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Cyclophosphamide

Cyclophosphamide is an alkylating chemotherapy drug used to treat many cancers, including lymphomas, multiple myeloma, leukemias, and breast and ovarian cancer, and, in some oral and injection products, a kidney condition in children called minimal change nephrotic syndrome.

Brand names CytoxanFrindovyx
Rx Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 28 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026 🚨Recall on record
Other forms & routes:
Injection
Cyclophosphamide at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Cyclophosphamide is an alkylating chemotherapy drug, turned by the liver into forms that cross-link tumor DNA, used for lymphomas, multiple myeloma, leukemias and several solid tumors plus some children with minimal change nephrotic syndrome (a kidney condition); on the market since about 1959 and available as a generic, it is a backbone of many combination cancer regimens. Hair loss, nausea and vomiting are what people notice most, and it reliably drops white blood cell counts, so expect regular blood tests. Report fever or chills, blood in your urine, or new breathing or heart symptoms promptly, since serious infection and bladder bleeding (hemorrhagic cystitis) are the biggest risks.

Clinical pearls

  • Take oral doses in the morning and drink plenty of fluids, emptying your bladder often, to protect against bladder bleeding.
  • Tell your anesthesiologist if you had cyclophosphamide within 10 days of surgery; some muscle relaxants can prolong breathing paralysis.
  • If you take warfarin, expect more frequent clotting tests, because cyclophosphamide can push its effect up or down.
  • Females should use effective contraception for up to a year afterward, and males with female partners for four months afterward.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asInjection, Capsule, Tablet
Earliest FDA record1959
Companies listing it with the FDA24
FDA label last updatedJan 19, 2026
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Cyclophosphamide, written from its FDA label.

What Cyclophosphamide is used for

▾

Cyclophosphamide is an alkylating drug with these supported uses, depending on the product:

  • Malignant lymphomas, including Hodgkin's disease, lymphocytic, mixed-cell and histiocytic lymphoma, and Burkitt's lymphoma
  • Multiple myeloma
  • Leukemias (chronic lymphocytic, chronic granulocytic, acute myelogenous and monocytic, acute lymphoblastic)
  • Mycosis fungoides (advanced disease)
  • Neuroblastoma (disseminated disease)
  • Ovarian adenocarcinoma
  • Retinoblastoma
  • Breast cancer
  • Minimal change nephrotic syndrome in children after steroid failure or intolerance: listed for Cyclophosphamide capsules, tablets and some Cyclophosphamide for Injection products, not for Frindovyx or the injection solution labels
  • One Cyclophosphamide Injection concentrate is for adults only, not children

How Cyclophosphamide works

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Your liver converts cyclophosphamide into active metabolites. These interfere with the growth of rapidly dividing cancer cells, likely by cross-linking tumor cell DNA. The exact mechanism is not fully characterized.

Cyclophosphamide dosage

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The route depends on the product. Injections go into a vein, some injection powders can also be taken by mouth, and capsules and tablets are swallowed.

  • Drink or receive plenty of fluids during and right after a dose to protect the bladder.
  • The label says to give it in the morning.
  • Schedules vary, from short courses to daily use, and are set by your prescriber.

Follow your prescriber and the product label.

Dosing details from the FDA-approved label

From the Cyclophosphamide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Malignant Diseases, Adults and Pediatric Patients - Intravenous (initial course, patients with no hematologic deficiency)
    • 40 mg/kg to 50 mg/kg given intravenously in divided doses over a period of 2 to 5 days
    • Other intravenous regimens include 10 mg/kg to 15 mg/kg given every 7 to 10 days or 3 mg/kg to 5 mg/kg twice weekly
    • Adjust the dosage based on the specific regimen administered, response to treatment, myelosuppression or other adverse reactions, and patient risk factors
  • Malignant Diseases, Adults and Pediatric Patients - Oral
    • 1 mg per kg per day to 5 mg per kg per day for both initial and maintenance dosing
    • Adjust the dosage based on the specific regimen administered, response to treatment, myelosuppression or other adverse reactions, and patient risk factors
  • Minimal Change Nephrotic Syndrome in Pediatric Patients
    • 2 mg per kg orally once daily for 8 to 12 weeks
    • Maximum: maximum cumulative dose 168 mg per kg
    • Treatment beyond 90 days increases the probability of sterility in males
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION During or immediately after cyclophosphamide for Injection administration, administer adequate amounts of fluid to reduce the risk of urinary tract toxicity ( 2.1 ). Malignant Diseases: Adult and Pediatric Patients ( 2.2 ) Intravenous: Initial course for patients with no hematologic deficiency: 40 mg per kg to 50 mg per kg in divided doses over 2 to 5 days. Other regimens include 10 mg per kg to 15 mg per kg given every 7 to 10 days or 3 mg per kg to 5 mg per kg twice weekly. Oral: 1 mg per kg per day to 5 mg per kg per day for both initial and maintenance dosing. Minimal Change Nephrotic Syndrome in Pediatric Patients ( 2.3 ) Oral : 2 mg per kg daily for 8 to 12 weeks (maximum cumulative dose 168 mg per kg). Treatment beyond 90 days increases the probability of sterility in males. ( 8.4 ) 2.1 Important Administration Instructions During or immediately after the administration of cyclophosphamide for injection, adequate amounts of fluid should be ingested or infused to force diuresis in order to reduce the risk of urinary tract toxicity. Therefore, cyclophosphamide for injection should be administered in the morning. 2.2 Recommended Dosage for Malignant Diseases Adults and Pediatric Patients Intravenous Use When used as the only oncolytic drug therapy, the recommended dosage for the initial course of cyclophosphamide for injection for patients with no hematologic deficiency is 40 mg per kg to 50 mg per kg given intravenously in divided doses over a period of 2 to 5 days. Other intravenous regimens include 10 mg per kg to 15 mg per kg given every 7 to 10 days or 3 mg per kg to 5 mg per kg twice weekly. Oral Use The recommended dosage for oral cyclophosphamide is 1 mg per kg per day to 5 mg per kg per day for both initial and maintenance dosing. Adjust the dosage of cyclophosphamide for injection based on the specific regimen administered, response to treatment, myelosuppression or other adverse reactions, and patient risk factors [ see Warnings and Precautions (5) ] . 2.3 Recommended Dosage for Minimal Change Nephrotic Syndrome in Pediatric Patients The recommended dosage is 2 mg per kg orally once daily for 8 to 12 weeks (maximum cumulative dose 168 mg per kg) is recommended. Treatment beyond 90 days increases the probability of sterility in males [see Use in Specific Populations (8.4) ].

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Cyclophosphamide side effects

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The most commonly reported side effects are:

Common side effects

  • Low white blood cell counts (neutropenia), sometimes with fever
  • Fever
  • Hair loss
  • Nausea
  • Vomiting
  • Diarrhea

When to get medical help

  • Get medical help for fever, chills or other signs of infection, since cyclophosphamide can weaken your immune system.
  • Call your doctor about blood in your urine or painful urination, which can signal bladder damage (hemorrhagic cystitis).
  • Seek help for chest pain, irregular or fast heartbeat, swelling, or new shortness of breath, which can signal heart or lung problems.
  • Report new cough or breathing trouble, since lung inflammation can appear even years later.
  • Report yellow skin or eyes, belly swelling or pain, which can signal liver problems.
  • Seek emergency help for signs of a severe allergic reaction, such as swelling or trouble breathing.
  • Report confusion, seizures or severe skin blistering and peeling right away.

Cyclophosphamide warnings and precautions

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  • Infections and low blood counts: severe immune suppression can cause serious or fatal infections, so blood counts are monitored.
  • Bladder toxicity: bleeding and bladder damage can occur. Fluids, frequent urination and sometimes mesna help prevent it.
  • Heart and lung toxicity: heart failure, heart rhythm problems and lung scarring or inflammation (which can appear years later) can occur.
  • Liver: veno-occlusive liver disease can be fatal.
  • Other cancers: secondary cancers have been reported.
  • Pregnancy and fertility: it can harm a fetus and cause sterility.
  • Wound healing may be impaired, and low sodium has been reported.

Cyclophosphamide interactions

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Several medicines can change how cyclophosphamide works or how safe it is:

  • Protease inhibitors: may increase toxic effects such as infections and low white cells.
  • Radiation or drugs with similar toxicities: may add to side effects.
  • Warfarin and other coumarins: effect may go up or down.
  • Cyclosporine: levels may fall.
  • Tamoxifen: may raise the risk of blood clots.
  • Metronidazole: encephalopathy has been reported.
  • Succinylcholine and similar muscle relaxants: may cause prolonged breathing paralysis, so tell your anesthesiologist about recent cyclophosphamide.

Interactions listed in the FDA-approved label

From the Cyclophosphamide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Protease inhibitors: Concomitant use may increase the concentration of cytotoxic metabolites and may enhance the toxicities of cyclophosphamide, including higher incidence of infections, neutropenia, and mucositis. Monitor for increased toxicities in patients receiving protease inhibitors.
  • Radiation therapy or drugs with similar toxicities (myelosuppression/immunosuppression, nephrotoxicity including hemorrhagic cystitis, cardiotoxicity, pulmonary toxicity, secondary malignancies, hepatotoxicity including liver necrosis and VOD): Can potentiate toxicities of cyclophosphamide. Monitor for increased toxicities in patients receiving radiation therapy or drugs known to cause these toxicities.
  • Metronidazole: Acute encephalopathy has been reported in a patient receiving cyclophosphamide and metronidazole. Monitor for neurologic toxicities in patients receiving metronidazole.
  • Tamoxifen: Concomitant use of tamoxifen and a cyclophosphamide-containing chemotherapy regimen may increase the risk of thromboembolic complications. Monitor for signs and symptoms of thromboembolic events in patients receiving tamoxifen.
  • Coumarins (warfarin): Both increased and decreased warfarin effect have been reported in patients receiving warfarin and cyclophosphamide. Monitor anticoagulant activity closely in patients receiving warfarin or other coumarins.
  • Cyclosporine: Concomitant administration of cyclophosphamide may decrease serum concentrations of cyclosporine, which may result in an increased incidence of graft-versus-host disease. Monitor for signs and symptoms of graft-versus-host disease in patients receiving cyclosporine.
  • Depolarizing muscle relaxants (e.g., succinylcholine): Cyclophosphamide causes a marked and persistent inhibition of cholinesterase activity; prolonged apnea may occur with concurrent depolarizing muscle relaxants. If a patient has been treated with cyclophosphamide within 10 days of general anesthesia, alert the anesthesiologist.
Read the label’s full interactions text

7 DRUG INTERACTIONS 7.1 Effect of Other Drugs on Cyclophosphamide Exposure Protease Inhibitors Concomitant use of protease inhibitors may increase the concentration of cytotoxic metabolites and may enhance the toxicities of cyclophosphamide, including higher incidence of infections, neutropenia, and mucositis. Monitor for increased toxicities in patients receiving protease inhibitors. 7.2 Drugs That Potentiate Cyclophosphamide Toxicities Radiation therapy or drugs with similar toxicities to cyclophosphamide for injection can potentiate toxicities for cyclophosphamide. Monitor for increased toxicities in patients receiving radiation therapy or drugs known to cause: Myelosuppression and/or immunosuppression [see Warnings and Precautions (5.1) ] Nephrotoxicity including hemorrhagic cystitis [see Warnings and Precautions (5.2) ] Cardiotoxicity [see Warnings and Precautions (5.3) ] Pulmonary toxicity [see Warnings and Precautions (5.4) ] Secondary malignancies [see Warnings and Precautions (5.5) ] Hepatotoxicity including liver necrosis and VOD [see Warnings and Precautions(5.6) ] 7.3 Effect of Cyclophosphamide on Other Drugs Metronidazole Acute encephalopathy has been reported in a patient receiving cyclophosphamide and metronidazole. Monitor for neurologic toxicities in patients receiving metronidazole. Tamoxifen Concomitant use of tamoxifen and a cyclophosphamide-containing chemotherapy regimen may increase the risk of thromboembolic complications. Monitor for signs and symptoms of thromboembolic events in patients receiving tamoxifen. Coumarins Both increased and decreased warfarin effect have been reported in patients receiving warfarin and cyclophosphamide. Monitor anticoagulant activity closely in patients receiving warfarin or other coumarins. Cyclosporine Concomitant administration of cyclophosphamide may decrease serum concentrations of cyclosporine. This interaction may result in an increased incidence of graft-versus-host disease.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿220 supplements and herbs with documented Cyclophosphamide interactions, ranked by severity Check Cyclophosphamide against a supplement or herb →

