Duloxetine

Generic name: Pronounced as (doo lox' e teen)
Brand names
  • Cymbalta®
  • Drizalma Sprinkle®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2022

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants (''mood elevators'') such as duloxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take duloxetine, but in some cases, a doctor may decide that duloxetine is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take duloxetine or other antidepressants even if you are an adult over 24 years of age. These changes may occur even if you do not have a mental illness and you are taking duloxetine to treat a different type of condition. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive or hostile behavior; irritability; acting without thinking; severe restlessness; frenzied abnormal excitement; or any other unusual changes in behavior. Be sure that your family or caregiver checks on you daily and knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Your healthcare provider will want to see you often while you are taking duloxetine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with duloxetine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood), depression, or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Duloxetine is used to treat depression in adults and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults and children 7 years of age and older. Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes) in adults and fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep) in adults and children 13 years of age and older. It is also used to treat ongoing bone or muscle pain such as lower back pain or osteoarthritis (joint pain or stiffness that may worsen over time) in adults. Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

Duloxetine comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule to take by mouth. When duloxetine is used to treat depression, it is usually taken once or twice a day with or without food. When duloxetine is used to treat generalized anxiety disorder, the pain of diabetic neuropathy, fibromyalgia, or ongoing bone or muscle pain, it is usually taken once a day with or without food. Take duloxetine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take duloxetine exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.

Swallow the delayed-release capsules whole; do not split, chew, or crush them. Do not open the delayed-release capsules and mix the contents with liquids or sprinkle the contents on food.

Your doctor may start you on a low dose of medication and increase your dose after one week.

Duloxetine may help control your symptoms but will not cure your condition. It may take 1 to 4 weeks or longer before you feel the full benefit of duloxetine. Continue to take duloxetine even if you feel well. Do not stop taking duloxetine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking duloxetine, you may experience withdrawal symptoms such as nausea; vomiting; diarrhea; anxiety; dizziness; tiredness; headache; pain, burning, numbness, or tingling in the hands or feet; irritability; difficulty falling asleep or staying asleep; sweating; and nightmares. Tell your doctor if you experience any of these symptoms when your dose of duloxetine is decreased.

Duloxetine is also sometimes used to treat stress urinary incontinence (leakage of urine during physical activity such as coughing, sneezing, laughing, and exercise) in women. Talk to your doctor about using this medication to treat your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking duloxetine,

  • tell your doctor and pharmacist if you are allergic to duloxetine, any other medications, or any of the ingredients in duloxetine delayed-release capsules. Ask your doctor or pharmacist for a list of the ingredients.

  • tell your doctor if you are taking thioridazine or a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid (Zyvox); methylene blue; phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take duloxetine. If you stop taking duloxetine, you should wait at least 5 days before you start to take an MAO inhibitor.

  • tell your doctor and pharmacist what other prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: amphetamines such as amphetamine (in Adderall, others), dextroamphetamine (Dexedrine, in Adderall), and methamphetamine (Desoxyn); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; cimetidine (Tagamet); ciprofloxacin (Cipro); diuretics ('water pills'); fentanyl (Abstral, Actiq, Fentora, Onsolis, others); medications for irregular heartbeat such as amiodarone (Cordarone), flecainide (Tambocor), moricizine (Ethmozine), propafenone (Rythmol), and quinidine (in Nuedexta); medications for anxiety, high blood pressure, mental illness, pain, and nausea; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, Onzetra, Tosmyra, in Treximet), and zolmitriptan (Zomig); lithium (Lithobid); proton pump inhibitors such as lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (Aciphex); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), and paroxetine (Paxil); sleeping pills; theophylline (Theo-24, Theochron); tramadol (Ultram); and tranquilizers. Many other medications may interact with duloxetine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what nutritional supplements and herbal products you are taking, especially products containing St. John's wort or tryptophan.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol or if you use or have ever used street drugs or have ever overused prescription medications. Also tell your doctor if you have a low level of sodium in your blood; glaucoma (increased pressure in the eye that may cause loss of sight); if you have recently had a heart attack; or if you have or have ever had high blood pressure; seizures; coronary artery disease (blockage or narrowing of the blood vessels that lead to the heart); bleeding problems; any type of stomach problem such as slow stomach emptying; or heart, liver, or kidney disease. If you have diabetes, be sure to talk to your doctor about how serious your condition is so your doctor can decide if duloxetine is right for you.

  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking duloxetine, call your doctor. Duloxetine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking duloxetine.

  • you should know that duloxetine may make you drowsy, dizzy, or may affect your judgment, thinking or coordination. Do not drive a car or operate machinery until you know how this medication affects you.

  • ask your doctor about the safe use of alcoholic beverages while you are taking duloxetine. Alcohol can increase the risk of serious side effects from duloxetine.

  • you should know that duloxetine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking duloxetine or with an increase in dose. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • you should know that duloxetine may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.

  • you should know that duloxetine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Duloxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • constipation

    • diarrhea

    • weight changes

    • heartburn

    • stomach pain

    • decreased appetite

    • dry mouth

    • increased urination

    • sweating or night sweats

    • dizziness

    • headache

    • weight changes

    • tiredness

    • drowsiness

    • muscle pain or cramps

    • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

    • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

    • uncontrollable shaking of a part of the body

  • Some side effects can be serious. If you experience any of the following side effects, or those mentioned in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

    • unusual bruising or bleeding

    • pain in the upper right part of the stomach

    • swelling of the abdomen

    • itching

    • yellowing of the skin or eyes

    • dark colored urine

    • loss of appetite

    • extreme tiredness or weakness

    • confusion

    • unsteady walking that may cause falling

    • flu-like symptoms

    • agitation, fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

    • seizures

    • hallucinations (seeing things or hearing voices that do not exist)

    • fever

    • blisters or peeling skin

    • rash

    • hives

    • difficulty breathing or swallowing

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • hoarseness

    • difficulty urinating

  • Duloxetine may decrease appetite and cause weight loss in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Talk to your child's doctor about the risks of giving duloxetine to your child.

  • Duloxetine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • agitation

  • hallucinating (seeing things or hearing voices that do not exist)

  • fast heartbeat

  • fever

  • loss of coordination

  • nausea

  • vomiting

  • diarrhea

  • drowsiness

  • seizures

  • dizziness

  • lightheadedness

  • fainting

  • unresponsiveness

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Duloxetine can be decreased when combined with Moxifloxacin.
Repaglinide Repaglinide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Repaglinide.
Montelukast Montelukast The metabolism of Duloxetine can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Duloxetine can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Duloxetine can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Duloxetine can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Duloxetine.
Dolasetron Dolasetron The metabolism of Duloxetine can be decreased when combined with Dolasetron.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Duloxetine.
Anagrelide Anagrelide The risk or severity of hemorrhage can be increased when Duloxetine is combined with Anagrelide.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Duloxetine.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Duloxetine.
Clopidogrel Clopidogrel The risk or severity of hemorrhage can be increased when Duloxetine is combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of serotonin syndrome can be increased when Diphenoxylate is combined with Duloxetine.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Duloxetine can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Duloxetine can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Duloxetine.
Guanfacine Guanfacine The risk or severity of orthostatic hypotension and syncope can be increased when Guanfacine is combined with Duloxetine.
Magnesium Hydroxide Magnesium Hydroxide Duloxetine may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The metabolism of Duloxetine can be decreased when combined with Methylergometrine.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Miglitol.
Mycophenolate Mycophenolate Duloxetine may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Duloxetine.
Olsalazine Olsalazine The risk or severity of gastrointestinal bleeding can be increased when Olsalazine is combined with Duloxetine.
Paregoric Paregoric The risk or severity of orthostatic hypotension and syncope can be increased when Morphine is combined with Duloxetine.
Penbutolol Penbutolol The risk or severity of orthostatic hypotension and syncope can be increased when Acebutolol is combined with Duloxetine.
Pentazocine Pentazocine The risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Duloxetine.
Potassium Potassium Potassium may increase the excretion rate of Duloxetine which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Duloxetine may decrease the excretion rate of Prednisone which could result in a higher serum level.
Ranitidine Ranitidine The metabolism of Ranitidine can be decreased when combined with Duloxetine.
Reserpine Reserpine The risk or severity of orthostatic hypotension and syncope can be increased when Reserpine is combined with Duloxetine.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Duloxetine is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Duloxetine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Duloxetine.
Tizanidine Tizanidine The risk or severity of orthostatic hypotension and syncope can be increased when Tizanidine is combined with Duloxetine.
Triamcinolone Triamcinolone The metabolism of Duloxetine can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Duloxetine.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection The metabolism of Duloxetine can be decreased when combined with Doxycycline.
Famotidine Injection Famotidine Injection The metabolism of Duloxetine can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection The metabolism of Duloxetine can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Duloxetine.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Duloxetine can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Duloxetine can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The metabolism of Duloxetine can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Duloxetine can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of adverse effects can be increased when Metoclopramide is combined with Duloxetine.
Metronidazole Injection Metronidazole Injection The metabolism of Duloxetine can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Morphine is combined with Duloxetine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Duloxetine may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Duloxetine.
Altretamine Altretamine Amphetamine may increase the serotonergic activities of Duloxetine.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Duloxetine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Duloxetine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Enoxaparin.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Duloxetine.
Torsemide Torsemide The risk or severity of orthostatic hypotension and syncope can be increased when Torasemide is combined with Duloxetine.
Olanzapine Olanzapine The risk or severity of orthostatic hypotension and syncope can be increased when Olanzapine is combined with Duloxetine.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Duloxetine.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Duloxetine.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Duloxetine.
Eprosartan Eprosartan The risk or severity of orthostatic hypotension and syncope can be increased when Eprosartan is combined with Duloxetine.
Hydroxychloroquine Hydroxychloroquine The metabolism of Duloxetine can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Meloxicam.
Orlistat Orlistat The metabolism of Duloxetine can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Duloxetine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Telmisartan Telmisartan The risk or severity of orthostatic hypotension and syncope can be increased when Telmisartan is combined with Duloxetine.
Temozolomide Temozolomide Duloxetine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Duloxetine.
Anakinra Anakinra The metabolism of Duloxetine can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Duloxetine.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Duloxetine.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of hemorrhage can be increased when Duloxetine is combined with Pentosan polysulfate.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Duloxetine.
Etanercept Injection Etanercept Injection The metabolism of Duloxetine can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Duloxetine can be increased when combined with Modafinil.
Perindopril Perindopril The risk or severity of orthostatic hypotension and syncope can be increased when Perindopril is combined with Duloxetine.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Choline magnesium trisalicylate.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Duloxetine.
Epinephrine Injection Epinephrine Injection Duloxetine may increase the tachycardic activities of Epinephrine.
Eplerenone Eplerenone The risk or severity of orthostatic hypotension and syncope can be increased when Eplerenone is combined with Duloxetine.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Escitalopram.
Olmesartan Olmesartan The risk or severity of orthostatic hypotension and syncope can be increased when Olmesartan is combined with Duloxetine.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine.
Adalimumab Injection Adalimumab Injection The metabolism of Duloxetine can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Duloxetine.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Duloxetine.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Duloxetine.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Duloxetine.
Atazanavir Atazanavir The metabolism of Duloxetine can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Duloxetine can be decreased when combined with Almotriptan.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Duloxetine.
Mefloquine Mefloquine The metabolism of Duloxetine can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Duloxetine.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Duloxetine.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Duloxetine.
Aprepitant Aprepitant The metabolism of Duloxetine can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Duloxetine may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Duloxetine can be decreased when combined with Interferon beta-1a.
