Dasatinib

Generic name: Pronounced as (da sa' ti nib)
Brand names
  • Sprycel®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2018

Dasatinib is used to treat a certain type of chronic myeloid leukemia (CML; a type of cancer of the white blood cells) as a first treatment and in people who can no longer benefit from other leukemia medications including imatinib (Gleevec) or in those who cannot take these medications because of side effects. Dasatinib is also used to treat a certain type of chronic CML in children. Dasatinib is also used to treat a certain type of acute lymphoblastic leukemia (ALL; a type of cancer of the white blood cells) in people who can no longer benefit from other leukemia medications or who cannot take these medications because of side effects. Dasatinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

Dasatinib comes as a tablet to take by mouth. It is usually taken once a day, in the morning or in the evening, with or without food. Take dasatinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dasatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them. Wear latex or nitrile gloves when handling tablets that are accidently crushed or broken to prevent contact with the medication.

Your doctor may adjust your dose or permanently stop your treatment of dasatinib depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take dasatinib even if you feel well. Do not stop taking dasatinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking dasatinib,

  • tell your doctor and pharmacist if you are allergic to dasatinib, any other medications, or any of the ingredients in dasatinib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); anthracycline medications for cancer such as daunorubicin (Cerubidine), doxorubicin (Doxil), and epirubicin (Ellence); certain antifungals such as ketoconazole (Nizoral), itraconazole (Onmel, Sporanox), and voriconazole (Vfend); clarithromycin (Biaxin, in PrevPac); dexamethasone; certain medications used to treat human immunodeficiency virus (HIV) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase); certain medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), mexiletine (Mexitil), procainamide, propafenone (Rythmol), quinidine (in Nuedexta), and sotalol (Betapace, Betapace AF, Sorine), medications to reduce stomach acid such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), ranitidine (Zantac), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); nefazodone; rifampin (Rimactane, Rifadin, in Rifater, in Rifamate); and telithromycin (Ketek); Many other medications may also interact with dasatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • if you are taking antacids, such as aluminum hydroxide/magnesium hydroxide (Maalox), calcium carbonate (Tums), or calcium carbonate and magnesium (Rolaids), take them 2 hours before or 2 hours after you take dasatinib.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had lactose intolerance (inability to digest dairy products), low levels of potassium or magnesium in your blood, long QT syndrome (a heart condition that may cause dizziness, fainting, or irregular heartbeat), problems with your immune system, or liver, lung, or heart disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking dasatinib and for 30 days after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking dasatinib, call your doctor. Women who are pregnant should not handle crushed or broken dasatinib tablets. Dasatinib may harm the fetus.

  • do not breastfeed while taking dasatinib and for 2 weeks after your final dose.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking dasatinib.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking dasatinib.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Dasatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • muscle pain

    • weakness

    • joint pain

    • pain, burning or tingling in the hands or the feet

    • rash

    • skin redness

    • peeling skin

    • swelling, redness, and pain inside the mouth

    • mouth sores

    • diarrhea

    • nausea

    • vomiting

    • constipation

    • stomach pain or swelling

    • loss of appetite

    • weight loss

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • fever, sore throat, chills, and/or other signs of infection

    • swelling of the eyes, hands, arms, feet, ankles, or lower legs

    • sudden weight gain

    • difficulty breathing, especially when lying down

    • coughing up pink or bloody mucus

    • dry cough

    • chest pain that becomes worse when coughing, sneezing, or breathing deeply

    • chest pressure

    • dizziness

    • fainting

    • rapid, irregular, or pounding heartbeat

    • headache

    • tiredness

    • confusion

    • temporary breast enlargement (in children)

    • unusual bruising or bleeding

    • black and tarry stools

    • red blood in stools

    • bloody vomit

    • vomiting material that looks like coffee grounds

    • slow or difficult speech

    • weakness or numbness of an arm or leg

  • Dasatinib may cause slowed growth or bone pain in children. Your child's doctor will monitor your child's development carefully while he or she is taking dasatinib. Talk to your doctor about the risks of giving this medication to your child.

  • Dasatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • unusual bruising or bleeding

  • fever, sore throat, chills, and/or other signs of infection

  • shortness of breath

  • fast heartbeat

  • headache

  • pale skin

  • confusion

  • tiredness

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to dasatinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Dasatinib can be decreased when combined with Moxifloxacin.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Dasatinib is combined with Acebutolol.
Triamcinolone Triamcinolone The metabolism of Dasatinib can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The metabolism of Dasatinib can be decreased when combined with Zolmitriptan.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Dasatinib.
Trimipramine Trimipramine The risk or severity of QTc prolongation can be increased when Trimipramine is combined with Dasatinib.
Tenofovir Tenofovir The metabolism of Dasatinib can be decreased when combined with Tenofovir.
Tegaserod Tegaserod The metabolism of Dasatinib can be decreased when combined with Tegaserod.
Gemifloxacin Gemifloxacin The metabolism of Gemifloxacin can be decreased when combined with Dasatinib.
Apomorphine Injection Apomorphine Injection The metabolism of Dasatinib can be decreased when combined with Apomorphine.
Voriconazole Voriconazole The metabolism of Dasatinib can be decreased when combined with Voriconazole.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Dasatinib.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Dasatinib.
Rasagiline Rasagiline The metabolism of Rasagiline can be decreased when combined with Dasatinib.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Dasatinib.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Dasatinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Dasatinib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Dasatinib.
Tretinoin Tretinoin The metabolism of Dasatinib can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Dasatinib is combined with Bendamustine.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Dasatinib.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Dasatinib is combined with Betaxolol.
Everolimus Everolimus The metabolism of Dasatinib can be decreased when combined with Everolimus.
Fingolimod Fingolimod Dasatinib may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Dasatinib is combined with Eribulin.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Dasatinib is combined with Lurasidone.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Dasatinib.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Dasatinib is combined with Belimumab.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Dasatinib.
Linagliptin Linagliptin The metabolism of Dasatinib can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Rilpivirine can be decreased when combined with Dasatinib.
Abiraterone Abiraterone The serum concentration of Dasatinib can be increased when it is combined with Abiraterone.
Rivaroxaban Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Dasatinib can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Dasatinib.
Vandetanib Vandetanib The metabolism of Dasatinib can be decreased when combined with Vandetanib.
Vemurafenib Vemurafenib The serum concentration of Dasatinib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Dasatinib which could result in a higher serum level.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Dasatinib is combined with Belatacept.
Ivacaftor Ivacaftor The metabolism of Dasatinib can be decreased when combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Dasatinib.
Crizotinib Crizotinib The metabolism of Dasatinib can be decreased when combined with Crizotinib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Dasatinib.
Enzalutamide Enzalutamide The metabolism of Dasatinib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Dasatinib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Dasatinib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Dasatinib can be decreased when combined with Bosutinib.
Teriflunomide Teriflunomide The serum concentration of Dasatinib can be decreased when it is combined with Teriflunomide.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Dasatinib is combined with Bedaquiline.
Icosapent Ethyl Icosapent Ethyl Dasatinib may increase the anticoagulant activities of Icosapent ethyl.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Dasatinib.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Dasatinib is combined with Dimethyl fumarate.
Ponatinib Ponatinib The serum concentration of Dasatinib can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Dasatinib can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Dasatinib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Dasatinib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Dasatinib can be increased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Dasatinib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir Dasatinib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Dasatinib.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Dasatinib.
Perampanel Perampanel The metabolism of Dasatinib can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Dasatinib.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Dasatinib.
Simeprevir Simeprevir The metabolism of Dasatinib can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Dasatinib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dasatinib can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Dasatinib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Dasatinib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Dasatinib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Dasatinib can be increased when combined with Eslicarbazepine.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Dasatinib is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Dasatinib is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Dasatinib.
Testosterone Injection Testosterone Injection The metabolism of Dasatinib can be increased when combined with Testosterone.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Vorapaxar.
Tasimelteon Tasimelteon The metabolism of Dasatinib can be decreased when combined with Tasimelteon.
Riociguat Riociguat Dasatinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Dasatinib.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Defibrotide.
Cobicistat Cobicistat The metabolism of Dasatinib can be decreased when combined with Cobicistat.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Dasatinib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Dasatinib.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Dasatinib is combined with Tetrabenazine.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Dasatinib can be decreased when combined with Drospirenone.
Viloxazine Viloxazine The metabolism of Dasatinib can be decreased when combined with Viloxazine.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Dasatinib.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Dasatinib.
Tranylcypromine Tranylcypromine The metabolism of Dasatinib can be decreased when combined with Tranylcypromine.
Tetracycline Tetracycline The metabolism of Dasatinib can be decreased when combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Dasatinib.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Dasatinib is combined with Thioridazine.
Trifluoperazine Trifluoperazine The metabolism of Dasatinib can be decreased when combined with Trifluoperazine.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Dasatinib.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Dasatinib.
Warfarin Warfarin The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Warfarin.
Triamterene Triamterene The metabolism of Dasatinib can be decreased when combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone Dasatinib may increase the anticoagulant activities of Sulfinpyrazone.
Valproic Acid Valproic Acid The metabolism of Dasatinib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Dasatinib can be increased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Dasatinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Dasatinib.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Dasatinib.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Dasatinib.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Dasatinib.
Vinblastine Vinblastine The metabolism of Dasatinib can be increased when combined with Vinblastine.
Thiothixene Thiothixene The metabolism of Thiothixene can be decreased when combined with Dasatinib.
Aspirin Aspirin The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Acetylsalicylic acid.
Triazolam Triazolam The metabolism of Dasatinib can be decreased when combined with Triazolam.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Dasatinib.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Dasatinib.
Verapamil Verapamil The metabolism of Dasatinib can be decreased when combined with Verapamil.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Dasatinib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Dasatinib.
Teniposide Injection Teniposide Injection The metabolism of Dasatinib can be decreased when combined with Teniposide.
Tramadol Tramadol The metabolism of Dasatinib can be decreased when combined with Tramadol.
Ticlopidine Ticlopidine Dasatinib may increase the anticoagulant activities of Ticlopidine.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Dasatinib.
Indinavir Indinavir The metabolism of Dasatinib can be decreased when combined with Indinavir.
Zafirlukast Zafirlukast The metabolism of Dasatinib can be decreased when combined with Zafirlukast.
Donepezil Donepezil Dasatinib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Nelfinavir Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Dasatinib.
Sildenafil Sildenafil The serum concentration of Dasatinib can be increased when it is combined with Sildenafil.
Celecoxib Celecoxib Dasatinib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Dasatinib.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Dasatinib.
Rabeprazole Rabeprazole Rabeprazole can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists