Cyclophosphamide Injection

Generic name: Pronounced as (sye kloe foss' fa mide)
Brand names
  • Cytoxan® Injection
  • Neosar® Injection
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 08/15/2021

Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that first appear as skin rashes); multiple myeloma (a type of cancer of the bone marrow); and certain types of leukemia (cancer of the white blood cells), including chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML, ANLL), and acute lymphoblastic leukemia (ALL). It is also used to treat retinoblastoma (cancer in the eye), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), and breast cancer. Cyclophosphamide is also used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications or in children who experienced intolerable side effects with other medications. Cyclophosphamide is in a class of medications called alkylating agents. When cyclophosphamide is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When cyclophosphamide is used to treat nephrotic syndrome, it works by suppressing your body's immune system.

Cyclophosphamide injection comes as a powder to be added to fluid and injected intravenously (into a vein) by a doctor or nurse in a medical office or hospital outpatient clinic. It may also be injected intramuscularly (into a muscle), intraperitoneally (into the abdominal cavity), or intrapleurally (into the chest cavity). The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have.

Your doctor may need to delay your treatment or adjust your dose if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with cyclophosphamide injection.

Cyclophosphamide injection is also sometimes used to treat a certain type of lung cancer (small cell lung cancer; SCLC). It is also used to treat rhabdomyosarcoma (a type of cancer of the muscles) and Ewing's sarcoma (a type of bone cancer) in children. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving cyclophosphamide injection,

  • tell your doctor and pharmacist if you are allergic to cyclophosphamide, other alkylating agents such as bendamustine (Treanda®), busulfan (Myerlan®), Busulfex®), carumustine (BiCNU®, Gliadel® Wafer), chlorambucil (Leukeran®), ifosfamide (Ifex®), lomustine (CeeNU®), melphalan (Alkeran®), procarbazine (Mutalane®), or temozolomide (Temodar®), any other medications, or any of the ingredients in cyclophosphamide injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: allopurinol (Zyloprim®), cortisone acetate, doxorubicin (Adriamycin®, Doxil®), hydrocortisone (Cortef®), or phenobarbital (Luminal® Sodium). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with cyclophosphamide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have previously received treatment with other chemotherapy medications or if you have had x-rays recently. Also tell your doctor if you have or have ever had kidney or liver disease.

  • you should know that cyclophosphamide may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. Cyclophosphamide may cause permanent infertility (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin receiving this drug. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. Cyclophosphamide may harm the fetus.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving cyclophosphamide injection.

Drink plenty of fluids while you are receiving this medication.

  • Cyclophosphamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • loss of appetite or weight

    • abdominal pain

    • diarrhea

    • hair loss

    • sores on the mouth or tongue

    • changes in skin color

    • changes in color or growth of finger or toe nails

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • sore throat, fever, chills, or other signs of infection

    • poor or slow wound healing

    • unusual bruising or bleeding

    • black, tarry stools

    • painful urination or red urine

    • rash

    • hives

    • itching

    • difficulty breathing or swallowing

    • shortness of breath

    • cough

    • swelling in the legs, ankles, or feet

    • chest pain

    • yellowing of the skin or eyes

  • Cyclophosphamide may increase the risk that you will develop other cancers. Talk to your doctor about the risks of receiving cyclophosphamide injection.

  • Cyclophosphamide may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

This medication will be stored in the hospital or medical facility where you receive each dose.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • black, tarry stools

  • red urine

  • unusual bruising or bleeding

  • unusual tiredness or weakness

  • sore throat, cough, fever, or other signs of infection

  • swelling in the legs, ankles, or feet

  • chest pain

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to cyclophosphamide.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • CPM
  • CTX
  • CYT

Drug Interaction
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be increased when combined with Cyclophosphamide.
Zidovudine Injection Zidovudine Injection The metabolism of Cyclophosphamide can be decreased when combined with Zidovudine.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Cyclophosphamide.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Cyclophosphamide.
Tegaserod Tegaserod The metabolism of Cyclophosphamide can be decreased when combined with Tegaserod.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Cyclophosphamide.
Voriconazole Voriconazole The metabolism of Cyclophosphamide can be decreased when combined with Voriconazole.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Cyclophosphamide.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Cyclophosphamide.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Cyclophosphamide.
Dronabinol Dronabinol The metabolism of Cyclophosphamide can be decreased when combined with Dronabinol.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Azacitidine.
Antipyrine-Benzocaine Otic Antipyrine-Benzocaine Otic The risk or severity of methemoglobinemia can be increased when Cyclophosphamide is combined with Benzocaine.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Cyclophosphamide.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Bendamustine.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Cyclophosphamide.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Cyclophosphamide.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Cyclophosphamide.
Fingolimod Fingolimod Cyclophosphamide may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Eribulin.
Lurasidone Lurasidone Cyclophosphamide may increase the neurotoxic activities of Lurasidone.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Cyclophosphamide.
Belimumab Injection Belimumab Injection The risk or severity of leukopenia can be increased when Belimumab is combined with Cyclophosphamide.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Cyclophosphamide.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Cyclophosphamide.
Rilpivirine Rilpivirine The metabolism of Cyclophosphamide can be decreased when combined with Rilpivirine.
Abiraterone Abiraterone The metabolism of Cyclophosphamide can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Cyclophosphamide.
Ticagrelor Ticagrelor The metabolism of Cyclophosphamide can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Cyclophosphamide.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Cyclophosphamide.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Cyclophosphamide.
Vemurafenib Vemurafenib The metabolism of Cyclophosphamide can be increased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Cyclophosphamide can be decreased when combined with Vismodegib.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Belatacept.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Cyclophosphamide.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Cyclophosphamide.
Crizotinib Crizotinib The metabolism of Cyclophosphamide can be decreased when combined with Crizotinib.
Pertuzumab Injection Pertuzumab Injection The risk or severity of cardiotoxicity can be increased when Cyclophosphamide is combined with Pertuzumab.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Carfilzomib.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be increased when combined with Cyclophosphamide.
Regorafenib Regorafenib The metabolism of Cyclophosphamide can be increased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Cyclophosphamide.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Cyclophosphamide.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Cyclophosphamide.
Tofacitinib Tofacitinib Cyclophosphamide may increase the immunosuppressive activities of Tofacitinib.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Dimethyl fumarate.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Cyclophosphamide.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Cyclophosphamide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Cyclophosphamide.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Cyclophosphamide.
Dabrafenib Dabrafenib The serum concentration of Cyclophosphamide can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Cyclophosphamide.
Trametinib Trametinib The metabolism of Cyclophosphamide can be increased when combined with Trametinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Cyclophosphamide.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Cyclophosphamide.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Cyclophosphamide.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Cyclophosphamide.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Cyclophosphamide.
Simeprevir Simeprevir The metabolism of Cyclophosphamide can be decreased when combined with Simeprevir.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Cyclophosphamide.
Apremilast Apremilast The metabolism of Cyclophosphamide can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Cyclophosphamide can be increased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Cyclophosphamide can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Cyclophosphamide can be increased when combined with Eslicarbazepine.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Cyclophosphamide.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Cyclophosphamide.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Cyclophosphamide.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Cyclophosphamide.
Riociguat Riociguat The metabolism of Riociguat can be increased when combined with Cyclophosphamide.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Cyclophosphamide.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Cyclophosphamide.
Cobicistat Cobicistat The metabolism of Cyclophosphamide can be decreased when combined with Cobicistat.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Cyclophosphamide.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Cyclophosphamide.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Cyclophosphamide.
Trazodone Trazodone The metabolism of Trazodone can be decreased when combined with Cyclophosphamide.
Tranylcypromine Tranylcypromine The metabolism of Cyclophosphamide can be decreased when combined with Tranylcypromine.
Tetracycline Tetracycline The metabolism of Cyclophosphamide can be decreased when combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Cyclophosphamide.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Cyclophosphamide.
Trifluoperazine Trifluoperazine Cyclophosphamide may increase the neurotoxic activities of Trifluoperazine.
Sulfadiazine Sulfadiazine The metabolism of Cyclophosphamide can be decreased when combined with Sulfadiazine.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Cyclophosphamide.
Warfarin Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Cyclophosphamide.
Sulfinpyrazone Sulfinpyrazone The metabolism of Cyclophosphamide can be increased when combined with Sulfinpyrazone.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Cyclophosphamide.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Cyclophosphamide.
Levothyroxine Levothyroxine The metabolism of Cyclophosphamide can be decreased when combined with Levothyroxine.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Cyclophosphamide.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Cyclophosphamide.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Mercaptopurine.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Cyclophosphamide.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Cyclophosphamide.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Cyclophosphamide.
Thiothixene Thiothixene Cyclophosphamide may increase the neurotoxic activities of Thiothixene.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Cyclophosphamide.
Triazolam Triazolam The metabolism of Triazolam can be decreased when combined with Cyclophosphamide.
Trimethoprim Trimethoprim The metabolism of Cyclophosphamide can be decreased when combined with Trimethoprim.
Timolol Timolol The metabolism of Cyclophosphamide can be decreased when combined with Timolol.
Verapamil Verapamil The metabolism of Cyclophosphamide can be decreased when combined with Verapamil.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Cyclophosphamide.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of pulmonary toxicity can be increased when Erythropoietin is combined with Cyclophosphamide.
Teniposide Injection Teniposide Injection The metabolism of Cyclophosphamide can be increased when combined with Teniposide.
Tramadol Tramadol The metabolism of Cyclophosphamide can be increased when combined with Tramadol.
Ticlopidine Ticlopidine The metabolism of Cyclophosphamide can be decreased when combined with Ticlopidine.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Cyclophosphamide.
Indinavir Indinavir The serum concentration of the active metabolites of Cyclophosphamide can be increased when Cyclophosphamide is used in combination with Indinavir.
Zafirlukast Zafirlukast The metabolism of Cyclophosphamide can be decreased when combined with Zafirlukast.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Cyclophosphamide.
Nelfinavir Nelfinavir The serum concentration of the active metabolites of Cyclophosphamide can be increased when Cyclophosphamide is used in combination with Nelfinavir.
Sildenafil Sildenafil The metabolism of Cyclophosphamide can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Cyclophosphamide.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Cyclophosphamide.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Cyclophosphamide.
Rabeprazole Rabeprazole The metabolism of Cyclophosphamide can be decreased when combined with Rabeprazole.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists