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Etoposide

Etoposide is a chemotherapy medicine (a topoisomerase inhibitor) used with other cancer drugs to treat small cell lung cancer and refractory testicular cancer, depending on the product.

Brand names VePesidToposarEtopophosAvopef
Drug class Topoisomerase Inhibitor
Rx Forms 2
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 9 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Other forms & routes:
Etoposide at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Etoposide is a chemotherapy medicine that breaks DNA in cancer cells by blocking the enzyme topoisomerase II; on the market since about 1983 and available generically, it is a standard partner to other drugs for small cell lung cancer and, as an injection, for testicular cancer that resisted earlier treatment. It is a demanding drug, and nausea, mouth sores and hair loss (which usually grows back) are what people notice most. Its boxed warning is severe bone marrow suppression, a drop in blood counts that can cause serious infection or bleeding; blood tests come before every cycle, and fever, chills or unusual bruising means calling your cancer team at once.

Clinical pearls

  • Keep etoposide capsules in the refrigerator; the capsule dose runs higher than the IV dose, so the two are not interchangeable.
  • During the infusion, speak up right away about wheezing, throat tightness, or pain and swelling where the IV goes in.
  • If you take warfarin, etoposide can push your INR (clotting test) up, so expect more frequent checks during treatment.
  • Etoposide can harm an unborn baby, so women and men with female partners need birth control for months afterward.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Avopef can cause severe bone marrow suppression, which can lead to serious infection or bleeding. This means your blood cell counts can drop dangerously low.

It should not be given if your neutrophil count is below 500 cells/mm³ or your platelets are below 50,000/mm³. Your blood counts will be checked before each dose and cycle, and at regular times during and after treatment. Report fever, chills, signs of infection, or unusual bleeding or bruising right away.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asInjection, Capsule
Earliest FDA record1983
Companies listing it with the FDA10
FDA label last updatedJul 14, 2026
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Etoposide, written from its FDA label.

What Etoposide is used for

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Etoposide is a chemotherapy medicine used together with other cancer treatments.

  • Small cell lung cancer: first-line treatment with other chemotherapy (Etopophos with cisplatin; Avopef with chemotherapy and immunotherapy; VePesid and Etoposide capsules and Etoposide Injection with other approved chemotherapy).
  • Refractory testicular tumors/cancer: Etopophos, Avopef and Etoposide Injection products, in combination with other chemotherapy. Etoposide capsules and VePesid are not labeled for this use.

How Etoposide works

▾

Etoposide breaks DNA strands in cancer cells. It acts through the enzyme DNA topoisomerase II or through the formation of free radicals.

The damaged cells stop dividing, mainly at the G2 stage of the cell cycle, and then die.

Etoposide dosage

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Etoposide is given in repeated courses, usually over several days. Courses are repeated about every 3 to 4 weeks after recovery from side effects.

  • Injections are given into a vein by a healthcare professional, slowly (for example, Avopef over 30 to 60 minutes).
  • Capsules (Etoposide, VePesid) are taken by mouth and stored in the refrigerator.
  • Doses are adjusted for other drugs that lower blood counts, prior radiation or chemotherapy, and kidney problems.

Follow your prescriber's directions and your label.

Dosing details from the FDA-approved label

From the Etoposide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Refractory Testicular Cancer (Avopef, intravenous)
    • 50 mg/m2 to 100 mg/m2 administered intravenously daily on Days 1 to 5, or 100 mg/m2 administered intravenously daily on Days 1, 3 and 5
    • Repeat treatment cycles every 3 to 4 weeks
    • Dilute to a final concentration of 0.2 to 0.4 mg/mL and infuse over 30 to 60 minutes
  • Small Cell Lung Cancer (Avopef, intravenous)
    • 35 mg/m2 administered intravenously daily on Days 1 to 4, or 50 mg/m2 administered intravenously daily on Days 1 to 5
    • Repeat treatment cycles every 3 to 4 weeks
    • Dilute to a final concentration of 0.2 to 0.4 mg/mL and infuse over 30 to 60 minutes
  • Renal impairment, CLcr 15 to 50 mL/min, Refractory Testicular Cancer (Avopef)
    • 37 mg/m2 to 75 mg/m2 Days 1 through 5, or 75 mg/m2 Days 1, 3 and 5
    • Repeat cycles every 3 to 4 weeks
    • No dosage modification for CLcr > 50 mL/min; dosage not established for CLcr < 15 mL/min
  • Renal impairment, CLcr 15 to 50 mL/min, Small Cell Lung Cancer (Avopef)
    • 26 mg/m2 Days 1 through 4, or 37 mg/m2 Days 1 through 5
    • Repeat cycles every 3 to 4 weeks
    • No dosage modification for CLcr > 50 mL/min; dosage not established for CLcr < 15 mL/min
  • Refractory testicular tumors (Etopophos)
    • 50 to 100 mg/m2 per day administered intravenously over 5 minutes to 3.5 hours on days 1 through 5, or 100 mg/m2 administered intravenously over 5 minutes to 3.5 hours on days 1, 3, and 5, of each 21-day (or 28-day cycle)
    • In CLcr 15-50 mL/min, administer 75% of the recommended dose; do not give by bolus injection
  • Small cell lung cancer (Etopophos)
    • 35 mg/m2 per day administered intravenously over 5 minutes to 3.5 hours for 4 days, or 50 mg/m2 per day administered intravenously over 5 minutes to 3.5 hours for 5 days
    • In CLcr 15-50 mL/min, administer 75% of the recommended dose
  • Small cell lung cancer (VePesid oral capsules)
    • Two times the IV dose rounded to the nearest 50 mg (i.e., two times 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days)
    • Courses repeated at 3- to 4-week intervals
    • Modify dosage for myelosuppressive effects of other drugs or prior x-ray therapy or chemotherapy; see PRECAUTIONS for renal impairment
  • Testicular cancer (Etoposide Injection, USP)
    • In combination with other approved chemotherapeutic agents, 50 to 100 mg/m2/day on days 1 through 5 to 100 mg/m2/day on days 1, 3, and 5
    • Courses repeated at 3- to 4-week intervals
    • See PRECAUTIONS for renal impairment dosing adjustments
  • Small cell lung cancer (Etoposide Injection, USP)
    • In combination with other approved chemotherapeutic drugs, 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days
    • Courses repeated at 3- to 4-week intervals
    • See PRECAUTIONS for renal impairment dosing adjustments
  • Small cell lung cancer (Etoposide Capsules)
    • Two times the IV dose rounded to the nearest 50 mg
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION: Note: Plastic devices made of acrylic or ABS (a polymer composed of acrylonitrile, butadiene, and styrene) have been reported to crack and leak when used with undiluted Etoposide Injection, USP. Etoposide Injection, USP The usual dose of Etoposide Injection, USP in testicular cancer in combination with other approved chemotherapeutic agents ranges from 50 to 100 mg/m 2 /day on days 1 through 5 to 100 mg/m 2 /day on days 1, 3, and 5. In small cell lung cancer, the Etoposide Injection, USP dose in combination with other approved chemotherapeutic drugs ranges from 35 mg/m 2 /day for 4 days to 50 mg/m 2 /day for 5 days. For recommended dosing adjustments in patients with renal impairment (see PRECAUTIONS ) . Chemotherapy courses are repeated at 3- to 4-week intervals after adequate recovery from any toxicity. Etoposide Capsules In small cell lung cancer, the recommended dose of etoposide capsules is two times the IV dose rounded to the nearest 50 mg. The dosage, by either route, should be modified to take into account the myelosuppressive effects of other drugs in the combination or the effects of prior x-ray therapy or chemotherapy which may have compromised bone marrow reserve. Administration Precautions As with other potentially toxic compounds, caution should be exercised in handling and preparing the solution of etoposide. Skin reactions associated with accidental exposure to etoposide may occur. The use of gloves is recommended. If etoposide solution contacts the skin or mucosa, immediately and thoroughly wash the skin with soap and water and flush the mucosa with water. Preparation for Intravenous Administration Etoposide Injection, USP must be diluted prior to use with either 5% Dextrose Injection, USP, or 0.9% Sodium Chloride Injection, USP, to give a final concentration of 0.2 to 0.4 mg/mL. If solutions are prepared at concentrations above 0.4 mg/mL, precipitation may occur. Hypotension following rapid intravenous administration has been reported, hence, it is recommended that the etoposide solution be administered over a 30- to 60-minute period. A longer duration of administration may be used if the volume of fluid to be infused is a concern. Etoposide should not be given by rapid intravenous injection.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Etoposide side effects

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Many people have side effects, and these are the most common:

Common side effects

  • Low white blood cell counts, which raise infection risk
  • Low platelet counts and anemia
  • Nausea and vomiting
  • Loss of appetite
  • Diarrhea
  • Mouth sores
  • Hair loss, which is usually reversible
  • Low white blood cells, platelets, or red blood cells

When to get medical help

  • Fever, chills or other signs of infection, which can be serious when blood counts are low
  • Unusual bleeding or bruising
  • Signs of a severe allergic reaction during infusion: chills, fever, fast heartbeat, wheezing, trouble breathing, swelling of the face or tongue, throat tightness, or low blood pressure
  • Pain, swelling or redness at the IV site, because leakage into the tissue can cause serious damage
  • Severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis
  • Vision changes, seizures, or new lung symptoms such as cough or shortness of breath

Etoposide warnings and precautions

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  • Severe bone marrow suppression can cause serious infection, bleeding, and death. Blood counts are monitored.
  • Allergic and infusion reactions can be severe or fatal. Slow infusion helps prevent low blood pressure.
  • Extravasation (IV leakage) can cause swelling, pain, cellulitis, and tissue death.
  • Secondary leukemia has occurred.
  • Low albumin can increase side effects.
  • Harm to an unborn baby is possible.

Etoposide interactions

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Some medicines and substances can change how etoposide works or how safe it is.

  • Strong CYP3A inhibitors may raise etoposide levels.
  • Strong CYP3A inducers may lower etoposide levels and reduce effectiveness.
  • Warfarin: INR can rise, so closer monitoring is needed.
  • Aspirin, sodium salicylate, and phenylbutazone can displace etoposide from blood proteins in lab studies.
  • Cisplatin is associated with slower clearance of etoposide.
  • Avopef contains alcohol, which may affect driving right after infusion.

Interactions listed in the FDA-approved label

From the Etoposide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Strong CYP3A inhibitors: Etoposide is a CYP3A4 substrate; strong CYP3A inhibitors may increase etoposide exposure, which may increase the risk of AVOPEF-associated adverse reactions. Avoid concomitant use of strong CYP3A inhibitors.
  • Strong CYP3A inducers: Etoposide is a CYP3A4 substrate; strong CYP3A inducers may reduce etoposide exposure, which may decrease the effectiveness of AVOPEF. Avoid concomitant use of strong CYP3A inducers.
  • Vitamin K antagonists (warfarin): Co-administration of AVOPEF with warfarin can result in elevated international normalized ratio (INR). Monitor INR more frequently and modify the dosage of the vitamin K antagonists as appropriate.
Read the label’s full interactions text

7 DRUG INTERACTIONS CYP3A Inhibitors and CYP3A Inducers : Avoid concomitant use of strong CYP3A inhibitors and strong CYP3A inducers with AVOPEF. ( 7.1 ) Vitamin K Antagonists : Monitor INR more frequently and modify the dosage of the vitamin K antagonists as appropriate. Co-administration of AVOPEF with warfarin can result in elevated international normalized ratio (INR). ( 7.2 ) 7.1 Effect of Other Drugs on AVOPEF CYP3A Inhibitors Avoid concomitant use of strong CYP3A inhibitors. Etoposide is a CYP3A4 substrate. Strong CYP3A inhibitors may increase etoposide exposure, which may increase the risk of AVOPEF-associated adverse reactions [see Clinical Pharmacology (12.3) ]. CYP3A Inducers Avoid concomitant use of strong CYP3A inducers. Etoposide is a CYP3A4 substrate. Strong CYP3A inducers may reduce etoposide exposure, which may decrease the effectiveness of AVOPEF [see Clinical Pharmacology (12.3) ]. 7.2 Effect of AVOPEF on Other Drugs Vitamin K Antagonists Monitor INR more frequently and modify the dosage of the vitamin K antagonists as appropriate. Co-administration of AVOPEF with warfarin can result in elevated international normalized ratio (INR).

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Before taking Etoposide

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  • Allergy to etoposide or its ingredients (a contraindication for Avopef).
  • Pregnancy or possible pregnancy. Use effective contraception and tell your doctor right away.
  • Breastfeeding: avoid during treatment and for 1 week after the last Avopef dose.
  • Reduced kidney function: the dose is lowered for creatinine clearance of 15 to 50 mL/min.
  • Low albumin levels.
  • Age 65 or older: more side effects were reported.
  • Children: Avopef safety and effectiveness are not established.
  • Fertility effects are possible in women and men.

Etoposide overdose

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No proven antidote has been established for etoposide injection overdose. If you think too much was given or taken, contact your care team or poison control right away.

What Etoposide does in the body

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Etoposide causes DNA strand breaks, which stops cells at the G2 stage before they divide. At high concentrations it causes cells entering division to burst. At lower concentrations it stops cells from entering prophase. It does not interfere with microtubule assembly.

How your body processes Etoposide

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After IV dosing, etoposide leaves the blood in two phases, with a terminal half-life of about 4 to 11 hours. It is highly bound to blood proteins (97%) and enters the cerebrospinal fluid poorly. It is cleared by the kidneys and by metabolism and bile, partly through CYP3A4.

Capsules have an average bioavailability of about 50%, with a wide range of 25% to 75%.

How to store Etoposide

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Store at 20°C to 25° C (68°F to 77° F); excursions permitted to 15°C to 30°C (59°F to 86°F). store the partially used multiple-dose vial in the original carton at controlled room temperature, 20°C to 25°C (68°F to 77°F) for up to 28 days .

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

152

Supplements & herbs that interact with Etoposide

152 supplements and herbal products have documented interactions with Etoposide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 5
  • Moderate · 107
  • Minor · 40
Every supplement checked against Etoposide — ranked by severity The full interaction hub: 5 major · 107 moderate · 40 minor · every one linked to its full report. Check Etoposide against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Etoposide: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Etoposide — the kind of thing our pharmacy team would talk through with you at the counter.

What is etoposide for?

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It's a chemotherapy medicine used with other cancer drugs. It is used for small cell lung cancer, and the injection forms are also used for refractory testicular cancer, meaning cancer that hasn't responded to other treatment.

How will I get it?

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It comes as an IV injection given by your healthcare team, slowly over time, or as capsules you take by mouth. It's given in repeated courses, usually every 3 to 4 weeks. Capsules need to be kept in the refrigerator, and your prescriber will decide your dose.

What side effects should I expect?

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Common ones are low blood counts, nausea and vomiting, poor appetite, diarrhea, mouth sores, and hair loss. Hair loss is usually reversible, and nausea can often be controlled with anti-nausea medicine.

When should I call my doctor?

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Call right away for fever, chills, or signs of infection, unusual bleeding or bruising, or trouble breathing. Also report swelling of the face or tongue, a severe rash, or pain and swelling where the IV goes in.

Can I take it with my other medicines?

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Tell us about everything you take. Strong CYP3A inhibitors and inducers should be avoided, and warfarin needs extra INR monitoring. Aspirin can also affect how etoposide binds to blood proteins.

Is it safe in pregnancy?

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No. Etoposide can harm an unborn baby, so effective contraception is advised. For Avopef, that means during treatment and for 6 months afterward for women, or 4 months for men with female partners. Don't breastfeed during treatment.

Is Etoposide available over the counter?

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No. Etoposide is a prescription medicine: every Etoposide product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Etoposide first available?

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The earliest FDA record we hold for Etoposide is from 1983: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Etoposide was first used.

Who makes Etoposide?

▾
10 companies currently list Etoposide products in the FDA's NDC Directory, including BluePoint Laboratories, Hikma Pharmaceuticals USA Inc., Meitheal Pharmaceuticals Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Etoposide on HelloPharmacist

Detailed data & references for Etoposide Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Etoposide forms and strengths (how it comes)

Etoposide is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Etoposide inactive ingredients by manufacturer.

Injection

Into a vein
Brands Avopef Etopophos
How this form is used
What it may be used for
  • Etopophos is used for refractory testicular tumors with other chemotherapy and for first-line small cell lung cancer with cisplatin.
  • Avopef is used in adults for refractory testicular cancer and for first-line small cell lung cancer, with other chemotherapy and/or immunotherapy.
  • Etoposide Injection is used with other chemotherapy for refractory testicular tumors and first-line small cell lung cancer.
Important instructions
  • Avopef is diluted and given by IV infusion over 30 to 60 minutes to lower the risk of low blood pressure.
  • Etopophos must not be given as a bolus (quick) injection.
  • Etopophos dose is reduced to 75% for creatinine clearance of 15 to 50 mL/min.
  • Etoposide Injection labels advise gloves for handling and warn that some acrylic or ABS plastic devices can crack and leak with undiluted product.
Available strengths 4 strengths
28 FDA-listed product records ⓘ

Capsule

By mouth
Brands VePesid
How this form is used
What it may be used for
  • VePesid Capsules are used with other approved chemotherapy as first-line treatment of small cell lung cancer.
  • Etoposide capsules are used with other approved chemotherapy as first-line treatment of small cell lung cancer.
Important instructions
  • VePesid Capsules must be stored in the refrigerator.
  • Etoposide capsules must be stored in the refrigerator.
  • For VePesid and Etoposide capsules, wear impervious gloves when handling the blister packs.
  • VePesid and Etoposide capsule doses are set at twice the IV dose in small cell lung cancer, so follow your prescriber's directions.
Available strengths 1 strength
5 FDA-listed product records ⓘ

Etoposide on the U.S. market: products, makers and brands

How Etoposide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

10 companies list 19 Etoposide product records with the FDA, mostly as injection, capsule; the earliest marketing or approval year on record is 1983. Brand names on the directory include VePesid, Toposar, Etopophos and 1 more; the rest are generics.

2
Dose forms ⓘ
10
Labelers (makers, repackagers, distributors)
4
Brand names
19
FDA-listed product records ⓘ
1983
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (4) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

BluePoint Laboratories21%
Hikma Pharmaceuticals USA Inc.21%
Meitheal Pharmaceuticals Inc.16%
Avyxa Pharma, LLC11%
Accord Healthcare Inc.5%
Amneal Pharmaceuticals NY LLC5%
Other makers21%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Etoposide is used (Medicaid data)

A general measure of how commonly Etoposide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Etoposide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

14,672
Medicaid prescriptions filled (Q1–Q4 2025)
$970,346 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Etoposide prescribed? Of the 1,601 medications we measure, Etoposide ranks #858 by Medicaid prescriptions — more than 46% of them.

Where Etoposide ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Etoposide product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 20 mg/mL injectable solution is the most-dispensed Etoposide product — about 98% of these Medicaid prescriptions.

etoposide 20 MG/ML Injectable Solution Most dispensed

14,326 Medicaid prescriptions (Q1–Q4 2025) 98% of Etoposide prescriptions shown $716,164 gross reimbursement (before rebates) ≈ $50 per prescription (gross)

Summed across the 15 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310248

etoposide 100 MG Injection

178 Medicaid prescriptions (Q1–Q4 2025) 1% of Etoposide prescriptions shown $10,841 gross reimbursement (before rebates) ≈ $61 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1734340

etoposide 50 MG Oral Capsule

168 Medicaid prescriptions (Q1–Q4 2025) 1% of Etoposide prescriptions shown $243,340 gross reimbursement (before rebates) ≈ $1,448 per prescription (gross)

Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197687

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Etoposide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 17 of 36 listed Etoposide NDCs with Medicaid activity.

Compare Etoposide products

A representative set of FDA-listed product records for Etoposide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Capsule
50 mg Oral Amneal Pharmaceuticals NY LLC NDA View NDC →
50 mg Oral Mylan Pharmaceuticals Inc. ANDA View NDC →
50 mg Oral Onesource Specialty Pharma Limited NDA View NDC →
💊Injection
20 mg/mL Intravenous Accord Healthcare Inc. ANDA View NDC →
100 mg/5 mL Intravenous AVYXA Pharma, LLC NDA View NDC →
500 mg/25 mL Intravenous AVYXA Pharma, LLC NDA View NDC →
20 mg/mL Intravenous BluePoint Laboratories × 4 listings ANDA View NDC →
20 mg/mL Intravenous Fresenius Kabi USA, LLC ANDA View NDC →
100 mg Intravenous H2-Pharma, LLC NDA View NDC →
20 mg/mL Intravenous Hikma Pharmaceuticals USA Inc. × 4 listings ANDA View NDC →
20 mg/mL Intravenous Meitheal Pharmaceuticals Inc. × 3 listings ANDA View NDC →

Showing 19 of 19 products — FDA National Drug Code Directory. See every product, package size and price: browse all 19 Etoposide NDCs →

Etoposide recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Etoposide recalls since July 2021.

✅No Etoposide recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Etoposide RxCUI 4179 3 dose forms · 4 strengths
  1. Dose form (SCDF) Injectable Solution RxCUI 376890 In current FDA listings
    Clinical drug / strength (SCD) 20 MG/ML RxCUI 310248
  2. Dose form (SCDF) Injection RxCUI 1734339 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 1734340
  3. Dose form (SCDF) Oral Capsule RxCUI 372132 In current FDA listings
    Clinical drug / strength (SCD) 50 MG RxCUI 197687 100 MG RxCUI 199315

Look up RxCUI 4179 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Etoposide brand names

Etoposide is sold under 4 brand names in the FDA directory — VePesid, Toposar, Etopophos, Avopef. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

VePesid Toposar Etopophos Avopef

Who makes Etoposide: manufacturers and labelers

10 companies list Etoposide products with the FDA. By number of product records, the largest are BluePoint Laboratories, Hikma Pharmaceuticals USA Inc., Meitheal Pharmaceuticals Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

BluePoint Laboratories 4 Hikma Pharmaceuticals USA Inc. 4 Meitheal Pharmaceuticals Inc. 3 Avyxa Pharma, LLC 2 Accord Healthcare Inc. 1 Amneal Pharmaceuticals NY LLC 1 Fresenius Kabi USA, LLC 1 H2-Pharma, LLC 1 Mylan Pharmaceuticals Inc. 1 Onesource Specialty Pharma Limited 1

Etoposide drug class (RxNorm)

Etoposide belongs to the Topoisomerase Inhibitor class.

Pharmacologic class Topoisomerase Inhibitor
Drug family (ATC) Podophyllotoxin derivatives
How it works Topoisomerase Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Etoposide page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 14, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Etoposide.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Etoposide after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
9
Finished products in the current FDA directory
19
Companies listing them (makers, repackagers, distributors)
10
FDA labeler codes behind them ⓘ
10
Linked representative label ⓘ
Fresenius Kabi USA, LLC
Linked label effective
Jul 14, 2026
Composite sections available
24
Linked SPL Set ID
fe870629-104d-4d67-a7c6-f53bc588121e
Linked SPL Document ID
25cb14ea-3672-4f9a-9f4a-56052aec57ac
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Fresenius Kabi USA, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →