Raloxifene

Generic name: Pronounced as (ral ox' i feen)
Brand names
  • Evista®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 10/15/2018

Taking raloxifene may increase the risk that you will develop a blood clot in your legs or lungs. Tell your doctor if you have or have ever had a blood clot in your legs, lungs, or eyes. Your doctor will probably tell you not to take raloxifene. Stop taking raloxifene and call your doctor immediately if you experience any of the following symptoms: leg pain; feeling of warmth in the lower leg; swelling of the hands, feet, ankles, or lower legs; sudden chest pain; shortness of breath; coughing up blood; or sudden changes in vision, such as loss of vision or blurred vision.

Remaining still for a long time may increase the chance that you will develop a blood clot. Your doctor will probably tell you to stop taking raloxifene at least three days before a scheduled surgery and not to take the medication if you require an extended period of bed rest for any reason. If you will be having surgery, be sure to tell your doctor that you are taking raloxifene. If you travel while you are taking raloxifene, avoid remaining still (such as sitting in an airplane or car) for long periods of time during your trip.

If you have coronary artery disease (hardening of the arteries that lead to the heart that may cause chest pain or heart attacks) or if you are at high risk of developing coronary artery disease, taking raloxifene may increase the chance that you will have a serious or fatal stroke. Tell your doctor if you have ever had a stroke or mini-stroke, if you smoke, and if you have or have ever had high blood pressure or an irregular heartbeat.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with raloxifene and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

Raloxifene is used to prevent and treat osteoporosis (condition in which the bones become thin and weak and break easily) in postmenopausal (women who have experienced a change of life; end of menstrual periods) women. Raloxifene is also used to decrease the risk of developing invasive breast cancer (breast cancer that has spread outside of the milk ducts or lobules into the surrounding breast tissue) in postmenopausal women who are at high risk of developing this type of cancer or who have osteoporosis. Raloxifene cannot be used to treat invasive breast cancer or to prevent invasive breast cancer from coming back in women who have already had the condition. Raloxifene also cannot be used to decrease the risk of developing noninvasive breast cancer. Raloxifene should not be used in women who have not yet experienced menopause. Raloxifene is in a class of medications called selective estrogen receptor modulators (SERMs). Raloxifene prevents and treats osteoporosis by mimicking the effects of estrogen (a female hormone produced by the body) to increase the density (thickness) of bone. Raloxifene decreases the risk of developing invasive breast cancer by blocking the effects of estrogen on breast tissue. This may stop the development of tumors that need estrogen to grow.

Raloxifene comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take raloxifene at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take raloxifene exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take raloxifene even if you feel well. Do not stop taking raloxifene without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking raloxifene,

  • tell your doctor and pharmacist if you are allergic to raloxifene, any other medications, or any of the ingredients in raloxifene tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), cholestyramine (Prevalite), colestipol (Colestid), diazepam (Valium), diazoxide (Proglycem), medications that contain estrogen such as hormone replacement therapy (ERT or HRT), and lidocaine (Akten, Lidoderm, Xylocaine). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have any type of cancer and if you have or have ever had breast lumps or breast cancer; heart failure; kidney disease; or liver disease. If you have ever taken estrogen, tell your doctor if your triglycerides increased during your treatment.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Do not become pregnant while taking raloxifene. If you become pregnant while taking raloxifene, call your doctor immediately. Raloxifene may harm the fetus.

  • you should know that raloxifene has not been found to cause spotting or menstrual-like bleeding nor to increase the risk of cancer of the lining of the uterus. Tell your doctor if you develop vaginal bleeding or spotting. Your doctor will need to examine you or order tests to find the cause of the bleeding.

  • you should know that although raloxifene decreases the chance that you will develop invasive breast cancer, there is still a risk that you will develop this condition. You will still need regularly scheduled breast exams and mammograms before you start taking raloxifene and during your treatment with raloxifene. Call your doctor if you notice tenderness, enlargement, lumps, or any other changes in your breasts.

  • if you are taking raloxifene to treat osteoporosis, talk to your doctor about other things you can do to prevent osteoporosis from developing or worsening. Your doctor will probably tell you to avoid smoking and drinking large amounts of alcohol and to follow a regular program of weight-bearing exercise.

You should eat and drink plenty of foods and drinks that are rich in calcium and vitamin D while you are taking raloxifene. Your doctor will tell you which foods and drinks are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods or if you have a condition that makes it difficult for your body to absorb the nutrients that you eat, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Raloxifene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • hot flashes (more common in the first 6 months of raloxifene therapy)

    • leg cramps

    • swelling of the hands, feet, ankles, or lower legs

    • flu-like syndrome

    • joint pain

    • sweating

    • difficulty falling asleep or staying asleep

  • Some side effects can be serious. If you experience any of the symptoms mentioned in the IMPORTANT WARNING section, call your doctor immediately.

  • Raloxifene may cause other side effects. Call your doctor if you experience any unusual symptoms while you are taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • leg cramps

  • dizziness

  • loss of coordination

  • vomiting

  • rash

  • diarrhea

  • tremor

  • flushing

Keep all appointments with your doctor and the laboratory.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Keoxifene

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Raloxifene.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Raloxifene.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Raloxifene.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Raloxifene.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Raloxifene.
Candesartan Candesartan The excretion of Raloxifene can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Raloxifene.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Raloxifene.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The excretion of Raloxifene can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Raloxifene can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Raloxifene.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Raloxifene.
Reserpine Reserpine The excretion of Raloxifene can be decreased when combined with Reserpine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Raloxifene.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Raloxifene.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Raloxifene.
Zidovudine Injection Zidovudine Injection The metabolism of Raloxifene can be increased when combined with Zidovudine.
Cyclosporine Cyclosporine The metabolism of Raloxifene can be decreased when combined with Cyclosporine.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Raloxifene.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Raloxifene.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Raloxifene.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Raloxifene.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Raloxifene.
Sirolimus Sirolimus The metabolism of Raloxifene can be decreased when combined with Sirolimus.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Raloxifene.
Atazanavir Atazanavir The metabolism of Raloxifene can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Raloxifene.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Raloxifene.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Raloxifene.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Raloxifene.
Progesterone Progesterone Progesterone may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Raloxifene.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Raloxifene.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Raloxifene.
Erlotinib Erlotinib The metabolism of Raloxifene can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Raloxifene.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Raloxifene.
Deferasirox Deferasirox The metabolism of Raloxifene can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Raloxifene can be increased when combined with Tipranavir.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Raloxifene.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Raloxifene.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Raloxifene.
Darunavir Darunavir The excretion of Raloxifene can be decreased when combined with Darunavir.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Raloxifene.
Sorafenib Sorafenib The metabolism of Raloxifene can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Raloxifene can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Raloxifene.
Dasatinib Dasatinib The metabolism of Raloxifene can be decreased when combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Raloxifene.
Ivermectin Ivermectin The excretion of Raloxifene can be decreased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Raloxifene can be decreased when combined with Temsirolimus.
Nilotinib Nilotinib The metabolism of Raloxifene can be decreased when combined with Nilotinib.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Raloxifene.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Raloxifene.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Raloxifene.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Raloxifene.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Raloxifene.
Eltrombopag Eltrombopag The metabolism of Raloxifene can be decreased when combined with Eltrombopag.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Raloxifene.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Raloxifene.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Raloxifene.
Everolimus Everolimus The metabolism of Raloxifene can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Raloxifene.
Dronedarone Dronedarone The metabolism of Raloxifene can be decreased when combined with Dronedarone.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Raloxifene.
Pazopanib Pazopanib The metabolism of Raloxifene can be decreased when combined with Pazopanib.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Raloxifene.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Raloxifene.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Raloxifene can be decreased when combined with Cabazitaxel.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Raloxifene.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Raloxifene.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Raloxifene.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Telaprevir Telaprevir The metabolism of Raloxifene can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Raloxifene.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Raloxifene.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Raloxifene.
Vandetanib Vandetanib The metabolism of Raloxifene can be decreased when combined with Vandetanib.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Raloxifene.
Vemurafenib Vemurafenib The metabolism of Raloxifene can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Axitinib Axitinib The metabolism of Raloxifene can be decreased when combined with Axitinib.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Raloxifene.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Raloxifene.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Raloxifene.
Regorafenib Regorafenib The metabolism of Raloxifene can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Raloxifene.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Raloxifene.
Ponatinib Ponatinib The metabolism of Raloxifene can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Raloxifene.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Raloxifene.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Raloxifene.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be decreased when combined with Raloxifene.
Ospemifene Ospemifene The risk or severity of adverse effects can be increased when Raloxifene is combined with Ospemifene.
Afatinib Afatinib Afatinib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Raloxifene.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Raloxifene.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Raloxifene.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Raloxifene.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Raloxifene.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Raloxifene.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Raloxifene.
Idelalisib Idelalisib The metabolism of Raloxifene can be decreased when combined with Idelalisib.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Raloxifene.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Raloxifene.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Raloxifene.
Olaparib Olaparib The metabolism of Raloxifene can be decreased when combined with Olaparib.
Caspofungin Injection Caspofungin Injection The excretion of Raloxifene can be decreased when combined with Caspofungin.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Raloxifene.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Raloxifene.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Raloxifene.
Palbociclib Palbociclib The metabolism of Raloxifene can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The excretion of Raloxifene can be decreased when combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Raloxifene.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Raloxifene.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Raloxifene.
Rolapitant Rolapitant Rolapitant may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Daclatasvir Daclatasvir Daclatasvir may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Raloxifene.
Eluxadoline Eluxadoline The excretion of Raloxifene can be decreased when combined with Eluxadoline.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Raloxifene.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Raloxifene.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Raloxifene.
Alectinib Alectinib The metabolism of Raloxifene can be decreased when combined with Alectinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Raloxifene.
Dexamethasone Injection Dexamethasone Injection Dexamethasone may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Raloxifene.
Venetoclax Venetoclax The metabolism of Raloxifene can be decreased when combined with Venetoclax.
Cobicistat Cobicistat Cobicistat may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Raloxifene.
Rucaparib Rucaparib The metabolism of Raloxifene can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Raloxifene.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Raloxifene.
Safinamide Safinamide Safinamide may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Midostaurin can be decreased when combined with Raloxifene.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Raloxifene.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Raloxifene.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Raloxifene.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Raloxifene.
Abemaciclib Abemaciclib The metabolism of Raloxifene can be decreased when combined with Abemaciclib.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Raloxifene.
Letermovir Letermovir Letermovir may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Ertugliflozin Ertugliflozin The metabolism of Raloxifene can be decreased when combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Apalutamide Apalutamide The metabolism of Raloxifene can be decreased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Raloxifene can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Baricitinib Baricitinib The metabolism of Raloxifene can be decreased when combined with Baricitinib.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Raloxifene.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Raloxifene.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Raloxifene.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Dacomitinib Dacomitinib The metabolism of Raloxifene can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Raloxifene.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Raloxifene.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Raloxifene.
Rifamycin Rifamycin The excretion of Raloxifene can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Raloxifene.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Raloxifene.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Raloxifene.
Alpelisib Alpelisib The metabolism of Alpelisib can be decreased when combined with Raloxifene.
Selinexor Selinexor The excretion of Raloxifene can be decreased when combined with Selinexor.
Darolutamide Darolutamide The serum concentration of Raloxifene can be increased when it is combined with Darolutamide.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Raloxifene.
Pexidartinib Pexidartinib The metabolism of Raloxifene can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Raloxifene.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Raloxifene.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Raloxifene.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Raloxifene.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Raloxifene.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Raloxifene.
Lasmiditan Lasmiditan The serum concentration of Raloxifene can be increased when it is combined with Lasmiditan.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Raloxifene.
Bempedoic Acid Bempedoic Acid The excretion of Raloxifene can be decreased when combined with Bempedoic acid.
Cenobamate Cenobamate The metabolism of Cenobamate can be decreased when combined with Raloxifene.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Raloxifene.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Raloxifene.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Raloxifene.
Remdesivir Injection Remdesivir Injection The excretion of Raloxifene can be decreased when combined with Remdesivir.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Capmatinib Capmatinib The serum concentration of Raloxifene can be increased when it is combined with Capmatinib.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Raloxifene.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Raloxifene.
Indomethacin Indomethacin The metabolism of Raloxifene can be decreased when combined with Indomethacin.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Raloxifene.
Phenobarbital Phenobarbital The metabolism of Raloxifene can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Raloxifene.
Primidone Primidone The metabolism of Raloxifene can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Raloxifene.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Raloxifene.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Raloxifene.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Raloxifene.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Raloxifene.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Raloxifene.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Raloxifene.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Raloxifene.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Raloxifene.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Raloxifene.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Raloxifene.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Raloxifene.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Raloxifene.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Raloxifene.
Digoxin Digoxin The excretion of Raloxifene can be decreased when combined with Digoxin.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Raloxifene.
Quinine Quinine The metabolism of Raloxifene can be decreased when combined with Quinine.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Raloxifene.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Raloxifene.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Raloxifene.
Probenecid Probenecid The metabolism of Raloxifene can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Raloxifene can be decreased when combined with Quinidine.
Rifampin Rifampin The metabolism of Raloxifene can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Raloxifene.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Raloxifene.
Levothyroxine Levothyroxine Raloxifene can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Raloxifene.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Raloxifene.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Raloxifene.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Raloxifene.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Raloxifene.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Raloxifene.
Nystatin Nystatin The excretion of Raloxifene can be decreased when combined with Nystatin.
Ketoconazole Ketoconazole The metabolism of Raloxifene can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Raloxifene.
Vincristine Injection Vincristine Injection The metabolism of Raloxifene can be decreased when combined with Vincristine.
Dipyridamole Dipyridamole The excretion of Raloxifene can be decreased when combined with Dipyridamole.
Vinblastine Vinblastine The metabolism of Raloxifene can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Raloxifene.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Raloxifene.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Raloxifene.
Nifedipine Nifedipine The excretion of Raloxifene can be decreased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Raloxifene.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Raloxifene.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Raloxifene.
Gemfibrozil Gemfibrozil The metabolism of Raloxifene can be decreased when combined with Gemfibrozil.
Pimozide Pimozide The metabolism of Raloxifene can be decreased when combined with Pimozide.
Flurbiprofen Flurbiprofen The metabolism of Raloxifene can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Raloxifene.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Raloxifene.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Raloxifene.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Raloxifene.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Raloxifene.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Raloxifene.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Raloxifene.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Raloxifene.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Raloxifene.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Raloxifene which could result in a lower serum level and potentially a reduction in efficacy.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Raloxifene.
Nefazodone Nefazodone The excretion of Raloxifene can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Raloxifene can be increased when combined with Lamotrigine.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Raloxifene.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Raloxifene.
Lansoprazole Lansoprazole Lansoprazole may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Raloxifene.
Nicardipine Nicardipine The metabolism of Raloxifene can be decreased when combined with Nicardipine.
Bupropion Bupropion The serum concentration of Bupropion can be increased when it is combined with Raloxifene.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Raloxifene.
Saquinavir Saquinavir Saquinavir may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Raloxifene.
Indinavir Indinavir The metabolism of Raloxifene can be decreased when combined with Indinavir.
Ritonavir Ritonavir Ritonavir may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Raloxifene.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Raloxifene.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Raloxifene.
Valsartan Valsartan The excretion of Raloxifene can be decreased when combined with Valsartan.
Nelfinavir Nelfinavir The metabolism of Raloxifene can be increased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Raloxifene.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Raloxifene.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Raloxifene.
Efavirenz Efavirenz The metabolism of Efavirenz can be decreased when combined with Raloxifene.
Sildenafil Sildenafil The excretion of Raloxifene can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Raloxifene.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Raloxifene.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Raloxifene.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Raloxifene.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists