Duloxetine

Duloxetine is used to treat depression in adults and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults and children 7 years of age and older. Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes) in adults and fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep) in adults and children 13 years of age and older. It is also used to treat ongoing bone or muscle pain such as lower back pain or osteoarthritis (joint pain or stiffness that may worsen over time) in adults. Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

Duloxetine comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule to take by mouth. When duloxetine is used to treat depression, it is usually taken once or twice a day with or without food. When duloxetine is used to treat generalized anxiety disorder, the pain of diabetic neuropathy, fibromyalgia, or ongoing bone or muscle pain, it is usually taken once a day with or without food. Take duloxetine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take duloxetine exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.

Swallow the delayed-release capsules whole; do not split, chew, or crush them. Do not open the delayed-release capsules and mix the contents with liquids or sprinkle the contents on food.

Your doctor may start you on a low dose of medication and increase your dose after one week.

Duloxetine may help control your symptoms but will not cure your condition. It may take 1 to 4 weeks or longer before you feel the full benefit of duloxetine. Continue to take duloxetine even if you feel well. Do not stop taking duloxetine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking duloxetine, you may experience withdrawal symptoms such as nausea; vomiting; diarrhea; anxiety; dizziness; tiredness; headache; pain, burning, numbness, or tingling in the hands or feet; irritability; difficulty falling asleep or staying asleep; sweating; and nightmares. Tell your doctor if you experience any of these symptoms when your dose of duloxetine is decreased.

Duloxetine is also sometimes used to treat stress urinary incontinence (leakage of urine during physical activity such as coughing, sneezing, laughing, and exercise) in women. Talk to your doctor about using this medication to treat your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking duloxetine,

• tell your doctor and pharmacist if you are allergic to duloxetine, any other medications, or any of the ingredients in duloxetine delayed-release capsules. Ask your doctor or pharmacist for a list of the ingredients.

• tell your doctor if you are taking thioridazine or a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid (Zyvox); methylene blue; phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take duloxetine. If you stop taking duloxetine, you should wait at least 5 days before you start to take an MAO inhibitor.

• tell your doctor and pharmacist what other prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: amphetamines such as amphetamine (in Adderall, others), dextroamphetamine (Dexedrine, in Adderall), and methamphetamine (Desoxyn); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; cimetidine (Tagamet); ciprofloxacin (Cipro); diuretics ('water pills'); fentanyl (Abstral, Actiq, Fentora, Onsolis, others); medications for irregular heartbeat such as amiodarone (Cordarone), flecainide (Tambocor), moricizine (Ethmozine), propafenone (Rythmol), and quinidine (in Nuedexta); medications for anxiety, high blood pressure, mental illness, pain, and nausea; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, Onzetra, Tosmyra, in Treximet), and zolmitriptan (Zomig); lithium (Lithobid); proton pump inhibitors such as lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (Aciphex); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), and paroxetine (Paxil); sleeping pills; theophylline (Theo-24, Theochron); tramadol (Ultram); and tranquilizers. Many other medications may interact with duloxetine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what nutritional supplements and herbal products you are taking, especially products containing St. John's wort or tryptophan.

• tell your doctor if you drink or have ever drunk large amounts of alcohol or if you use or have ever used street drugs or have ever overused prescription medications. Also tell your doctor if you have a low level of sodium in your blood; glaucoma (increased pressure in the eye that may cause loss of sight); if you have recently had a heart attack; or if you have or have ever had high blood pressure; seizures; coronary artery disease (blockage or narrowing of the blood vessels that lead to the heart); bleeding problems; any type of stomach problem such as slow stomach emptying; or heart, liver, or kidney disease. If you have diabetes, be sure to talk to your doctor about how serious your condition is so your doctor can decide if duloxetine is right for you.

• tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking duloxetine, call your doctor. Duloxetine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking duloxetine.

• you should know that duloxetine may make you drowsy, dizzy, or may affect your judgment, thinking or coordination. Do not drive a car or operate machinery until you know how this medication affects you.

• ask your doctor about the safe use of alcoholic beverages while you are taking duloxetine. Alcohol can increase the risk of serious side effects from duloxetine.

• you should know that duloxetine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking duloxetine or with an increase in dose. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

• you should know that duloxetine may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.

• you should know that duloxetine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Duloxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • constipation

  • diarrhea

  • weight changes

  • heartburn

  • stomach pain

  • decreased appetite

  • dry mouth

  • increased urination

  • sweating or night sweats

  • dizziness

  • headache

  • weight changes

  • tiredness

  • drowsiness

  • muscle pain or cramps

  • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

  • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

  • uncontrollable shaking of a part of the body

• Some side effects can be serious. If you experience any of the following side effects, or those mentioned in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

  • unusual bruising or bleeding

  • pain in the upper right part of the stomach

  • swelling of the abdomen

  • itching

  • yellowing of the skin or eyes

  • dark colored urine

  • loss of appetite

  • extreme tiredness or weakness

  • confusion

  • unsteady walking that may cause falling

  • flu-like symptoms

  • agitation, fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

  • seizures

  • hallucinations (seeing things or hearing voices that do not exist)

  • fever

  • blisters or peeling skin

  • rash

  • hives

  • difficulty breathing or swallowing

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • hoarseness

  • difficulty urinating

• Duloxetine may decrease appetite and cause weight loss in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Talk to your child's doctor about the risks of giving duloxetine to your child.

• Duloxetine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• agitation

• hallucinating (seeing things or hearing voices that do not exist)

• fast heartbeat

• fever

• loss of coordination

• nausea

• vomiting

• diarrhea

• drowsiness

• seizures

• dizziness

• lightheadedness

• fainting

• unresponsiveness

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The metabolism of Duloxetine can be decreased when combined with Moxifloxacin.
Repaglinide	Repaglinide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Repaglinide.
Montelukast	Montelukast The metabolism of Duloxetine can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin glargine.
Leflunomide	Leflunomide The serum concentration of Duloxetine can be decreased when it is combined with Leflunomide.
Delavirdine	Delavirdine The metabolism of Duloxetine can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Duloxetine can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Duloxetine.
Dolasetron	Dolasetron The metabolism of Duloxetine can be decreased when combined with Dolasetron.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Duloxetine.
Anagrelide	Anagrelide The risk or severity of hemorrhage can be increased when Duloxetine is combined with Anagrelide.
Candesartan	Candesartan The metabolism of Candesartan can be decreased when combined with Duloxetine.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Duloxetine.
Clopidogrel	Clopidogrel The risk or severity of hemorrhage can be increased when Duloxetine is combined with Clopidogrel.
Diphenoxylate	Diphenoxylate The risk or severity of serotonin syndrome can be increased when Diphenoxylate is combined with Duloxetine.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Duloxetine can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The metabolism of Duloxetine can be decreased when combined with Conjugated estrogens.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Duloxetine.
Guanfacine	Guanfacine The risk or severity of orthostatic hypotension and syncope can be increased when Guanfacine is combined with Duloxetine.
Magnesium Hydroxide	Magnesium Hydroxide Duloxetine may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine	Methylergonovine The metabolism of Duloxetine can be decreased when combined with Methylergometrine.
Miglitol	Miglitol The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Miglitol.
Mycophenolate	Mycophenolate Duloxetine may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Duloxetine.
Olsalazine	Olsalazine The risk or severity of gastrointestinal bleeding can be increased when Olsalazine is combined with Duloxetine.
Paregoric	Paregoric The risk or severity of orthostatic hypotension and syncope can be increased when Morphine is combined with Duloxetine.
Penbutolol	Penbutolol The risk or severity of orthostatic hypotension and syncope can be increased when Acebutolol is combined with Duloxetine.
Pentazocine	Pentazocine The risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Duloxetine.
Potassium	Potassium Potassium may increase the excretion rate of Duloxetine which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Duloxetine may decrease the excretion rate of Prednisone which could result in a higher serum level.
Ranitidine	Ranitidine The metabolism of Ranitidine can be decreased when combined with Duloxetine.
Reserpine	Reserpine The risk or severity of orthostatic hypotension and syncope can be increased when Reserpine is combined with Duloxetine.
Rizatriptan	Rizatriptan The risk or severity of adverse effects can be increased when Duloxetine is combined with Rizatriptan.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Duloxetine.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Duloxetine.
Tizanidine	Tizanidine The risk or severity of orthostatic hypotension and syncope can be increased when Tizanidine is combined with Duloxetine.
Triamcinolone	Triamcinolone The metabolism of Duloxetine can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Duloxetine.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection The metabolism of Duloxetine can be decreased when combined with Doxycycline.
Famotidine Injection	Famotidine Injection The metabolism of Duloxetine can be decreased when combined with Famotidine.
Fluconazole Injection	Fluconazole Injection The metabolism of Duloxetine can be decreased when combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Duloxetine.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The metabolism of Duloxetine can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The metabolism of Duloxetine can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection	Levofloxacin Injection The metabolism of Duloxetine can be decreased when combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The metabolism of Duloxetine can be increased when combined with Methylprednisolone.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of adverse effects can be increased when Metoclopramide is combined with Duloxetine.
Metronidazole Injection	Metronidazole Injection The metabolism of Duloxetine can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Morphine is combined with Duloxetine.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Duloxetine may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Duloxetine.
Altretamine	Altretamine Amphetamine may increase the serotonergic activities of Duloxetine.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cyclosporine	Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Duloxetine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Duloxetine.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Enoxaparin.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Duloxetine.
Torsemide	Torsemide The risk or severity of orthostatic hypotension and syncope can be increased when Torasemide is combined with Duloxetine.
Olanzapine	Olanzapine The risk or severity of orthostatic hypotension and syncope can be increased when Olanzapine is combined with Duloxetine.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Duloxetine.
Dofetilide	Dofetilide The metabolism of Dofetilide can be decreased when combined with Duloxetine.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Duloxetine.
Eprosartan	Eprosartan The risk or severity of orthostatic hypotension and syncope can be increased when Eprosartan is combined with Duloxetine.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Duloxetine can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Meloxicam.
Orlistat	Orlistat The metabolism of Duloxetine can be increased when combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Duloxetine.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Telmisartan	Telmisartan The risk or severity of orthostatic hypotension and syncope can be increased when Telmisartan is combined with Duloxetine.
Temozolomide	Temozolomide Duloxetine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Duloxetine.
Anakinra	Anakinra The metabolism of Duloxetine can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Duloxetine.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Duloxetine.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of hemorrhage can be increased when Duloxetine is combined with Pentosan polysulfate.
Trimipramine	Trimipramine The metabolism of Trimipramine can be decreased when combined with Duloxetine.
Etanercept Injection	Etanercept Injection The metabolism of Duloxetine can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil	Modafinil The metabolism of Duloxetine can be increased when combined with Modafinil.
Perindopril	Perindopril The risk or severity of orthostatic hypotension and syncope can be increased when Perindopril is combined with Duloxetine.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Choline magnesium trisalicylate.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Duloxetine.
Epinephrine Injection	Epinephrine Injection Duloxetine may increase the tachycardic activities of Epinephrine.
Eplerenone	Eplerenone The risk or severity of orthostatic hypotension and syncope can be increased when Eplerenone is combined with Duloxetine.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Escitalopram.
Olmesartan	Olmesartan The risk or severity of orthostatic hypotension and syncope can be increased when Olmesartan is combined with Duloxetine.
Zonisamide	Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine.
Adalimumab Injection	Adalimumab Injection The metabolism of Duloxetine can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Duloxetine.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Duloxetine.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Duloxetine.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Duloxetine.
Atazanavir	Atazanavir The metabolism of Duloxetine can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan The metabolism of Duloxetine can be decreased when combined with Almotriptan.
Eletriptan	Eletriptan The metabolism of Eletriptan can be decreased when combined with Duloxetine.
Mefloquine	Mefloquine The metabolism of Duloxetine can be decreased when combined with Mefloquine.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Duloxetine.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Duloxetine.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Duloxetine.
Aprepitant	Aprepitant The metabolism of Duloxetine can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Duloxetine may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection	Interferon Beta-1a Subcutaneous Injection The metabolism of Duloxetine can be decreased when combined with Interferon beta-1a.
Memantine	Memantine Duloxetine may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod	Tegaserod The metabolism of Tegaserod can be decreased when combined with Duloxetine.
Tadalafil	Tadalafil Duloxetine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Duloxetine.
Gemifloxacin	Gemifloxacin The metabolism of Duloxetine can be decreased when combined with Gemifloxacin.
Progesterone	Progesterone The metabolism of Progesterone can be decreased when combined with Duloxetine.
Apomorphine Injection	Apomorphine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Apomorphine is combined with Duloxetine.
Infliximab Injection	Infliximab Injection The metabolism of Duloxetine can be increased when combined with Infliximab.
Oxandrolone	Oxandrolone The metabolism of Duloxetine can be decreased when combined with Oxandrolone.
Protriptyline	Protriptyline The metabolism of Duloxetine can be decreased when combined with Protriptyline.
Rifaximin	Rifaximin The metabolism of Duloxetine can be increased when combined with Rifaximin.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Duloxetine.
Tinidazole	Tinidazole Duloxetine may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium	Trospium Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan The metabolism of Duloxetine can be increased when combined with Bosentan.
Cefditoren	Cefditoren Duloxetine may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet	Cinacalcet The metabolism of Duloxetine can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Duloxetine.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Duloxetine is combined with Eszopiclone.
Ganciclovir	Ganciclovir Duloxetine may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Insulin aspart.
Ribavirin	Ribavirin Duloxetine may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin	Solifenacin The metabolism of Solifenacin can be decreased when combined with Duloxetine.
Valganciclovir	Valganciclovir Duloxetine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole	Voriconazole The metabolism of Duloxetine can be decreased when combined with Voriconazole.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the serotonergic activities of Duloxetine.
Entecavir	Entecavir The metabolism of Duloxetine can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The metabolism of Duloxetine can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Duloxetine can be increased when it is combined with Peginterferon alfa-2b.
Pramlintide Injection	Pramlintide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Pramlintide.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Exenatide Injection	Exenatide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Exenatide.
Isocarboxazid	Isocarboxazid The risk or severity of orthostatic hypotension and syncope can be increased when Isocarboxazid is combined with Duloxetine.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Duloxetine.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Duloxetine.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Duloxetine.
Pregabalin	Pregabalin The therapeutic efficacy of Duloxetine can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The serum concentration of Duloxetine can be increased when it is combined with Deferasirox.
Phenylephrine	Phenylephrine Duloxetine may increase the tachycardic activities of Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Duloxetine.
Felbamate	Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Duloxetine.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Insulin detemir.
Ranolazine	Ranolazine The serum concentration of Duloxetine can be increased when it is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Duloxetine can be increased when combined with Abatacept.
Rasagiline	Rasagiline The risk or severity of orthostatic hypotension and syncope can be increased when Rasagiline is combined with Duloxetine.
Imatinib	Imatinib The metabolism of Duloxetine can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Sitagliptin.
Varenicline	Varenicline Duloxetine may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib	Gefitinib The metabolism of Gefitinib can be decreased when combined with Duloxetine.
Albuterol	Albuterol Duloxetine may increase the tachycardic activities of Salbutamol.
Paliperidone	Paliperidone The metabolism of Paliperidone can be decreased when combined with Duloxetine.
Bortezomib	Bortezomib The metabolism of Bortezomib can be decreased when combined with Duloxetine.
Clofarabine Injection	Clofarabine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Clofarabine is combined with Duloxetine.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin glulisine.
Lubiprostone	Lubiprostone Duloxetine may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Posaconazole	Posaconazole The metabolism of Duloxetine can be decreased when combined with Posaconazole.
Primaquine	Primaquine The metabolism of Duloxetine can be decreased when combined with Primaquine.
Aliskiren	Aliskiren The risk or severity of orthostatic hypotension and syncope can be increased when Aliskiren is combined with Duloxetine.
Darunavir	Darunavir The metabolism of Duloxetine can be decreased when combined with Darunavir.
Pemetrexed Injection	Pemetrexed Injection Duloxetine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Duloxetine.
Lisdexamfetamine	Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Duloxetine.
Nabilone	Nabilone The risk or severity of orthostatic hypotension and syncope can be increased when Nabilone is combined with Duloxetine.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Duloxetine.
Sorafenib	Sorafenib The metabolism of Duloxetine can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Duloxetine can be decreased when combined with Sunitinib.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Lapatinib	Lapatinib The metabolism of Lapatinib can be decreased when combined with Duloxetine.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Duloxetine.
Pegaptanib Injection	Pegaptanib Injection Duloxetine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Duloxetine.
Mexiletine	Mexiletine The metabolism of Duloxetine can be decreased when combined with Mexiletine.
Armodafinil	Armodafinil The metabolism of Duloxetine can be decreased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Duloxetine may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Ivermectin	Ivermectin The metabolism of Duloxetine can be increased when combined with Ivermectin.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Duloxetine.
Lenalidomide	Lenalidomide Duloxetine may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib	Nilotinib The metabolism of Duloxetine can be decreased when combined with Nilotinib.
Bexarotene	Bexarotene The metabolism of Duloxetine can be increased when combined with Bexarotene.
Budesonide	Budesonide The metabolism of Duloxetine can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Duloxetine can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Duloxetine is combined with Desmopressin.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Duloxetine.
Doripenem Injection	Doripenem Injection Duloxetine may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine	Etravirine The metabolism of Duloxetine can be increased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of orthostatic hypotension and syncope can be increased when Arsenic trioxide is combined with Duloxetine.
Mitoxantrone Injection	Mitoxantrone Injection The metabolism of Duloxetine can be decreased when combined with Mitoxantrone.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Duloxetine is combined with Desvenlafaxine.
Cevimeline	Cevimeline The metabolism of Duloxetine can be decreased when combined with Cevimeline.
Nebivolol	Nebivolol The risk or severity of orthostatic hypotension and syncope can be increased when Nebivolol is combined with Duloxetine.
Tretinoin	Tretinoin The risk or severity of orthostatic hypotension and syncope can be increased when Tretinoin is combined with Duloxetine.
Bendamustine Injection	Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Duloxetine.
Pilocarpine	Pilocarpine The metabolism of Duloxetine can be decreased when combined with Pilocarpine.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Duloxetine.
Certolizumab Injection	Certolizumab Injection The metabolism of Duloxetine can be increased when combined with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Duloxetine.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Duloxetine.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Duloxetine.
Mitotane	Mitotane The metabolism of Duloxetine can be increased when combined with Mitotane.
Methylnaltrexone Injection	Methylnaltrexone Injection Duloxetine may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Duloxetine.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Duloxetine.
Naltrexone Injection	Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Naltrexone.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Eltrombopag	Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Duloxetine.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Duloxetine is combined with Milnacipran.
Plerixafor Injection	Plerixafor Injection Duloxetine may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine	Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Duloxetine.
Betaxolol	Betaxolol The risk or severity of orthostatic hypotension and syncope can be increased when Betaxolol is combined with Duloxetine.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Duloxetine.
Prasugrel	Prasugrel The risk or severity of hemorrhage can be increased when Duloxetine is combined with Prasugrel.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Duloxetine.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Duloxetine.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Duloxetine can be decreased when combined with Tolvaptan.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Duloxetine.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine.
Pralatrexate Injection	Pralatrexate Injection Duloxetine may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection The metabolism of Duloxetine can be decreased when combined with Palonosetron.
Saxagliptin	Saxagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Saxagliptin.
Telavancin Injection	Telavancin Injection Duloxetine may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Duloxetine.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Topotecan	Topotecan The metabolism of Duloxetine can be decreased when combined with Topotecan.
Golimumab Injection	Golimumab Injection The metabolism of Duloxetine can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Duloxetine can be decreased when combined with Pazopanib.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Duloxetine is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Duloxetine.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Duloxetine.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Duloxetine.
Oxymorphone	Oxymorphone The risk or severity of serotonin syndrome can be increased when Oxymorphone is combined with Duloxetine.
Dabigatran	Dabigatran The risk or severity of hemorrhage can be increased when Duloxetine is combined with Dabigatran.
Liraglutide Injection	Liraglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Liraglutide.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Duloxetine can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine Duloxetine may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Duloxetine.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Duloxetine.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Duloxetine.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Duloxetine.
Vilazodone	Vilazodone The metabolism of Vilazodone can be decreased when combined with Duloxetine.
Ipilimumab Injection	Ipilimumab Injection Duloxetine may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The risk or severity of orthostatic hypotension and syncope can be increased when Aldesleukin is combined with Duloxetine.
Terbutaline Injection	Terbutaline Injection Duloxetine may increase the tachycardic activities of Terbutaline.
Azilsartan	Azilsartan The risk or severity of orthostatic hypotension and syncope can be increased when Azilsartan medoxomil is combined with Duloxetine.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be decreased when combined with Duloxetine.
Roflumilast	Roflumilast The metabolism of Roflumilast can be decreased when combined with Duloxetine.
Linagliptin	Linagliptin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Linagliptin.
Rilpivirine	Rilpivirine The metabolism of Duloxetine can be decreased when combined with Rilpivirine.
Telaprevir	Telaprevir The metabolism of Duloxetine can be decreased when combined with Glecaprevir.
Potassium Iodide	Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Duloxetine.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Duloxetine can be decreased when combined with Cyclophosphamide.
Abiraterone	Abiraterone The metabolism of Duloxetine can be decreased when combined with Abiraterone.
Rivaroxaban	Rivaroxaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Rivaroxaban.
Ticagrelor	Ticagrelor The risk or severity of hemorrhage can be increased when Duloxetine is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Duloxetine can be decreased when combined with Brentuximab vedotin.
Ruxolitinib	Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Duloxetine.
Vandetanib	Vandetanib The metabolism of Vandetanib can be decreased when combined with Duloxetine.
Clobazam	Clobazam The metabolism of Duloxetine can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The serum concentration of Duloxetine can be increased when it is combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Duloxetine can be decreased when combined with Vismodegib.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Duloxetine.
Deferiprone	Deferiprone Duloxetine may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Duloxetine.
Crizotinib	Crizotinib The metabolism of Duloxetine can be decreased when combined with Crizotinib.
Cabergoline	Cabergoline The metabolism of Duloxetine can be decreased when combined with Cabergoline.
Naloxone Injection	Naloxone Injection The metabolism of Duloxetine can be decreased when combined with Naloxone.
Fondaparinux Injection	Fondaparinux Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Fondaparinux.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Duloxetine.
Iloprost	Iloprost The risk or severity of orthostatic hypotension and syncope can be increased when Iloprost is combined with Duloxetine.
Enzalutamide	Enzalutamide The metabolism of Duloxetine can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The metabolism of Mirabegron can be decreased when combined with Duloxetine.
Regorafenib	Regorafenib The metabolism of Duloxetine can be decreased when combined with Regorafenib.
Bosutinib	Bosutinib The metabolism of Duloxetine can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The metabolism of Duloxetine can be increased when combined with Corticotropin.
Teriflunomide	Teriflunomide The serum concentration of Duloxetine can be decreased when it is combined with Teriflunomide.
Lorcaserin	Lorcaserin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Mecasermin.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Duloxetine.
Teduglutide Injection	Teduglutide Injection Duloxetine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl	Icosapent Ethyl Duloxetine may increase the antiplatelet activities of Icosapent ethyl.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Duloxetine.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Duloxetine.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Duloxetine.
Pomalidomide	Pomalidomide The metabolism of Duloxetine can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Duloxetine can be decreased when combined with Trastuzumab emtansine.
Apixaban	Apixaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Apixaban.
Canagliflozin	Canagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Canagliflozin is combined with Duloxetine.
Methazolamide	Methazolamide The risk or severity of orthostatic hypotension and syncope can be increased when Methazolamide is combined with Duloxetine.
Dabrafenib	Dabrafenib The metabolism of Duloxetine can be decreased when combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Duloxetine.
Trametinib	Trametinib The metabolism of Trametinib can be increased when combined with Duloxetine.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Duloxetine.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Duloxetine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Duloxetine.
Lomitapide	Lomitapide The metabolism of Lomitapide can be decreased when combined with Duloxetine.
Ketorolac Injection	Ketorolac Injection The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ketorolac.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of orthostatic hypotension and syncope can be increased when Obinutuzumab is combined with Duloxetine.
Simeprevir	Simeprevir The metabolism of Duloxetine can be decreased when combined with Simeprevir.
Sofosbuvir	Sofosbuvir Duloxetine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Dapagliflozin is combined with Duloxetine.
Apremilast	Apremilast The metabolism of Duloxetine can be increased when combined with Apremilast.
Droxidopa	Droxidopa Duloxetine may increase the tachycardic activities of Droxidopa.
Ceritinib	Ceritinib The metabolism of Ceritinib can be decreased when combined with Duloxetine.
Siltuximab Injection	Siltuximab Injection The metabolism of Duloxetine can be increased when combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Albiglutide.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Duloxetine.
Belinostat Injection	Belinostat Injection The metabolism of Duloxetine can be increased when combined with Belinostat.
Idelalisib	Idelalisib The metabolism of Idelalisib can be decreased when combined with Duloxetine.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be increased when combined with Duloxetine.
Oritavancin Injection	Oritavancin Injection The metabolism of Duloxetine can be increased when combined with Oritavancin.
Empagliflozin	Empagliflozin The risk or severity of orthostatic hypotension and syncope can be increased when Empagliflozin is combined with Duloxetine.
Vorapaxar	Vorapaxar The risk or severity of hemorrhage can be increased when Duloxetine is combined with Vorapaxar.
Hydrocodone	Hydrocodone Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant	Suvorexant Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection	Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Dulaglutide.
Edoxaban	Edoxaban The risk or severity of hemorrhage can be increased when Duloxetine is combined with Edoxaban.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The metabolism of Duloxetine can be decreased when combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Duloxetine can be decreased when combined with Olaparib.
Methamphetamine	Methamphetamine The metabolism of Duloxetine can be decreased when combined with Metamfetamine.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Duloxetine.
Riociguat	Riociguat The risk or severity of orthostatic hypotension and syncope can be increased when Riociguat is combined with Duloxetine.
Lanreotide Injection	Lanreotide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Lanreotide.
Pirfenidone	Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Duloxetine.
Nintedanib	Nintedanib The metabolism of Nintedanib can be decreased when combined with Duloxetine.
Secukinumab Injection	Secukinumab Injection The metabolism of Duloxetine can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The metabolism of Risperidone can be decreased when combined with Duloxetine.
Palbociclib	Palbociclib The metabolism of Duloxetine can be decreased when combined with Palbociclib.
Insulin Human Inhalation	Insulin Human Inhalation The metabolism of Duloxetine can be increased when combined with Insulin human.
Lenvatinib	Lenvatinib The metabolism of Duloxetine can be decreased when combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Duloxetine can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The metabolism of Panobinostat can be decreased when combined with Duloxetine.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of orthostatic hypotension and syncope can be increased when Dinutuximab is combined with Duloxetine.
Haloperidol Injection	Haloperidol Injection The risk or severity of CNS depression can be increased when Duloxetine is combined with Haloperidol.
Amiloride	Amiloride The risk or severity of orthostatic hypotension and syncope can be increased when Amiloride is combined with Duloxetine.
Isavuconazonium Injection	Isavuconazonium Injection The metabolism of Duloxetine can be increased when combined with Isavuconazonium.
Macitentan	Macitentan Duloxetine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib	Sonidegib The metabolism of Sonidegib can be decreased when combined with Duloxetine.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Duloxetine.
Rolapitant	Rolapitant The metabolism of Duloxetine can be decreased when combined with Rolapitant.
Prednisolone	Prednisolone The metabolism of Duloxetine can be increased when combined with Prednisolone.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Duloxetine.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Duloxetine.
Cariprazine	Cariprazine The metabolism of Cariprazine can be decreased when combined with Duloxetine.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Duloxetine may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The metabolism of Duloxetine can be increased when combined with Insulin degludec.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Duloxetine.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Duloxetine.
Osimertinib	Osimertinib The serum concentration of Duloxetine can be decreased when it is combined with Osimertinib.
Alectinib	Alectinib The metabolism of Alectinib can be decreased when combined with Duloxetine.
Ixazomib	Ixazomib The metabolism of Ixazomib can be decreased when combined with Duloxetine.
Rifapentine	Rifapentine The metabolism of Duloxetine can be increased when combined with Rifapentine.
Lesinurad	Lesinurad The metabolism of Lesinurad can be increased when combined with Duloxetine.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amphotericin B is combined with Duloxetine.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Duloxetine can be increased when combined with Dexamethasone.
Defibrotide Injection	Defibrotide Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Defibrotide.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Duloxetine.
Venetoclax	Venetoclax The metabolism of Duloxetine can be decreased when combined with Venetoclax.
Cobicistat	Cobicistat The metabolism of Duloxetine can be decreased when combined with Cobicistat.
Midodrine	Midodrine Duloxetine may increase the tachycardic activities of Midodrine.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Duloxetine is combined with Pimavanserin.
Obeticholic Acid	Obeticholic Acid The metabolism of Duloxetine can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Duloxetine can be decreased when combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection The risk or severity of orthostatic hypotension and syncope can be increased when Furosemide is combined with Duloxetine.
Rucaparib	Rucaparib The metabolism of Rucaparib can be decreased when combined with Duloxetine.
Lixisenatide Injection	Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Lixisenatide.
Ribociclib	Ribociclib The metabolism of Duloxetine can be decreased when combined with Ribociclib.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Duloxetine.
Brigatinib	Brigatinib The metabolism of Duloxetine can be decreased when combined with Brigatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Duloxetine.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Duloxetine.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Duloxetine.
Deflazacort	Deflazacort The metabolism of Duloxetine can be increased when combined with Deflazacort.
Safinamide	Safinamide Safinamide may increase the serotonergic activities of Duloxetine.
Naldemedine	Naldemedine Duloxetine may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection	Sarilumab Injection The metabolism of Duloxetine can be increased when combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Duloxetine can be decreased when combined with Midostaurin.
Neratinib	Neratinib The metabolism of Neratinib can be decreased when combined with Duloxetine.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Duloxetine.
Enasidenib	Enasidenib The metabolism of Duloxetine can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Duloxetine can be increased when combined with Fosaprepitant.
Benznidazole	Benznidazole Duloxetine may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Duloxetine.
Delafloxacin	Delafloxacin Duloxetine may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Duloxetine.
Betrixaban	Betrixaban The risk or severity of bleeding can be increased when Duloxetine is combined with Betrixaban.
Acalabrutinib	Acalabrutinib The metabolism of Duloxetine can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Letermovir can be decreased when combined with Duloxetine.
Semaglutide Injection	Semaglutide Injection The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Semaglutide.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Duloxetine.
Ertugliflozin	Ertugliflozin The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The metabolism of Duloxetine can be increased when combined with Apalutamide.
Fostamatinib	Fostamatinib The metabolism of Duloxetine can be decreased when combined with Fostamatinib.
Avatrombopag	Avatrombopag The metabolism of Duloxetine can be increased when combined with Avatrombopag.
Baricitinib	Baricitinib The metabolism of Baricitinib can be decreased when combined with Duloxetine.
Lofexidine	Lofexidine The therapeutic efficacy of Duloxetine can be increased when used in combination with Lofexidine.
Plazomicin Injection	Plazomicin Injection Duloxetine may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Duloxetine.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Duloxetine.
Binimetinib	Binimetinib The metabolism of Binimetinib can be decreased when combined with Duloxetine.
Ivosidenib	Ivosidenib The metabolism of Duloxetine can be decreased when combined with Ivosidenib.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Duloxetine.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Duloxetine.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Duloxetine.
Dacomitinib	Dacomitinib The metabolism of Duloxetine can be decreased when combined with Dacomitinib.
Duvelisib	Duvelisib The metabolism of Duvelisib can be decreased when combined with Duloxetine.
Stiripentol	Stiripentol The metabolism of Duloxetine can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Duloxetine can be decreased when used in combination with Gilteritinib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The risk or severity of orthostatic hypotension and syncope can be increased when Paclitaxel is combined with Duloxetine.
Rifamycin	Rifamycin The metabolism of Duloxetine can be increased when combined with Rifamycin.
Prucalopride	Prucalopride The metabolism of Prucalopride can be decreased when combined with Duloxetine.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Duloxetine can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Duloxetine.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Caplacizumab.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Duloxetine.
Alpelisib	Alpelisib The serum concentration of Duloxetine can be decreased when it is combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Duloxetine.
Solriamfetol	Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Duloxetine.
Triclabendazole	Triclabendazole The metabolism of Duloxetine can be decreased when combined with Triclabendazole.
Entrectinib	Entrectinib The metabolism of Entrectinib can be decreased when combined with Duloxetine.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Duloxetine.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Duloxetine.
Pitolisant	Pitolisant The serum concentration of Duloxetine can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The metabolism of Duloxetine can be decreased when combined with Fedratinib.
Lefamulin	Lefamulin The metabolism of Lefamulin can be decreased when combined with Duloxetine.
Phenytoin Injection	Phenytoin Injection The metabolism of Duloxetine can be increased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Duloxetine can be increased when combined with Fosphenytoin.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Duloxetine.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Duloxetine.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Duloxetine.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Duloxetine.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Lasmiditan is combined with Duloxetine.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Duloxetine.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Duloxetine.
Cenobamate	Cenobamate The serum concentration of Duloxetine can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Duloxetine.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Duloxetine.
Capmatinib	Capmatinib The metabolism of Duloxetine can be decreased when combined with Capmatinib.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Duloxetine.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Fenfluramine.
Octreotide	Octreotide The metabolism of Duloxetine can be decreased when combined with Octreotide.
Pralsetinib	Pralsetinib The metabolism of Duloxetine can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Duloxetine can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Duloxetine.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Viloxazine.
Vitamin E (Alpha-Tocopherol)	Vitamin E (Alpha-Tocopherol) The metabolism of Vitamin E can be increased when combined with Duloxetine.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Duloxetine.
Fenoprofen	Fenoprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Fenoprofen.
Indomethacin	Indomethacin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Indomethacin.
Mefenamic Acid	Mefenamic Acid The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Mefenamic acid.
Naproxen	Naproxen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Naproxen.
Tolmetin	Tolmetin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Tolmetin.
Sulindac	Sulindac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Sulindac.
Trazodone	Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Duloxetine.
Isotretinoin	Isotretinoin Duloxetine may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Hydroxyurea	Hydroxyurea The metabolism of Duloxetine can be decreased when combined with Hydroxyurea.
Floxuridine	Floxuridine The metabolism of Duloxetine can be decreased when combined with Floxuridine.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Duloxetine.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Duloxetine.
Methotrexate Injection	Methotrexate Injection The metabolism of Duloxetine can be decreased when combined with Methotrexate.
Levorphanol	Levorphanol The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Duloxetine.
Primidone	Primidone The metabolism of Duloxetine can be increased when combined with Primidone.
Methsuximide	Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Duloxetine.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Duloxetine is combined with Diethylpropion.
Chlorpromazine	Chlorpromazine The risk or severity of orthostatic hypotension and syncope can be increased when Chlorpromazine is combined with Duloxetine.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Diazepam.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Oxazepam.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Duloxetine is combined with Flurazepam.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Duloxetine is combined with Clorazepic acid.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Duloxetine.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of orthostatic hypotension and syncope can be increased when Phenoxybenzamine is combined with Duloxetine.
Carmustine	Carmustine The metabolism of Duloxetine can be decreased when combined with Carmustine.
Amantadine	Amantadine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Amantadine.
Codeine	Codeine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Codeine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Duloxetine.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Duloxetine.
Bromocriptine	Bromocriptine The risk or severity of orthostatic hypotension and syncope can be increased when Bromocriptine is combined with Duloxetine.
Metaproterenol	Metaproterenol Duloxetine may increase the tachycardic activities of Orciprenaline.
Tranylcypromine	Tranylcypromine The risk or severity of orthostatic hypotension and syncope can be increased when Tranylcypromine is combined with Duloxetine.
Phenelzine	Phenelzine The risk or severity of orthostatic hypotension and syncope can be increased when Phenelzine is combined with Duloxetine.
Procarbazine	Procarbazine Procarbazine may increase the serotonergic activities of Duloxetine.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Duloxetine.
Tetracycline	Tetracycline The metabolism of Duloxetine can be decreased when combined with Tetracycline.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Prochlorperazine	Prochlorperazine The metabolism of Duloxetine can be decreased when combined with Prochlorperazine.
Thioridazine	Thioridazine The risk or severity of orthostatic hypotension and syncope can be increased when Thioridazine is combined with Duloxetine.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Trifluoperazine.
Bleomycin	Bleomycin Bleomycin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Dapsone	Dapsone The metabolism of Duloxetine can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine The risk or severity of hypoglycemia can be increased when Sulfadiazine is combined with Duloxetine.
Oxycodone	Oxycodone The risk or severity of serotonin syndrome can be increased when Oxycodone is combined with Duloxetine.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Duloxetine.
Oxybutynin	Oxybutynin The metabolism of Duloxetine can be decreased when combined with Oxybutynin.
Benztropine	Benztropine The metabolism of Duloxetine can be decreased when combined with Benzatropine.
Maprotiline	Maprotiline The metabolism of Maprotiline can be decreased when combined with Duloxetine.
Ibuprofen	Ibuprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ibuprofen.
Trihexyphenidyl	Trihexyphenidyl Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The metabolism of Perphenazine can be decreased when combined with Duloxetine.
Azathioprine	Azathioprine The metabolism of Azathioprine can be decreased when combined with Duloxetine.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Duloxetine is combined with Fluphenazine.
Phentermine	Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Duloxetine.
Methylphenidate	Methylphenidate Methylphenidate may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Amoxapine	Amoxapine The metabolism of Amoxapine can be decreased when combined with Duloxetine.
Sulfasalazine	Sulfasalazine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Sulfasalazine.
Hydrocortisone	Hydrocortisone The metabolism of Duloxetine can be increased when combined with Hydrocortisone.
Doxorubicin	Doxorubicin The metabolism of Duloxetine can be decreased when combined with Doxorubicin.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Duloxetine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Duloxetine is combined with Molindone.
Methyldopa	Methyldopa The risk or severity of orthostatic hypotension and syncope can be increased when Methyldopa is combined with Duloxetine.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Duloxetine.
Prazosin	Prazosin The risk or severity of orthostatic hypotension and syncope can be increased when Prazosin is combined with Duloxetine.
Hydralazine	Hydralazine The risk or severity of orthostatic hypotension and syncope can be increased when Hydralazine is combined with Duloxetine.
Cimetidine	Cimetidine The metabolism of Cimetidine can be decreased when combined with Duloxetine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Warfarin	Warfarin The serum concentration of Warfarin can be increased when it is combined with Duloxetine.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Duloxetine.
Loperamide	Loperamide The metabolism of Duloxetine can be decreased when combined with Loperamide.
Promethazine	Promethazine The metabolism of Duloxetine can be decreased when combined with Promethazine.
Meclofenamate	Meclofenamate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Meclofenamic acid.
Daunorubicin	Daunorubicin The metabolism of Duloxetine can be decreased when combined with Daunorubicin.
Nitrofurantoin	Nitrofurantoin Duloxetine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin	Griseofulvin The metabolism of Duloxetine can be increased when combined with Griseofulvin.
Digoxin	Digoxin Digoxin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Duloxetine.
Chloroquine	Chloroquine The metabolism of Chloroquine can be decreased when combined with Duloxetine.
Quinine	Quinine The metabolism of Quinine can be decreased when combined with Duloxetine.
Ethosuximide	Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Duloxetine.
Calcitriol	Calcitriol The metabolism of Duloxetine can be increased when combined with Calcitriol.
Triamterene	Triamterene The risk or severity of orthostatic hypotension and syncope can be increased when Triamterene is combined with Duloxetine.
Sulfinpyrazone	Sulfinpyrazone Duloxetine may increase the antiplatelet activities of Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Chlorothiazide is combined with Duloxetine.
Chlorthalidone	Chlorthalidone The risk or severity of orthostatic hypotension and syncope can be increased when Chlorthalidone is combined with Duloxetine.
Metolazone	Metolazone The risk or severity of orthostatic hypotension and syncope can be increased when Metolazone is combined with Duloxetine.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Duloxetine which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital	Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Duloxetine.
Desipramine	Desipramine The metabolism of Desipramine can be decreased when combined with Duloxetine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Duloxetine.
Imipramine	Imipramine The risk or severity of orthostatic hypotension and syncope can be increased when Imipramine is combined with Duloxetine.
Probenecid	Probenecid The metabolism of Probenecid can be increased when combined with Duloxetine.
Quinidine	Quinidine The metabolism of Duloxetine can be decreased when combined with Quinidine.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Duloxetine.
Isoniazid	Isoniazid The metabolism of Duloxetine can be decreased when combined with Isoniazid.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Duloxetine can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The metabolism of Duloxetine can be decreased when combined with Disopyramide.
Valproic Acid	Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Duloxetine.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Duloxetine.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Duloxetine.
Levothyroxine	Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Duloxetine.
Liothyronine	Liothyronine Liothyronine may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Methimazole	Methimazole The metabolism of Duloxetine can be decreased when combined with Methimazole.
Propylthiouracil	Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Duloxetine.
Chlorpropamide	Chlorpropamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Chlorpropamide.
Tolbutamide	Tolbutamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Tolbutamide.
Tolazamide	Tolazamide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Tolazamide.
Dextromethorphan	Dextromethorphan The metabolism of Duloxetine can be decreased when combined with Dextromethorphan.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Duloxetine is combined with Cyclobenzaprine.
Niacin	Niacin The metabolism of Duloxetine can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Duloxetine.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Cyproheptadine	Cyproheptadine The therapeutic efficacy of Duloxetine can be decreased when used in combination with Cyproheptadine.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Duloxetine.
Chlorpheniramine	Chlorpheniramine The metabolism of Duloxetine can be decreased when combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Duloxetine.
Meclizine	Meclizine The metabolism of Duloxetine can be decreased when combined with Meclizine.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Methyclothiazide	Methyclothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Methyclothiazide is combined with Duloxetine.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of orthostatic hypotension and syncope can be increased when Hydrochlorothiazide is combined with Duloxetine.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Duloxetine.
Chlorzoxazone	Chlorzoxazone The metabolism of Duloxetine can be decreased when combined with Chlorzoxazone.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Duloxetine.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Duloxetine.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Danazol	Danazol The metabolism of Duloxetine can be decreased when combined with Danazol.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The risk or severity of orthostatic hypotension and syncope can be increased when Propranolol is combined with Duloxetine.
Minoxidil	Minoxidil The risk or severity of orthostatic hypotension and syncope can be increased when Minoxidil is combined with Duloxetine.
Pseudoephedrine	Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Pseudoephedrine.
Nortriptyline	Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Duloxetine.
Spironolactone	Spironolactone The risk or severity of orthostatic hypotension and syncope can be increased when Spironolactone is combined with Duloxetine.
Amphotericin B Injection	Amphotericin B Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amphotericin B is combined with Duloxetine.
Phytonadione	Phytonadione Duloxetine may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Nadolol	Nadolol The risk or severity of orthostatic hypotension and syncope can be increased when Nadolol is combined with Duloxetine.
Butorphanol Injection	Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Butorphanol is combined with Duloxetine.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Nalbuphine is combined with Duloxetine.
Allopurinol	Allopurinol Allopurinol may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Duloxetine.
Flavoxate	Flavoxate Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine	Papaverine The risk or severity of orthostatic hypotension and syncope can be increased when Papaverine is combined with Duloxetine.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Duloxetine.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Duloxetine.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Dacarbazine	Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Duloxetine.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Duloxetine.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Ketoconazole	Ketoconazole The metabolism of Duloxetine can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Duloxetine.
Thiotepa Injection	Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Duloxetine.
Vincristine Injection	Vincristine Injection The metabolism of Vincristine can be decreased when combined with Duloxetine.
Captopril	Captopril The risk or severity of orthostatic hypotension and syncope can be increased when Captopril is combined with Duloxetine.
Dipyridamole	Dipyridamole The risk or severity of orthostatic hypotension and syncope can be increased when Dipyridamole is combined with Duloxetine.
Isoxsuprine	Isoxsuprine The risk or severity of orthostatic hypotension and syncope can be increased when Isoxsuprine is combined with Duloxetine.
Vinblastine	Vinblastine The metabolism of Duloxetine can be decreased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid The risk or severity of orthostatic hypotension and syncope can be increased when Etacrynic acid is combined with Duloxetine.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Metoprolol	Metoprolol The risk or severity of orthostatic hypotension and syncope can be increased when Metoprolol is combined with Duloxetine.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Duloxetine is combined with Thiothixene.
Aspirin	Aspirin Duloxetine may increase the antiplatelet activities of Acetylsalicylic acid.
Salsalate	Salsalate The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Salsalate.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Duloxetine.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Duloxetine.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Duloxetine.
Dicyclomine	Dicyclomine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim	Trimethoprim Trimethoprim may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Diltiazem	Diltiazem The risk or severity of orthostatic hypotension and syncope can be increased when Diltiazem is combined with Duloxetine.
Nifedipine	Nifedipine The risk or severity of orthostatic hypotension and syncope can be increased when Nifedipine is combined with Duloxetine.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Duloxetine.
Verapamil	Verapamil The risk or severity of orthostatic hypotension and syncope can be increased when Verapamil is combined with Duloxetine.
Atenolol	Atenolol The risk or severity of orthostatic hypotension and syncope can be increased when Atenolol is combined with Duloxetine.
Pindolol	Pindolol The risk or severity of orthostatic hypotension and syncope can be increased when Pindolol is combined with Duloxetine.
Cisplatin Injection	Cisplatin Injection Duloxetine may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal	Diflunisal The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Diflunisal.
Piroxicam	Piroxicam The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Piroxicam.
Bumetanide	Bumetanide The risk or severity of orthostatic hypotension and syncope can be increased when Bumetanide is combined with Duloxetine.
Streptozocin	Streptozocin The metabolism of Duloxetine can be increased when combined with Streptozocin.
Etoposide	Etoposide The metabolism of Duloxetine can be decreased when combined with Etoposide.
Glyburide	Glyburide The metabolism of Duloxetine can be decreased when combined with Glyburide.
Glipizide	Glipizide The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Glipizide.
Indapamide	Indapamide The risk or severity of orthostatic hypotension and syncope can be increased when Indapamide is combined with Duloxetine.
Amoxicillin	Amoxicillin Duloxetine may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Dicloxacillin	Dicloxacillin The metabolism of Duloxetine can be increased when combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The metabolism of Duloxetine can be increased when combined with Nafcillin.
Oxacillin Injection	Oxacillin Injection Duloxetine may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline	Pentoxifylline The risk or severity of hemorrhage can be increased when Duloxetine is combined with Pentoxifylline.
Pentamidine Injection	Pentamidine Injection The metabolism of Duloxetine can be decreased when combined with Pentamidine.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Labetalol	Labetalol The risk or severity of orthostatic hypotension and syncope can be increased when Labetalol is combined with Duloxetine.
Auranofin	Auranofin Duloxetine may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Gemfibrozil	Gemfibrozil The metabolism of Duloxetine can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz Duloxetine may increase the tachycardic activities of Guanabenz.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Ketoprofen	Ketoprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ketoprofen.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Pimozide	Pimozide The risk or severity of QTc prolongation can be increased when Duloxetine is combined with Pimozide.
Enalapril	Enalapril The risk or severity of orthostatic hypotension and syncope can be increased when Enalapril is combined with Duloxetine.
Flurbiprofen	Flurbiprofen The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Flurbiprofen.
Amiodarone	Amiodarone The risk or severity of orthostatic hypotension and syncope can be increased when Amiodarone is combined with Duloxetine.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Duloxetine.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Duloxetine.
Ciprofloxacin	Ciprofloxacin The metabolism of Duloxetine can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Mesalazine.
Diclofenac	Diclofenac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Diclofenac.
Fluoxetine	Fluoxetine The serum concentration of Duloxetine can be increased when it is combined with Fluoxetine.
Nimodipine	Nimodipine The risk or severity of orthostatic hypotension and syncope can be increased when Nimodipine is combined with Duloxetine.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The metabolism of Duloxetine can be decreased when combined with Interferon alfa-2b.
Clozapine	Clozapine The risk or severity of orthostatic hypotension and syncope can be increased when Clozapine is combined with Duloxetine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Duloxetine is combined with Estazolam.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Duloxetine.
Ofloxacin	Ofloxacin The metabolism of Duloxetine can be decreased when combined with Ofloxacin.
Didanosine	Didanosine Duloxetine may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Duloxetine may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin	Clarithromycin The metabolism of Duloxetine can be decreased when combined with Clarithromycin.
Benazepril	Benazepril The risk or severity of orthostatic hypotension and syncope can be increased when Benazepril is combined with Duloxetine.
Etodolac	Etodolac The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Etodolac.
Felodipine	Felodipine The risk or severity of orthostatic hypotension and syncope can be increased when Felodipine is combined with Duloxetine.
Fosinopril	Fosinopril The risk or severity of orthostatic hypotension and syncope can be increased when Fosinopril is combined with Duloxetine.
Nabumetone	Nabumetone The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Nabumetone.
Quinapril	Quinapril The risk or severity of orthostatic hypotension and syncope can be increased when Quinapril is combined with Duloxetine.
Ramipril	Ramipril The risk or severity of orthostatic hypotension and syncope can be increased when Ramipril is combined with Duloxetine.
Simvastatin	Simvastatin The metabolism of Simvastatin can be decreased when combined with Duloxetine.
Amlodipine	Amlodipine The risk or severity of orthostatic hypotension and syncope can be increased when Amlodipine is combined with Duloxetine.
Teniposide Injection	Teniposide Injection The metabolism of Duloxetine can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The metabolism of Duloxetine can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril The risk or severity of orthostatic hypotension and syncope can be increased when Lisinopril is combined with Duloxetine.
Oxaprozin	Oxaprozin The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Oxaprozin.
Atovaquone	Atovaquone The metabolism of Duloxetine can be decreased when combined with Atovaquone.
Rifabutin	Rifabutin The metabolism of Duloxetine can be increased when combined with Rifabutin.
Sotalol	Sotalol The risk or severity of orthostatic hypotension and syncope can be increased when Sotalol is combined with Duloxetine.
Bisoprolol	Bisoprolol The risk or severity of orthostatic hypotension and syncope can be increased when Bisoprolol is combined with Duloxetine.
Zolpidem	Zolpidem Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The risk or severity of orthostatic hypotension and syncope can be increased when Doxazosin is combined with Duloxetine.
Terazosin	Terazosin The risk or severity of orthostatic hypotension and syncope can be increased when Terazosin is combined with Duloxetine.
Isradipine	Isradipine The risk or severity of orthostatic hypotension and syncope can be increased when Isradipine is combined with Duloxetine.
Omeprazole	Omeprazole The metabolism of Duloxetine can be increased when combined with Omeprazole.
Cisapride	Cisapride The metabolism of Duloxetine can be decreased when combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Duloxetine is combined with Gabapentin.
Fluvastatin	Fluvastatin The metabolism of Duloxetine can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The metabolism of Duloxetine can be decreased when combined with Venlafaxine.
Famciclovir	Famciclovir The metabolism of Duloxetine can be decreased when combined with Famciclovir.
Fluvoxamine	Fluvoxamine The metabolism of Duloxetine can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Nefazodone can be decreased when combined with Duloxetine.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Duloxetine is combined with Lamotrigine.
Losartan	Losartan The risk or severity of orthostatic hypotension and syncope can be increased when Losartan is combined with Duloxetine.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Duloxetine.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Duloxetine can be decreased when combined with Vinorelbine.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Moexipril	Moexipril The risk or severity of orthostatic hypotension and syncope can be increased when Moexipril is combined with Duloxetine.
Lansoprazole	Lansoprazole The metabolism of Duloxetine can be increased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Duloxetine.
Nicardipine	Nicardipine The risk or severity of orthostatic hypotension and syncope can be increased when Nicardipine is combined with Duloxetine.
Bupropion	Bupropion The metabolism of Bupropion can be decreased when combined with Duloxetine.
Ticlopidine	Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Duloxetine.
Saquinavir	Saquinavir The metabolism of Duloxetine can be decreased when combined with Saquinavir.
Metformin	Metformin The risk or severity of hypoglycemia can be increased when Metformin is combined with Duloxetine.
Dalteparin Injection	Dalteparin Injection The risk or severity of hemorrhage can be increased when Duloxetine is combined with Dalteparin.
Nisoldipine	Nisoldipine The risk or severity of orthostatic hypotension and syncope can be increased when Nisoldipine is combined with Duloxetine.
Lamivudine	Lamivudine Duloxetine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Duloxetine.
Amifostine Injection	Amifostine Injection The risk or severity of orthostatic hypotension and syncope can be increased when Amifostine is combined with Duloxetine.
Acarbose	Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Duloxetine.
Glimepiride	Glimepiride The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Duloxetine.
Gemcitabine Injection	Gemcitabine Injection Gemcitabine may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Ritonavir	Ritonavir The serum concentration of Duloxetine can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Duloxetine can be decreased when combined with Docetaxel.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Duloxetine may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine	Clomipramine The risk or severity of orthostatic hypotension and syncope can be increased when Clomipramine is combined with Duloxetine.
Zafirlukast	Zafirlukast The metabolism of Duloxetine can be decreased when combined with Zafirlukast.
Fosfomycin	Fosfomycin Duloxetine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine	Mirtazapine Duloxetine may increase the serotonergic activities of Mirtazapine.
Trandolapril	Trandolapril The risk or severity of orthostatic hypotension and syncope can be increased when Trandolapril is combined with Duloxetine.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Duloxetine is combined with Topiramate.
Zileuton	Zileuton The metabolism of Zileuton can be decreased when combined with Duloxetine.
Valsartan	Valsartan The risk or severity of orthostatic hypotension and syncope can be increased when Valsartan is combined with Duloxetine.
Insulin Lispro Injection	Insulin Lispro Injection The metabolism of Duloxetine can be increased when combined with Insulin lispro.
Pramipexole	Pramipexole The risk or severity of orthostatic hypotension and syncope can be increased when Pramipexole is combined with Duloxetine.
Donepezil	Donepezil The metabolism of Duloxetine can be decreased when combined with Donepezil.
Nelfinavir	Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Duloxetine.
Azithromycin	Azithromycin The metabolism of Azithromycin can be decreased when combined with Duloxetine.
Carvedilol	Carvedilol The risk or severity of orthostatic hypotension and syncope can be increased when Carvedilol is combined with Duloxetine.
Nilutamide	Nilutamide The metabolism of Nilutamide can be decreased when combined with Duloxetine.
Flutamide	Flutamide The metabolism of Flutamide can be decreased when combined with Duloxetine.
Selegiline	Selegiline The risk or severity of orthostatic hypotension and syncope can be increased when Selegiline is combined with Duloxetine.
Bicalutamide	Bicalutamide The metabolism of Duloxetine can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Sertraline can be decreased when combined with Duloxetine.
Propafenone	Propafenone The metabolism of Duloxetine can be decreased when combined with Propafenone.
Raloxifene	Raloxifene The metabolism of Duloxetine can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan The risk or severity of orthostatic hypotension and syncope can be increased when Irbesartan is combined with Duloxetine.
Tamsulosin	Tamsulosin The risk or severity of orthostatic hypotension and syncope can be increased when Tamsulosin is combined with Duloxetine.
Ropinirole	Ropinirole The risk or severity of orthostatic hypotension and syncope can be increased when Ropinirole is combined with Duloxetine.
Quetiapine	Quetiapine The risk or severity of orthostatic hypotension and syncope can be increased when Quetiapine is combined with Duloxetine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Duloxetine.
Paroxetine	Paroxetine The metabolism of Paroxetine can be decreased when combined with Duloxetine.
Tolcapone	Tolcapone The risk or severity of orthostatic hypotension and syncope can be increased when Tolcapone is combined with Duloxetine.
Citalopram	Citalopram The metabolism of Duloxetine can be decreased when combined with Citalopram.
Capecitabine	Capecitabine The metabolism of Duloxetine can be decreased when combined with Capecitabine.
Efavirenz	Efavirenz The metabolism of Duloxetine can be decreased when combined with Efavirenz.
Abacavir	Abacavir Duloxetine may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Duloxetine.
Pioglitazone	Pioglitazone The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Pioglitazone.
Celecoxib	Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Duloxetine.
Rosiglitazone	Rosiglitazone The metabolism of Duloxetine can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Duloxetine.
Thalidomide	Thalidomide Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Balsalazide	Balsalazide The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Balsalazide.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Duloxetine.
Galantamine	Galantamine The metabolism of Galantamine can be decreased when combined with Duloxetine.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Duloxetine.
Rabeprazole	Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Duloxetine.
Terbinafine	Terbinafine The metabolism of Duloxetine can be decreased when combined with Terbinafine.