Herb & supplement monograph

European Buckthorn Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how European Buckthorn interacts with medications. The heart of this page is the interaction list — every drug European Buckthorn is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what European Buckthorn is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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European Buckthorn Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, European Buckthorn drug interactions carry a moderate overall risk for most people, mainly tied to its strong laxative effect and especially with overuse. Nearly all of the listed interactions are rated moderate, with one major concern involving a heart medication.

Interactions deserving the most attention

The interaction that deserves the most attention involves digoxin, a heart medicine with a narrow safety margin; heavy use of European Buckthorn can lower potassium, which may make digoxin more toxic. Potassium-depleting diuretics such as furosemide raise a similar concern, since combining them could compound potassium loss. People taking warfarin should also be careful, because the diarrhea this supplement can cause may strengthen warfarin's effect and raise bleeding risk. Pairing it with other stimulant laxatives can add to fluid and electrolyte loss.

What the rest of the list means

A long interaction list here does not mean every combination is dangerous. Almost all of these concerns trace back to one shared mechanism, the supplement's laxative action, and most are theoretical or based on limited evidence rather than proven harm in people. The risk rises mainly with overuse or long-term heavy use rather than occasional, modest amounts.

Check your medications against European Buckthorn

Based on HelloPharmacist’s European Buckthorn interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with European Buckthorn

99 medications have a known interaction with European Buckthorn, graded by severity. Select any drug for the full evidence-based detail.

1 major interaction. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with European Buckthorn.

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AI summaries are generated from our European Buckthorn interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

DigoxinDigitek, Lanoxicaps, Lanoxin

Major Digoxin (lanoxin)