Methadone

Generic name: Pronounced as (meth' a done)
Brand names
  • Diskets®
  • Dolophine®
  • Methadose®
  • Methadose® Oral Concentrate
  • Westadone®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2021

Methadone may be habit forming. Take methadone exactly as directed. Do not take a larger dose, take it more often, or take it for a longer period of time or in a different way than prescribed by your doctor. While taking methadone, discuss with your healthcare provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse methadone if you have or have ever had any of these conditions. Talk to your healthcare provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

Methadone may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take methadone. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema), a head injury, a brain tumor, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath.

Taking certain other medications during your treatment with methadone may increase the risk that you will experience serious, life-threatening side effects such as breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: antipsychotics such as aripiprazole (Abilify), asenapine (Saphris), cariprazine (Vraylar), chlorpromazine, clozapine (Versacloz), fluphenazine, haloperidol (Haldol), iloperidone (Fanapt), loxapine, lurasidone (Latuda), molindone, olanzapine (Zyprexa), paliperidone (Invega), perphenazine, pimavanserin (Nuplazid), quetiapine (Seroquel), risperidone (Risperdal), thioridazine, thiothixene, trifluoperazine, and ziprasidone (Geodon); benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), and triazolam (Halcion); opiate (narcotic) medications for pain and cough; medications for nausea or mental illness; muscle relaxants; sedatives; sleeping pills; or tranquilizers. Your doctor may need to change the doses of your medications and will monitor you carefully. If you take methadone with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with methadone increases the risk that you will experience serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment.

Do not allow anyone else to take your medication. Methadone may harm or cause death to other people who take your medication, especially children. Store methadone in a safe place so that no one else can take it accidentally or on purpose. Be especially careful to keep methadone out of the reach of children. Keep track of how many tablets or how much liquid is left so you will know if any medication is missing. Dispose of any unwanted methadone tablets or oral solution properly according to instructions. (See STORAGE and DISPOSAL.)

Methadone may cause a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death). Tell your doctor if you or anyone in your family has or has ever had long QT syndrome; or if you have or ever had a slow or irregular heartbeat; low blood levels of potassium or magnesium, or heart disease. Tell your doctor and pharmacist if you are taking or plan to take any of the following medications: antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); certain antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); diuretics ('water pills'); erythromycin (Eryc, Erythrocin, others); fludrocortisone; certain laxatives; medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide, ibutilide (Corvert), procainamide, and quinidine (in Nuedexta); nicardipine (Cardene); and risperidone (Risperdal); and sertraline (Zoloft). If you experience any of the following symptoms, call your doctor immediately: pounding heartbeat, dizziness, lightheadedness, or fainting.

Tell your doctor if you are pregnant or plan to become pregnant. If you take methadone regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.

Talk to your doctor about the risks of taking methadone for your condition.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with methadone and each time you fill your prescription if a Medication Guide is available for the methadone product you are taking. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Use of methadone to treat opiate addiction:

If you have been addicted to an opiate (narcotic drug such as heroin), and you are taking methadone to help you stop taking or continue not taking the drug, you must enroll in a treatment program. The treatment program must be approved by the state and federal governments and must treat patients according to specific federal laws. You may have to take your medication at the treatment program facility under the supervision of the program staff. Ask your doctor or the treatment program staff if you have any questions about enrolling in the program or taking or getting your medication.

Methadone is used to relieve severe pain in people who are expected to need pain medication around the clock for a long time and who cannot be treated with other medications. It also is used to prevent withdrawal symptoms in patients who were addicted to opiate drugs and are enrolled in treatment programs in order to stop taking or continue not taking the drugs. Methadone is in a class of medications called opiate (narcotic) analgesics. Methadone works to treat pain by changing the way the brain and nervous system respond to pain. It works to treat people who were addicted to opiate drugs by producing similar effects and preventing withdrawal symptoms in people who have stopped using these drugs.

Methadone comes as a tablet, a dispersible (can be dissolved in liquid) tablet, a solution (liquid), and a concentrated solution to take by mouth. When methadone is used to relieve pain, it may be taken every 8 to 12 hours. If you take methadone as part of a treatment program, your doctor will prescribe the dosing schedule that is best for you. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take methadone exactly as directed.

If you are using the dispersible tablets, do not chew or swallow before mixing the tablet in a liquid. If your doctor has told you to take only part of a tablet, break the tablet carefully along the lines that have been scored into it. Place the tablet or piece of the tablet in at least 120 mL (4 ounces) of water, orange juice, Tang®, citrus flavors of Kool-Aid®, or a citrus fruit drink to dissolve. Drink the entire mixture right away. If some tablet residue remains in the cup after you drink the mixture, add a small amount of liquid to the cup and drink it all.

Your doctor may change your dose of methadone during your treatment. Your doctor may decrease your dose or tell you to take methadone less often as your treatment continues. If you experience pain during your treatment, your doctor may increase your dose or may prescribe an additional medication to control your pain. Talk to your doctor about how you are feeling during your treatment with methadone. Do not take extra doses of methadone or take doses of methadone earlier than they are scheduled even if you experience pain.

Do not stop taking methadone without talking to your doctor. Your doctor will probably want to decrease your dose gradually. If you suddenly stop taking methadone, you may experience withdrawal symptoms such as restlessness, teary eyes, runny nose, yawning, sweating, chills, muscle pain, widened pupils (black circles in the middle of the eyes), irritability, anxiety, backache, joint pain, weakness, stomach cramps, difficulty falling asleep or staying asleep, nausea, decreased appetite, vomiting, or diarrhea.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking methadone,

  • tell your doctor and pharmacist if you are allergic to methadone, any other medications, or any of the ingredients in the methadone product you plan to take. Ask your doctor or pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antihistamines; buprenorphine (Suboxone, in Zubsolv); butorphanol; carbamazepine (Cabatrol, Equetro, Tegretol, others); cyclobenzaprine (Amrix); dextromethorphan (found in many cough medications; in Nuedexta); medications for glaucoma, irritable bowel disease, Parkinson's disease, ulcers, and urinary problems; certain medications for HIV including abacavir (Ziagen, in Trizivir), darunavir (Prezista), didanosine (Videx), efavirenz (Sustiva, in Atripla), lopinavir (in Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), stavudine (Zerit), tipranavir (Aptivus), and zidovudine (Retrovir, in Combivir); lithium (Lithobid); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Alsuma, Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); nalbuphine; naloxone (Evzio, Narcan, in Zubsolv); naltrexone (ReVia, Vivitrol, in Embeda); pentazocine (Talwin); phenobarbital; phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); 5HT3 serotonin blockers such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran, Zuplenz), or palonosetron (Aloxi); selective serotonin-reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), and paroxetine (Brisdelle, Prozac, Pexeva); serotonin and norepinephrine reuptake inhibitors such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), milnacipran (Savella); and venlafaxine (Effexor); tramadol (Conzip, Ultram, in Ultracet); and trazodone (Oleptro). Also tell your doctor or pharmacist if you are taking or receiving the following medications or have stopped taking them in the past 14 days: monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelpar), and tranylcypromine (Parnate). Many other medications may also interact with methadone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort and tryptophan.

  • tell your doctor if you have any of the conditions mentioned in the IMPORTANT WARNING section or have or have ever had a blockage in your intestine or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you that you should not take methadone.

  • tell your doctor if you have or have ever had difficulty urinating; an enlarged prostate (a male reproductive gland); Addison's disease (a condition in which the adrenal gland does not make enough of certain natural substances); seizures; or thyroid, pancreas, gallbladder, liver, or kidney disease.

  • tell your doctor if you are breastfeeding. If you breastfeed during your treatment with methadone, your baby may receive some methadone in breastmilk. Watch your baby closely for any changes in behavior or breathing, especially when you start taking methadone. If your baby develops any of these symptoms, call your baby's doctor immediately or get emergency medical help: unusual sleepiness, difficulty breastfeeding, difficulty breathing, or limpness. Talk to your baby's doctor when you are ready to wean your baby. You will need to wean your baby gradually so that your baby will not develop withdrawal symptoms when he or she stops receiving methadone in breastmilk.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking methadone.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking methadone.

  • you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • you should know that methadone may cause dizziness when you get up too quickly from a lying position. This is more common when you first start taking methadone. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • you should know that methadone may cause constipation. Talk to your doctor about changing your diet or using other medications to prevent or treat constipation while you are taking methadone.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

If your doctor has told you to take methadone for pain, take the missed dose as soon as you remember it and then continue your regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you are taking methadone to treat opioid addiction, skip the missed dose and take the next dose the next day as scheduled. Do not take a double dose to make up for a missed one.

  • Methadone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • weight gain

    • stomach pain

    • dry mouth

    • sore tongue

    • flushing

    • difficulty urinating

    • mood changes

    • vision problems

    • difficulty falling asleep or staying asleep

  • Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical help:

    • seizures

    • itching

    • hives

    • rash

    • swelling of the eyes, face, mouth, tongue, or throat

    • hoarseness

    • difficulty breathing or swallowing

    • extreme drowsiness

    • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

    • nausea, vomiting, loss of appetite, weakness, or dizziness

    • inability to get or keep an erection

    • irregular menstruation

    • decreased sexual desire

  • Methadone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). You must immediately dispose of any methadone that is outdated or no longer needed through a medicine take-back program. If you do not have a take-back program nearby or one that you can access promptly, flush any methadone tablets or solution that are outdated or no longer needed down the toilet. Talk to your pharmacist about the proper disposal of your medication.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

While taking methadone, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

Symptoms of overdose may include the following:

  • small, pinpoint pupils (black circles in the center of the eyes)

  • slow or shallow breathing

  • difficulty breathing

  • sleepiness

  • drowsiness

  • cool, clammy, or blue skin

  • unable to respond or wake up

  • limp muscles

Keep all appointments with your doctor or clinic. Your doctor may order certain lab tests to check your response to methadone.

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking methadone.

This prescription is not refillable. If you continue to experience pain after you finish taking the methadone, call your doctor. If you take this medication on a regular basis, be sure to schedule appointments with your doctor so that you do not run out of medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Methadone.
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Methadone.
Montelukast Montelukast The metabolism of Methadone can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Methadone can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Methadone can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be increased when combined with Methadone.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Methadone.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Methadone is combined with Dolasetron.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Methadone.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Methadone is combined with Anagrelide.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Methadone.
Candesartan Candesartan The metabolism of Methadone can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Methadone.
Clopidogrel Clopidogrel Methadone can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Methadone is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Methadone can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Methadone.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Methadone is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide Methadone may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Methadone.
Mycophenolate Mycophenolate Methadone may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Methadone is combined with Naratriptan.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Methadone which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Methadone is combined with Morphine.
Penbutolol Penbutolol The metabolism of Acebutolol can be decreased when combined with Methadone.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Methadone is combined with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Methadone.
Potassium Potassium Methadone may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Methadone may decrease the excretion rate of Prednisone which could result in a higher serum level.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Methadone.
Ranitidine Ranitidine The metabolism of Methadone can be decreased when combined with Ranitidine.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Methadone is combined with Reserpine.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Methadone is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Methadone is combined with Sumatriptan.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Methadone.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Methadone is combined with Tizanidine.
Triamcinolone Triamcinolone The metabolism of Methadone can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Methadone is combined with Zolmitriptan.
Ampicillin Injection Ampicillin Injection Methadone may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Methadone which could result in a higher serum level.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Methadone.
Fluconazole Injection Fluconazole Injection The metabolism of Methadone can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Methadone.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Methadone is combined with Hydromorphone.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Methadone is combined with Levofloxacin.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Methadone is combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Metoclopramide can be decreased when used in combination with Methadone.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Methadone.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Methadone is combined with Morphine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Methadone which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Methadone may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The serum concentration of Zidovudine can be increased when it is combined with Methadone.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Methadone is combined with Amphetamine.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Methadone which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Methadone.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Methadone is combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Methadone is combined with Granisetron.
Torsemide Torsemide The metabolism of Methadone can be decreased when combined with Torasemide.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Methadone is combined with Olanzapine.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Methadone is combined with Alosetron.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Methadone.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Methadone is combined with Entacapone.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydroxychloroquine is combined with Methadone.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Methadone which could result in a higher serum level.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Methadone is combined with Oxcarbazepine.
Pantoprazole Pantoprazole The metabolism of Methadone can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan The metabolism of Methadone can be decreased when combined with Telmisartan.
Temozolomide Temozolomide Methadone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Methadone is combined with Zaleplon.
Anakinra Anakinra The metabolism of Methadone can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Methadone is combined with Desloratadine.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Methadone.
Rivastigmine Rivastigmine The therapeutic efficacy of Methadone can be decreased when used in combination with Rivastigmine.
Trimipramine Trimipramine The risk or severity of adverse effects can be increased when Methadone is combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Methadone can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Methadone is combined with Glycopyrronium.
Modafinil Modafinil The metabolism of Methadone can be decreased when combined with Modafinil.
Perindopril Perindopril Methadone may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Methadone which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Methadone which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Methadone.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Methadone.
Epinephrine Injection Epinephrine Injection The metabolism of Methadone can be decreased when combined with Epinephrine.
Eplerenone Eplerenone Methadone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Methadone is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Methadone is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Methadone can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Methadone is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Methadone is combined with Atomoxetine.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Methadone is combined with Dexmethylphenidate.
Atazanavir Atazanavir The metabolism of Atazanavir can be increased when combined with Methadone.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Methadone is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Methadone is combined with Eletriptan.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Methadone.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Methadone.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Methadone.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Methadone.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Methadone.
Aprepitant Aprepitant The metabolism of Methadone can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Methadone may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine The risk or severity of adverse effects can be increased when Methadone is combined with Memantine.
Tegaserod Tegaserod The metabolism of Methadone can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Methadone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Fosamprenavir Fosamprenavir The serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Methadone resulting in a loss in efficacy.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Methadone is combined with Frovatriptan.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Methadone is combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Methadone can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Methadone is combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Methadone can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Methadone can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Methadone is combined with Protriptyline.
Rifaximin Rifaximin The metabolism of Methadone can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of adverse effects can be increased when Methadone is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Methadone.
Tinidazole Tinidazole Methadone may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium The risk or severity of adverse effects can be increased when Methadone is combined with Trospium.
Bosentan Bosentan The metabolism of Methadone can be increased when combined with Bosentan.
Cefditoren Cefditoren Methadone may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Methadone can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Methadone which could result in a higher serum level.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Methadone.
Eszopiclone Eszopiclone The risk or severity of adverse effects can be increased when Methadone is combined with Eszopiclone.
Ganciclovir Ganciclovir Methadone may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Methadone may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of adverse effects can be increased when Solifenacin is combined with Methadone.
Valganciclovir Valganciclovir Methadone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Methadone can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Methadone which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Methadone is combined with Amphetamine.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The serum concentration of Methadone can be increased when it is combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Methadone can be increased when it is combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate The risk or severity of adverse effects can be increased when Methadone is combined with Sodium oxybate.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Methadone.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Methadone is combined with Isocarboxazid.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Methadone is combined with Ramelteon.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Methadone.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Methadone.
Pregabalin Pregabalin The risk or severity of adverse effects can be increased when Methadone is combined with Pregabalin.
Deferasirox Deferasirox The metabolism of Methadone can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Methadone.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Methadone is combined with Felbamate.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Methadone.
Abatacept Injection Abatacept Injection The metabolism of Methadone can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Methadone is combined with Rasagiline.
Imatinib Imatinib The risk or severity of QTc prolongation can be increased when Imatinib is combined with Methadone.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Methadone.
Varenicline Varenicline Methadone may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Methadone can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Methadone.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Methadone is combined with Paliperidone.
Exemestane Exemestane The serum concentration of Methadone can be increased when it is combined with Exemestane.
Bortezomib Bortezomib The metabolism of Methadone can be increased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Methadone may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Methadone.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Methadone is combined with Oxaliplatin.
Posaconazole Posaconazole The risk or severity of QTc prolongation can be increased when Posaconazole is combined with Methadone.
Primaquine Primaquine The metabolism of Primaquine can be decreased when combined with Methadone.
Darunavir Darunavir The serum concentration of Methadone can be decreased when it is combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection Methadone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Methadone is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Methadone.
Nabilone Nabilone The risk or severity of adverse effects can be increased when Methadone is combined with Nabilone.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Methadone.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Methadone.
Sorafenib Sorafenib The metabolism of Methadone can be increased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Methadone.
Dronabinol Dronabinol The risk or severity of adverse effects can be increased when Methadone is combined with Dronabinol.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Lapatinib is combined with Methadone.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Methadone is combined with Levocetirizine.
Pegaptanib Injection Pegaptanib Injection Methadone may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Methadone.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Methadone.
Armodafinil Armodafinil The metabolism of Methadone can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Methadone may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Methadone.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Methadone.
Lenalidomide Lenalidomide Methadone may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Methadone.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Methadone is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Methadone can be decreased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Methadone can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Methadone can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Methadone is combined with Desmopressin.
Betaine Betaine The therapeutic efficacy of Methadone can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Methadone is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Methadone is combined with Botulinum Toxin Type B.
Doripenem Injection Doripenem Injection Methadone may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Methadone can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Methadone is combined with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Methadone is combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Methadone.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Methadone.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Methadone.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Methadone.
Certolizumab Injection Certolizumab Injection The metabolism of Methadone can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Methadone.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Methadone.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Methadone which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Methadone.
Alvimopan Alvimopan The risk or severity of adverse effects can be increased when Methadone is combined with Alvimopan.
Methylnaltrexone Injection Methylnaltrexone Injection The therapeutic efficacy of Methadone can be decreased when used in combination with Methylnaltrexone.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Methadone is combined with Rufinamide.
Midazolam Midazolam Midazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Methadone is combined with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Methadone may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Methadone can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Methadone is combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Methadone can be decreased when combined with Dexlansoprazole.
Plerixafor Injection Plerixafor Injection Methadone may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Methadone.
Fesoterodine Fesoterodine The risk or severity of adverse effects can be increased when Methadone is combined with Fesoterodine.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Methadone.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Methadone.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Methadone is combined with Iloperidone.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Methadone.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Methadone is combined with Lacosamide.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Methadone.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Methadone can be increased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Methadone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Methadone is combined with Botulinum toxin type A.
Pralatrexate Injection Pralatrexate Injection Methadone may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Methadone is combined with Palonosetron.
Saxagliptin Saxagliptin Methadone may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Methadone is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Methadone.
Tapentadol Tapentadol The risk or severity of adverse effects can be increased when Methadone is combined with Tapentadol.
Topotecan Topotecan Methadone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Methadone can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Methadone can be increased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Methadone is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Methadone is combined with Vigabatrin.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Methadone.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Methadone.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Methadone.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Methadone.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Methadone is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Methadone can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Methadone may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Methadone.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Methadone is combined with Botulinum toxin type A.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Methadone.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Methadone which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Methadone is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Methadone.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Methadone is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Methadone may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Methadone which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Methadone.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Methadone.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Methadone.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Methadone.
Rilpivirine Rilpivirine The serum concentration of Methadone can be decreased when it is combined with Rilpivirine.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Methadone can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Methadone can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Methadone.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Methadone.
Ticagrelor Ticagrelor Ticagrelor can cause a decrease in the absorption of Methadone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Methadone.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Methadone.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Methadone.
Clobazam Clobazam Clobazam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be increased when combined with Methadone.
Vismodegib Vismodegib The metabolism of Methadone can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Methadone.
Deferiprone Deferiprone Methadone may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Methadone.
Crizotinib Crizotinib The metabolism of Methadone can be increased when combined with Crizotinib.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Methadone is combined with Cabergoline.
Naloxone Injection Naloxone Injection The therapeutic efficacy of Naloxone can be decreased when used in combination with Methadone.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Methadone.
Fondaparinux Injection Fondaparinux Injection Methadone may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Methadone is combined with Tiagabine.
Enzalutamide Enzalutamide The therapeutic efficacy of Enzalutamide can be decreased when used in combination with Methadone.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Methadone.
Regorafenib Regorafenib The metabolism of Methadone can be increased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Methadone can be increased when combined with Bosutinib.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Methadone.
Teriflunomide Teriflunomide The metabolism of Methadone can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Methadone.
Teduglutide Injection Teduglutide Injection Methadone may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Methadone is combined with Bedaquiline.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Methadone.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Methadone.
Ponatinib Ponatinib The metabolism of Methadone can be increased when combined with Ponatinib.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Methadone is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Methadone.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Methadone.
Canagliflozin Canagliflozin Methadone may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Methadone.
Dabrafenib Dabrafenib The serum concentration of Methadone can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Methadone.
Trametinib Trametinib The metabolism of Methadone can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Methadone is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Methadone which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Methadone is combined with Vortioxetine.
Perampanel Perampanel The risk or severity of adverse effects can be increased when Methadone is combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Methadone.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Methadone.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Methadone which could result in a higher serum level.
Sofosbuvir Sofosbuvir Methadone may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Methadone.
Apremilast Apremilast The metabolism of Methadone can be increased when combined with Apremilast.
Droxidopa Droxidopa Methadone may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Methadone.
Siltuximab Injection Siltuximab Injection The metabolism of Methadone can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Methadone is combined with Eslicarbazepine.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Methadone.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Methadone.
Oritavancin Injection Oritavancin Injection The metabolism of Methadone can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Methadone.
Hydrocodone Hydrocodone The risk or severity of adverse effects can be increased when Methadone is combined with Hydrocodone.
Suvorexant Suvorexant The risk or severity of adverse effects can be increased when Methadone is combined with Suvorexant.
Edoxaban Edoxaban Methadone may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Methadone.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Methadone is combined with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Methadone is combined with Tasimelteon.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Methadone.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Methadone.
Secukinumab Injection Secukinumab Injection The metabolism of Methadone can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Methadone is combined with Risperidone.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Methadone.
Lenvatinib Lenvatinib The metabolism of Methadone can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Methadone can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Methadone.
Haloperidol Injection Haloperidol Injection The risk or severity of adverse effects can be increased when Methadone is combined with Haloperidol.
Ivabradine Ivabradine Ivabradine may increase the QTc-prolonging activities of Methadone.
Amiloride Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Methadone.
Macitentan Macitentan Methadone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Methadone.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Methadone is combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Rolapitant can be decreased when combined with Methadone.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Methadone.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Methadone is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Methadone is combined with Ziprasidone.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Methadone is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Methadone may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Methadone is combined with Eluxadoline.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Methadone.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Methadone.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Methadone.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Methadone.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Methadone.
Rifapentine Rifapentine The metabolism of Methadone can be increased when combined with Rifapentine.
Lesinurad Lesinurad Methadone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Methadone which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The metabolism of Methadone can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Methadone is combined with Brivaracetam.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Methadone.
Cobicistat Cobicistat The serum concentration of Methadone can be increased when it is combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Methadone.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Methadone is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Methadone is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Methadone.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Methadone.
Lixisenatide Injection Lixisenatide Injection Methadone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Methadone is combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Methadone.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of adverse effects can be increased when Methadone is combined with Doxepin.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Methadone.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Methadone is combined with Deutetrabenazine.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Methadone.
Deflazacort Deflazacort The metabolism of Methadone can be increased when combined with Deflazacort.
Safinamide Safinamide The risk or severity of adverse effects can be increased when Methadone is combined with Safinamide.
Naldemedine Naldemedine The therapeutic efficacy of Methadone can be decreased when used in combination with Naldemedine.
Midostaurin Midostaurin The metabolism of Methadone can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Methadone.
Enasidenib Enasidenib The metabolism of Methadone can be increased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Methadone.
Benznidazole Benznidazole Methadone may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Methadone.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Methadone.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Methadone.
Acalabrutinib Acalabrutinib The metabolism of Methadone can be increased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Methadone can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Methadone is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Methadone which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection The risk or severity of adverse effects can be increased when Methadone is combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Methadone can be increased when it is combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Methadone can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Methadone.
Lofexidine Lofexidine The risk or severity of adverse effects can be increased when Methadone is combined with Lofexidine.
Plazomicin Injection Plazomicin Injection Methadone may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Methadone.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Methadone.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Methadone.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Methadone.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Methadone.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Methadone.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Methadone is combined with Cannabidiol.
Dacomitinib Dacomitinib The metabolism of Methadone can be increased when combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Methadone.
Stiripentol Stiripentol The risk or severity of adverse effects can be increased when Methadone is combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Methadone can be decreased when used in combination with Gilteritinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Methadone is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Methadone.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Methadone.
Rifamycin Rifamycin The metabolism of Rifamycin can be increased when combined with Methadone.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Methadone.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Methadone.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Methadone can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Methadone.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Methadone which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Methadone.
Esomeprazole Injection Esomeprazole Injection The metabolism of Methadone can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Methadone can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Methadone is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Methadone is combined with Solriamfetol.
Triclabendazole Triclabendazole The metabolism of Methadone can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Methadone.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Methadone.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Methadone.
Pitolisant Pitolisant The serum concentration of Methadone can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Methadone.
Lefamulin Lefamulin Methadone may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The risk or severity of adverse effects can be increased when Methadone is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The risk or severity of adverse effects can be increased when Methadone is combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Methadone.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Methadone.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Methadone.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Methadone is combined with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of adverse effects can be increased when Methadone is combined with Lasmiditan.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Methadone.
Cenobamate Cenobamate The serum concentration of Methadone can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Methadone.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Methadone.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Methadone.
Selpercatinib Selpercatinib The serum concentration of Methadone can be increased when it is combined with Selpercatinib.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Methadone.
Fenfluramine Fenfluramine The risk or severity of adverse effects can be increased when Methadone is combined with Fenfluramine.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Methadone.
Pralsetinib Pralsetinib The metabolism of Methadone can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Methadone can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Methadone can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Relugolix is combined with Methadone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Methadone.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Methadone is combined with Viloxazine.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Methadone which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Methadone.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Methadone which could result in a higher serum level.
Indomethacin Indomethacin The metabolism of Methadone can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Methadone can be decreased when combined with Mefenamic acid.
Naproxen Naproxen Naproxen may decrease the excretion rate of Methadone which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Methadone which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Methadone which could result in a higher serum level.
Trazodone Trazodone The risk or severity of adverse effects can be increased when Methadone is combined with Trazodone.
Isotretinoin Isotretinoin Methadone may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Methadone may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Methadone can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Methadone can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The risk or severity of adverse effects can be increased when Methadone is combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Methadone is combined with Metaxalone.
Methotrexate Injection Methotrexate Injection The metabolism of Methadone can be decreased when combined with Methotrexate.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Methadone is combined with Levorphanol.
Primidone Primidone The risk or severity of adverse effects can be increased when Methadone is combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Methadone is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Methadone is combined with Diethylpropion.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Methadone is combined with Chlorpromazine.
Diazepam Diazepam Diazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Oxazepam Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Flurazepam Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Clorazepate Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Lorazepam Lorazepam Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Carmustine Carmustine Carmustine may decrease the excretion rate of Methadone which could result in a higher serum level.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Methadone is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Methadone is combined with Codeine.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Methadone is combined with Meprobamate.
Chlordiazepoxide Chlordiazepoxide Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Methadone is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The risk or severity of adverse effects can be increased when Methadone is combined with Tranylcypromine.
Phenelzine Phenelzine The risk or severity of adverse effects can be increased when Methadone is combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Methadone is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Methadone is combined with Ergoloid mesylate.
Tetracycline Tetracycline Methadone may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Methadone is combined with Prochlorperazine.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Methadone is combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Methadone is combined with Trifluoperazine.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Methadone which could result in a higher serum level.
Dapsone Dapsone The metabolism of Methadone can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Methadone.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Methadone is combined with Oxycodone.
Oxybutynin Oxybutynin The risk or severity of adverse effects can be increased when Oxybutynin is combined with Methadone.
Benztropine Benztropine The risk or severity of adverse effects can be increased when Methadone is combined with Benzatropine.
Maprotiline Maprotiline The risk or severity of adverse effects can be increased when Methadone is combined with Maprotiline.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Methadone.
Trihexyphenidyl Trihexyphenidyl The risk or severity of adverse effects can be increased when Methadone is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine The risk or severity of adverse effects can be increased when Methadone is combined with Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Methadone is combined with Perphenazine.
Azathioprine Azathioprine Methadone may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Methadone is combined with Fluphenazine.
Phentermine Phentermine Phentermine may increase the analgesic activities of Methadone.
Methylphenidate Methylphenidate Methadone may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of adverse effects can be increased when Methadone is combined with Amoxapine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Methadone which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Methadone can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Methadone can be increased when combined with Doxorubicin.
Mechlorethamine Mechlorethamine The therapeutic efficacy of Methadone can be decreased when used in combination with Mechlorethamine.
Pyridostigmine Pyridostigmine The therapeutic efficacy of Methadone can be decreased when used in combination with Pyridostigmine.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Methadone which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Methadone can be increased when combined with Carbamazepine.
Molindone Molindone The risk or severity of adverse effects can be increased when Methadone is combined with Molindone.
Methyldopa Methyldopa Methadone may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine Clonidine The risk or severity of adverse effects can be increased when Methadone is combined with Clonidine.
Hydralazine Hydralazine Methadone may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Methadone.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Methadone which could result in a higher serum level.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Methadone.
Clonazepam Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Methadone.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Methadone is combined with Promethazine.
Meclofenamate Meclofenamate The therapeutic efficacy of Methadone can be decreased when used in combination with Meclofenamic acid.
Daunorubicin Daunorubicin The metabolism of Methadone can be increased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin The therapeutic efficacy of Nitrofurantoin can be decreased when used in combination with Methadone.
Griseofulvin Griseofulvin The metabolism of Methadone can be increased when combined with Griseofulvin.
Digoxin Digoxin Methadone may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Methadone is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Methadone.
Quinine Quinine The risk or severity of adverse effects can be increased when Methadone is combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Methadone is combined with Ethosuximide.
Triamterene Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Methadone.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Methadone.
Sulfinpyrazone Sulfinpyrazone The metabolism of Methadone can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Methadone.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Methadone.
Metolazone Metolazone Methadone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Methadone.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Methadone.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Methadone is combined with Secobarbital.
Desipramine Desipramine The risk or severity of adverse effects can be increased when Methadone is combined with Desipramine.
Amitriptyline Amitriptyline The risk or severity of adverse effects can be increased when Methadone is combined with Amitriptyline.
Imipramine Imipramine The risk or severity of adverse effects can be increased when Methadone is combined with Imipramine.
Probenecid Probenecid The metabolism of Methadone can be decreased when combined with Probenecid.
Quinidine Quinidine The risk or severity of adverse effects can be increased when Methadone is combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Methadone.
Isoniazid Isoniazid The metabolism of Methadone can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Methadone may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Rifampin Rifampin The metabolism of Methadone can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of adverse effects can be increased when Methadone is combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Methadone is combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Methadone.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Methadone is combined with Butabarbital.
Levothyroxine Levothyroxine The therapeutic efficacy of Methadone can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Methadone.
Methimazole Methimazole The metabolism of Methadone can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Methadone may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Methadone.
Tolazamide Tolazamide Methadone may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Methadone is combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The risk or severity of adverse effects can be increased when Methadone is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Methadone can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Methadone is combined with Baclofen.
Doxylamine Doxylamine The risk or severity of adverse effects can be increased when Methadone is combined with Doxylamine.
Cyproheptadine Cyproheptadine The risk or severity of adverse effects can be increased when Methadone is combined with Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Methadone is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Methadone is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Methadone is combined with Dexbrompheniramine.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Methadone is combined with Meclizine.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Methadone which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Methadone.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Methadone.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Methadone is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Methadone is combined with Chlorzoxazone.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Methadone is combined with Carisoprodol.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methadone is combined with Methocarbamol.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Methadone which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Methadone which could result in a higher serum level.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Methadone.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Methadone.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Methadone.
Nortriptyline Nortriptyline The risk or severity of adverse effects can be increased when Methadone is combined with Nortriptyline.
Spironolactone Spironolactone The metabolism of Methadone can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Methadone which could result in a higher serum level.
Phytonadione Phytonadione Methadone may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Methadone which could result in a higher serum level.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Methadone.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Methadone is combined with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Methadone is combined with Nalbuphine.
Allopurinol Allopurinol Methadone may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Methadone.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Methadone is combined with Trimethobenzamide.
Flavoxate Flavoxate The risk or severity of adverse effects can be increased when Methadone is combined with Flavoxate.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Methadone is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Methadone.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Methadone.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Methadone which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Methadone which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Methadone which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Methadone which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Methadone which could result in a higher serum level.
Dacarbazine Dacarbazine Methadone may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Methadone is combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Methadone which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Methadone which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Methadone can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Methadone is combined with Pyrantel.
Thiotepa Injection Thiotepa Injection The metabolism of Methadone can be increased when combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Methadone.
Vinblastine Vinblastine The metabolism of Methadone can be increased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Methadone.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Methadone which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Methadone can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Methadone is combined with Hydroxyzine.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Methadone is combined with Thiothixene.
Aspirin Aspirin Methadone may decrease the excretion rate of Acetylsalicylic acid which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Methadone which could result in a higher serum level.
Alprazolam Alprazolam Alprazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Temazepam Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Triazolam Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Dicyclomine Dicyclomine The risk or severity of adverse effects can be increased when Methadone is combined with Dicyclomine.
Hyoscyamine Hyoscyamine The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Methadone.
Propantheline Propantheline The risk or severity of adverse effects can be increased when Methadone is combined with Propantheline.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Methadone.
Diltiazem Diltiazem The metabolism of Methadone can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Methadone.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Methadone.
Verapamil Verapamil The metabolism of Methadone can be decreased when combined with Verapamil.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Methadone.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Methadone is combined with Pindolol.
Cisplatin Injection Cisplatin Injection Cisplatin may decrease the excretion rate of Methadone which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Methadone which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Methadone which could result in a higher serum level.
Bumetanide Bumetanide Methadone may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Methadone.
Glyburide Glyburide The metabolism of Methadone can be decreased when combined with Glyburide.
Glipizide Glipizide Methadone may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Methadone.
Amoxicillin Amoxicillin Methadone may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Methadone may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Methadone may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Methadone.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Methadone which could result in a higher serum level.
Labetalol Labetalol The metabolism of Methadone can be decreased when combined with Labetalol.
Auranofin Auranofin Methadone may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Methadone.
Gemfibrozil Gemfibrozil The metabolism of Methadone can be decreased when combined with Gemfibrozil.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Methadone which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Methadone which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Methadone which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Methadone which could result in a higher serum level.
Pimozide Pimozide The risk or severity of adverse effects can be increased when Methadone is combined with Pimozide.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Methadone which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Methadone can be increased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Methadone may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Methadone.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Methadone.
Ciprofloxacin Ciprofloxacin The metabolism of Methadone can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Methadone which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Methadone which could result in a higher serum level.
Fluoxetine Fluoxetine The risk or severity of adverse effects can be increased when Methadone is combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Methadone is combined with Nimodipine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The serum concentration of Methadone can be increased when it is combined with Interferon alfa-2b.
Clozapine Clozapine The risk or severity of adverse effects can be increased when Methadone is combined with Clozapine.
Estazolam Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Methadone.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Methadone is combined with Ofloxacin.
Didanosine Didanosine The serum concentration of Didanosine can be decreased when it is combined with Methadone.
Pentostatin Injection Pentostatin Injection Methadone may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin Clarithromycin The metabolism of Methadone can be decreased when combined with Clarithromycin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Methadone which could result in a higher serum level.
Felodipine Felodipine The metabolism of Methadone can be decreased when combined with Felodipine.
Fosinopril Fosinopril Methadone may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Methadone which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Methadone.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Methadone.
Teniposide Injection Teniposide Injection The metabolism of Methadone can be increased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Methadone can be increased when it is combined with Itraconazole.
Lisinopril Lisinopril Methadone may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Methadone which could result in a higher serum level.
Atovaquone Atovaquone The metabolism of Methadone can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Methadone can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Methadone.
Bisoprolol Bisoprolol Methadone may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Zolpidem Zolpidem The risk or severity of adverse effects can be increased when Methadone is combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Methadone.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Isradipine is combined with Methadone.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Methadone.
Cisapride Cisapride The risk or severity of adverse effects can be increased when Methadone is combined with Cisapride.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Methadone is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Methadone can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Methadone is combined with Venlafaxine.
Nizatidine Nizatidine The therapeutic efficacy of Methadone can be decreased when used in combination with Nizatidine.
Stavudine Stavudine The serum concentration of Stavudine can be decreased when it is combined with Methadone.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Methadone.
Fluvoxamine Fluvoxamine The risk or severity of adverse effects can be increased when Methadone is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Methadone is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Methadone is combined with Lamotrigine.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Methadone.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Methadone which could result in a higher serum level.
Tramadol Tramadol The risk or severity of adverse effects can be increased when Methadone is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Methadone can be increased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Methadone which could result in a higher serum level.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Methadone.
Lansoprazole Lansoprazole The metabolism of Methadone can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Methadone can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Methadone can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Methadone is combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Methadone can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Methadone can be decreased when combined with Saquinavir.
Metformin Metformin Metformin may decrease the excretion rate of Methadone which could result in a higher serum level.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Methadone.
Lamivudine Lamivudine Methadone may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Methadone is combined with Riluzole.
Acarbose Acarbose Acarbose may decrease the excretion rate of Methadone which could result in a higher serum level.
Glimepiride Glimepiride The metabolism of Methadone can be decreased when combined with Glimepiride.
Anastrozole Anastrozole The serum concentration of Methadone can be increased when it is combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection Methadone may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir The metabolism of Methadone can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Methadone can be decreased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Methadone.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Methadone which could result in a higher serum level.
Meropenem Injection Meropenem Injection Methadone may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The risk or severity of adverse effects can be increased when Methadone is combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Methadone can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Methadone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine Methadone may increase the serotonergic activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Methadone is combined with Topiramate.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Methadone.
Valsartan Valsartan The metabolism of Methadone can be decreased when combined with Valsartan.
Pramipexole Pramipexole Methadone may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Methadone is combined with Donepezil.
Nelfinavir Nelfinavir The serum concentration of Methadone can be decreased when it is combined with Nelfinavir.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Methadone.
Loratadine Loratadine The metabolism of Methadone can be decreased when combined with Loratadine.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Methadone.
Nilutamide Nilutamide The metabolism of Methadone can be decreased when combined with Nilutamide.
Flutamide Flutamide Methadone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The risk or severity of adverse effects can be increased when Methadone is combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Methadone can be increased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Methadone is combined with Sertraline.
Propafenone Propafenone The metabolism of Methadone can be decreased when combined with Propafenone.
Letrozole Letrozole The serum concentration of Methadone can be increased when it is combined with Letrozole.
Raloxifene Raloxifene The metabolism of Methadone can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Methadone can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Methadone.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Methadone is combined with Ropinirole.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Methadone.
Quetiapine Quetiapine The risk or severity of adverse effects can be increased when Methadone is combined with Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Methadone which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Methadone which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Methadone which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Methadone is combined with Cetirizine.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Methadone is combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Methadone is combined with Tolcapone.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Methadone is combined with Citalopram.
Capecitabine Capecitabine The metabolism of Methadone can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The risk or severity of adverse effects can be increased when Methadone is combined with Efavirenz.
Abacavir Abacavir The therapeutic efficacy of Abacavir can be decreased when used in combination with Methadone.
Sildenafil Sildenafil The metabolism of Methadone can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Methadone can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Methadone.
Rosiglitazone Rosiglitazone The metabolism of Methadone can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of adverse effects can be increased when Methadone is combined with Tolterodine.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Methadone is combined with Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Methadone which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Methadone which could result in a higher serum level.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Methadone.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Methadone.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Methadone is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Methadone can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Methadone.

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