with Topotecan. |
Golimumab Injection | Golimumab Injection The metabolism of Duloxetine can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The metabolism of Duloxetine can be decreased when combined with Pazopanib. |
Asenapine | Asenapine The risk or severity of adverse effects can be increased when Duloxetine is combined with Asenapine. |
Vigabatrin | Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Duloxetine. |
Pitavastatin | Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Duloxetine. |
Albendazole | Albendazole The metabolism of Albendazole can be decreased when combined with Duloxetine. |
Oxymorphone | Oxymorphone The risk or severity of serotonin syndrome can be increased when Oxymorphone is combined with Duloxetine. |
Dabigatran | Dabigatran The risk or severity of hemorrhage can be increased when Duloxetine is combined with Dabigatran. |
Liraglutide Injection | Liraglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Liraglutide. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Duloxetine can be increased when combined with Tocilizumab. |
Dalfampridine | Dalfampridine Duloxetine may decrease the excretion rate of Dalfampridine which could result in a higher serum level. |
IncobotulinumtoxinA Injection | IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine. |
Cabazitaxel Injection | Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Duloxetine. |
Ceftaroline Injection | Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Lurasidone | Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Duloxetine. |
Acetaminophen Injection | Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Duloxetine. |
Vilazodone | Vilazodone The metabolism of Vilazodone can be decreased when combined with Duloxetine. |
Ipilimumab Injection | Ipilimumab Injection Duloxetine may decrease the excretion rate of Ipilimumab which could result in a higher serum level. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The risk or severity of orthostatic hypotension and syncope can be increased when Aldesleukin is combined with Duloxetine. |
Terbutaline Injection | Terbutaline Injection Duloxetine may increase the tachycardic activities of Terbutaline. |
Azilsartan | Azilsartan The risk or severity of orthostatic hypotension and syncope can be increased when Azilsartan medoxomil is combined with Duloxetine. |
Busulfan Injection | Busulfan Injection The metabolism of Busulfan can be decreased when combined with Duloxetine. |
Roflumilast | Roflumilast The metabolism of Roflumilast can be decreased when combined with Duloxetine. |
Linagliptin | Linagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Linagliptin. |
Rilpivirine | Rilpivirine The metabolism of Duloxetine can be decreased when combined with Rilpivirine. |
Telaprevir | Telaprevir The metabolism of Duloxetine can be decreased when combined with Glecaprevir. |
Potassium Iodide | Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Duloxetine. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Duloxetine can be decreased when combined with Cyclophosphamide. |
Abiraterone | Abiraterone The metabolism of Duloxetine can be decreased when combined with Abiraterone. |
Rivaroxaban | Rivaroxaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Rivaroxaban. |
Ticagrelor | Ticagrelor The risk or severity of hemorrhage can be increased when Duloxetine is combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The metabolism of Duloxetine can be decreased when combined with Brentuximab vedotin. |
Ruxolitinib | Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Duloxetine. |
Vandetanib | Vandetanib The metabolism of Vandetanib can be decreased when combined with Duloxetine. |
Clobazam | Clobazam The metabolism of Duloxetine can be decreased when combined with Clobazam. |
Vemurafenib | Vemurafenib The serum concentration of Duloxetine can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib The metabolism of Duloxetine can be decreased when combined with Vismodegib. |
Ivacaftor | Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Duloxetine. |
Deferiprone | Deferiprone Duloxetine may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
Axitinib | Axitinib The metabolism of Axitinib can be decreased when combined with Duloxetine. |
Crizotinib | Crizotinib The metabolism of Duloxetine can be decreased when combined with Crizotinib. |
Cabergoline | Cabergoline The metabolism of Duloxetine can be decreased when combined with Cabergoline. |
Naloxone Injection | Naloxone Injection The metabolism of Duloxetine can be decreased when combined with Naloxone. |
Fondaparinux Injection | Fondaparinux Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Fondaparinux. |
Ezogabine | Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Duloxetine. |
Iloprost | Iloprost The risk or severity of orthostatic hypotension and syncope can be increased when Iloprost is combined with Duloxetine. |
Enzalutamide | Enzalutamide The metabolism of Duloxetine can be increased when combined with Enzalutamide. |
Mirabegron | Mirabegron The metabolism of Mirabegron can be decreased when combined with Duloxetine. |
Regorafenib | Regorafenib The metabolism of Duloxetine can be decreased when combined with Regorafenib. |
Bosutinib | Bosutinib The metabolism of Duloxetine can be decreased when combined with Bosutinib. |
Corticotropin, Repository Injection | Corticotropin, Repository Injection The metabolism of Duloxetine can be increased when combined with Corticotropin. |
Teriflunomide | Teriflunomide The serum concentration of Duloxetine can be decreased when it is combined with Teriflunomide. |
Lorcaserin | Lorcaserin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Mecasermin. |
Cabozantinib (thyroid cancer) | Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Duloxetine. |
Teduglutide Injection | Teduglutide Injection Duloxetine may decrease the excretion rate of Teduglutide which could result in a higher serum level. |
Icosapent Ethyl | Icosapent Ethyl Duloxetine may increase the antiplatelet activities of Icosapent ethyl. |
Tofacitinib | Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Duloxetine. |
Alogliptin | Alogliptin The metabolism of Alogliptin can be decreased when combined with Duloxetine. |
Ponatinib | Ponatinib The metabolism of Ponatinib can be decreased when combined with Duloxetine. |
Pomalidomide | Pomalidomide The metabolism of Duloxetine can be decreased when combined with Pomalidomide. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The metabolism of Duloxetine can be decreased when combined with Trastuzumab emtansine. |
Apixaban | Apixaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Apixaban. |
Canagliflozin | Canagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Canagliflozin is combined with Duloxetine. |
Methazolamide | Methazolamide The risk or severity of orthostatic hypotension and syncope can be increased when Methazolamide is combined with Duloxetine. |
Dabrafenib | Dabrafenib The metabolism of Duloxetine can be decreased when combined with Dabrafenib. |
Ospemifene | Ospemifene The metabolism of Ospemifene can be decreased when combined with Duloxetine. |
Trametinib | Trametinib The metabolism of Trametinib can be increased when combined with Duloxetine. |
Levomilnacipran | Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Duloxetine. |
Ertapenem Injection | Ertapenem Injection Ertapenem may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Vortioxetine | Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Duloxetine. |
Perampanel | Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Duloxetine. |
Ibrutinib | Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Duloxetine. |
Lomitapide | Lomitapide The metabolism of Lomitapide can be decreased when combined with Duloxetine. |
Ketorolac Injection | Ketorolac Injection The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ketorolac. |
Obinutuzumab Injection | Obinutuzumab Injection The risk or severity of orthostatic hypotension and syncope can be increased when Obinutuzumab is combined with Duloxetine. |
Simeprevir | Simeprevir The metabolism of Duloxetine can be decreased when combined with Simeprevir. |
Sofosbuvir | Sofosbuvir Duloxetine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
Dapagliflozin | Dapagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Dapagliflozin is combined with Duloxetine. |
Apremilast | Apremilast The metabolism of Duloxetine can be increased when combined with Apremilast. |
Droxidopa | Droxidopa Duloxetine may increase the tachycardic activities of Droxidopa. |
Ceritinib | Ceritinib The metabolism of Ceritinib can be decreased when combined with Duloxetine. |
Siltuximab Injection | Siltuximab Injection The metabolism of Duloxetine can be increased when combined with Siltuximab. |
Albiglutide Injection | Albiglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Albiglutide. |
Eslicarbazepine | Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Duloxetine. |
Belinostat Injection | Belinostat Injection The metabolism of Duloxetine can be increased when combined with Belinostat. |
Idelalisib | Idelalisib The metabolism of Idelalisib can be decreased when combined with Duloxetine. |
Testosterone Injection | Testosterone Injection The metabolism of Testosterone can be increased when combined with Duloxetine. |
Oritavancin Injection | Oritavancin Injection The metabolism of Duloxetine can be increased when combined with Oritavancin. |
Empagliflozin | Empagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Empagliflozin is combined with Duloxetine. |
Vorapaxar | Vorapaxar The risk or severity of hemorrhage can be increased when Duloxetine is combined with Vorapaxar. |
Hydrocodone | Hydrocodone Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
Suvorexant | Suvorexant Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
Dulaglutide Injection | Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Dulaglutide. |
Edoxaban | Edoxaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Edoxaban. |
Peginterferon Beta-1a Injection | Peginterferon Beta-1a Injection The metabolism of Duloxetine can be decreased when combined with Peginterferon beta-1a. |
Olaparib | Olaparib The metabolism of Duloxetine can be decreased when combined with Olaparib. |
Methamphetamine | Methamphetamine The metabolism of Duloxetine can be decreased when combined with Metamfetamine. |
Tasimelteon | Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Duloxetine. |
Riociguat | Riociguat The risk or severity of orthostatic hypotension and syncope can be increased when Riociguat is combined with Duloxetine. |
Lanreotide Injection | Lanreotide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Lanreotide. |
Pirfenidone | Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Duloxetine. |
Nintedanib | Nintedanib The metabolism of Nintedanib can be decreased when combined with Duloxetine. |
Secukinumab Injection | Secukinumab Injection The metabolism of Duloxetine can be increased when combined with Secukinumab. |
Risperidone Injection | Risperidone Injection The metabolism of Risperidone can be decreased when combined with Duloxetine. |
Palbociclib | Palbociclib The metabolism of Duloxetine can be decreased when combined with Palbociclib. |
Insulin Human Inhalation | Insulin Human Inhalation The metabolism of Duloxetine can be increased when combined with Insulin human. |
Lenvatinib | Lenvatinib The metabolism of Duloxetine can be decreased when combined with Lenvatinib. |
Naloxegol | Naloxegol The metabolism of Duloxetine can be decreased when combined with Naloxegol. |
Panobinostat | Panobinostat The metabolism of Panobinostat can be decreased when combined with Duloxetine. |
Dinutuximab Injection | Dinutuximab Injection The risk or severity of orthostatic hypotension and syncope can be increased when Dinutuximab is combined with Duloxetine. |
Haloperidol Injection | Haloperidol Injection The risk or severity of CNS depression can be increased when Duloxetine is combined with Haloperidol. |
Amiloride | Amiloride The risk or severity of orthostatic hypotension and syncope can be increased when Amiloride is combined with Duloxetine. |
Isavuconazonium Injection | Isavuconazonium Injection The metabolism of Duloxetine can be increased when combined with Isavuconazonium. |
Macitentan | Macitentan Duloxetine may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Sonidegib | Sonidegib The metabolism of Sonidegib can be decreased when combined with Duloxetine. |
Flibanserin | Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Duloxetine. |
Rolapitant | Rolapitant The metabolism of Duloxetine can be decreased when combined with Rolapitant. |
Prednisolone | Prednisolone The metabolism of Duloxetine can be increased when combined with Prednisolone. |
Brexpiprazole | Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Duloxetine. |
Ziprasidone Injection | Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Duloxetine. |
Cariprazine | Cariprazine The metabolism of Cariprazine can be decreased when combined with Duloxetine. |
Penicillin G Procaine Injection | Penicillin G Procaine Injection Duloxetine may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. |
Eluxadoline | Eluxadoline The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Eluxadoline. |
Insulin Degludec (rDNA Origin) Injection | Insulin Degludec (rDNA Origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin degludec. |
Cobimetinib | Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Duloxetine. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Duloxetine. |
Osimertinib | Osimertinib The serum concentration of Duloxetine can be decreased when it is combined with Osimertinib. |
Alectinib | Alectinib The metabolism of Alectinib can be decreased when combined with Duloxetine. |
Ixazomib | Ixazomib The metabolism of Ixazomib can be decreased when combined with Duloxetine. |
Rifapentine | Rifapentine The metabolism of Duloxetine can be increased when combined with Rifapentine. |
Lesinurad | Lesinurad The metabolism of Lesinurad can be increased when combined with Duloxetine. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amphotericin B is combined with Duloxetine. |
Dexamethasone Injection | Dexamethasone Injection The metabolism of Duloxetine can be increased when combined with Dexamethasone. |
Defibrotide Injection | Defibrotide Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Defibrotide. |
Brivaracetam Injection | Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Duloxetine. |
Venetoclax | Venetoclax The metabolism of Duloxetine can be decreased when combined with Venetoclax. |
Cobicistat | Cobicistat The metabolism of Duloxetine can be decreased when combined with Cobicistat. |
Midodrine | Midodrine Duloxetine may increase the tachycardic activities of Midodrine. |
Pimavanserin | Pimavanserin The risk or severity of adverse effects can be increased when Duloxetine is combined with Pimavanserin. |
Obeticholic Acid | Obeticholic Acid The metabolism of Duloxetine can be decreased when combined with Obeticholic acid. |
Diphenhydramine Injection | Diphenhydramine Injection The metabolism of Duloxetine can be decreased when combined with Diphenhydramine. |
Furosemide Injection | Furosemide Injection The risk or severity of orthostatic hypotension and syncope can be increased when Furosemide is combined with Duloxetine. |
Rucaparib | Rucaparib The metabolism of Rucaparib can be decreased when combined with Duloxetine. |
Lixisenatide Injection | Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Lixisenatide. |
Ribociclib | Ribociclib The metabolism of Duloxetine can be decreased when combined with Ribociclib. |
Parathyroid Hormone Injection | Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Duloxetine. |
Brigatinib | Brigatinib The metabolism of Duloxetine can be decreased when combined with Brigatinib. |
Doxepin (Insomnia) | Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Duloxetine. |
Deutetrabenazine | Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Duloxetine. |
Valbenazine | Valbenazine The metabolism of Valbenazine can be decreased when combined with Duloxetine. |
Deflazacort | Deflazacort The metabolism of Duloxetine can be increased when combined with Deflazacort. |
Safinamide | Safinamide Safinamide may increase the serotonergic activities of Duloxetine. |
Naldemedine | Naldemedine Duloxetine may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
Sarilumab Injection | Sarilumab Injection The metabolism of Duloxetine can be increased when combined with Sarilumab. |
Midostaurin | Midostaurin The metabolism of Duloxetine can be decreased when combined with Midostaurin. |
Neratinib | Neratinib The metabolism of Neratinib can be decreased when combined with Duloxetine. |
Abaloparatide Injection | Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Duloxetine. |
Enasidenib | Enasidenib The metabolism of Duloxetine can be decreased when combined with Enasidenib. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The metabolism of Duloxetine can be increased when combined with Fosaprepitant. |
Benznidazole | Benznidazole Duloxetine may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
Copanlisib Injection | Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Duloxetine. |
Delafloxacin | Delafloxacin Duloxetine may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
Abemaciclib | Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Duloxetine. |
Betrixaban | Betrixaban The risk or severity of bleeding can be increased when Duloxetine is combined with Betrixaban. |
Acalabrutinib | Acalabrutinib The metabolism of Duloxetine can be decreased when combined with Acalabrutinib. |
Letermovir | Letermovir The metabolism of Letermovir can be decreased when combined with Duloxetine. |
Semaglutide Injection | Semaglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Semaglutide. |
Tetrabenazine | Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Duloxetine. |
Ertugliflozin | Ertugliflozin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Ertugliflozin. |
Buprenorphine Injection | Buprenorphine Injection Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
Apalutamide | Apalutamide The metabolism of Duloxetine can be increased when combined with Apalutamide. |
Fostamatinib | Fostamatinib The metabolism of Duloxetine can be decreased when combined with Fostamatinib. |
Avatrombopag | Avatrombopag The metabolism of Duloxetine can be increased when combined with Avatrombopag. |
Baricitinib | Baricitinib The metabolism of Baricitinib can be decreased when combined with Duloxetine. |
Lofexidine | Lofexidine The therapeutic efficacy of Duloxetine can be increased when used in combination with Lofexidine. |
Plazomicin Injection | Plazomicin Injection Duloxetine may decrease the excretion rate of Plazomicin which could result in a higher serum level. |
Eliglustat | Eliglustat The metabolism of Eliglustat can be decreased when combined with Duloxetine. |
Encorafenib | Encorafenib The metabolism of Encorafenib can be decreased when combined with Duloxetine. |
Binimetinib | Binimetinib The metabolism of Binimetinib can be decreased when combined with Duloxetine. |
Ivosidenib | Ivosidenib The metabolism of Duloxetine can be decreased when combined with Ivosidenib. |
Elagolix | Elagolix The metabolism of Elagolix can be decreased when combined with Duloxetine. |
Tafenoquine | Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Duloxetine. |
Cannabidiol | Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Duloxetine. |
Dacomitinib | Dacomitinib The metabolism of Duloxetine can be decreased when combined with Dacomitinib. |
Duvelisib | Duvelisib The metabolism of Duvelisib can be decreased when combined with Duloxetine. |
Stiripentol | Stiripentol The metabolism of Duloxetine can be decreased when combined with Stiripentol. |
Gilteritinib | Gilteritinib The therapeutic efficacy of Duloxetine can be decreased when used in combination with Gilteritinib. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The risk or severity of orthostatic hypotension and syncope can be increased when Paclitaxel is combined with Duloxetine. |
Rifamycin | Rifamycin The metabolism of Duloxetine can be increased when combined with Rifamycin. |
Prucalopride | Prucalopride The metabolism of Prucalopride can be decreased when combined with Duloxetine. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Duloxetine can be increased when combined with Emapalumab. |
Siponimod | Siponimod The metabolism of Siponimod can be decreased when combined with Duloxetine. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Caplacizumab-yhdp Injection | Caplacizumab-yhdp Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Caplacizumab. |
Erdafitinib | Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Duloxetine. |
Alpelisib | Alpelisib The serum concentration of Duloxetine can be decreased when it is combined with Alpelisib. |
Brexanolone Injection | Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Duloxetine. |
Solriamfetol | Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Duloxetine. |
Triclabendazole | Triclabendazole The metabolism of Duloxetine can be decreased when combined with Triclabendazole. |
Entrectinib | Entrectinib The metabolism of Entrectinib can be decreased when combined with Duloxetine. |
Pexidartinib | Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Duloxetine. |
Istradefylline | Istradefylline The metabolism of Istradefylline can be decreased when combined with Duloxetine. |
Pitolisant | Pitolisant The serum concentration of Duloxetine can be decreased when it is combined with Pitolisant. |
Fedratinib | Fedratinib The metabolism of Duloxetine can be decreased when combined with Fedratinib. |
Lefamulin | Lefamulin The metabolism of Lefamulin can be decreased when combined with Duloxetine. |
Phenytoin Injection | Phenytoin Injection The metabolism of Duloxetine can be increased when combined with Phenytoin. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Duloxetine can be increased when combined with Fosphenytoin. |
Zanubrutinib | Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Duloxetine. |
Voxelotor | Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Duloxetine. |
Avapritinib | Avapritinib The metabolism of Avapritinib can be decreased when combined with Duloxetine. |
Lumateperone | Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Duloxetine. |
Lasmiditan | Lasmiditan The risk or severity of serotonin syndrome can be increased when Lasmiditan is combined with Duloxetine. |
Ubrogepant | Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Duloxetine. |
Tazemetostat | Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Duloxetine. |
Cenobamate | Cenobamate The serum concentration of Duloxetine can be decreased when it is combined with Cenobamate. |
Selumetinib | Selumetinib The metabolism of Selumetinib can be decreased when combined with Duloxetine. |
Tucatinib | Tucatinib The metabolism of Tucatinib can be decreased when combined with Duloxetine. |
Capmatinib | Capmatinib The metabolism of Duloxetine can be decreased when combined with Capmatinib. |
Lemborexant | Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Duloxetine. |
Fenfluramine | Fenfluramine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Fenfluramine. |
Octreotide | Octreotide The metabolism of Duloxetine can be decreased when combined with Octreotide. |
Pralsetinib | Pralsetinib The metabolism of Duloxetine can be increased when combined with Pralsetinib. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Duloxetine can be decreased when it is combined with Satralizumab. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Duloxetine. |
Viloxazine | Viloxazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Viloxazine. |
Vitamin E (Alpha-Tocopherol) | Vitamin E (Alpha-Tocopherol) The metabolism of Vitamin E can be increased when combined with Duloxetine. |
Tobramycin Injection | Tobramycin Injection Tobramycin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Duloxetine. |
Fenoprofen | Fenoprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Fenoprofen. |
Indomethacin | Indomethacin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Indomethacin. |
Mefenamic Acid | Mefenamic Acid The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Mefenamic acid. |
Naproxen | Naproxen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Naproxen. |
Tolmetin | Tolmetin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Tolmetin. |
Sulindac | Sulindac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Sulindac. |
Trazodone | Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Duloxetine. |
Isotretinoin | Isotretinoin Duloxetine may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
Sucralfate | Sucralfate Sucralfate may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Hydroxyurea | Hydroxyurea The metabolism of Duloxetine can be decreased when combined with Hydroxyurea. |
Floxuridine | Floxuridine The metabolism of Duloxetine can be decreased when combined with Floxuridine. |
Phenobarbital | Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Duloxetine. |
Metaxalone | Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Duloxetine. |
Methotrexate Injection | Methotrexate Injection The metabolism of Duloxetine can be decreased when combined with Methotrexate. |
Levorphanol | Levorphanol The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Duloxetine. |
Primidone | Primidone The metabolism of Duloxetine can be increased when combined with Primidone. |
Methsuximide | Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Duloxetine. |
Diethylpropion | Diethylpropion The risk or severity of adverse effects can be increased when Duloxetine is combined with Diethylpropion. |
Chlorpromazine | Chlorpromazine The risk or severity of orthostatic hypotension and syncope can be increased when Chlorpromazine is combined with Duloxetine. |
Diazepam | Diazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Diazepam. |
Oxazepam | Oxazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Oxazepam. |
Flurazepam | Flurazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Flurazepam. |
Clorazepate | Clorazepate The risk or severity of adverse effects can be increased when Duloxetine is combined with Clorazepic acid. |
Lorazepam | Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Duloxetine. |
Phenoxybenzamine | Phenoxybenzamine The risk or severity of orthostatic hypotension and syncope can be increased when Phenoxybenzamine is combined with Duloxetine. |
Carmustine | Carmustine The metabolism of Duloxetine can be decreased when combined with Carmustine. |
Amantadine | Amantadine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Amantadine. |
Codeine | Codeine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Codeine. |
Meprobamate | Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Duloxetine. |
Chlordiazepoxide | Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Duloxetine. |
Bromocriptine | Bromocriptine The risk or severity of orthostatic hypotension and syncope can be increased when Bromocriptine is combined with Duloxetine. |
Metaproterenol | Metaproterenol Duloxetine may increase the tachycardic activities of Orciprenaline. |
Tranylcypromine | Tranylcypromine The risk or severity of orthostatic hypotension and syncope can be increased when Tranylcypromine is combined with Duloxetine. |
Phenelzine | Phenelzine The risk or severity of orthostatic hypotension and syncope can be increased when Phenelzine is combined with Duloxetine. |
Procarbazine | Procarbazine Procarbazine may increase the serotonergic activities of Duloxetine. |
Ergoloid Mesylates | Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Duloxetine. |
Tetracycline | Tetracycline The metabolism of Duloxetine can be decreased when combined with Tetracycline. |
Minocycline | Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Duloxetine. |
Prochlorperazine | Prochlorperazine The metabolism of Duloxetine can be decreased when combined with Prochlorperazine. |
Thioridazine | Thioridazine The risk or severity of orthostatic hypotension and syncope can be increased when Thioridazine is combined with Duloxetine. |
Trifluoperazine | Trifluoperazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Trifluoperazine. |
Bleomycin | Bleomycin Bleomycin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Dapsone | Dapsone The metabolism of Duloxetine can be decreased when combined with Dapsone. |
Sulfadiazine | Sulfadiazine The risk or severity of hypoglycemia can be increased when Sulfadiazine is combined with Duloxetine. |
Oxycodone | Oxycodone The risk or severity of serotonin syndrome can be increased when Oxycodone is combined with Duloxetine. |
Methadone | Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Duloxetine. |
Oxybutynin | Oxybutynin The metabolism of Duloxetine can be decreased when combined with Oxybutynin. |
Benztropine | Benztropine The metabolism of Duloxetine can be decreased when combined with Benzatropine. |
Maprotiline | Maprotiline The metabolism of Maprotiline can be decreased when combined with Duloxetine. |
Ibuprofen | Ibuprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ibuprofen. |
Trihexyphenidyl | Trihexyphenidyl Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl. |
Orphenadrine | Orphenadrine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
Perphenazine | Perphenazine The metabolism of Perphenazine can be decreased when combined with Duloxetine. |
Azathioprine | Azathioprine The metabolism of Azathioprine can be decreased when combined with Duloxetine. |
Fluphenazine | Fluphenazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Fluphenazine. |
Phentermine | Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Duloxetine. |
Methylphenidate | Methylphenidate Methylphenidate may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Amoxapine | Amoxapine The metabolism of Amoxapine can be decreased when combined with Duloxetine. |
Sulfasalazine | Sulfasalazine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Sulfasalazine. |
Hydrocortisone | Hydrocortisone The metabolism of Duloxetine can be increased when combined with Hydrocortisone. |
Doxorubicin | Doxorubicin The metabolism of Duloxetine can be decreased when combined with Doxorubicin. |