Memantine Memantine Duloxetine may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Tegaserod can be decreased when combined with Duloxetine.
Tadalafil Tadalafil Duloxetine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Duloxetine.
Gemifloxacin Gemifloxacin The metabolism of Duloxetine can be decreased when combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Duloxetine.
Apomorphine Injection Apomorphine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Apomorphine is combined with Duloxetine.
Infliximab Injection Infliximab Injection The metabolism of Duloxetine can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Duloxetine can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The metabolism of Duloxetine can be decreased when combined with Protriptyline.
Rifaximin Rifaximin The metabolism of Duloxetine can be increased when combined with Rifaximin.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Duloxetine.
Tinidazole Tinidazole Duloxetine may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The metabolism of Duloxetine can be increased when combined with Bosentan.
Cefditoren Cefditoren Duloxetine may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Duloxetine can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Duloxetine.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Duloxetine is combined with Eszopiclone.
Ganciclovir Ganciclovir Duloxetine may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Insulin aspart.
Ribavirin Ribavirin Duloxetine may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The metabolism of Solifenacin can be decreased when combined with Duloxetine.
Valganciclovir Valganciclovir Duloxetine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Duloxetine can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the serotonergic activities of Duloxetine.
Entecavir Entecavir The metabolism of Duloxetine can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Duloxetine can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Duloxetine can be increased when it is combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Pramlintide.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Exenatide Injection Exenatide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Exenatide.
Isocarboxazid Isocarboxazid The risk or severity of orthostatic hypotension and syncope can be increased when Isocarboxazid is combined with Duloxetine.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Duloxetine.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Duloxetine.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Duloxetine.
Pregabalin Pregabalin The therapeutic efficacy of Duloxetine can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Duloxetine can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine Duloxetine may increase the tachycardic activities of Phenylephrine.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Duloxetine.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Duloxetine.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Insulin detemir.
Ranolazine Ranolazine The serum concentration of Duloxetine can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Duloxetine can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of orthostatic hypotension and syncope can be increased when Rasagiline is combined with Duloxetine.
Imatinib Imatinib The metabolism of Duloxetine can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Sitagliptin.
Varenicline Varenicline Duloxetine may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Gefitinib can be decreased when combined with Duloxetine.
Albuterol Albuterol Duloxetine may increase the tachycardic activities of Salbutamol.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Duloxetine.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Duloxetine.
Clofarabine Injection Clofarabine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Clofarabine is combined with Duloxetine.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Duloxetine may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Posaconazole Posaconazole The metabolism of Duloxetine can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Duloxetine can be decreased when combined with Primaquine.
Aliskiren Aliskiren The risk or severity of orthostatic hypotension and syncope can be increased when Aliskiren is combined with Duloxetine.
Darunavir Darunavir The metabolism of Duloxetine can be decreased when combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection Duloxetine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Duloxetine.
Lisdexamfetamine Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Duloxetine.
Nabilone Nabilone The risk or severity of orthostatic hypotension and syncope can be increased when Nabilone is combined with Duloxetine.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Duloxetine.
Sorafenib Sorafenib The metabolism of Duloxetine can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Duloxetine can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Duloxetine.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Duloxetine.
Pegaptanib Injection Pegaptanib Injection Duloxetine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Duloxetine.
Mexiletine Mexiletine The metabolism of Duloxetine can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Duloxetine can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Duloxetine may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Ivermectin Ivermectin The metabolism of Duloxetine can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Duloxetine.
Lenalidomide Lenalidomide Duloxetine may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Duloxetine can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Duloxetine can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Duloxetine can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Duloxetine can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Duloxetine is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Duloxetine.
Doripenem Injection Doripenem Injection Duloxetine may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Duloxetine can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of orthostatic hypotension and syncope can be increased when Arsenic trioxide is combined with Duloxetine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Duloxetine can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Duloxetine is combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Duloxetine can be decreased when combined with Cevimeline.
Nebivolol Nebivolol The risk or severity of orthostatic hypotension and syncope can be increased when Nebivolol is combined with Duloxetine.
Tretinoin Tretinoin The risk or severity of orthostatic hypotension and syncope can be increased when Tretinoin is combined with Duloxetine.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Duloxetine.
Pilocarpine Pilocarpine The metabolism of Duloxetine can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Duloxetine.
Certolizumab Injection Certolizumab Injection The metabolism of Duloxetine can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Duloxetine.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Duloxetine.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Duloxetine.
Mitotane Mitotane The metabolism of Duloxetine can be increased when combined with Mitotane.
Methylnaltrexone Injection Methylnaltrexone Injection Duloxetine may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Duloxetine.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Duloxetine.
Naltrexone Injection Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Duloxetine.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Duloxetine is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Duloxetine may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Duloxetine.
Betaxolol Betaxolol The risk or severity of orthostatic hypotension and syncope can be increased when Betaxolol is combined with Duloxetine.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Duloxetine.
Prasugrel Prasugrel The risk or severity of hemorrhage can be increased when Duloxetine is combined with Prasugrel.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Duloxetine.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Duloxetine.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Duloxetine can be decreased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Duloxetine.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine.
Pralatrexate Injection Pralatrexate Injection Duloxetine may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The metabolism of Duloxetine can be decreased when combined with Palonosetron.
Saxagliptin Saxagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Saxagliptin.
Telavancin Injection Telavancin Injection Duloxetine may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Duloxetine.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Topotecan Topotecan The metabolism of Duloxetine can be decreased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Duloxetine can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Duloxetine can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Duloxetine is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Duloxetine.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Duloxetine.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Duloxetine.
Oxymorphone Oxymorphone The risk or severity of serotonin syndrome can be increased when Oxymorphone is combined with Duloxetine.
Dabigatran Dabigatran The risk or severity of hemorrhage can be increased when Duloxetine is combined with Dabigatran.
Liraglutide Injection Liraglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Liraglutide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Duloxetine can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Duloxetine may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Duloxetine.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Duloxetine.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Duloxetine.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Duloxetine.
Ipilimumab Injection Ipilimumab Injection Duloxetine may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of orthostatic hypotension and syncope can be increased when Aldesleukin is combined with Duloxetine.
Terbutaline Injection Terbutaline Injection Duloxetine may increase the tachycardic activities of Terbutaline.
Azilsartan Azilsartan The risk or severity of orthostatic hypotension and syncope can be increased when Azilsartan medoxomil is combined with Duloxetine.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Duloxetine.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Duloxetine.
Linagliptin Linagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Duloxetine can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Duloxetine can be decreased when combined with Glecaprevir.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Duloxetine.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Duloxetine can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Duloxetine can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of hemorrhage can be increased when Duloxetine is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Duloxetine can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Duloxetine.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Duloxetine.
Clobazam Clobazam The metabolism of Duloxetine can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Duloxetine can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Duloxetine can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Duloxetine.
Deferiprone Deferiprone Duloxetine may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Duloxetine.
Crizotinib Crizotinib The metabolism of Duloxetine can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Duloxetine can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Duloxetine can be decreased when combined with Naloxone.
Fondaparinux Injection Fondaparinux Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Fondaparinux.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Duloxetine.
Iloprost Iloprost The risk or severity of orthostatic hypotension and syncope can be increased when Iloprost is combined with Duloxetine.
Enzalutamide Enzalutamide The metabolism of Duloxetine can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Duloxetine.
Regorafenib Regorafenib The metabolism of Duloxetine can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Duloxetine can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Duloxetine can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The serum concentration of Duloxetine can be decreased when it is combined with Teriflunomide.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Duloxetine.
Teduglutide Injection Teduglutide Injection Duloxetine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl Duloxetine may increase the antiplatelet activities of Icosapent ethyl.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Duloxetine.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Duloxetine.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Duloxetine.
Pomalidomide Pomalidomide The metabolism of Duloxetine can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Duloxetine can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Apixaban.
Canagliflozin Canagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Canagliflozin is combined with Duloxetine.
Methazolamide Methazolamide The risk or severity of orthostatic hypotension and syncope can be increased when Methazolamide is combined with Duloxetine.
Dabrafenib Dabrafenib The metabolism of Duloxetine can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Duloxetine.
Trametinib Trametinib The metabolism of Trametinib can be increased when combined with Duloxetine.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Duloxetine.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Duloxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Duloxetine.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Duloxetine.
Ketorolac Injection Ketorolac Injection The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of orthostatic hypotension and syncope can be increased when Obinutuzumab is combined with Duloxetine.
Simeprevir Simeprevir The metabolism of Duloxetine can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Duloxetine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Dapagliflozin is combined with Duloxetine.
Apremilast Apremilast The metabolism of Duloxetine can be increased when combined with Apremilast.
Droxidopa Droxidopa Duloxetine may increase the tachycardic activities of Droxidopa.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Duloxetine.
Siltuximab Injection Siltuximab Injection The metabolism of Duloxetine can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Albiglutide.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Duloxetine.
Belinostat Injection Belinostat Injection The metabolism of Duloxetine can be increased when combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Duloxetine.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Duloxetine.
Oritavancin Injection Oritavancin Injection The metabolism of Duloxetine can be increased when combined with Oritavancin.
Empagliflozin Empagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Empagliflozin is combined with Duloxetine.
Vorapaxar Vorapaxar The risk or severity of hemorrhage can be increased when Duloxetine is combined with Vorapaxar.
Hydrocodone Hydrocodone Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Dulaglutide.
Edoxaban Edoxaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Edoxaban.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Duloxetine can be decreased when combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Duloxetine can be decreased when combined with Olaparib.
Methamphetamine Methamphetamine The metabolism of Duloxetine can be decreased when combined with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Duloxetine.
Riociguat Riociguat The risk or severity of orthostatic hypotension and syncope can be increased when Riociguat is combined with Duloxetine.
Lanreotide Injection Lanreotide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Lanreotide.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Duloxetine.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Duloxetine.
Secukinumab Injection Secukinumab Injection The metabolism of Duloxetine can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Duloxetine.
Palbociclib Palbociclib The metabolism of Duloxetine can be decreased when combined with Palbociclib.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Duloxetine can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Duloxetine can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Duloxetine can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Duloxetine.
Dinutuximab Injection Dinutuximab Injection The risk or severity of orthostatic hypotension and syncope can be increased when Dinutuximab is combined with Duloxetine.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Duloxetine is combined with Haloperidol.
Amiloride Amiloride The risk or severity of orthostatic hypotension and syncope can be increased when Amiloride is combined with Duloxetine.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Duloxetine can be increased when combined with Isavuconazonium.
Macitentan Macitentan Duloxetine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Duloxetine.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Duloxetine.
Rolapitant Rolapitant The metabolism of Duloxetine can be decreased when combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Duloxetine can be increased when combined with Prednisolone.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Duloxetine.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Duloxetine.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Duloxetine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Duloxetine may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin degludec.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Duloxetine.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Duloxetine.
Osimertinib Osimertinib The serum concentration of Duloxetine can be decreased when it is combined with Osimertinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Duloxetine.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Duloxetine.
Rifapentine Rifapentine The metabolism of Duloxetine can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Duloxetine.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amphotericin B is combined with Duloxetine.
Dexamethasone Injection Dexamethasone Injection The metabolism of Duloxetine can be increased when combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Duloxetine.
Venetoclax Venetoclax The metabolism of Duloxetine can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Duloxetine can be decreased when combined with Cobicistat.
Midodrine Midodrine Duloxetine may increase the tachycardic activities of Midodrine.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Duloxetine is combined with Pimavanserin.
Obeticholic Acid Obeticholic Acid The metabolism of Duloxetine can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Duloxetine can be decreased when combined with Diphenhydramine.
Furosemide Injection Furosemide Injection The risk or severity of orthostatic hypotension and syncope can be increased when Furosemide is combined with Duloxetine.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Duloxetine.
Lixisenatide Injection Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Lixisenatide.
Ribociclib Ribociclib The metabolism of Duloxetine can be decreased when combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Duloxetine.
Brigatinib Brigatinib The metabolism of Duloxetine can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Duloxetine.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Duloxetine.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Duloxetine.
Deflazacort Deflazacort The metabolism of Duloxetine can be increased when combined with Deflazacort.
Safinamide Safinamide Safinamide may increase the serotonergic activities of Duloxetine.
Naldemedine Naldemedine Duloxetine may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The metabolism of Duloxetine can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Duloxetine can be decreased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Duloxetine.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Duloxetine.
Enasidenib Enasidenib The metabolism of Duloxetine can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Duloxetine can be increased when combined with Fosaprepitant.
Benznidazole Benznidazole Duloxetine may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Duloxetine.
Delafloxacin Delafloxacin Duloxetine may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Duloxetine.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Duloxetine is combined with Betrixaban.
Acalabrutinib Acalabrutinib The metabolism of Duloxetine can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Duloxetine.
Semaglutide Injection Semaglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Semaglutide.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Duloxetine.
Ertugliflozin Ertugliflozin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The metabolism of Duloxetine can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Duloxetine can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Duloxetine can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Duloxetine.
Lofexidine Lofexidine The therapeutic efficacy of Duloxetine can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Duloxetine may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Duloxetine.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Duloxetine.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Duloxetine.
Ivosidenib Ivosidenib The metabolism of Duloxetine can be decreased when combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Duloxetine.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Duloxetine.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Duloxetine.
Dacomitinib Dacomitinib The metabolism of Duloxetine can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Duloxetine.
Stiripentol Stiripentol The metabolism of Duloxetine can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Duloxetine can be decreased when used in combination with Gilteritinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The risk or severity of orthostatic hypotension and syncope can be increased when Paclitaxel is combined with Duloxetine.
Rifamycin Rifamycin The metabolism of Duloxetine can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Duloxetine.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Duloxetine can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Duloxetine.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Caplacizumab.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Duloxetine.
Alpelisib Alpelisib The serum concentration of Duloxetine can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Duloxetine.
Solriamfetol Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Duloxetine.
Triclabendazole Triclabendazole The metabolism of Duloxetine can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Duloxetine.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Duloxetine.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Duloxetine.
Pitolisant Pitolisant The serum concentration of Duloxetine can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Duloxetine can be decreased when combined with Fedratinib.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Duloxetine.
Phenytoin Injection Phenytoin Injection The metabolism of Duloxetine can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Duloxetine can be increased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Duloxetine.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Duloxetine.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Duloxetine.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Duloxetine.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Lasmiditan is combined with Duloxetine.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Duloxetine.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Duloxetine.
Cenobamate Cenobamate The serum concentration of Duloxetine can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Duloxetine.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Duloxetine.
Capmatinib Capmatinib The metabolism of Duloxetine can be decreased when combined with Capmatinib.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Duloxetine.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Fenfluramine.
Octreotide Octreotide The metabolism of Duloxetine can be decreased when combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Duloxetine can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Duloxetine can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Duloxetine.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Viloxazine.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Vitamin E can be increased when combined with Duloxetine.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Duloxetine.
Fenoprofen Fenoprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Fenoprofen.
Indomethacin Indomethacin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Mefenamic acid.
Naproxen Naproxen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Naproxen.
Tolmetin Tolmetin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Tolmetin.
Sulindac Sulindac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Sulindac.
Trazodone Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Duloxetine.
Isotretinoin Isotretinoin Duloxetine may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Duloxetine can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Duloxetine can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Duloxetine.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Duloxetine.
Methotrexate Injection Methotrexate Injection The metabolism of Duloxetine can be decreased when combined with Methotrexate.
Levorphanol Levorphanol The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Duloxetine.
Primidone Primidone The metabolism of Duloxetine can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Duloxetine.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Duloxetine is combined with Diethylpropion.
Chlorpromazine Chlorpromazine The risk or severity of orthostatic hypotension and syncope can be increased when Chlorpromazine is combined with Duloxetine.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Duloxetine is combined with Clorazepic acid.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Duloxetine.
Phenoxybenzamine Phenoxybenzamine The risk or severity of orthostatic hypotension and syncope can be increased when Phenoxybenzamine is combined with Duloxetine.
Carmustine Carmustine The metabolism of Duloxetine can be decreased when combined with Carmustine.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Amantadine.
Codeine Codeine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Codeine.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Duloxetine.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Duloxetine.
Bromocriptine Bromocriptine The risk or severity of orthostatic hypotension and syncope can be increased when Bromocriptine is combined with Duloxetine.
Metaproterenol Metaproterenol Duloxetine may increase the tachycardic activities of Orciprenaline.
Tranylcypromine Tranylcypromine The risk or severity of orthostatic hypotension and syncope can be increased when Tranylcypromine is combined with Duloxetine.
Phenelzine Phenelzine The risk or severity of orthostatic hypotension and syncope can be increased when Phenelzine is combined with Duloxetine.
Procarbazine Procarbazine Procarbazine may increase the serotonergic activities of Duloxetine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Duloxetine.
Tetracycline Tetracycline The metabolism of Duloxetine can be decreased when combined with Tetracycline.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Prochlorperazine Prochlorperazine The metabolism of Duloxetine can be decreased when combined with Prochlorperazine.
Thioridazine Thioridazine The risk or severity of orthostatic hypotension and syncope can be increased when Thioridazine is combined with Duloxetine.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Trifluoperazine.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Dapsone Dapsone The metabolism of Duloxetine can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The risk or severity of hypoglycemia can be increased when Sulfadiazine is combined with Duloxetine.
Oxycodone Oxycodone The risk or severity of serotonin syndrome can be increased when Oxycodone is combined with Duloxetine.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Duloxetine.
Oxybutynin Oxybutynin The metabolism of Duloxetine can be decreased when combined with Oxybutynin.
Benztropine Benztropine The metabolism of Duloxetine can be decreased when combined with Benzatropine.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Duloxetine.
Ibuprofen Ibuprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Duloxetine.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Duloxetine.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Fluphenazine.
Phentermine Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Duloxetine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Amoxapine Amoxapine The metabolism of Amoxapine can be decreased when combined with Duloxetine.
Sulfasalazine Sulfasalazine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Duloxetine can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Duloxetine can be decreased when combined with Doxorubicin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Duloxetine.
Molindone Molindone The risk or severity of adverse effects can be increased when Duloxetine is combined with Molindone.
Methyldopa Methyldopa The risk or severity of orthostatic hypotension and syncope can be increased when Methyldopa is combined with Duloxetine.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Duloxetine.
Prazosin Prazosin The risk or severity of orthostatic hypotension and syncope can be increased when Prazosin is combined with Duloxetine.
Hydralazine Hydralazine The risk or severity of orthostatic hypotension and syncope can be increased when Hydralazine is combined with Duloxetine.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Duloxetine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Duloxetine.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Duloxetine.
Loperamide Loperamide The metabolism of Duloxetine can be decreased when combined with Loperamide.
Promethazine Promethazine The metabolism of Duloxetine can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Meclofenamic acid.
Daunorubicin Daunorubicin The metabolism of Duloxetine can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Duloxetine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Duloxetine can be increased when combined with Griseofulvin.
Digoxin Digoxin Digoxin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Duloxetine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Duloxetine.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Duloxetine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Duloxetine.
Calcitriol Calcitriol The metabolism of Duloxetine can be increased when combined with Calcitriol.
Triamterene Triamterene The risk or severity of orthostatic hypotension and syncope can be increased when Triamterene is combined with Duloxetine.
Sulfinpyrazone Sulfinpyrazone Duloxetine may increase the antiplatelet activities of Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Chlorothiazide is combined with Duloxetine.
Chlorthalidone Chlorthalidone The risk or severity of orthostatic hypotension and syncope can be increased when Chlorthalidone is combined with Duloxetine.
Metolazone Metolazone The risk or severity of orthostatic hypotension and syncope can be increased when Metolazone is combined with Duloxetine.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Duloxetine which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Duloxetine.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Duloxetine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Duloxetine.
Imipramine Imipramine The risk or severity of orthostatic hypotension and syncope can be increased when Imipramine is combined with Duloxetine.
Probenecid Probenecid The metabolism of Probenecid can be increased when combined with Duloxetine.
Quinidine Quinidine The metabolism of Duloxetine can be decreased when combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Duloxetine.
Isoniazid Isoniazid The metabolism of Duloxetine can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Rifampin Rifampin The metabolism of Duloxetine can be increased when combined with Rifampicin.
Disopyramide Disopyramide The metabolism of Duloxetine can be decreased when combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Duloxetine.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Duloxetine.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Duloxetine.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Duloxetine.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Methimazole Methimazole The metabolism of Duloxetine can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Duloxetine.
Chlorpropamide Chlorpropamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Chlorpropamide.
Tolbutamide Tolbutamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Tolbutamide.
Tolazamide Tolazamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Duloxetine can be decreased when combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Duloxetine is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Duloxetine can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Duloxetine.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Cyproheptadine Cyproheptadine The therapeutic efficacy of Duloxetine can be decreased when used in combination with Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Duloxetine.
Chlorpheniramine Chlorpheniramine The metabolism of Duloxetine can be decreased when combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Duloxetine.
Meclizine Meclizine The metabolism of Duloxetine can be decreased when combined with Meclizine.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Methyclothiazide Methyclothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Methyclothiazide is combined with Duloxetine.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Hydrochlorothiazide is combined with Duloxetine.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Duloxetine.
Chlorzoxazone Chlorzoxazone The metabolism of Duloxetine can be decreased when combined with Chlorzoxazone.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Duloxetine.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Duloxetine.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Danazol Danazol The metabolism of Duloxetine can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of orthostatic hypotension and syncope can be increased when Propranolol is combined with Duloxetine.
Minoxidil Minoxidil The risk or severity of orthostatic hypotension and syncope can be increased when Minoxidil is combined with Duloxetine.
Pseudoephedrine Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Duloxetine.
Spironolactone Spironolactone The risk or severity of orthostatic hypotension and syncope can be increased when Spironolactone is combined with Duloxetine.
Amphotericin B Injection Amphotericin B Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amphotericin B is combined with Duloxetine.
Phytonadione Phytonadione Duloxetine may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Nadolol Nadolol The risk or severity of orthostatic hypotension and syncope can be increased when Nadolol is combined with Duloxetine.
Butorphanol Injection Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Butorphanol is combined with Duloxetine.
Nalbuphine Injection Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Nalbuphine is combined with Duloxetine.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Duloxetine.
Flavoxate Flavoxate Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine Papaverine The risk or severity of orthostatic hypotension and syncope can be increased when Papaverine is combined with Duloxetine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Duloxetine.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Duloxetine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Duloxetine.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Duloxetine.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Duloxetine can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Duloxetine.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Duloxetine.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Duloxetine.
Captopril Captopril The risk or severity of orthostatic hypotension and syncope can be increased when Captopril is combined with Duloxetine.
Dipyridamole Dipyridamole The risk or severity of orthostatic hypotension and syncope can be increased when Dipyridamole is combined with Duloxetine.
Isoxsuprine Isoxsuprine The risk or severity of orthostatic hypotension and syncope can be increased when Isoxsuprine is combined with Duloxetine.
Vinblastine Vinblastine The metabolism of Duloxetine can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid The risk or severity of orthostatic hypotension and syncope can be increased when Etacrynic acid is combined with Duloxetine.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Metoprolol Metoprolol The risk or severity of orthostatic hypotension and syncope can be increased when Metoprolol is combined with Duloxetine.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Duloxetine is combined with Thiothixene.
Aspirin Aspirin Duloxetine may increase the antiplatelet activities of Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Salsalate.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Duloxetine.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Duloxetine.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Duloxetine.
Dicyclomine Dicyclomine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Diltiazem Diltiazem The risk or severity of orthostatic hypotension and syncope can be increased when Diltiazem is combined with Duloxetine.
Nifedipine Nifedipine The risk or severity of orthostatic hypotension and syncope can be increased when Nifedipine is combined with Duloxetine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Duloxetine.
Verapamil Verapamil The risk or severity of orthostatic hypotension and syncope can be increased when Verapamil is combined with Duloxetine.
Atenolol Atenolol The risk or severity of orthostatic hypotension and syncope can be increased when Atenolol is combined with Duloxetine.
Pindolol Pindolol The risk or severity of orthostatic hypotension and syncope can be increased when Pindolol is combined with Duloxetine.
Cisplatin Injection Cisplatin Injection Duloxetine may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Diflunisal.
Piroxicam Piroxicam The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Piroxicam.
Bumetanide Bumetanide The risk or severity of orthostatic hypotension and syncope can be increased when Bumetanide is combined with Duloxetine.
Streptozocin Streptozocin The metabolism of Duloxetine can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Duloxetine can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Duloxetine can be decreased when combined with Glyburide.
Glipizide Glipizide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Glipizide.
Indapamide Indapamide The risk or severity of orthostatic hypotension and syncope can be increased when Indapamide is combined with Duloxetine.
Amoxicillin Amoxicillin Duloxetine may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Dicloxacillin Dicloxacillin The metabolism of Duloxetine can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Duloxetine can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Duloxetine may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The risk or severity of hemorrhage can be increased when Duloxetine is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The metabolism of Duloxetine can be decreased when combined with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Labetalol Labetalol The risk or severity of orthostatic hypotension and syncope can be increased when Labetalol is combined with Duloxetine.
Auranofin Auranofin Duloxetine may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Duloxetine can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz Duloxetine may increase the tachycardic activities of Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ketoprofen.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Pimozide Pimozide The risk or severity of QTc prolongation can be increased when Duloxetine is combined with Pimozide.
Enalapril Enalapril The risk or severity of orthostatic hypotension and syncope can be increased when Enalapril is combined with Duloxetine.
Flurbiprofen Flurbiprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of orthostatic hypotension and syncope can be increased when Amiodarone is combined with Duloxetine.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Duloxetine.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Duloxetine.
Ciprofloxacin Ciprofloxacin The metabolism of Duloxetine can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Mesalazine.
Diclofenac Diclofenac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Diclofenac.
Fluoxetine Fluoxetine The serum concentration of Duloxetine can be increased when it is combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of orthostatic hypotension and syncope can be increased when Nimodipine is combined with Duloxetine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Duloxetine can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine The risk or severity of orthostatic hypotension and syncope can be increased when Clozapine is combined with Duloxetine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Duloxetine is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Duloxetine.
Ofloxacin Ofloxacin The metabolism of Duloxetine can be decreased when combined with Ofloxacin.
Didanosine Didanosine Duloxetine may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Duloxetine may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin Clarithromycin The metabolism of Duloxetine can be decreased when combined with Clarithromycin.
Benazepril Benazepril The risk or severity of orthostatic hypotension and syncope can be increased when Benazepril is combined with Duloxetine.
Etodolac Etodolac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Etodolac.
Felodipine Felodipine The risk or severity of orthostatic hypotension and syncope can be increased when Felodipine is combined with Duloxetine.
Fosinopril Fosinopril The risk or severity of orthostatic hypotension and syncope can be increased when Fosinopril is combined with Duloxetine.
Nabumetone Nabumetone The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Nabumetone.
Quinapril Quinapril The risk or severity of orthostatic hypotension and syncope can be increased when Quinapril is combined with Duloxetine.
Ramipril Ramipril The risk or severity of orthostatic hypotension and syncope can be increased when Ramipril is combined with Duloxetine.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Duloxetine.
Amlodipine Amlodipine The risk or severity of orthostatic hypotension and syncope can be increased when Amlodipine is combined with Duloxetine.
Teniposide Injection Teniposide Injection The metabolism of Duloxetine can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Duloxetine can be decreased when combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of orthostatic hypotension and syncope can be increased when Lisinopril is combined with Duloxetine.
Oxaprozin Oxaprozin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Oxaprozin.
Atovaquone Atovaquone The metabolism of Duloxetine can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Duloxetine can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of orthostatic hypotension and syncope can be increased when Sotalol is combined with Duloxetine.
Bisoprolol Bisoprolol The risk or severity of orthostatic hypotension and syncope can be increased when Bisoprolol is combined with Duloxetine.
Zolpidem Zolpidem Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The risk or severity of orthostatic hypotension and syncope can be increased when Doxazosin is combined with Duloxetine.
Terazosin Terazosin The risk or severity of orthostatic hypotension and syncope can be increased when Terazosin is combined with Duloxetine.
Isradipine Isradipine The risk or severity of orthostatic hypotension and syncope can be increased when Isradipine is combined with Duloxetine.
Omeprazole Omeprazole The metabolism of Duloxetine can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Duloxetine can be decreased when combined with Cisapride.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Duloxetine is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Duloxetine can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Duloxetine can be decreased when combined with Venlafaxine.
Famciclovir Famciclovir The metabolism of Duloxetine can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Duloxetine can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Nefazodone can be decreased when combined with Duloxetine.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Duloxetine is combined with Lamotrigine.
Losartan Losartan The risk or severity of orthostatic hypotension and syncope can be increased when Losartan is combined with Duloxetine.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Duloxetine.
Vinorelbine Injection Vinorelbine Injection The metabolism of Duloxetine can be decreased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Moexipril Moexipril The risk or severity of orthostatic hypotension and syncope can be increased when Moexipril is combined with Duloxetine.
Lansoprazole Lansoprazole The metabolism of Duloxetine can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Duloxetine.
Nicardipine Nicardipine The risk or severity of orthostatic hypotension and syncope can be increased when Nicardipine is combined with Duloxetine.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Duloxetine.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Duloxetine.
Saquinavir Saquinavir The metabolism of Duloxetine can be decreased when combined with Saquinavir.
Metformin Metformin The risk or severity of hypoglycemia can be increased when Metformin is combined with Duloxetine.
Dalteparin Injection Dalteparin Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Dalteparin.
Nisoldipine Nisoldipine The risk or severity of orthostatic hypotension and syncope can be increased when Nisoldipine is combined with Duloxetine.
Lamivudine Lamivudine Duloxetine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Duloxetine.
Amifostine Injection Amifostine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amifostine is combined with Duloxetine.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Duloxetine.
Glimepiride Glimepiride The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Duloxetine.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of Duloxetine can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Duloxetine can be decreased when combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Meropenem Injection Meropenem Injection Duloxetine may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The risk or severity of orthostatic hypotension and syncope can be increased when Clomipramine is combined with Duloxetine.
Zafirlukast Zafirlukast The metabolism of Duloxetine can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Duloxetine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine Duloxetine may increase the serotonergic activities of Mirtazapine.
Trandolapril Trandolapril The risk or severity of orthostatic hypotension and syncope can be increased when Trandolapril is combined with Duloxetine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Duloxetine is combined with Topiramate.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Duloxetine.
Valsartan Valsartan The risk or severity of orthostatic hypotension and syncope can be increased when Valsartan is combined with Duloxetine.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Duloxetine can be increased when combined with Insulin lispro.
Pramipexole Pramipexole The risk or severity of orthostatic hypotension and syncope can be increased when Pramipexole is combined with Duloxetine.
Donepezil Donepezil The metabolism of Duloxetine can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Duloxetine.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Duloxetine.
Carvedilol Carvedilol The risk or severity of orthostatic hypotension and syncope can be increased when Carvedilol is combined with Duloxetine.
Nilutamide Nilutamide The metabolism of Nilutamide can be decreased when combined with Duloxetine.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Duloxetine.
Selegiline Selegiline The risk or severity of orthostatic hypotension and syncope can be increased when Selegiline is combined with Duloxetine.
Bicalutamide Bicalutamide The metabolism of Duloxetine can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Duloxetine.
Propafenone Propafenone The metabolism of Duloxetine can be decreased when combined with Propafenone.
Raloxifene Raloxifene The metabolism of Duloxetine can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The risk or severity of orthostatic hypotension and syncope can be increased when Irbesartan is combined with Duloxetine.
Tamsulosin Tamsulosin The risk or severity of orthostatic hypotension and syncope can be increased when Tamsulosin is combined with Duloxetine.
Ropinirole Ropinirole The risk or severity of orthostatic hypotension and syncope can be increased when Ropinirole is combined with Duloxetine.
Quetiapine Quetiapine The risk or severity of orthostatic hypotension and syncope can be increased when Quetiapine is combined with Duloxetine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Duloxetine.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Duloxetine.
Tolcapone Tolcapone The risk or severity of orthostatic hypotension and syncope can be increased when Tolcapone is combined with Duloxetine.
Citalopram Citalopram The metabolism of Duloxetine can be decreased when combined with Citalopram.
Capecitabine Capecitabine The metabolism of Duloxetine can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Duloxetine can be decreased when combined with Efavirenz.
Abacavir Abacavir Duloxetine may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Duloxetine.
Pioglitazone Pioglitazone The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Pioglitazone.
Celecoxib Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Duloxetine.
Rosiglitazone Rosiglitazone The metabolism of Duloxetine can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Duloxetine.
Thalidomide Thalidomide Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Balsalazide Balsalazide The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Balsalazide.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Duloxetine.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Duloxetine.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Duloxetine.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Duloxetine.
Terbinafine Terbinafine The metabolism of Duloxetine can be decreased when combined with Terbinafine.

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