Before taking Cyclophosphamide

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  • Do not use it if you had a severe allergic reaction to cyclophosphamide or its ingredients, or if you have urinary outflow obstruction.
  • Pregnancy: it can cause birth defects and miscarriage. Pregnancy status should be checked first, and effective contraception is advised.
  • Do not breastfeed during treatment and for 1 week after the last dose.
  • Tell your doctor about heart, lung, liver or kidney disease, and active infections including urinary tract infection.
  • Older adults may need cautious dosing.
  • Severe kidney or liver impairment may need closer monitoring.

Cyclophosphamide overdose

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No specific antidote is known. Too much can cause serious blood count drops, bladder damage, heart problems including heart failure, liver vein blockage and mouth sores. Treatment is supportive, with close monitoring, and rapid hemodialysis is indicated since the drug can be removed by dialysis. Mesna may help limit bladder damage.

What Cyclophosphamide does in the body

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Cyclophosphamide is converted mainly in the liver into active alkylating metabolites. These interfere with the growth of susceptible, rapidly dividing cancer cells.

How your body processes Cyclophosphamide

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After an oral dose, blood levels peak at about one hour, and the amount absorbed is about 87% to 96% of the amount from an IV dose. After IV use, the half-life is about 3 to 12 hours. The liver activates about 75% of a dose, and it is cleared mostly as metabolites, with 10% to 20% unchanged in urine. Kidney or severe liver impairment can raise exposure or change how it works, and dialysis removes it.

How to store Cyclophosphamide

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Store vials at or below 25°C (77°F). of cyclophosphamide vials, temperature influences can lead to melting of the active ingredient, cyclophosphamide.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

220

Supplements & herbs that interact with Cyclophosphamide

220 supplements and herbal products have documented interactions with Cyclophosphamide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 6
  • Moderate · 176
  • Minor · 38
ACTIVATED CHARCOAL Major BEER Major GRAPEFRUIT Major SIBERIAN COCKLEBUR Major ST. JOHN'S WORT Major WINE Major ACACIA RIGIDULA Moderate ACEROLA Moderate +212 more
Every supplement checked against Cyclophosphamide — ranked by severity The full interaction hub: 6 major · 176 moderate · 38 minor · every one linked to its full report. Check Cyclophosphamide against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Cyclophosphamide has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

VITAMIN E Insufficient Evidence
See the full Cyclophosphamide nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Cyclophosphamide: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Cyclophosphamide — the kind of thing our pharmacy team would talk through with you at the counter.

What is cyclophosphamide for?

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It is mainly a chemotherapy drug for cancers such as lymphomas, multiple myeloma, leukemias and breast and ovarian cancer. Some oral and injection products are also approved for children with minimal change nephrotic syndrome who did not respond to steroids. Your prescriber will tell you why you are getting it.

How should I take it?

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It may be given into a vein or taken by mouth, depending on your product. Drink plenty of fluids and empty your bladder often to protect it. The label says morning dosing is best. Follow your prescriber's exact schedule.

What side effects should I expect?

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Common ones are low white blood cell counts, fever, hair loss, nausea, vomiting and diarrhea. Your blood counts will be checked regularly. Call right away for fever or infection signs, blood in your urine, chest pain, or trouble breathing.

Can I take it with my other medicines?

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Tell us about everything you take. Protease inhibitors, warfarin, cyclosporine, tamoxifen and metronidazole can interact. Also tell any surgeon or anesthesiologist if you had cyclophosphamide in the past 10 days.

Is it safe during pregnancy or breastfeeding?