Phenazopyridine | Phenazopyridine Phenazopyridine may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Carbamazepine | Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Duloxetine. |
Molindone | Molindone The risk or severity of adverse effects can be increased when Duloxetine is combined with Molindone. |
Methyldopa | Methyldopa The risk or severity of orthostatic hypotension and syncope can be increased when Methyldopa is combined with Duloxetine. |
Clonidine | Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Duloxetine. |
Prazosin | Prazosin The risk or severity of orthostatic hypotension and syncope can be increased when Prazosin is combined with Duloxetine. |
Hydralazine | Hydralazine The risk or severity of orthostatic hypotension and syncope can be increased when Hydralazine is combined with Duloxetine. |
Cimetidine | Cimetidine The metabolism of Cimetidine can be decreased when combined with Duloxetine. |
Gentamicin Injection | Gentamicin Injection Gentamicin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Warfarin | Warfarin The serum concentration of Warfarin can be increased when it is combined with Duloxetine. |
Clonazepam | Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Duloxetine. |
Loperamide | Loperamide The metabolism of Duloxetine can be decreased when combined with Loperamide. |
Promethazine | Promethazine The metabolism of Duloxetine can be decreased when combined with Promethazine. |
Meclofenamate | Meclofenamate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Meclofenamic acid. |
Daunorubicin | Daunorubicin The metabolism of Duloxetine can be decreased when combined with Daunorubicin. |
Nitrofurantoin | Nitrofurantoin Duloxetine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level. |
Griseofulvin | Griseofulvin The metabolism of Duloxetine can be increased when combined with Griseofulvin. |
Digoxin | Digoxin Digoxin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Loxapine | Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Duloxetine. |
Chloroquine | Chloroquine The metabolism of Chloroquine can be decreased when combined with Duloxetine. |
Quinine | Quinine The metabolism of Quinine can be decreased when combined with Duloxetine. |
Ethosuximide | Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Duloxetine. |
Calcitriol | Calcitriol The metabolism of Duloxetine can be increased when combined with Calcitriol. |
Triamterene | Triamterene The risk or severity of orthostatic hypotension and syncope can be increased when Triamterene is combined with Duloxetine. |
Sulfinpyrazone | Sulfinpyrazone Duloxetine may increase the antiplatelet activities of Sulfinpyrazone. |
Chlorothiazide | Chlorothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Chlorothiazide is combined with Duloxetine. |
Chlorthalidone | Chlorthalidone The risk or severity of orthostatic hypotension and syncope can be increased when Chlorthalidone is combined with Duloxetine. |
Metolazone | Metolazone The risk or severity of orthostatic hypotension and syncope can be increased when Metolazone is combined with Duloxetine. |
Isosorbide | Isosorbide Isosorbide may increase the excretion rate of Duloxetine which could result in a lower serum level and potentially a reduction in efficacy. |
Secobarbital | Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Duloxetine. |
Desipramine | Desipramine The metabolism of Desipramine can be decreased when combined with Duloxetine. |
Amitriptyline | Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Duloxetine. |
Imipramine | Imipramine The risk or severity of orthostatic hypotension and syncope can be increased when Imipramine is combined with Duloxetine. |
Probenecid | Probenecid The metabolism of Probenecid can be increased when combined with Duloxetine. |
Quinidine | Quinidine The metabolism of Duloxetine can be decreased when combined with Quinidine. |
Procainamide | Procainamide The metabolism of Procainamide can be decreased when combined with Duloxetine. |
Isoniazid | Isoniazid The metabolism of Duloxetine can be decreased when combined with Isoniazid. |
Pyrazinamide | Pyrazinamide Pyrazinamide may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Rifampin | Rifampin The metabolism of Duloxetine can be increased when combined with Rifampicin. |
Disopyramide | Disopyramide The metabolism of Duloxetine can be decreased when combined with Disopyramide. |
Valproic Acid | Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Duloxetine. |
Tamoxifen | Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Duloxetine. |
Butabarbital | Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Duloxetine. |
Levothyroxine | Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Duloxetine. |
Liothyronine | Liothyronine Liothyronine may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Methimazole | Methimazole The metabolism of Duloxetine can be decreased when combined with Methimazole. |
Propylthiouracil | Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Duloxetine. |
Chlorpropamide | Chlorpropamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Chlorpropamide. |
Tolbutamide | Tolbutamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Tolbutamide. |
Tolazamide | Tolazamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Tolazamide. |
Dextromethorphan | Dextromethorphan The metabolism of Duloxetine can be decreased when combined with Dextromethorphan. |
Cyclobenzaprine | Cyclobenzaprine The risk or severity of CNS depression can be increased when Duloxetine is combined with Cyclobenzaprine. |
Niacin | Niacin The metabolism of Duloxetine can be decreased when combined with Niacin. |
Baclofen | Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Duloxetine. |
Doxylamine | Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Duloxetine. |
Cyproheptadine | Cyproheptadine The therapeutic efficacy of Duloxetine can be decreased when used in combination with Cyproheptadine. |
Clemastine | Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Duloxetine. |
Chlorpheniramine | Chlorpheniramine The metabolism of Duloxetine can be decreased when combined with Chlorpheniramine. |
Brompheniramine | Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Duloxetine. |
Meclizine | Meclizine The metabolism of Duloxetine can be decreased when combined with Meclizine. |
Ethambutol | Ethambutol Ethambutol may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Methyclothiazide | Methyclothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Methyclothiazide is combined with Duloxetine. |
Hydrochlorothiazide | Hydrochlorothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Hydrochlorothiazide is combined with Duloxetine. |
Dantrolene | Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Duloxetine. |
Chlorzoxazone | Chlorzoxazone The metabolism of Duloxetine can be decreased when combined with Chlorzoxazone. |
Carisoprodol | Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Duloxetine. |
Methocarbamol | Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Duloxetine. |
Pyridoxine | Pyridoxine Pyridoxine may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Folic Acid | Folic Acid Folic acid may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Danazol | Danazol The metabolism of Duloxetine can be decreased when combined with Danazol. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) The risk or severity of orthostatic hypotension and syncope can be increased when Propranolol is combined with Duloxetine. |
Minoxidil | Minoxidil The risk or severity of orthostatic hypotension and syncope can be increased when Minoxidil is combined with Duloxetine. |
Pseudoephedrine | Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Pseudoephedrine. |
Nortriptyline | Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Duloxetine. |
Spironolactone | Spironolactone The risk or severity of orthostatic hypotension and syncope can be increased when Spironolactone is combined with Duloxetine. |
Amphotericin B Injection | Amphotericin B Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amphotericin B is combined with Duloxetine. |
Phytonadione | Phytonadione Duloxetine may decrease the excretion rate of Phylloquinone which could result in a higher serum level. |
Amikacin Injection | Amikacin Injection Amikacin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Nadolol | Nadolol The risk or severity of orthostatic hypotension and syncope can be increased when Nadolol is combined with Duloxetine. |
Butorphanol Injection | Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Butorphanol is combined with Duloxetine. |
Nalbuphine Injection | Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Nalbuphine is combined with Duloxetine. |
Allopurinol | Allopurinol Allopurinol may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Trimethobenzamide | Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Duloxetine. |
Flavoxate | Flavoxate Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Flavoxate. |
Papaverine | Papaverine The risk or severity of orthostatic hypotension and syncope can be increased when Papaverine is combined with Duloxetine. |
Fluorouracil Injection | Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Duloxetine. |
Colchicine | Colchicine The metabolism of Colchicine can be decreased when combined with Duloxetine. |
Cefaclor | Cefaclor Cefaclor may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Cefadroxil | Cefadroxil Cefadroxil may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Cefazolin Injection | Cefazolin Injection Cefazolin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Cephalexin | Cephalexin Cephalexin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Cefoxitin Injection | Cefoxitin Injection Cefoxitin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Dacarbazine | Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Duloxetine. |
Acetazolamide | Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Duloxetine. |
Cefotaxime Injection | Cefotaxime Injection Cefotaxime may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Ketoconazole | Ketoconazole The metabolism of Duloxetine can be decreased when combined with Ketoconazole. |
Pyrantel | Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Duloxetine. |
Thiotepa Injection | Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Duloxetine. |
Vincristine Injection | Vincristine Injection The metabolism of Vincristine can be decreased when combined with Duloxetine. |
Captopril | Captopril The risk or severity of orthostatic hypotension and syncope can be increased when Captopril is combined with Duloxetine. |
Dipyridamole | Dipyridamole The risk or severity of orthostatic hypotension and syncope can be increased when Dipyridamole is combined with Duloxetine. |
Isoxsuprine | Isoxsuprine The risk or severity of orthostatic hypotension and syncope can be increased when Isoxsuprine is combined with Duloxetine. |
Vinblastine | Vinblastine The metabolism of Duloxetine can be decreased when combined with Vinblastine. |
Ethacrynic Acid | Ethacrynic Acid The risk or severity of orthostatic hypotension and syncope can be increased when Etacrynic acid is combined with Duloxetine. |
Colistimethate Injection | Colistimethate Injection Colistimethate may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Metoprolol | Metoprolol The risk or severity of orthostatic hypotension and syncope can be increased when Metoprolol is combined with Duloxetine. |
Hydroxyzine | Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Duloxetine. |
Thiothixene | Thiothixene The risk or severity of adverse effects can be increased when Duloxetine is combined with Thiothixene. |
Aspirin | Aspirin Duloxetine may increase the antiplatelet activities of Acetylsalicylic acid. |
Salsalate | Salsalate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Salsalate. |
Alprazolam | Alprazolam The metabolism of Alprazolam can be decreased when combined with Duloxetine. |
Temazepam | Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Duloxetine. |
Triazolam | Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Duloxetine. |
Dicyclomine | Dicyclomine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine. |
Hyoscyamine | Hyoscyamine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine. |
Propantheline | Propantheline Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Propantheline. |
Trimethoprim | Trimethoprim Trimethoprim may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Diltiazem | Diltiazem The risk or severity of orthostatic hypotension and syncope can be increased when Diltiazem is combined with Duloxetine. |
Nifedipine | Nifedipine The risk or severity of orthostatic hypotension and syncope can be increased when Nifedipine is combined with Duloxetine. |
Timolol | Timolol The metabolism of Timolol can be decreased when combined with Duloxetine. |
Verapamil | Verapamil The risk or severity of orthostatic hypotension and syncope can be increased when Verapamil is combined with Duloxetine. |
Atenolol | Atenolol The risk or severity of orthostatic hypotension and syncope can be increased when Atenolol is combined with Duloxetine. |
Pindolol | Pindolol The risk or severity of orthostatic hypotension and syncope can be increased when Pindolol is combined with Duloxetine. |
Cisplatin Injection | Cisplatin Injection Duloxetine may decrease the excretion rate of Cisplatin which could result in a higher serum level. |
Diflunisal | Diflunisal The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Diflunisal. |
Piroxicam | Piroxicam The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Piroxicam. |
Bumetanide | Bumetanide The risk or severity of orthostatic hypotension and syncope can be increased when Bumetanide is combined with Duloxetine. |
Streptozocin | Streptozocin The metabolism of Duloxetine can be increased when combined with Streptozocin. |
Etoposide | Etoposide The metabolism of Duloxetine can be decreased when combined with Etoposide. |
Glyburide | Glyburide The metabolism of Duloxetine can be decreased when combined with Glyburide. |
Glipizide | Glipizide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Glipizide. |
Indapamide | Indapamide The risk or severity of orthostatic hypotension and syncope can be increased when Indapamide is combined with Duloxetine. |
Amoxicillin | Amoxicillin Duloxetine may decrease the excretion rate of Amoxicillin which could result in a higher serum level. |
Dicloxacillin | Dicloxacillin The metabolism of Duloxetine can be increased when combined with Dicloxacillin. |
Nafcillin Injection | Nafcillin Injection The metabolism of Duloxetine can be increased when combined with Nafcillin. |
Oxacillin Injection | Oxacillin Injection Duloxetine may decrease the excretion rate of Oxacillin which could result in a higher serum level. |
Pentoxifylline | Pentoxifylline The risk or severity of hemorrhage can be increased when Duloxetine is combined with Pentoxifylline. |
Pentamidine Injection | Pentamidine Injection The metabolism of Duloxetine can be decreased when combined with Pentamidine. |
Ceftriaxone Injection | Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Labetalol | Labetalol The risk or severity of orthostatic hypotension and syncope can be increased when Labetalol is combined with Duloxetine. |
Auranofin | Auranofin Duloxetine may decrease the excretion rate of Auranofin which could result in a higher serum level. |
Leuprolide Injection | Leuprolide Injection Leuprolide may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Gemfibrozil | Gemfibrozil The metabolism of Duloxetine can be decreased when combined with Gemfibrozil. |
Guanabenz | Guanabenz Duloxetine may increase the tachycardic activities of Guanabenz. |
Dipivefrin Ophthalmic | Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Ceftazidime Injection | Ceftazidime Injection Ceftazidime may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Ketoprofen | Ketoprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ketoprofen. |
Cefotetan Injection | Cefotetan Injection Cefotetan may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Pimozide | Pimozide The risk or severity of QTc prolongation can be increased when Duloxetine is combined with Pimozide. |
Enalapril | Enalapril The risk or severity of orthostatic hypotension and syncope can be increased when Enalapril is combined with Duloxetine. |
Flurbiprofen | Flurbiprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Flurbiprofen. |
Amiodarone | Amiodarone The risk or severity of orthostatic hypotension and syncope can be increased when Amiodarone is combined with Duloxetine. |
Aztreonam Injection | Aztreonam Injection Aztreonam may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Buspirone | Buspirone The metabolism of Buspirone can be decreased when combined with Duloxetine. |
Lovastatin | Lovastatin The metabolism of Lovastatin can be decreased when combined with Duloxetine. |
Ciprofloxacin | Ciprofloxacin The metabolism of Duloxetine can be decreased when combined with Ciprofloxacin. |
Mesalamine | Mesalamine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Mesalazine. |
Diclofenac | Diclofenac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Diclofenac. |
Fluoxetine | Fluoxetine The serum concentration of Duloxetine can be increased when it is combined with Fluoxetine. |
Nimodipine | Nimodipine The risk or severity of orthostatic hypotension and syncope can be increased when Nimodipine is combined with Duloxetine. |
Interferon Alfa-2b Injection | Interferon Alfa-2b Injection The metabolism of Duloxetine can be decreased when combined with Interferon alfa-2b. |
Clozapine | Clozapine The risk or severity of orthostatic hypotension and syncope can be increased when Clozapine is combined with Duloxetine. |
Estazolam | Estazolam The risk or severity of adverse effects can be increased when Duloxetine is combined with Estazolam. |
Idarubicin | Idarubicin The metabolism of Idarubicin can be decreased when combined with Duloxetine. |
Ofloxacin | Ofloxacin The metabolism of Duloxetine can be decreased when combined with Ofloxacin. |
Didanosine | Didanosine Duloxetine may decrease the excretion rate of Didanosine which could result in a higher serum level. |
Pentostatin Injection | Pentostatin Injection Duloxetine may decrease the excretion rate of Pentostatin which could result in a higher serum level. |
Clarithromycin | Clarithromycin The metabolism of Duloxetine can be decreased when combined with Clarithromycin. |
Benazepril | Benazepril The risk or severity of orthostatic hypotension and syncope can be increased when Benazepril is combined with Duloxetine. |
Etodolac | Etodolac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Etodolac. |
Felodipine | Felodipine The risk or severity of orthostatic hypotension and syncope can be increased when Felodipine is combined with Duloxetine. |
Fosinopril | Fosinopril The risk or severity of orthostatic hypotension and syncope can be increased when Fosinopril is combined with Duloxetine. |
Nabumetone | Nabumetone The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Nabumetone. |
Quinapril | Quinapril The risk or severity of orthostatic hypotension and syncope can be increased when Quinapril is combined with Duloxetine. |
Ramipril | Ramipril The risk or severity of orthostatic hypotension and syncope can be increased when Ramipril is combined with Duloxetine. |
Simvastatin | Simvastatin The metabolism of Simvastatin can be decreased when combined with Duloxetine. |
Amlodipine | Amlodipine The risk or severity of orthostatic hypotension and syncope can be increased when Amlodipine is combined with Duloxetine. |
Teniposide Injection | Teniposide Injection The metabolism of Duloxetine can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole The metabolism of Duloxetine can be decreased when combined with Itraconazole. |
Lisinopril | Lisinopril The risk or severity of orthostatic hypotension and syncope can be increased when Lisinopril is combined with Duloxetine. |
Oxaprozin | Oxaprozin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Oxaprozin. |
Atovaquone | Atovaquone The metabolism of Duloxetine can be decreased when combined with Atovaquone. |
Rifabutin | Rifabutin The metabolism of Duloxetine can be increased when combined with Rifabutin. |
Sotalol | Sotalol The risk or severity of orthostatic hypotension and syncope can be increased when Sotalol is combined with Duloxetine. |
Bisoprolol | Bisoprolol The risk or severity of orthostatic hypotension and syncope can be increased when Bisoprolol is combined with Duloxetine. |
Zolpidem | Zolpidem Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
Doxazosin | Doxazosin The risk or severity of orthostatic hypotension and syncope can be increased when Doxazosin is combined with Duloxetine. |
Terazosin | Terazosin The risk or severity of orthostatic hypotension and syncope can be increased when Terazosin is combined with Duloxetine. |
Isradipine | Isradipine The risk or severity of orthostatic hypotension and syncope can be increased when Isradipine is combined with Duloxetine. |
Omeprazole | Omeprazole The metabolism of Duloxetine can be increased when combined with Omeprazole. |
Cisapride | Cisapride The metabolism of Duloxetine can be decreased when combined with Cisapride. |
Gabapentin | Gabapentin The risk or severity of adverse effects can be increased when Duloxetine is combined with Gabapentin. |
Fluvastatin | Fluvastatin The metabolism of Duloxetine can be decreased when combined with Fluvastatin. |
Venlafaxine | Venlafaxine The metabolism of Duloxetine can be decreased when combined with Venlafaxine. |
Famciclovir | Famciclovir The metabolism of Duloxetine can be decreased when combined with Famciclovir. |
Fluvoxamine | Fluvoxamine The metabolism of Duloxetine can be decreased when combined with Fluvoxamine. |
Nefazodone | Nefazodone The metabolism of Nefazodone can be decreased when combined with Duloxetine. |
Lamotrigine | Lamotrigine The risk or severity of adverse effects can be increased when Duloxetine is combined with Lamotrigine. |
Losartan | Losartan The risk or severity of orthostatic hypotension and syncope can be increased when Losartan is combined with Duloxetine. |
Valacyclovir | Valacyclovir Valaciclovir may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Tramadol | Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Duloxetine. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Duloxetine can be decreased when combined with Vinorelbine. |
Carboplatin Injection | Carboplatin Injection Carboplatin may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Moexipril | Moexipril The risk or severity of orthostatic hypotension and syncope can be increased when Moexipril is combined with Duloxetine. |
Lansoprazole | Lansoprazole The metabolism of Duloxetine can be increased when combined with Lansoprazole. |
Ifosfamide Injection | Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Duloxetine. |
Nicardipine | Nicardipine The risk or severity of orthostatic hypotension and syncope can be increased when Nicardipine is combined with Duloxetine. |
Bupropion | Bupropion The metabolism of Bupropion can be decreased when combined with Duloxetine. |
Ticlopidine | Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Duloxetine. |
Saquinavir | Saquinavir The metabolism of Duloxetine can be decreased when combined with Saquinavir. |
Metformin | Metformin The risk or severity of hypoglycemia can be increased when Metformin is combined with Duloxetine. |
Dalteparin Injection | Dalteparin Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Dalteparin. |
Nisoldipine | Nisoldipine The risk or severity of orthostatic hypotension and syncope can be increased when Nisoldipine is combined with Duloxetine. |
Lamivudine | Lamivudine Duloxetine may decrease the excretion rate of Lamivudine which could result in a higher serum level. |
Riluzole | Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Duloxetine. |
Amifostine Injection | Amifostine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amifostine is combined with Duloxetine. |
Acarbose | Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Duloxetine. |
Glimepiride | Glimepiride The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Duloxetine. |
Gemcitabine Injection | Gemcitabine Injection Gemcitabine may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Ritonavir | Ritonavir The serum concentration of Duloxetine can be increased when it is combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Duloxetine can be decreased when combined with Docetaxel. |
Cidofovir Injection | Cidofovir Injection Cidofovir may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Meropenem Injection | Meropenem Injection Duloxetine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
Clomipramine | Clomipramine The risk or severity of orthostatic hypotension and syncope can be increased when Clomipramine is combined with Duloxetine. |
Zafirlukast | Zafirlukast The metabolism of Duloxetine can be decreased when combined with Zafirlukast. |
Fosfomycin | Fosfomycin Duloxetine may decrease the excretion rate of Fosfomycin which could result in a higher serum level. |
Mirtazapine | Mirtazapine Duloxetine may increase the serotonergic activities of Mirtazapine. |
Trandolapril | Trandolapril The risk or severity of orthostatic hypotension and syncope can be increased when Trandolapril is combined with Duloxetine. |
Topiramate | Topiramate The risk or severity of adverse effects can be increased when Duloxetine is combined with Topiramate. |
Zileuton | Zileuton The metabolism of Zileuton can be decreased when combined with Duloxetine. |
Valsartan | Valsartan The risk or severity of orthostatic hypotension and syncope can be increased when Valsartan is combined with Duloxetine. |
Insulin Lispro Injection | Insulin Lispro Injection The metabolism of Duloxetine can be increased when combined with Insulin lispro. |
Pramipexole | Pramipexole The risk or severity of orthostatic hypotension and syncope can be increased when Pramipexole is combined with Duloxetine. |
Donepezil | Donepezil The metabolism of Duloxetine can be decreased when combined with Donepezil. |
Nelfinavir | Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Duloxetine. |
Azithromycin | Azithromycin The metabolism of Azithromycin can be decreased when combined with Duloxetine. |
Carvedilol | Carvedilol The risk or severity of orthostatic hypotension and syncope can be increased when Carvedilol is combined with Duloxetine. |
Nilutamide | Nilutamide The metabolism of Nilutamide can be decreased when combined with Duloxetine. |
Flutamide | Flutamide The metabolism of Flutamide can be decreased when combined with Duloxetine. |
Selegiline | Selegiline The risk or severity of orthostatic hypotension and syncope can be increased when Selegiline is combined with Duloxetine. |
Bicalutamide | Bicalutamide The metabolism of Duloxetine can be decreased when combined with Bicalutamide. |
Sertraline | Sertraline The metabolism of Sertraline can be decreased when combined with Duloxetine. |
Propafenone | Propafenone The metabolism of Duloxetine can be decreased when combined with Propafenone. |
Raloxifene | Raloxifene The metabolism of Duloxetine can be decreased when combined with Raloxifene. |
Irbesartan | Irbesartan The risk or severity of orthostatic hypotension and syncope can be increased when Irbesartan is combined with Duloxetine. |
Tamsulosin | Tamsulosin The risk or severity of orthostatic hypotension and syncope can be increased when Tamsulosin is combined with Duloxetine. |
Ropinirole | Ropinirole The risk or severity of orthostatic hypotension and syncope can be increased when Ropinirole is combined with Duloxetine. |
Quetiapine | Quetiapine The risk or severity of orthostatic hypotension and syncope can be increased when Quetiapine is combined with Duloxetine. |
Cefepime Injection | Cefepime Injection Cefepime may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Cefprozil | Cefprozil Cefprozil may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Cefpodoxime | Cefpodoxime Cefpodoxime may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Cetirizine | Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Duloxetine. |
Paroxetine | Paroxetine The metabolism of Paroxetine can be decreased when combined with Duloxetine. |
Tolcapone | Tolcapone The risk or severity of orthostatic hypotension and syncope can be increased when Tolcapone is combined with Duloxetine. |
Citalopram | Citalopram The metabolism of Duloxetine can be decreased when combined with Citalopram. |
Capecitabine | Capecitabine The metabolism of Duloxetine can be decreased when combined with Capecitabine. |
Efavirenz | Efavirenz The metabolism of Duloxetine can be decreased when combined with Efavirenz. |
Abacavir | Abacavir Duloxetine may decrease the excretion rate of Abacavir which could result in a higher serum level. |
Sildenafil | Sildenafil The metabolism of Sildenafil can be decreased when combined with Duloxetine. |
Pioglitazone | Pioglitazone The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Pioglitazone. |
Celecoxib | Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Duloxetine. |
Rosiglitazone | Rosiglitazone The metabolism of Duloxetine can be decreased when combined with Rosiglitazone. |
Tolterodine | Tolterodine The metabolism of Tolterodine can be decreased when combined with Duloxetine. |
Thalidomide | Thalidomide Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
Oseltamivir | Oseltamivir Oseltamivir may decrease the excretion rate of Duloxetine which could result in a higher serum level. |
Balsalazide | Balsalazide The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Balsalazide. |
Nateglinide | Nateglinide The metabolism of Nateglinide can be decreased when combined with Duloxetine. |
Galantamine | Galantamine The metabolism of Galantamine can be decreased when combined with Duloxetine. |
Levetiracetam | Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Duloxetine. |
Rabeprazole | Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Duloxetine. |
Terbinafine | Terbinafine The metabolism of Duloxetine can be decreased when combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists