FDA-filed SPL labeling · retrieved through openFDA

Venlafaxine

Venlafaxine is an SNRI antidepressant used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder.

Brand names Effexor XREffexor
Drug classes ⓘ Norepinephrine Uptake Inhibitors
Rx Forms 3 Route Oral
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 200 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveOct 9, 2025
Clinical labels in scope ⓘ200
AvailabilityRx
Earliest approval/marketing year ⓘ1993
FDA-listed product records ⓘ910
Boxed warningYes
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 22, 2026
⭐ Venlafaxine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Venlafaxine is a well-established SNRI used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder, depending on the formulation. It works by boosting serotonin and norepinephrine in the brain, and most people take it once daily with food. Like all antidepressants, it carries an important warning about suicidal thoughts in younger patients, and it should never be stopped abruptly — always work with your prescriber to taper the dose slowly.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Antidepressants, including venlafaxine, can increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults (under 25). This risk was seen in short-term studies of antidepressants. All patients starting venlafaxine — regardless of age — should be monitored closely for any worsening of depression or new thoughts of suicide, especially during the first few weeks of treatment and after any dose change. Family members and caregivers should also be alert to sudden mood shifts or unusual behavior and report these to a healthcare provider right away. Note: venlafaxine extended-release capsules are not approved for use in children and adolescents.

Read the full warning on DailyMed →

📖 Venlafaxine: Patient Information Guide

A plain-language walkthrough of Venlafaxine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Venlafaxine is an SNRI (serotonin-norepinephrine reuptake inhibitor) available in several formulations, each with specific approved uses:

  • All formulations: Major depressive disorder (MDD)
  • Extended-release capsules (including Effexor XR): Major depressive disorder, Generalized anxiety disorder (GAD), Social anxiety disorder (SAD), and Panic disorder (PD) — all in adults
  • Extended-release tablets: Major depressive disorder and Social anxiety disorder
  • Immediate-release tablets: Major depressive disorder only
⚙️How it works▾

Venlafaxine is an SNRI — it blocks the brain from reabsorbing ("reuptaking") two key chemical messengers: serotonin and norepinephrine. Keeping more of these available in the spaces between nerve cells is thought to lift mood, ease anxiety, and stabilize emotional responses. It also weakly slows dopamine reuptake. Unlike older antidepressants, venlafaxine doesn't significantly bind to the receptors linked to sedation, dry mouth, or certain heart effects, which helps explain its somewhat different side-effect profile.

💊How it's taken▾

The specific form and schedule matter with venlafaxine — always follow your prescriber's instructions.

  • Extended-release capsules and tablets: Taken once daily with food, at roughly the same time each day (morning or evening). Tablets must be swallowed whole. Capsules may be swallowed whole or opened and sprinkled on applesauce — swallow immediately, don't chew, and follow with water.
  • Immediate-release tablets: Taken in two or three divided doses per day, with food.
  • Stopping: Never stop venlafaxine abruptly. Your prescriber will guide you through a gradual taper to avoid withdrawal-like symptoms.
🤒Side effects — in detail▾

The most common side effects reported in clinical studies include:

  • Nausea (the most common — often improves with time)
  • Drowsiness or difficulty sleeping
  • Dry mouth
  • Sweating, including night sweats
  • Dizziness
  • Decreased appetite
  • Tremor
  • Sexual side effects: decreased libido, difficulty reaching orgasm, or erectile dysfunction in men

Seek medical attention right away for signs of serotonin syndrome (agitation, racing heart, high fever, severe muscle stiffness), significant blood pressure rise, unusual bleeding, signs of low sodium (confusion, weakness, seizures), or sudden eye pain.

⚠️Warnings & precautions▾
  • Suicidal thoughts and behaviors: Antidepressants increase the risk of suicidal thinking in people under 25. Watch closely, especially in the first weeks of treatment or after a dose change. Venlafaxine extended-release capsules are not approved for pediatric patients.
  • Serotonin syndrome: A potentially life-threatening reaction that can occur, especially when combined with other serotonergic drugs or MAOIs. Symptoms include agitation, fever, rapid heartbeat, and muscle twitching.
  • Blood pressure increases: Venlafaxine can raise blood pressure in a dose-related way. Blood pressure should be checked before starting and monitored regularly throughout treatment.
  • Discontinuation syndrome: Stopping suddenly can cause dizziness, nausea, electric shock sensations, and other distressing symptoms. Always taper gradually.
  • Bleeding risk: Venlafaxine affects serotonin in platelets and can increase bleeding, particularly when combined with NSAIDs, aspirin, or blood thinners.
  • Mania activation: May trigger mania or hypomania in people with bipolar disorder. Screening for bipolar history before starting is recommended.
  • Hyponatremia (low sodium): Can occur, especially in older adults and those on diuretics. Symptoms include headache, confusion, and in severe cases, seizures.
  • Angle-closure glaucoma: Pupil dilation from venlafaxine can trigger an eye pressure crisis in those with untreated narrow-angle glaucoma.
🔀What it interacts with▾

Venlafaxine has several important drug interactions to be aware of before starting:

  • MAOIs (e.g., phenelzine, selegiline, linezolid, IV methylene blue): Absolutely contraindicated together or within 14 days of each other — risk of fatal serotonin syndrome.
  • Other serotonergic drugs (SSRIs, other SNRIs, triptans, tricyclic antidepressants, lithium, tramadol, fentanyl, meperidine, methadone, buspirone, amphetamines, St. John's Wort): Increased serotonin syndrome risk.
  • NSAIDs, aspirin, warfarin, and other antiplatelet/anticoagulant drugs: Higher bleeding risk — close monitoring is needed.
  • CYP3A inhibitors (certain antifungals, some HIV drugs, some antibiotics): Can raise venlafaxine blood levels and increase the chance of side effects.
  • CYP2D6 substrates (various antidepressants, antipsychotics, and other drugs): Venlafaxine can increase their levels, potentially causing toxicity.
  • Alcohol and CNS-active drugs: Use with caution — effects are not fully studied.
  • Weight-loss medications (including phentermine): Not recommended with venlafaxine.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Do not take if you are allergic to venlafaxine or desvenlafaxine, or any ingredients in the product.
  • Do not take if you currently take an MAOI or have taken one within the past 14 days.
  • Tell your doctor if you have high blood pressure, heart disease, or a history of stroke.
  • Tell your doctor if you have ever experienced mania, hypomania, or have been diagnosed with bipolar disorder.
  • Tell your doctor if you have a seizure disorder.
  • Tell your doctor if you have narrow-angle glaucoma or are at risk.
  • Tell your doctor if you have kidney or liver disease — dosage adjustments may be needed.
  • Pregnancy: Use in mid to late pregnancy may increase preeclampsia risk; use close to delivery may increase risk of postpartum hemorrhage and neonatal adaptation symptoms. Discuss with your doctor.
  • Breastfeeding: Venlafaxine and its active metabolite pass into breast milk. Discuss benefits and risks with your provider.
  • Children and adolescents: Venlafaxine extended-release capsules are not approved for pediatric use.
  • Older adults: More likely to develop low sodium (hyponatremia) — monitor accordingly.
🚑If you take too much▾

Taking too much venlafaxine can cause drowsiness, nausea, rapid heartbeat, seizures, changes in consciousness, and abnormal heart rhythms. In serious cases, overdose — especially when combined with alcohol or other drugs — can be life-threatening. If you suspect an overdose, call Poison Control at 1-800-222-1222 or seek emergency medical care immediately. There is no specific antidote, so treatment focuses on supportive care.

📡Pharmacodynamics — effects in the body▾

Venlafaxine and its active metabolite ODV (O-desmethylvenlafaxine) are potent inhibitors of serotonin and norepinephrine reuptake in nerve cells, and weakly inhibit dopamine reuptake. They do not significantly bind to the receptors (muscarinic, histamine H1, or alpha-1 adrenergic) associated with sedation, dry mouth, and certain cardiovascular effects common with older antidepressants. Studies at twice the maximum recommended dose showed no significant effect on the QT interval (a measure of heart electrical timing), which is reassuring from a cardiac standpoint.

🔬Pharmacokinetics — how your body processes it▾

Venlafaxine is well absorbed from the gut — at least 92% of an oral dose is absorbed, though the actual amount reaching the bloodstream (bioavailability) is about 45% due to first-pass metabolism in the liver. It is converted mainly into an active metabolite called ODV, primarily by a liver enzyme called CYP2D6; people who metabolize CYP2D6 slowly will have higher venlafaxine levels and lower ODV levels. The half-life (time for blood levels to drop by half) is about 5 hours for venlafaxine and about 11 hours for ODV, with steady-state levels reached within about 3 days. Most of the drug is cleared through urine within 48 hours. Food does not affect how much of the drug is absorbed. Extended-release capsules provide a slower, steadier release compared to immediate-release tablets, with the same overall exposure.

📦How to store it▾

Store at 20° to 25°C (68° to 77°F).

📄 Written from Venlafaxine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

110

Supplements & herbs that interact with Venlafaxine

110 supplements and herbal products have documented interactions with Venlafaxine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 8
  • Moderate · 82
  • Minor · 20
ACTIVATED CHARCOAL Major AMERICAN HELLEBORE Major ARSENIC Major CESIUM Major EPHEDRA Major GRAPEFRUIT Major LITHIUM Major SIDA CORDIFOLIA Major +102 more
Every supplement checked against Venlafaxine — ranked by severity The full interaction hub: 8 major · 82 moderate · 20 minor · every one linked to its full report. Check Venlafaxine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Venlafaxine has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

SODIUM Moderate Depletion
See the full Venlafaxine nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Venlafaxine — the kind of thing our pharmacy team would talk through with you at the counter.

What is venlafaxine actually used for? ▾
Venlafaxine treats major depressive disorder in all its forms. Depending on which formulation you're prescribed, it can also treat generalized anxiety disorder, social anxiety disorder, and panic disorder. Extended-release capsules (like Effexor XR) cover all four of those conditions, while extended-release tablets are approved for depression and social anxiety disorder, and immediate-release tablets are for depression only. Your prescriber chose the right form for your situation.
How long does it take for venlafaxine to start working? ▾
Most people don't feel a full benefit right away — it typically takes several weeks before you notice a meaningful improvement in mood or anxiety. Blood levels stabilize within about three days, but the brain changes that actually help symptoms take longer to build up. It's important to keep taking it as directed even if you don't feel better immediately, and to check in with your doctor if you have concerns.
What side effects should I expect, and which ones mean I should call my doctor? ▾
The most common side effects are nausea, dry mouth, sweating, drowsiness or insomnia, dizziness, and decreased appetite — and many of these tend to improve after the first couple of weeks. Sexual side effects like reduced sex drive or difficulty with orgasm are also common. What you should call your doctor about right away: any rise in blood pressure, unusual bruising or bleeding, signs of low sodium like confusion or weakness, or if you feel agitated, feverish, and your heart is racing (that could be serotonin syndrome, which needs immediate care).
Can I just stop taking venlafaxine if I want to? ▾
Please don't stop suddenly — this is one of the most important things to know about venlafaxine. Stopping abruptly can cause a range of unpleasant withdrawal-like symptoms, including dizziness, nausea, irritability, trouble sleeping, and strange electric shock-like sensations. These can sometimes be severe. Always work with your prescriber to taper the dose gradually, and in some people that process may take several months.
Are there any drugs or supplements I should avoid while taking venlafaxine? ▾
Yes — the most critical ones are MAOIs (a class of older antidepressants like phenelzine, or antibiotics like linezolid). Combining them with venlafaxine can cause a dangerous condition called serotonin syndrome, and there needs to be at least a 14-day gap between the two. Also use caution with other antidepressants, migraine triptans, opioid pain medications, St. John's Wort, aspirin, ibuprofen, naproxen, and blood thinners — all of these can interact. Always tell every provider and pharmacist you see that you're on venlafaxine.
Is venlafaxine safe to take during pregnancy or while breastfeeding? ▾
This is a conversation worth having carefully with your doctor. The available data haven't shown a clear risk of major birth defects, but using venlafaxine in mid to late pregnancy may slightly increase the risk of a condition called preeclampsia, and use close to delivery may raise the chance of postpartum bleeding and temporary symptoms in the newborn. Venlafaxine does pass into breast milk, though studies haven't shown harmful effects in nursing infants. At the same time, stopping an antidepressant during pregnancy also carries real risks — untreated depression can be harmful too. Your doctor can help weigh what's best for you and your baby.
Is Venlafaxine available over the counter? ▾
Venlafaxine is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Venlafaxine first available? ▾
Venlafaxine has been available in the United States since at least 1993, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Venlafaxine? ▾
Venlafaxine is supplied by 108 manufacturers listed in the FDA NDC Directory, including Remedyrepack Inc., A-S Medication Solutions, Bryant Ranch Prepack.

💬 Answers drafted from Venlafaxine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Venlafaxine supplement interactions110 checked — ranked by severity 🌿Drug & Supplement CheckerVenlafaxine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Venlafaxine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Venlafaxine comes

Venlafaxine is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Extended-release capsule

By mouth
Brands Effexor
Available strengths 4 strengths
37.5 mg 75 mg 100 mg 150 mg
426 FDA-listed product records ⓘ

📊 Venlafaxine across the U.S. market

How Venlafaxine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

3
Dose forms ⓘ
108
Manufacturers
7
Brand names
910
FDA-listed product records ⓘ
1993
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (22) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Remedyrepack Inc.10%
A-S Medication Solutions8%
Bryant Ranch Prepack8%
Zydus Lifesciences Limited5%
NuCare Pharmaceuticals,Inc.5%
Zydus Pharmaceuticals USA Inc.4%
Other makers61%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Venlafaxine is used

A general measure of how commonly Venlafaxine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Venlafaxine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

2,819,501
Medicaid prescriptions filled (Q1–Q4 2025)
$41.3M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Venlafaxine prescribed? Of the 1,596 medications we measure, Venlafaxine ranks #78 by Medicaid prescriptions — more than 95% of them.

Where Venlafaxine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #78 of 1,596
#73 Oxycodone 3,037,434 Rx #74 Clindamycin 3,018,439 Rx #75 Hydrocortisone Topical 2,941,220 Rx #76 Mupirocin 2,929,179 Rx #77 Empagliflozin 2,905,773 Rx #78 Venlafaxine 2,819,501 Rx #79 Propranolol (Infantile... 2,801,185 Rx #80 Propranolol (Cardiovas... 2,801,185 Rx #81 Propranolol 2,801,185 Rx #82 Alprazolam 2,797,728 Rx #83 Topiramate 2,782,995 Rx

Utilization by Venlafaxine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 150 mg 24 hr extended release oral capsule is the most-dispensed Venlafaxine product — about 36% of these Medicaid prescriptions.

24 HR venlafaxine 150 MG Extended Release Oral Capsule Most dispensed

1,007,048 Medicaid prescriptions (Q1–Q4 2025) 36% of Venlafaxine prescriptions shown $15M gross reimbursement (before rebates) ≈ $15 per prescription (gross)

Summed across the 26 of 224 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313581

24 HR venlafaxine 75 MG Extended Release Oral Capsule

958,382 Medicaid prescriptions (Q1–Q4 2025) 34% of Venlafaxine prescriptions shown $12.4M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 26 of 244 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313585

24 HR venlafaxine 37.5 MG Extended Release Oral Capsule

511,909 Medicaid prescriptions (Q1–Q4 2025) 18% of Venlafaxine prescriptions shown $5.9M gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 23 of 224 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313583

venlafaxine 75 MG Oral Tablet

93,360 Medicaid prescriptions (Q1–Q4 2025) 3% of Venlafaxine prescriptions shown $1.2M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 7 of 114 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313586

24 HR venlafaxine 225 MG Extended Release Oral Tablet

75,837 Medicaid prescriptions (Q1–Q4 2025) 3% of Venlafaxine prescriptions shown $3.3M gross reimbursement (before rebates) ≈ $43 per prescription (gross)

Summed across the 19 of 60 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 808748

venlafaxine 37.5 MG Oral Tablet

61,185 Medicaid prescriptions (Q1–Q4 2025) 2% of Venlafaxine prescriptions shown $739,225 gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 8 of 83 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313584

venlafaxine 100 MG Oral Tablet

28,571 Medicaid prescriptions (Q1–Q4 2025) 1% of Venlafaxine prescriptions shown $446,738 gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 7 of 64 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313580

24 HR venlafaxine 150 MG Extended Release Oral Tablet

26,787 Medicaid prescriptions (Q1–Q4 2025) <1% of Venlafaxine prescriptions shown $662,254 gross reimbursement (before rebates) ≈ $25 per prescription (gross)

Summed across the 18 of 57 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 808744

venlafaxine 25 MG Oral Tablet

16,284 Medicaid prescriptions (Q1–Q4 2025) <1% of Venlafaxine prescriptions shown $200,833 gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 8 of 52 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313582

venlafaxine 50 MG Oral Tablet

14,578 Medicaid prescriptions (Q1–Q4 2025) <1% of Venlafaxine prescriptions shown $193,123 gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 6 of 47 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314277

24 HR venlafaxine 75 MG Extended Release Oral Tablet

13,818 Medicaid prescriptions (Q1–Q4 2025) <1% of Venlafaxine prescriptions shown $529,201 gross reimbursement (before rebates) ≈ $38 per prescription (gross)

Summed across the 14 of 53 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 808753

24 HR venlafaxine 37.5 MG Extended Release Oral Tablet

9,820 Medicaid prescriptions (Q1–Q4 2025) <1% of Venlafaxine prescriptions shown $328,808 gross reimbursement (before rebates) ≈ $33 per prescription (gross)

Summed across the 9 of 35 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 808751

24 HR venlafaxine 112.5 MG Extended Release Oral Tablet

1,922 Medicaid prescriptions (Q1–Q4 2025) <1% of Venlafaxine prescriptions shown $471,781 gross reimbursement (before rebates) ≈ $245 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2605950

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Venlafaxine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 172 of 1,258 listed Venlafaxine NDCs with Medicaid activity.

🔍 Compare Venlafaxine products

A representative set of FDA-listed product records for Venlafaxine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 910 products — FDA National Drug Code Directory. See every product, package size and price: browse all 910 Venlafaxine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Venlafaxine RxCUI 39786 3 dose forms · 13 strengths
  3. Dose form (SCDF) Oral Tablet RxCUI 374285 In current FDA listings
    Clinical drug / strength (SCD) 25 MG RxCUI 313582 37.5 MG RxCUI 313584 50 MG RxCUI 314277 75 MG RxCUI 313586 100 MG RxCUI 313580

Look up RxCUI 39786 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Effexor XR Effexor

🏭 Manufacturers & labelers

Remedyrepack Inc. 71 A-S Medication Solutions 60 Bryant Ranch Prepack 56 Zydus Lifesciences Limited 33 NuCare Pharmaceuticals,Inc. 32 Zydus Pharmaceuticals USA Inc. 27 Sun Pharmaceutical Industries, Inc. 24 BluePoint Laboratories 22 Aurobindo Pharma Limited 22 Cadila Pharmaceuticals Limited 21 Preferred Pharmaceuticals Inc. 20 Yaopharma Co., Ltd. 20 Teva Pharmaceuticals USA, Inc. 16 American Health Packaging 15 Proficient Rx LP 15 Golden State Medical Supply, Inc. 15 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 15 Alembic Pharmaceuticals Limited 13 Rising Pharma Holdings, Inc. 13 Alembic Pharmaceuticals Inc. 13 Ascend Laboratories, LLC 12 Dr. Reddy's Laboratories Limited 10 Northstar Rx LLC 10 Camber Pharmaceuticals, Inc. 10

…and 16 more on the FDA NDC directory.

RxNorm drug class

Venlafaxine belongs to the Serotonin and Norepinephrine Reuptake Inhibitor class.

Pharmacologic class Serotonin and Norepinephrine Reuptake Inhibitor
Drug family (ATC) Other antidepressants
How it works Norepinephrine Uptake Inhibitors, Serotonin Uptake Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Oct 9, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Venlafaxine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Venlafaxine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
200
NDC products indexed
910
Distinct labelers/manufacturers represented
108
Linked representative label ⓘ
Almatica Pharma LLC
Linked label effective
Oct 9, 2025
Composite sections available
25
Linked SPL Set ID
e81a2daf-b8b2-7c05-b532-bc775700b100
Linked SPL Document ID
1b0762be-0db0-b997-b76b-b212a496f82c
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 200 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Almatica Pharma LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.