▾
No. It can cause birth defects and miscarriage. Use effective birth control during treatment, for up to 1 year after if you can become pregnant, and for 4 months after if you are a male with a female partner. Do not breastfeed during treatment and for 1 week after the last dose.

Will it affect fertility?

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It can. It may cause temporary or permanent infertility in men and women, and periods may stop. Talk with your doctor before starting if having children matters to you.

Is Cyclophosphamide available over the counter?

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No. Cyclophosphamide is a prescription medicine: every Cyclophosphamide product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Cyclophosphamide first available?

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The earliest FDA record we hold for Cyclophosphamide is from 1959: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Cyclophosphamide was first used.

Who makes Cyclophosphamide?

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24 companies currently list Cyclophosphamide products in the FDA's NDC Directory, including Baxter Healthcare Company, BluePoint Laboratories, Avyxa Pharma, LLC. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Cyclophosphamide on HelloPharmacist

📊Cyclophosphamide supplement interactions220 checked — ranked by severity 🌿Drug & Supplement CheckerCyclophosphamide vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Cyclophosphamide NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Cyclophosphamide Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Cyclophosphamide forms and strengths (how it comes)

Cyclophosphamide is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

By injection · By mouth · Into a vein
Brands Frindovyx
How this form is used
What it may be used for
  • Frindovyx is an intravenous injection for malignant diseases in adults and children, such as lymphomas, multiple myeloma, leukemias and breast cancer.
  • Cyclophosphamide for Injection products are used for malignant diseases and, in several labels, minimal change nephrotic syndrome in children.
  • One Cyclophosphamide Injection concentrate is for adults only because of its alcohol and propylene glycol content.
Important instructions
  • Frindovyx is given into a vein, with plenty of fluids during or right after to protect the bladder, and should be given in the morning.
  • Some Cyclophosphamide for Injection powder labels list both intravenous and oral use.
  • Cyclophosphamide injection products are given with plenty of fluids to reduce the risk of bladder and urinary tract toxicity.
Available strengths 14 strengths
200 mg/mL 500 mg/2.5 mL 500 mg/5 mL 500 mg/25 mL 500 mg/mL 1 g/2 mL
Show 8 more strengths Show fewer strengths
1 g/5 mL 1 g/50 mL 1000 mg/10 mL 2 g/4 mL 2 g/10 mL 2 g/100 mL 2 g/150 mL 2000 mg/20 mL
141 FDA-listed product records ⓘ

Capsule

By mouth
How this form is used
What it may be used for
  • Cyclophosphamide capsules are used for malignant diseases such as lymphomas, multiple myeloma, leukemias and breast cancer.
  • Cyclophosphamide capsules are also used for biopsy-proven minimal change nephrotic syndrome in children who did not respond to or cannot tolerate steroids.
Important instructions
  • Cyclophosphamide capsules are taken by mouth as directed by your prescriber.
Available strengths 2 strengths
25 mg 50 mg
24 FDA-listed product records ⓘ

Tablet

By mouth
How this form is used
What it may be used for
  • Cyclophosphamide tablets are used for malignant diseases such as lymphomas, multiple myeloma, leukemias and breast cancer.
  • Cyclophosphamide tablets are also used for minimal change nephrotic syndrome in children who did not respond to or cannot tolerate steroids.
Important instructions
  • Cyclophosphamide tablets are taken by mouth as directed by your prescriber.
Available strengths 2 strengths
25 mg 50 mg
6 FDA-listed product records ⓘ

Cyclophosphamide on the U.S. market: products, makers and brands

How Cyclophosphamide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

24 companies list 85 Cyclophosphamide product records with the FDA, mostly as injection, capsule, tablet; the earliest marketing or approval year on record is 1959. Brand names on the directory include Cytoxan, Frindovyx; the rest are generics.

