Milnacipran

Milnacipran is used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Milnacipran is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amount of serotonin and norepinephrine, natural substances that help stop the movement of pain signals in the brain.

Milnacipran comes as a tablet to be taken by mouth. The first dose of milnacipran is usually taken once on day 1 of therapy. After that, it is usually taken two times a day. Milnacipran may be taken with or without food, but taking it with food will decrease the chance that milnacipran will upset your stomach. Take milnacipran at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take milnacipran exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will start you on a low dose of milnacipran and gradually increase your dose during the first week of treatment.

Milnacipran may help control the symptoms of fibromyalgia, but will not cure it. Do not stop taking milnacipran without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking milnacipran, you may experience withdrawal symptoms such as mood changes, irritability, agitation, dizziness, numbness or tingling in the hands or feet, anxiety, confusion, headache, tiredness, difficulty falling asleep or staying asleep, ringing in the ears, abnormal excitement, or seizures. Tell your doctor if you experience any of these symptoms when your dose of milnacipran is decreased.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking milnacipran,

• tell your doctor and pharmacist if you are allergic to milnacipran, any other medications, or any of the ingredients in milnacipran tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

• tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take milnacipran. If you stop taking milnacipran, your doctor may tell you that you should wait at least 5 days before you start to take an MAO inhibitor.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, or herbal products you are taking or plan to take. Be sure to mention any of the following: amphetamines such as amphetamine (in Adderall, in Mydayis), dextroamphetamine (Dexedrine, in Adderall), and methamphetamine (Desoxyn); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); buspirone; clonidine (Catapres); digoxin (Lanoxin); diuretics ('water pills'); epinephrine (Epipen, Primatene Mist); fentanyl (Actiq, Duragesic, Fentora, Subsys); lithium (Lithobid); medications for anxiety, mental illness, pain, or seizures; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, in Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); sleeping pills; tramadol (Conzip, Qdola, Ultram, in Ultracet); tranquilizers; selective serotonin/norepinephrine reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta), desvenlafaxine (Pristiq), and venlafaxine (Effexor); and tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what nutritional supplements and herbal products you are taking, especially St. John's wort and tryptophan.

• tell your doctor if you drink or have ever drunk large amounts of alcohol and if you have or have ever had high blood pressure; seizures; an irregular heartbeat; an enlarged or inflamed prostate (a male reproductive gland); difficulty urinating; bleeding problems; low sodium levels in the blood; or heart, kidney, or liver disease.

• tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking milnacipran, call your doctor. Milnacipran may cause problems in newborns following delivery if it is taken during the last months of pregnancy.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking milnacipran.

• you should know that milnacipran may make you drowsy and may affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you.

• talk to your doctor about the safe use of alcoholic beverages while you are taking milnacipran.

• you should know that milnacipran may cause high blood pressure. Your blood pressure and pulse (heart rate) should be checked before starting treatment and regularly while you are receiving milnacipran.

• you should know that milnacipran may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Milnacipran may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • constipation

  • stomach pain

  • weight loss

  • dry mouth

  • feeling of extreme facial warmth and/or redness

  • headache

  • blurred vision

  • extreme tiredness

  • lack of energy

  • loss of appetite

  • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

  • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

  • pain or swelling of the testicles

  • difficulty urinating

  • rash

  • itching

• Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

  • fever, sweating, confusion, fast or irregular heartbeat, severe muscle stiffness or twitching, nausea, vomiting, or diarrhea

  • hallucinations (seeing things or hearing voices that do not exist)

  • confusion

  • difficulty concentrating

  • memory problems

  • sweating or fever

  • diarrhea

  • dizziness

  • uncontrollable shaking of a part of the body

  • severe muscle stiffness

  • weakness

  • unsteady walking that may cause falling

  • seizures

  • fainting

  • coma (loss of consciousness for a period of time)

  • fast or irregular heartbeat

  • difficulty breathing

  • pain in the upper right part of the stomach

  • yellowing of the skin or eyes

  • dark colored urine

  • unusual bleeding or bruising

  • nosebleeds

  • tiny red spots directly under the skin

• Milnacipran may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• extreme sleepiness

• confusion

• dizziness

• coma (loss of consciousness for a period of time)

• slowed or stopped heartbeat and breathing

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Repaglinide	Repaglinide The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Milnacipran.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glargine is combined with Milnacipran.
Delavirdine	Delavirdine The metabolism of Milnacipran can be decreased when combined with Delavirdine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Milnacipran.
Dolasetron	Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Milnacipran.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Milnacipran.
Anagrelide	Anagrelide The risk or severity of hemorrhage can be increased when Milnacipran is combined with Anagrelide.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Milnacipran.
Clopidogrel	Clopidogrel The risk or severity of hemorrhage can be increased when Milnacipran is combined with Clopidogrel.
Diphenoxylate	Diphenoxylate The risk or severity of serotonin syndrome can be increased when Diphenoxylate is combined with Milnacipran.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Fenofibrate	Fenofibrate The metabolism of Milnacipran can be decreased when combined with Fenofibrate.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Milnacipran.
Magnesium Hydroxide	Magnesium Hydroxide Milnacipran may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Miglitol	Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Milnacipran.
Mycophenolate	Mycophenolate Mycophenolic acid may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Milnacipran.
Olsalazine	Olsalazine The risk or severity of gastrointestinal bleeding can be increased when Olsalazine is combined with Milnacipran.
Paregoric	Paregoric The risk or severity of serotonin syndrome can be increased when Morphine is combined with Milnacipran.
Penbutolol	Penbutolol The serum concentration of Acebutolol can be increased when it is combined with Milnacipran.
Pentazocine	Pentazocine The risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Milnacipran.
Potassium	Potassium Potassium cation may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Prednisone may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Ranitidine	Ranitidine Ranitidine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Milnacipran.
Rizatriptan	Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Milnacipran.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Milnacipran.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Milnacipran.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Milnacipran.
Triamcinolone	Triamcinolone The metabolism of Milnacipran can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Milnacipran.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Doxycycline may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Fluconazole Injection	Fluconazole Injection Fluconazole may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Milnacipran.
Levofloxacin Injection	Levofloxacin Injection Levofloxacin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Meperidine Injection	Meperidine Injection The risk or severity of serotonin syndrome can be increased when Meperidine is combined with Milnacipran.
Methylprednisolone Injection	Methylprednisolone Injection The metabolism of Milnacipran can be increased when combined with Methylprednisolone.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of adverse effects can be increased when Metoclopramide is combined with Milnacipran.
Morphine Injection	Morphine Injection The risk or severity of serotonin syndrome can be increased when Morphine is combined with Milnacipran.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Milnacipran may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine	Altretamine Amphetamine may increase the serotonergic activities of Milnacipran.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cyclosporine	Cyclosporine The metabolism of Milnacipran can be decreased when combined with Cyclosporine.
Ondansetron	Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Milnacipran.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of hemorrhage can be increased when Milnacipran is combined with Enoxaparin.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Milnacipran.
Torsemide	Torsemide Torasemide may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Milnacipran.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Milnacipran.
Dofetilide	Dofetilide The metabolism of Dofetilide can be decreased when combined with Milnacipran.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Milnacipran.
Meloxicam	Meloxicam The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Meloxicam.
Orlistat	Orlistat The metabolism of Milnacipran can be increased when combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The metabolism of Milnacipran can be increased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Temozolomide	Temozolomide Temozolomide may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Milnacipran.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Milnacipran.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Milnacipran.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of hemorrhage can be increased when Milnacipran is combined with Pentosan polysulfate.
Trimipramine	Trimipramine The risk or severity of adverse effects can be increased when Trimipramine is combined with Milnacipran.
Glycopyrrolate	Glycopyrrolate Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil	Modafinil The metabolism of Milnacipran can be increased when combined with Modafinil.
Perindopril	Perindopril Perindopril may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Choline magnesium trisalicylate.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Milnacipran.
Epinephrine Injection	Epinephrine Injection Milnacipran may increase the tachycardic activities of Epinephrine.
Eplerenone	Eplerenone The metabolism of Eplerenone can be decreased when combined with Milnacipran.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Escitalopram is combined with Milnacipran.
Zonisamide	Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Milnacipran.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Milnacipran.
Atomoxetine	Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Milnacipran.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Milnacipran.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Milnacipran.
Atazanavir	Atazanavir The metabolism of Milnacipran can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Milnacipran.
Eletriptan	Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Milnacipran.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Milnacipran.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Milnacipran.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Milnacipran.
Emtricitabine	Emtricitabine Emtricitabine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Memantine	Memantine Memantine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Tegaserod	Tegaserod The risk or severity of serotonin syndrome can be increased when Tegaserod is combined with Milnacipran.
Tadalafil	Tadalafil Tadalafil may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Milnacipran.
Progesterone	Progesterone The metabolism of Milnacipran can be increased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Milnacipran.
Protriptyline	Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Milnacipran.
Rifaximin	Rifaximin The metabolism of Milnacipran can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The risk or severity of adverse effects can be increased when Duloxetine is combined with Milnacipran.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Milnacipran.
Tinidazole	Tinidazole Tinidazole may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Trospium	Trospium Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan The metabolism of Milnacipran can be increased when combined with Bosentan.
Cefditoren	Cefditoren Cefdinir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Milnacipran.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Milnacipran is combined with Eszopiclone.
Ganciclovir	Ganciclovir Ganciclovir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Insulin aspart is combined with Milnacipran.
Ribavirin	Ribavirin Ribavirin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Solifenacin	Solifenacin Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir	Valganciclovir Valganciclovir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Voriconazole	Voriconazole The metabolism of Milnacipran can be decreased when combined with Voriconazole.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the serotonergic activities of Milnacipran.
Pramlintide Injection	Pramlintide Injection The risk or severity of hypoglycemia can be increased when Pramlintide is combined with Milnacipran.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Exenatide Injection	Exenatide Injection The risk or severity of hypoglycemia can be increased when Exenatide is combined with Milnacipran.
Isocarboxazid	Isocarboxazid Isocarboxazid may increase the serotonergic activities of Milnacipran.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Milnacipran.
Darifenacin	Darifenacin Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Milnacipran.
Pregabalin	Pregabalin The therapeutic efficacy of Milnacipran can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The metabolism of Milnacipran can be increased when combined with Deferasirox.
Phenylephrine	Phenylephrine Milnacipran may increase the tachycardic activities of Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Milnacipran.
Felbamate	Felbamate The metabolism of Milnacipran can be increased when combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Insulin detemir is combined with Milnacipran.
Ranolazine	Ranolazine The metabolism of Milnacipran can be decreased when combined with Ranolazine.
Rasagiline	Rasagiline Rasagiline may increase the serotonergic activities of Milnacipran.
Sitagliptin	Sitagliptin The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Milnacipran.
Varenicline	Varenicline Varenicline may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Albuterol	Albuterol Milnacipran may increase the tachycardic activities of Salbutamol.
Paliperidone	Paliperidone The risk or severity of adverse effects can be increased when Paliperidone is combined with Milnacipran.
Bortezomib	Bortezomib The metabolism of Bortezomib can be decreased when combined with Milnacipran.
Clofarabine Injection	Clofarabine Injection Clofarabine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glulisine is combined with Milnacipran.
Lubiprostone	Lubiprostone Lubiprostone may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Posaconazole	Posaconazole The metabolism of Milnacipran can be decreased when combined with Posaconazole.
Darunavir	Darunavir The metabolism of Darunavir can be decreased when combined with Milnacipran.
Pemetrexed Injection	Pemetrexed Injection Milnacipran may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Milnacipran.
Lisdexamfetamine	Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Lisdexamfetamine is combined with Milnacipran.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Milnacipran.
Sorafenib	Sorafenib The metabolism of Milnacipran can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Milnacipran can be decreased when combined with Sunitinib.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Milnacipran.
Pegaptanib Injection	Pegaptanib Injection Pegaptanib may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Milnacipran.
Armodafinil	Armodafinil The metabolism of Milnacipran can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Azacitidine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Milnacipran.
Lenalidomide	Lenalidomide Lenalidomide may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Nilotinib	Nilotinib The metabolism of Milnacipran can be decreased when combined with Nilotinib.
Bexarotene	Bexarotene The metabolism of Milnacipran can be increased when combined with Bexarotene.
Budesonide	Budesonide The metabolism of Milnacipran can be increased when combined with Budesonide.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Milnacipran is combined with Desmopressin.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Milnacipran.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Milnacipran.
Doripenem Injection	Doripenem Injection Milnacipran may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine	Etravirine The metabolism of Milnacipran can be increased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Milnacipran is combined with Desvenlafaxine.
Cevimeline	Cevimeline Cevimeline may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Nebivolol	Nebivolol The serum concentration of Nebivolol can be increased when it is combined with Milnacipran.
Certolizumab Injection	Certolizumab Injection Milnacipran may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Milnacipran.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Milnacipran.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Mitotane	Mitotane The metabolism of Milnacipran can be increased when combined with Mitotane.
Methylnaltrexone Injection	Methylnaltrexone Injection Milnacipran may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Milnacipran.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Milnacipran.
Naltrexone Injection	Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Milnacipran.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Plerixafor Injection	Plerixafor Injection Milnacipran may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine	Fesoterodine Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol	Betaxolol The serum concentration of Betaxolol can be increased when it is combined with Milnacipran.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Milnacipran.
Prasugrel	Prasugrel The risk or severity of hemorrhage can be increased when Milnacipran is combined with Prasugrel.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Milnacipran.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Milnacipran.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Milnacipran can be decreased when combined with Tolvaptan.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Milnacipran.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Milnacipran.
Pralatrexate Injection	Pralatrexate Injection Milnacipran may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Milnacipran.
Saxagliptin	Saxagliptin The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Saxagliptin.
Telavancin Injection	Telavancin Injection Milnacipran may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Milnacipran.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Topotecan	Topotecan The metabolism of Milnacipran can be increased when combined with Topotecan.
Pazopanib	Pazopanib The metabolism of Pazopanib can be decreased when combined with Milnacipran.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Milnacipran is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Milnacipran.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Milnacipran.
Oxymorphone	Oxymorphone The risk or severity of serotonin syndrome can be increased when Oxymorphone is combined with Milnacipran.
Dabigatran	Dabigatran The risk or severity of hemorrhage can be increased when Milnacipran is combined with Dabigatran.
Liraglutide Injection	Liraglutide Injection The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Liraglutide.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Milnacipran can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine Milnacipran may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Milnacipran.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Milnacipran.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Lurasidone	Lurasidone The metabolism of Lurasidone can be decreased when combined with Milnacipran.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Milnacipran can be increased when combined with Acetaminophen.
Vilazodone	Vilazodone The risk or severity of adverse effects can be increased when Milnacipran is combined with Vilazodone.
Ipilimumab Injection	Ipilimumab Injection Milnacipran may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Terbutaline Injection	Terbutaline Injection Milnacipran may increase the tachycardic activities of Terbutaline.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be decreased when combined with Milnacipran.
Roflumilast	Roflumilast The metabolism of Milnacipran can be decreased when combined with Roflumilast.
Linagliptin	Linagliptin The metabolism of Linagliptin can be decreased when combined with Milnacipran.
Potassium Iodide	Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Milnacipran.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Milnacipran can be increased when combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban The risk or severity of hemorrhage can be increased when Milnacipran is combined with Rivaroxaban.
Ticagrelor	Ticagrelor The risk or severity of hemorrhage can be increased when Milnacipran is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Milnacipran.
Ruxolitinib	Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Milnacipran.
Vandetanib	Vandetanib The metabolism of Vandetanib can be decreased when combined with Milnacipran.
Clobazam	Clobazam The metabolism of Milnacipran can be increased when combined with Clobazam.
Vemurafenib	Vemurafenib The metabolism of Milnacipran can be increased when combined with Vemurafenib.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Milnacipran.
Deferiprone	Deferiprone Milnacipran may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Milnacipran.
Crizotinib	Crizotinib The metabolism of Crizotinib can be decreased when combined with Milnacipran.
Cabergoline	Cabergoline The metabolism of Milnacipran can be decreased when combined with Cabergoline.
Naloxone Injection	Naloxone Injection The metabolism of Milnacipran can be decreased when combined with Naloxone.
Fondaparinux Injection	Fondaparinux Injection The risk or severity of hemorrhage can be increased when Milnacipran is combined with Fondaparinux.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Milnacipran.
Iloprost	Iloprost The risk or severity of hemorrhage can be increased when Milnacipran is combined with Iloprost.
Enzalutamide	Enzalutamide The metabolism of Milnacipran can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron Milnacipran may increase the tachycardic activities of Mirabegron.
Regorafenib	Regorafenib The metabolism of Regorafenib can be decreased when combined with Milnacipran.
Bosutinib	Bosutinib The metabolism of Bosutinib can be decreased when combined with Milnacipran.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The metabolism of Milnacipran can be increased when combined with Corticotropin.
Lorcaserin	Lorcaserin The risk or severity of hypoglycemia can be increased when Mecasermin is combined with Milnacipran.
Teduglutide Injection	Teduglutide Injection Milnacipran may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl	Icosapent Ethyl Milnacipran may increase the antiplatelet activities of Icosapent ethyl.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Milnacipran.
Alogliptin	Alogliptin The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Alogliptin.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Milnacipran.
Pomalidomide	Pomalidomide The metabolism of Milnacipran can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Milnacipran.
Apixaban	Apixaban The risk or severity of hemorrhage can be increased when Milnacipran is combined with Apixaban.
Canagliflozin	Canagliflozin Milnacipran may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib	Dabrafenib The metabolism of Milnacipran can be increased when combined with Dabrafenib.
Trametinib	Trametinib The metabolism of Milnacipran can be increased when combined with Trametinib.
Levomilnacipran	Levomilnacipran The risk or severity of adverse effects can be increased when Milnacipran is combined with Levomilnacipran.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Vortioxetine	Vortioxetine The risk or severity of adverse effects can be increased when Milnacipran is combined with Vortioxetine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Milnacipran.
Lomitapide	Lomitapide The metabolism of Lomitapide can be decreased when combined with Milnacipran.
Avanafil	Avanafil The metabolism of Avanafil can be decreased when combined with Milnacipran.
Ketorolac Injection	Ketorolac Injection The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Ketorolac.
Sofosbuvir	Sofosbuvir Milnacipran may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Dapagliflozin.
Apremilast	Apremilast Milnacipran may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa	Droxidopa Milnacipran may increase the tachycardic activities of Droxidopa.
Ceritinib	Ceritinib The metabolism of Ceritinib can be decreased when combined with Milnacipran.
Siltuximab Injection	Siltuximab Injection The metabolism of Milnacipran can be increased when combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Albiglutide.
Eslicarbazepine	Eslicarbazepine The metabolism of Milnacipran can be increased when combined with Eslicarbazepine.
Idelalisib	Idelalisib The metabolism of Idelalisib can be decreased when combined with Milnacipran.
Testosterone Injection	Testosterone Injection The metabolism of Milnacipran can be increased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Milnacipran can be increased when combined with Oritavancin.
Empagliflozin	Empagliflozin The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Empagliflozin.
Vorapaxar	Vorapaxar The risk or severity of hemorrhage can be increased when Milnacipran is combined with Vorapaxar.
Hydrocodone	Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Suvorexant	Suvorexant Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection	Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Dulaglutide.
Edoxaban	Edoxaban The risk or severity of hemorrhage can be increased when Milnacipran is combined with Edoxaban.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Milnacipran.
Methamphetamine	Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Milnacipran.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Milnacipran.
Lanreotide Injection	Lanreotide Injection The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Lanreotide.
Nintedanib	Nintedanib The metabolism of Nintedanib can be decreased when combined with Milnacipran.
Risperidone Injection	Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Milnacipran.
Palbociclib	Palbociclib The metabolism of Palbociclib can be decreased when combined with Milnacipran.
Insulin Human Inhalation	Insulin Human Inhalation The risk or severity of hypoglycemia can be increased when Insulin human is combined with Milnacipran.
Lenvatinib	Lenvatinib The metabolism of Milnacipran can be increased when combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Naloxegol can be decreased when combined with Milnacipran.
Panobinostat	Panobinostat The metabolism of Panobinostat can be decreased when combined with Milnacipran.
Haloperidol Injection	Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Milnacipran.
Ivabradine	Ivabradine The metabolism of Ivabradine can be decreased when combined with Milnacipran.
Amiloride	Amiloride Amiloride may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection	Isavuconazonium Injection The metabolism of Milnacipran can be increased when combined with Isavuconazonium.
Macitentan	Macitentan Milnacipran may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib	Sonidegib The metabolism of Sonidegib can be decreased when combined with Milnacipran.
Flibanserin	Flibanserin The metabolism of Flibanserin can be decreased when combined with Milnacipran.
Prednisolone	Prednisolone The metabolism of Milnacipran can be increased when combined with Prednisolone.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Milnacipran.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Milnacipran.
Cariprazine	Cariprazine The risk or severity of adverse effects can be increased when Milnacipran is combined with Cariprazine.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Milnacipran may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The risk or severity of serotonin syndrome can be increased when Milnacipran is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Insulin degludec.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Milnacipran.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Milnacipran.
Osimertinib	Osimertinib The metabolism of Milnacipran can be increased when combined with Osimertinib.
Alectinib	Alectinib The metabolism of Alectinib can be decreased when combined with Milnacipran.
Ixazomib	Ixazomib The metabolism of Ixazomib can be decreased when combined with Milnacipran.
Rifapentine	Rifapentine The metabolism of Milnacipran can be increased when combined with Rifapentine.
Lesinurad	Lesinurad Milnacipran may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Milnacipran can be increased when combined with Dexamethasone.
Defibrotide Injection	Defibrotide Injection The risk or severity of hemorrhage can be increased when Milnacipran is combined with Defibrotide.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Milnacipran.
Venetoclax	Venetoclax The metabolism of Venetoclax can be decreased when combined with Milnacipran.
Cobicistat	Cobicistat The metabolism of Milnacipran can be decreased when combined with Cobicistat.
Midodrine	Midodrine Milnacipran may increase the tachycardic activities of Midodrine.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Milnacipran is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Milnacipran.
Furosemide Injection	Furosemide Injection Furosemide may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Lixisenatide Injection	Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Lixisenatide.
Ribociclib	Ribociclib The metabolism of Milnacipran can be decreased when combined with Ribociclib.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Milnacipran.
Brigatinib	Brigatinib The metabolism of Milnacipran can be increased when combined with Brigatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) The risk or severity of adverse effects can be increased when Doxepin is combined with Milnacipran.
Deutetrabenazine	Deutetrabenazine Milnacipran may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine	Valbenazine Milnacipran may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort	Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Milnacipran.
Safinamide	Safinamide Safinamide may increase the serotonergic activities of Milnacipran.
Naldemedine	Naldemedine Milnacipran may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection	Sarilumab Injection The metabolism of Milnacipran can be increased when combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Milnacipran can be decreased when combined with Midostaurin.
Neratinib	Neratinib The metabolism of Neratinib can be decreased when combined with Milnacipran.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Milnacipran.
Enasidenib	Enasidenib The metabolism of Milnacipran can be increased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Milnacipran can be increased when combined with Fosaprepitant.
Benznidazole	Benznidazole Milnacipran may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Milnacipran.
Delafloxacin	Delafloxacin The metabolism of Milnacipran can be increased when combined with Delafloxacin.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Milnacipran.
Betrixaban	Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Milnacipran.
Acalabrutinib	Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Milnacipran.
Semaglutide Injection	Semaglutide Injection The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Semaglutide.
Ertugliflozin	Ertugliflozin Ertugliflozin may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection	Buprenorphine Injection Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The metabolism of Milnacipran can be increased when combined with Apalutamide.
Baricitinib	Baricitinib The metabolism of Baricitinib can be decreased when combined with Milnacipran.
Lofexidine	Lofexidine The therapeutic efficacy of Milnacipran can be increased when used in combination with Lofexidine.
Plazomicin Injection	Plazomicin Injection Milnacipran may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Milnacipran.
Ivosidenib	Ivosidenib The metabolism of Milnacipran can be increased when combined with Ivosidenib.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Milnacipran.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Milnacipran.
Duvelisib	Duvelisib The metabolism of Duvelisib can be decreased when combined with Milnacipran.
Stiripentol	Stiripentol The metabolism of Milnacipran can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Milnacipran can be decreased when used in combination with Gilteritinib.
Lorlatinib	Lorlatinib The metabolism of Milnacipran can be increased when combined with Lorlatinib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Milnacipran can be increased when combined with Paclitaxel.
Rifamycin	Rifamycin The metabolism of Milnacipran can be increased when combined with Rifamycin.
Prucalopride	Prucalopride The metabolism of Prucalopride can be decreased when combined with Milnacipran.
Siponimod	Siponimod The risk or severity of adverse effects can be increased when Milnacipran is combined with Siponimod.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of hemorrhage can be increased when Milnacipran is combined with Caplacizumab.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Milnacipran.
Alpelisib	Alpelisib The metabolism of Milnacipran can be increased when combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Milnacipran.
Solriamfetol	Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Milnacipran.
Entrectinib	Entrectinib The metabolism of Entrectinib can be decreased when combined with Milnacipran.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Milnacipran.
Pitolisant	Pitolisant The serum concentration of Milnacipran can be decreased when it is combined with Pitolisant.
Pretomanid	Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Milnacipran.
Lefamulin	Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Milnacipran.
Phenytoin Injection	Phenytoin Injection The metabolism of Milnacipran can be increased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Milnacipran.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Milnacipran.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Milnacipran.
Lumateperone	Lumateperone The serum concentration of Milnacipran can be increased when it is combined with Lumateperone.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Lasmiditan is combined with Milnacipran.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Milnacipran.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Milnacipran.
Cenobamate	Cenobamate The serum concentration of Milnacipran can be decreased when it is combined with Cenobamate.
Pemigatinib	Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Milnacipran.
Selumetinib	Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Milnacipran.
Rimegepant	Rimegepant The metabolism of Rimegepant can be decreased when combined with Milnacipran.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Milnacipran.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Milnacipran.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Milnacipran.
Lurbinectedin Injection	Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Milnacipran.
Octreotide	Octreotide The risk or severity of hypoglycemia can be increased when Octreotide is combined with Milnacipran.
Pralsetinib	Pralsetinib The metabolism of Milnacipran can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Milnacipran can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Milnacipran can be decreased when combined with Drospirenone.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Milnacipran is combined with Viloxazine.
Vitamin E (Alpha-Tocopherol)	Vitamin E (Alpha-Tocopherol) The metabolism of Milnacipran can be increased when combined with Vitamin E.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Milnacipran.
Fenoprofen	Fenoprofen The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Fenoprofen.
Indomethacin	Indomethacin The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Indomethacin.
Mefenamic Acid	Mefenamic Acid The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Mefenamic acid.
Naproxen	Naproxen The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Naproxen.
Tolmetin	Tolmetin The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Tolmetin.
Sulindac	Sulindac The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Sulindac.
Trazodone	Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Milnacipran.
Isotretinoin	Isotretinoin Isotretinoin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Floxuridine	Floxuridine Floxuridine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Phenobarbital	Phenobarbital The metabolism of Milnacipran can be increased when combined with Phenobarbital.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Milnacipran.
Methotrexate Injection	Methotrexate Injection The metabolism of Milnacipran can be decreased when combined with Methotrexate.
Levorphanol	Levorphanol The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Milnacipran.
Primidone	Primidone The metabolism of Milnacipran can be increased when combined with Primidone.
Methsuximide	Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Milnacipran.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Milnacipran.
Chlorpromazine	Chlorpromazine The metabolism of Milnacipran can be increased when combined with Chlorpromazine.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Milnacipran.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Milnacipran.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Milnacipran.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Milnacipran.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Milnacipran.
Carmustine	Carmustine Carmustine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Amantadine	Amantadine The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Milnacipran.
Codeine	Codeine The risk or severity of serotonin syndrome can be increased when Milnacipran is combined with Codeine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Milnacipran.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Milnacipran.
Bromocriptine	Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Milnacipran.
Metaproterenol	Metaproterenol Milnacipran may increase the tachycardic activities of Orciprenaline.
Tranylcypromine	Tranylcypromine Tranylcypromine may increase the serotonergic activities of Milnacipran.
Phenelzine	Phenelzine Phenelzine may increase the serotonergic activities of Milnacipran.
Procarbazine	Procarbazine Procarbazine may increase the serotonergic activities of Milnacipran.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Milnacipran.
Tetracycline	Tetracycline Tetracycline may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Prochlorperazine	Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Milnacipran.
Thioridazine	Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Milnacipran.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Milnacipran.
Bleomycin	Bleomycin Bleomycin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Sulfadiazine	Sulfadiazine The risk or severity of hypoglycemia can be increased when Sulfadiazine is combined with Milnacipran.
Oxycodone	Oxycodone The risk or severity of serotonin syndrome can be increased when Oxycodone is combined with Milnacipran.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Milnacipran.
Oxybutynin	Oxybutynin Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine	Benztropine Benzatropine may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Maprotiline	Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Milnacipran.
Ibuprofen	Ibuprofen The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Milnacipran.
Trihexyphenidyl	Trihexyphenidyl Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Milnacipran.
Azathioprine	Azathioprine Azathioprine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Milnacipran.
Phentermine	Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Milnacipran.
Methylphenidate	Methylphenidate Methylphenidate may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Amoxapine	Amoxapine The risk or severity of adverse effects can be increased when Amoxapine is combined with Milnacipran.
Sulfasalazine	Sulfasalazine The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Sulfasalazine.
Hydrocortisone	Hydrocortisone The metabolism of Milnacipran can be increased when combined with Hydrocortisone.
Doxorubicin	Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Milnacipran.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Milnacipran can be increased when combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Molindone is combined with Milnacipran.
Methyldopa	Methyldopa Methyldopa may increase the tachycardic activities of Milnacipran.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Milnacipran.
Hydralazine	Hydralazine Hydralazine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cimetidine	Cimetidine Cimetidine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Warfarin	Warfarin The serum concentration of Warfarin can be increased when it is combined with Milnacipran.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Milnacipran.
Loperamide	Loperamide The metabolism of Milnacipran can be decreased when combined with Loperamide.
Promethazine	Promethazine The risk or severity of adverse effects can be increased when Promethazine is combined with Milnacipran.
Meclofenamate	Meclofenamate The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Meclofenamic acid.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Griseofulvin	Griseofulvin The metabolism of Milnacipran can be increased when combined with Griseofulvin.
Digoxin	Digoxin The risk or severity of hypotension can be increased when Milnacipran is combined with Digoxin.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Milnacipran.
Chloroquine	Chloroquine Chloroquine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Quinine	Quinine The metabolism of Milnacipran can be increased when combined with Quinine.
Ethosuximide	Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Milnacipran.
Calcitriol	Calcitriol The metabolism of Milnacipran can be increased when combined with Calcitriol.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Milnacipran can be increased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The risk or severity of hyponatremia can be increased when Milnacipran is combined with Chlorothiazide.
Chlorthalidone	Chlorthalidone The risk or severity of hyponatremia can be increased when Milnacipran is combined with Chlorthalidone.
Metolazone	Metolazone The risk or severity of hyponatremia can be increased when Milnacipran is combined with Metolazone.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital	Secobarbital The metabolism of Milnacipran can be increased when combined with Secobarbital.
Desipramine	Desipramine The risk or severity of adverse effects can be increased when Desipramine is combined with Milnacipran.
Amitriptyline	Amitriptyline The risk or severity of adverse effects can be increased when Amitriptyline is combined with Milnacipran.
Imipramine	Imipramine The risk or severity of adverse effects can be increased when Imipramine is combined with Milnacipran.
Probenecid	Probenecid The metabolism of Milnacipran can be increased when combined with Probenecid.
Quinidine	Quinidine The metabolism of Quinidine can be decreased when combined with Milnacipran.
Procainamide	Procainamide Milnacipran may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid	Isoniazid The risk or severity of serotonin syndrome can be increased when Isoniazid is combined with Milnacipran.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Milnacipran can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Disopyramide may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Valproic Acid	Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Milnacipran.
Tamoxifen	Tamoxifen The metabolism of Milnacipran can be increased when combined with Tamoxifen.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Milnacipran.
Levothyroxine	Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Milnacipran.
Liothyronine	Liothyronine Liothyronine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Methimazole	Methimazole The metabolism of Milnacipran can be decreased when combined with Methimazole.
Propylthiouracil	Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Milnacipran.
Chlorpropamide	Chlorpropamide The risk or severity of hypoglycemia can be increased when Chlorpropamide is combined with Milnacipran.
Tolbutamide	Tolbutamide The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Milnacipran.
Tolazamide	Tolazamide The risk or severity of hypoglycemia can be increased when Tolazamide is combined with Milnacipran.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Milnacipran.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Milnacipran is combined with Cyclobenzaprine.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Milnacipran.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Cyproheptadine	Cyproheptadine The therapeutic efficacy of Milnacipran can be decreased when used in combination with Cyproheptadine.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Milnacipran.
Chlorpheniramine	Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Milnacipran.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Milnacipran.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Milnacipran.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Methyclothiazide	Methyclothiazide The risk or severity of hyponatremia can be increased when Milnacipran is combined with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of hyponatremia can be increased when Milnacipran is combined with Hydrochlorothiazide.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Milnacipran.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Milnacipran.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Milnacipran.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Milnacipran.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Milnacipran.
Pseudoephedrine	Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Pseudoephedrine is combined with Milnacipran.
Nortriptyline	Nortriptyline The metabolism of Milnacipran can be decreased when combined with Nortriptyline.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Phytonadione	Phytonadione Phylloquinone may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Nadolol	Nadolol The serum concentration of Nadolol can be increased when it is combined with Milnacipran.
Butorphanol Injection	Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Butorphanol is combined with Milnacipran.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Nalbuphine is combined with Milnacipran.
Allopurinol	Allopurinol Allopurinol may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Milnacipran.
Flavoxate	Flavoxate Flavoxate may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Milnacipran.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Dacarbazine	Dacarbazine Dacarbazine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Milnacipran.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Ketoconazole	Ketoconazole The metabolism of Milnacipran can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Milnacipran.
Thiotepa Injection	Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Milnacipran.
Vincristine Injection	Vincristine Injection The metabolism of Vincristine can be decreased when combined with Milnacipran.
Dipyridamole	Dipyridamole The risk or severity of hemorrhage can be increased when Milnacipran is combined with Dipyridamole.
Isoxsuprine	Isoxsuprine Milnacipran may increase the tachycardic activities of Isoxsuprine.
Vinblastine	Vinblastine The metabolism of Milnacipran can be increased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Metoprolol	Metoprolol The serum concentration of Metoprolol can be increased when it is combined with Milnacipran.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Milnacipran.
Aspirin	Aspirin Milnacipran may increase the antiplatelet activities of Acetylsalicylic acid.
Salsalate	Salsalate The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Salsalate.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Milnacipran.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Milnacipran.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Milnacipran.
Dicyclomine	Dicyclomine Dicyclomine may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Hyoscyamine	Hyoscyamine Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Propantheline may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Trimethoprim	Trimethoprim Trimethoprim may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Nifedipine	Nifedipine The metabolism of Milnacipran can be increased when combined with Nifedipine.
Timolol	Timolol The serum concentration of Timolol can be increased when it is combined with Milnacipran.
Verapamil	Verapamil Verapamil may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Atenolol	Atenolol The serum concentration of Atenolol can be increased when it is combined with Milnacipran.
Pindolol	Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Milnacipran.
Cisplatin Injection	Cisplatin Injection Milnacipran may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal	Diflunisal The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Diflunisal.
Piroxicam	Piroxicam The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Piroxicam.
Bumetanide	Bumetanide Bumetanide may increase the excretion rate of Milnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide	Etoposide The metabolism of Milnacipran can be increased when combined with Etoposide.
Glyburide	Glyburide The risk or severity of hypoglycemia can be increased when Glyburide is combined with Milnacipran.
Glipizide	Glipizide The risk or severity of hypoglycemia can be increased when Glipizide is combined with Milnacipran.
Indapamide	Indapamide The risk or severity of hyponatremia can be increased when Milnacipran is combined with Indapamide.
Amoxicillin	Amoxicillin Amoxicillin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Dicloxacillin	Dicloxacillin The metabolism of Milnacipran can be increased when combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The metabolism of Milnacipran can be increased when combined with Nafcillin.
Oxacillin Injection	Oxacillin Injection Oxacillin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Pentoxifylline	Pentoxifylline Milnacipran may increase the antiplatelet activities of Pentoxifylline.
Pentamidine Injection	Pentamidine Injection Pentamidine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Labetalol	Labetalol The serum concentration of Labetalol can be increased when it is combined with Milnacipran.
Auranofin	Auranofin Auranofin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Gemfibrozil	Gemfibrozil Gemfibrozil may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Guanabenz	Guanabenz Milnacipran may increase the tachycardic activities of Guanabenz.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Ketoprofen	Ketoprofen The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Ketoprofen.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Pimozide	Pimozide The risk or severity of QTc prolongation can be increased when Milnacipran is combined with Pimozide.
Flurbiprofen	Flurbiprofen The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Flurbiprofen.
Amiodarone	Amiodarone The metabolism of Amiodarone can be decreased when combined with Milnacipran.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Buspirone	Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Milnacipran.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Milnacipran.
Ciprofloxacin	Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Mesalamine	Mesalamine The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Mesalazine.
Diclofenac	Diclofenac The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Diclofenac.
Fluoxetine	Fluoxetine The risk or severity of serotonin syndrome can be increased when Fluoxetine is combined with Milnacipran.
Clozapine	Clozapine The metabolism of Milnacipran can be increased when combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Estazolam is combined with Milnacipran.
Didanosine	Didanosine Didanosine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Pentostatin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Clarithromycin	Clarithromycin The metabolism of Milnacipran can be decreased when combined with Clarithromycin.
Etodolac	Etodolac The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Etodolac.
Fosinopril	Fosinopril Fosinopril may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Nabumetone	Nabumetone The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Nabumetone.
Teniposide Injection	Teniposide Injection The metabolism of Teniposide can be decreased when combined with Milnacipran.
Itraconazole	Itraconazole The metabolism of Milnacipran can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril Lisinopril may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Oxaprozin	Oxaprozin The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Oxaprozin.
Rifabutin	Rifabutin The metabolism of Milnacipran can be increased when combined with Rifabutin.
Sotalol	Sotalol The serum concentration of Sotalol can be increased when it is combined with Milnacipran.
Bisoprolol	Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Milnacipran.
Zolpidem	Zolpidem Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Milnacipran.
Isradipine	Isradipine Isradipine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Omeprazole	Omeprazole The metabolism of Milnacipran can be increased when combined with Omeprazole.
Cisapride	Cisapride The risk or severity of adverse effects can be increased when Cisapride is combined with Milnacipran.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Milnacipran.
Venlafaxine	Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Milnacipran.
Famciclovir	Famciclovir The metabolism of Famciclovir can be decreased when combined with Milnacipran.
Fluvoxamine	Fluvoxamine The risk or severity of adverse effects can be increased when Fluvoxamine is combined with Milnacipran.
Nefazodone	Nefazodone The metabolism of Milnacipran can be decreased when combined with Nefazodone.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Milnacipran.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Milnacipran.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Milnacipran.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Lansoprazole	Lansoprazole The metabolism of Milnacipran can be increased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Milnacipran can be increased when combined with Ifosfamide.
Nicardipine	Nicardipine Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Nicardipine.
Bupropion	Bupropion The risk or severity of adverse effects can be increased when Bupropion is combined with Milnacipran.
Ticlopidine	Ticlopidine The risk or severity of hemorrhage can be increased when Milnacipran is combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Saquinavir can be decreased when combined with Milnacipran.
Metformin	Metformin The risk or severity of hypoglycemia can be increased when Metformin is combined with Milnacipran.
Dalteparin Injection	Dalteparin Injection The risk or severity of hemorrhage can be increased when Milnacipran is combined with Dalteparin.
Nisoldipine	Nisoldipine Nisoldipine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Lamivudine	Lamivudine Lamivudine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Milnacipran.
Acarbose	Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Milnacipran.
Glimepiride	Glimepiride The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Milnacipran.
Gemcitabine Injection	Gemcitabine Injection Gemcitabine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Ritonavir	Ritonavir The serum concentration of Milnacipran can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Milnacipran.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Clomipramine	Clomipramine The risk or severity of adverse effects can be increased when Clomipramine is combined with Milnacipran.
Zafirlukast	Zafirlukast The metabolism of Milnacipran can be decreased when combined with Zafirlukast.
Fosfomycin	Fosfomycin Fosfomycin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Mirtazapine	Mirtazapine Milnacipran may increase the serotonergic activities of Mirtazapine.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Milnacipran.
Insulin Lispro Injection	Insulin Lispro Injection The risk or severity of hypoglycemia can be increased when Insulin lispro is combined with Milnacipran.
Pramipexole	Pramipexole Milnacipran may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Milnacipran.
Azithromycin	Azithromycin The metabolism of Azithromycin can be decreased when combined with Milnacipran.
Carvedilol	Carvedilol The serum concentration of Carvedilol can be increased when it is combined with Milnacipran.
Nilutamide	Nilutamide Nilutamide may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Flutamide	Flutamide Flutamide may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Selegiline	Selegiline Selegiline may increase the serotonergic activities of Milnacipran.
Bicalutamide	Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Milnacipran.
Sertraline	Sertraline The risk or severity of adverse effects can be increased when Sertraline is combined with Milnacipran.
Propafenone	Propafenone The serum concentration of Propafenone can be increased when it is combined with Milnacipran.
Tamsulosin	Tamsulosin Tamsulosin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Ropinirole	Ropinirole Milnacipran may increase the sedative activities of Ropinirole.
Quetiapine	Quetiapine The risk or severity of adverse effects can be increased when Quetiapine is combined with Milnacipran.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Milnacipran.
Paroxetine	Paroxetine The risk or severity of adverse effects can be increased when Paroxetine is combined with Milnacipran.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Milnacipran.
Citalopram	Citalopram The risk or severity of adverse effects can be increased when Citalopram is combined with Milnacipran.
Capecitabine	Capecitabine Capecitabine may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Efavirenz	Efavirenz The metabolism of Milnacipran can be decreased when combined with Efavirenz.
Abacavir	Abacavir Abacavir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Pioglitazone	Pioglitazone The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Pioglitazone.
Celecoxib	Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Milnacipran.
Rosiglitazone	Rosiglitazone The risk or severity of hypoglycemia can be increased when Rosiglitazone is combined with Milnacipran.
Tolterodine	Tolterodine Tolterodine may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Thalidomide	Thalidomide Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Balsalazide	Balsalazide The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Balsalazide.
Nateglinide	Nateglinide The risk or severity of hypoglycemia can be increased when Nateglinide is combined with Milnacipran.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Milnacipran.
Rabeprazole	Rabeprazole Rabeprazole may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Terbinafine	Terbinafine The metabolism of Milnacipran can be increased when combined with Terbinafine.