3
Dose forms ⓘ
24
Labelers (makers, repackagers, distributors)
2
Brand names
85
FDA-listed product records ⓘ
1959
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (19) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Baxter Healthcare Company14%
BluePoint Laboratories9%
Avyxa Pharma, LLC7%
Sandoz Inc7%
Amneal Pharmaceuticals LLC4%
Avenacy, LLC4%
Other makers55%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Cyclophosphamide is used (Medicaid data)

A general measure of how commonly Cyclophosphamide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Cyclophosphamide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

12,778
Medicaid prescriptions filled (Q1–Q4 2025)
$5.2M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Cyclophosphamide prescribed? Of the 1,601 medications we measure, Cyclophosphamide ranks #888 by Medicaid prescriptions — more than 45% of them.

Where Cyclophosphamide ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #888 of 1,601
#883 Ocrelizumab Injection 13,323 Rx #884 Clindamycin Injection 13,123 Rx #885 Lonapegsomatropin-tcgd... 13,066 Rx #886 Mebendazole 13,051 Rx #887 Ferric Citrate 12,907 Rx #888 Cyclophosphamide 12,778 Rx #889 Imatinib 12,484 Rx #890 Enalapril and Hydrochl... 12,397 Rx #891 Doxorubicin 12,297 Rx #892 Sertaconazole Topical 12,283 Rx #893 Glatiramer Injection 12,218 Rx

Utilization by Cyclophosphamide product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 200 mg/mL injectable solution is the most-dispensed Cyclophosphamide product — about 38% of these Medicaid prescriptions.

cyclophosphamide 200 MG/ML Injectable Solution Most dispensed

4,828 Medicaid prescriptions (Q1–Q4 2025) 38% of Cyclophosphamide prescriptions shown $1.9M gross reimbursement (before rebates) ≈ $401 per prescription (gross)

Summed across the 8 of 28 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2386859

cyclophosphamide 500 MG Injection

3,031 Medicaid prescriptions (Q1–Q4 2025) 24% of Cyclophosphamide prescriptions shown $763,478 gross reimbursement (before rebates) ≈ $252 per prescription (gross)

Summed across the 9 of 26 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1734917

cyclophosphamide 1000 MG Injection

2,585 Medicaid prescriptions (Q1–Q4 2025) 20% of Cyclophosphamide prescriptions shown $719,957 gross reimbursement (before rebates) ≈ $279 per prescription (gross)

Summed across the 9 of 26 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1734919

cyclophosphamide 50 MG Oral Capsule

1,015 Medicaid prescriptions (Q1–Q4 2025) 8% of Cyclophosphamide prescriptions shown $105,983 gross reimbursement (before rebates) ≈ $104 per prescription (gross)

Summed across the 3 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1437969

cyclophosphamide 500 MG/ML Injectable Solution

530 Medicaid prescriptions (Q2–Q4 2025) 4% of Cyclophosphamide prescriptions shown $1M gross reimbursement (before rebates) ≈ $1,925 per prescription (gross)

Summed across the 3 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2703027

cyclophosphamide 2000 MG Injection

433 Medicaid prescriptions (Q1–Q4 2025) 3% of Cyclophosphamide prescriptions shown $86,464 gross reimbursement (before rebates) ≈ $200 per prescription (gross)

Summed across the 7 of 25 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1734921

1 ML cyclophosphamide 500 MG/ML Injection

166 Medicaid prescriptions (Q1–Q4 2025) 1% of Cyclophosphamide prescriptions shown $315,697 gross reimbursement (before rebates) ≈ $1,902 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2644824

2 ML cyclophosphamide 500 MG/ML Injection

157 Medicaid prescriptions (Q1–Q4 2025) 1% of Cyclophosphamide prescriptions shown $232,996 gross reimbursement (before rebates) ≈ $1,484 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2644738

cyclophosphamide 25 MG Oral Capsule

22 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyclophosphamide prescriptions shown $1,497 gross reimbursement (before rebates) ≈ $68 per prescription (gross)

Summed across the 1 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1437968

cyclophosphamide 100 MG/ML Injectable Solution

11 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyclophosphamide prescriptions shown $5,348 gross reimbursement (before rebates) ≈ $486 per prescription (gross)

Summed across the 1 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2679073

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Cyclophosphamide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 43 of 135 listed Cyclophosphamide NDCs with Medicaid activity.

Compare Cyclophosphamide products

A representative set of FDA-listed product records for Cyclophosphamide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 85 of 85 products — FDA National Drug Code Directory. See every product, package size and price: browse all 85 Cyclophosphamide NDCs →

Cyclophosphamide recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list one Cyclophosphamide recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Sep 5, 2025 · Sandoz Inc
cGMP deviations: Temperature excursion during transportation.
  • Cyclophosphamide Injection 500 mg/5 mL (100 mg/mL), Hazardous Drug, Rx Only, Sterile, 5mL Multiple Dose Vial, Manufactured in Austria by Fareva Unterach GmbH for Sandoz Inc., Princeton, NJ 08540, Pro… Lots: Only the following 6 GTN Numbers for Lot # 110459 exp. date 02/28/2027: (01)00307813528104(21)10686040629319 (01)00307813528104(21)10687281435306 (01)00307813528104(21)10687409963168 (01)00307813528104(21)10701200331212 (01)00307813528104(… FDA record D-0651-2025 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Cyclophosphamide RxCUI 3002 4 dose forms · 15 strengths
  1. Dose form (SCDF) Injectable Solution RxCUI 376666 In current FDA listings
    Clinical drug / strength (SCD) 100 MG/ML RxCUI 2679073 200 MG/ML RxCUI 2386859 500 MG/ML RxCUI 2703027
  3. Dose form (SCDF) Oral Capsule RxCUI 1437967 In current FDA listings
    Clinical drug / strength (SCD) 25 MG RxCUI 1437968 50 MG RxCUI 1437969
  4. Dose form (SCDF) Oral Tablet RxCUI 371664 In current FDA listings
    Clinical drug / strength (SCD) 25 MG RxCUI 197549 50 MG RxCUI 197550

Look up RxCUI 3002 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Cyclophosphamide costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Capsule · Oral 50 mg $1.67 per capsule NDC details & price history
Capsule · Oral 25 mg $1.12 per capsule NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Cyclophosphamide brand names

Cyclophosphamide is sold under 2 brand names in the FDA directory — Cytoxan, Frindovyx. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Cytoxan Frindovyx

Who makes Cyclophosphamide: manufacturers and labelers

24 companies list Cyclophosphamide products with the FDA. By number of product records, the largest are Baxter Healthcare Company, BluePoint Laboratories, Avyxa Pharma, LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Baxter Healthcare Company 12 BluePoint Laboratories 8 Avyxa Pharma, LLC 6 Sandoz Inc 6 Amneal Pharmaceuticals LLC 3 Avenacy, LLC 3 Bamboo US Bidco LCC 3 Civica, Inc. 3 Dr. Reddy's Labratories Inc. 3 Epic Pharma, LLC 3 Eugia US LLC 3 Fresenius Kabi USA, LLC 3 Hainan Poly Pharm. Co., Ltd. 3 NorthStar Rx LLC 3 Sagent Pharmaceuticals 3 Slate Run Pharmaceuticals, LLC 3 XGen Pharmaceuticals DJB, Inc. 3 Alembic Pharmaceuticals Inc. 2 Alembic Pharmaceuticals Limited 2 Baxter Healthcare Corporation 2 Cipla USA Inc. 2 Hikma Pharmaceuticals USA Inc. 2 Nexus Pharmaceuticals, LLC 2 OPKO Pharmaceuticals, LLC 2

Cyclophosphamide drug class (RxNorm)

Cyclophosphamide belongs to the Alkylating Drug class.

Pharmacologic class Alkylating Drug
Drug family (ATC) Nitrogen mustard analogues
How it works Alkylating Activity

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Cyclophosphamide page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jan 19, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Cyclophosphamide.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Cyclophosphamide after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
28
Finished products in the current FDA directory
85
Companies listing them (makers, repackagers, distributors)
24
FDA labeler codes behind them ⓘ
23
Linked representative label ⓘ
Amneal Pharmaceuticals LLC
Linked label effective
Jan 19, 2026
Composite sections available
22
Linked SPL Set ID
520bfe39-dfd5-4a20-9a37-80078afded0d
Linked SPL Document ID
40ce8341-9b51-4187-920b-ad9cce7930e1
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Amneal Pharmaceuticals LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →