FDA-filed SPL labeling · retrieved through openFDA

Oxymetazoline

Oxymetazoline is a decongestant and alpha-adrenergic agonist used across several products to relieve nasal congestion, reduce facial redness from rosacea, and treat drooping of the upper eyelid.

Brand names AfrinAllerest 12 Hour Nasal SprayDristan 12-Hour Nasal SprayDuramist PlusNeo-Synephrine 12 Hour +11 more
Drug class ⓘ Vasoconstrictor
Rx/OTC Forms 6 Routes Nasal · Topical · Ophthalmic
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 197 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveDec 11, 2023
Clinical labels in scope ⓘ197
AvailabilityRx/OTC
Earliest approval/marketing year ⓘ1975
FDA-listed product records ⓘ485
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 15, 2026 🚨Recall on record · 3
Other forms & routes:
Nasal Topical
⭐ Oxymetazoline at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Oxymetazoline is a versatile drug available in nasal sprays for temporary congestion relief, a facial cream for rosacea-related redness, and a prescription eye drop for drooping eyelids — each form used differently and for a distinct purpose. Do not use nasal sprays for more than 3 days, as overuse can make congestion worse. If you have heart disease, high blood pressure, glaucoma, or are pregnant, talk to your doctor or pharmacist before using any form.
How we write & review this content — our editorial policy →

📖 Oxymetazoline: Patient Information Guide

A plain-language walkthrough of Oxymetazoline — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Oxymetazoline is available in several different forms, each approved for a distinct use.

  • Nasal congestion relief: Nasal sprays — including Afrin, Dristan, CVS Severe Nasal Congestion Relief, Best Choice, Assured Nasal Relief Original, and Family Care Nasal Relief — temporarily relieve nasal congestion due to colds, hay fever, and other upper respiratory allergies. They also help relieve sinus congestion and pressure by shrinking swollen nasal membranes.
  • Facial redness from rosacea: Rhofade (topical cream) and Oxymetazoline Hydrochloride cream are approved to treat persistent facial erythema (redness) associated with rosacea in adults.
  • Drooping upper eyelid: Upneeq (ophthalmic solution/eye drops) is approved to treat acquired blepharoptosis — a drooping of the upper eyelid — in adults.
⚙️How it works▾

Oxymetazoline activates alpha-adrenergic receptors — proteins on the surface of blood vessel walls and muscle cells that signal them to contract. When blood vessels constrict (tighten), swelling and redness go down. In the nasal passages, this shrinks swollen tissue so air moves through more freely. Applied to the skin, the cream targets alpha-1A adrenoceptors to reduce the visible redness of rosacea. In Upneeq eye drops, oxymetazoline acts specifically on receptors in Mueller's muscle, a small muscle in the upper eyelid, causing it to contract and lift a drooping lid.

💊How it's taken▾

How you use oxymetazoline depends on the form prescribed or recommended.

  • Nasal sprays: 2 or 3 sprays per nostril for adults and children 6 and older, no more than every 10–12 hours, with a maximum of 2 doses in 24 hours. Do not use for more than 3 days in a row.
  • Facial cream (Rhofade and Oxymetazoline Hydrochloride): Apply a pea-sized amount once daily in a thin layer across the full face, avoiding eyes and lips. Wash hands right after.
  • Upneeq eye drops: One drop into the affected eye(s) once daily. Remove contact lenses first; wait 15 minutes before reinserting. If using other eye drops, wait at least 15 minutes between products.

Always follow the directions on your product label or from your prescriber — do not adjust timing or amount on your own.

🤒Side effects — in detail▾

Side effects vary by form. Here are the most common ones reported on the label:

  • Application site skin irritation or dermatitis (facial cream)
  • Worsening of inflammatory rosacea lesions (facial cream)
  • Itching, redness, or pain at the application site (facial cream)
  • Temporary burning, stinging, or sneezing (nasal spray)
  • Temporary increase in nasal discharge (nasal spray)

Stop nasal spray use and see a doctor if symptoms persist beyond 3 days. For eye drops, seek immediate care if you experience eye pain, redness, blurred vision, or light sensitivity — these may signal a serious eye condition.

⚠️Warnings & precautions▾
  • Drooping eyelid may signal a serious condition: Upneeq is used for eyelid drooping, but that drooping can sometimes be caused by neurological diseases like stroke, cerebral aneurysm, myasthenia gravis, or Horner syndrome. If drooping comes with other neurological symptoms, see a doctor before using eye drops.
  • Blood pressure effects: Because oxymetazoline affects blood vessels, it can influence blood pressure. People with cardiovascular disease, uncontrolled high or low blood pressure, or dizziness when standing (orthostatic hypotension) should use any form with caution and contact a doctor immediately if their condition worsens.
  • Nasal spray overuse: Using nasal spray for more than 3 days can cause rebound congestion — meaning your stuffy nose comes back worse. Stick to the 3-day limit.
  • Angle closure glaucoma risk: Upneeq may increase the risk of acute angle closure glaucoma in people with untreated narrow-angle glaucoma. Seek emergency care if you develop eye pain, redness, blurred vision, or sensitivity to light.
  • Children and accidental ingestion: Keep all oxymetazoline products out of children's reach. If a child swallows any form, call Poison Control immediately at 1-800-222-1222.
🔀What it interacts with▾

Oxymetazoline can interact with several types of medications because of its effects on blood vessels and the nervous system.

  • Beta-blockers and antihypertensives (blood pressure medications): Oxymetazoline may affect blood pressure, making these combinations potentially unpredictable.
  • Cardiac glycosides (heart rhythm medications): Use with caution alongside oxymetazoline.
  • Alpha-adrenergic receptor blockers (used for heart disease or benign prostatic hypertrophy — an enlarged prostate): May interact with oxymetazoline's mechanism of action.
  • MAO inhibitors (certain antidepressants): These can affect how the body processes oxymetazoline; use with caution and inform your prescriber.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Tell your doctor if you have heart disease, high blood pressure, thyroid disease, or diabetes before using nasal sprays.
  • Tell your doctor if you have difficulty urinating due to an enlarged prostate before using nasal sprays.
  • Upneeq should be used with caution if you have severe or unstable cardiovascular disease, uncontrolled high or low blood pressure, or cerebral or coronary insufficiency (reduced blood flow to the brain or heart).
  • Tell your eye doctor if you have glaucoma — Upneeq may increase the risk of angle closure glaucoma in people with untreated narrow-angle glaucoma.
  • Tell your doctor if you have Sjögren's syndrome, as Upneeq should be used with caution.
  • Pregnancy: A possible link between second-trimester nasal oxymetazoline use and kidney development abnormalities in the baby has been identified in one study. Discuss the risks with your doctor before using any form during pregnancy.
  • Breastfeeding: It is not known how much oxymetazoline passes into breast milk. Talk to your healthcare provider before using.
  • Children: The facial cream has not been studied in children under 18. Nasal sprays should not be used in children under 6 without a doctor's guidance, and not at all in children under 2.
  • Older adults: Clinical trials of the facial cream did not find major safety differences in adults 65 and older compared to younger adults, but individual monitoring remains appropriate.
🚑If you take too much▾

The facial cream and eye drops are not for swallowing — if ingested accidentally, seek medical advice immediately. Accidental swallowing of oxymetazoline nasal spray — especially by children — has caused serious problems including nausea, vomiting, drowsiness, irregular heart rate, low blood pressure, and even coma. If this happens, call Poison Control right away at 1-800-222-1222 or go to the emergency room.

📡Pharmacodynamics — effects in the body▾

In clinical studies of Upneeq, the effect on eyelid lift was measured using a standard distance called MRD1 (marginal reflex distance 1) — the gap between the pupil's light reflection and the edge of the upper eyelid. The greatest eyelid lift was seen about 2 hours after a dose, and the effect continued through 8 hours after dosing. This shows Upneeq provides meaningful eyelid elevation for the better part of a day with once-daily use.

🔬Pharmacokinetics — how your body processes it▾

When oxymetazoline cream is applied to the face, small amounts are absorbed into the bloodstream, but levels remain very low. The drug is about 57% bound to plasma proteins in the blood. It is minimally broken down (metabolized) by the liver — studies show that nearly 96% of the drug remains unchanged after 2 hours of processing by liver enzymes. In lab studies, oxymetazoline did not significantly interfere with the liver enzyme system (cytochrome P450) that processes many other medications. How the body eliminates oxymetazoline after skin application has not been fully studied in humans.

📦How to store it▾

store between 20° and 25°C (68° to 77°F) retain carton for future reference on full labeling

📄 Written from Oxymetazoline’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Oxymetazoline — the kind of thing our pharmacy team would talk through with you at the counter.

Can I use the nasal spray for more than a few days if my congestion keeps coming back? ▾
It's really important to stick to 3 days maximum with oxymetazoline nasal spray. Using it longer can actually make your congestion worse — this is called rebound congestion, where your nose becomes dependent on the spray just to feel normal. If your stuffiness isn't better after 3 days, stop the spray and talk to your doctor about other options.
What exactly does Upneeq do for a drooping eyelid — will it fix the problem permanently? ▾
Upneeq doesn't fix the underlying cause of the drooping — it temporarily lifts the lid by stimulating a small muscle in your eyelid. The effect kicks in around 2 hours after you use it and lasts through most of the day. You'd use it once daily as needed. One important thing: a drooping eyelid can sometimes be a sign of a more serious neurological condition, so your doctor should evaluate it before you start using the drops.
I use blood pressure medication. Is it safe to use oxymetazoline? ▾
You should definitely let your doctor or pharmacist know before using any form of oxymetazoline. Because it constricts blood vessels, it can affect blood pressure and may interact with medications like beta-blockers, other antihypertensives, and certain heart medications. It doesn't mean you can't use it, but your provider should weigh in on whether it's appropriate for you.
Can I use the facial cream if I'm pregnant or breastfeeding? ▾
There's limited safety data for oxymetazoline cream during pregnancy. One study found a possible link between second-trimester nasal spray use and a kidney development issue in newborns — though the exposure levels were much higher than from the cream. It's not known how much gets into breast milk either. Play it safe and have a conversation with your doctor before using it while pregnant or nursing.
My child accidentally got into the nasal spray. What should I do? ▾
Don't wait — call Poison Control right away at 1-800-222-1222. Children who swallow oxymetazoline nasal spray can have serious reactions including drowsiness, slow breathing, changes in heart rate, and in severe cases, loss of consciousness. Always keep oxymetazoline products locked up and out of children's reach.
How do I apply Rhofade cream correctly so it works and doesn't irritate my skin? ▾
Use just a pea-sized amount — that's enough to cover your whole face in a thin layer, including your forehead, nose, cheeks, and chin. Avoid getting it near your eyes or lips. If you're using a pump bottle, prime it first before the initial use and throw away those first pumps. Wash your hands right after applying. Stick to once daily — using it more often doesn't make it work better and may cause more skin irritation.
Is Oxymetazoline available over the counter? ▾
Both — Oxymetazoline is sold both over the counter and by prescription, according to its FDA labeling. Lower strengths or certain forms are often available without a prescription, while higher strengths or specialized forms still require one. Ask your pharmacist which version is right for you.
When was Oxymetazoline first available? ▾
Oxymetazoline has been available in the United States since at least 1975, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Oxymetazoline? ▾
Oxymetazoline is supplied by 109 manufacturers listed in the FDA NDC Directory, including Bayer HealthCare LLC., Best Choice (valu Merchandisers Company), Topco Associates LLC.

💬 Answers drafted from Oxymetazoline’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

🌿Drug & Supplement CheckerOxymetazoline vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Oxymetazoline NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Oxymetazoline comes

Oxymetazoline is available in 6 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Nasal spray

In the nose
Brands Afrin Best Choice Nasal Nostrilla Vicks Sinex
How this form is used
What it may be used for
  • Temporarily relieves nasal congestion due to colds, hay fever, or other upper respiratory allergies
  • Helps relieve sinus congestion and pressure
  • Shrinks swollen nasal membranes to help restore easier breathing
Important instructions
  • For adults and children 6 and older: 2 or 3 sprays in each nostril, no more than every 10–12 hours; do not exceed 2 doses in 24 hours
  • Do not use for more than 3 days — prolonged use can cause congestion to come back or worsen
  • Shake well before use; without tilting your head, insert nozzle into nostril and spray with a firm, even stroke while sniffing deeply
  • Wipe the nozzle clean after each use and do not share the container with others
Available strengths 15 strengths
0.05 mg/100 mL 0.05 mg/mL 0.0005 g/mL 0.5 mg/mL 0.0005095 g/mL 7.5 mg/15 mL
Show 9 more strengths Show fewer strengths
15 mg/30 mL 0.025 g/100 mL 0.05 g/15 mL 0.05 g/100 mL 0.05 g/mL 50 mg/100 mL 50 mg/mL 0.5 g/100 mL 5 g/100 mL
453 FDA-listed product records ⓘ

Topical cream, ointment or gel

On the skin
Brands Rhofade
How this form is used
What it may be used for
  • Rhofade is used to treat persistent facial redness (erythema) associated with rosacea in adults
  • Oxymetazoline Hydrochloride cream is used to treat persistent facial redness associated with rosacea in adults
Important instructions
  • Rhofade: prime the pump before the first use by pressing until cream is dispensed, then pump 3 more times and discard that cream; tube forms do not require priming
  • Rhofade and Oxymetazoline Hydrochloride cream: apply a pea-sized amount once daily in a thin layer across the entire face — forehead, nose, cheeks, and chin — avoiding eyes and lips
  • Wash hands immediately after applying
  • For topical use only — not for use in the eyes, by mouth, or vaginally
Available strengths 2 strengths
10 mg/g 1 g/100 g
7 FDA-listed product records ⓘ

Topical solution

On the skin
Available strengths 2 strengths
0.5 mg/mL 0.05 g/100 mL
6 FDA-listed product records ⓘ

Eye drops

In the eye
Brands Upneeq
How this form is used
What it may be used for
  • Upneeq is used to treat acquired blepharoptosis (drooping of the upper eyelid) in adults
Important instructions
  • Upneeq: instill one drop into the affected eye(s) once daily
  • Upneeq: remove contact lenses before applying; wait 15 minutes before reinserting them
  • Upneeq: if using other eye drops, wait at least 15 minutes between each product
  • Upneeq: do not touch the dropper tip to your eye or any surface — discard the single-use container right after use
Available strengths 1 strength
1 mg/mL
4 FDA-listed product records ⓘ

Topical spray

On the skin
Brands Afrin
Available strengths 1 strength
0.05 g/100 mL
3 FDA-listed product records ⓘ

Nasal topical

In the nose
Available strengths 1 strength
0.05 {VP}/100{VP}
2 FDA-listed product records ⓘ

📊 Oxymetazoline across the U.S. market

How Oxymetazoline appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

6
Dose forms ⓘ
109
Manufacturers
40
Brand names
485
FDA-listed product records ⓘ
1975
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (9) · Kit (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bayer HealthCare LLC.9%
Best Choice (valu Merchandisers Company)6%
Topco Associates LLC4%
Discount Drug Mart4%
Procter & Gamble Manufacturing GmbH4%
Cvs Pharmacy, Inc.4%
Other makers68%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Oxymetazoline is used

A general measure of how commonly Oxymetazoline is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Oxymetazoline is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

20,124
Medicaid prescriptions filled (Q1–Q4 2025)
$2.1M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Oxymetazoline prescribed? Of the 1,594 medications we measure, Oxymetazoline ranks #796 by Medicaid prescriptions — more than 50% of them.

Where Oxymetazoline ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #796 of 1,594
#791 Vigabatrin 20,288 Rx #792 Sodium Acetate 20,278 Rx #793 Milrinone 20,244 Rx #794 Revefenacin Oral Inhal... 20,174 Rx #795 Raloxifene 20,163 Rx #796 Oxymetazoline 20,124 Rx #797 Budesonide Nasal Spray 20,113 Rx #798 Efinaconazole Topical 19,808 Rx #799 Gemcitabine Injection 19,565 Rx #800 Gemcitabine 19,565 Rx #801 Benazepril and Hydroch... 19,477 Rx

Utilization by Oxymetazoline product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.5 mg/mL nasal spray is the most-dispensed Oxymetazoline product — about 86% of these Medicaid prescriptions.

oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray Most dispensed

17,358 Medicaid prescriptions (Q1–Q4 2025) 86% of Oxymetazoline prescriptions shown $165,829 gross reimbursement (before rebates) ≈ $9.55 per prescription (gross)

Summed across the 11 of 351 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1000990

oxymetazoline hydrochloride 10 MG/ML Topical Cream

2,766 Medicaid prescriptions (Q1–Q4 2025) 14% of Oxymetazoline prescriptions shown $1.9M gross reimbursement (before rebates) ≈ $705 per prescription (gross)

Summed across the 2 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1869816

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Oxymetazoline, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 13 of 356 listed Oxymetazoline NDCs with Medicaid activity.

🔍 Compare Oxymetazoline products

A representative set of FDA-listed product records for Oxymetazoline — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 485 products — FDA National Drug Code Directory. See every product, package size and price: browse all 485 Oxymetazoline NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Oxymetazoline RxCUI 7812 5 dose forms · 10 strengths
  1. Dose form (SCDF) Nasal Gel RxCUI 2474263 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.0005 MG/MG RxCUI 2474264
  2. Dose form (SCDF) Nasal Solution RxCUI 377397 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.25 MG/ML RxCUI 1000978 hydrochloride 0.5 MG/ML RxCUI 1000987
  4. Dose form (SCDF) Ophthalmic Solution RxCUI 377448 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.25 MG/ML RxCUI 1000981 hydrochloride 0.5 MG/ML RxCUI 1001378 hydrochloride 1 MG/ML RxCUI 2391749
  5. Dose form (SCDF) Topical Cream RxCUI 1869815 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 10 MG/ML RxCUI 1869816

Look up RxCUI 7812 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Afrin Allerest 12 Hour Nasal Spray Dristan 12-Hour Nasal Spray Duramist Plus Neo-Synephrine 12 Hour Nostrilla Sinex Long-Acting Sudafed OM Zicam Sinus Relief Sinufrin Plus Qlearquil Nasal Decongestant Rhofade Upneeq nasal Best Choice Vicks Sinex

🏭 Manufacturers & labelers

Bayer HealthCare LLC. 31 Best Choice (valu Merchandisers Company) 21 Topco Associates LLC 15 Discount Drug Mart 15 Procter & Gamble Manufacturing GmbH 14 Cvs Pharmacy, Inc. 12 Strategic Sourcing Services LLC 12 WinCo FOODS, LLC 12 Rite Aid Corporation 10 Safeway 10 Dolgencorp, LLC 9 Amerisource Bergen 9 L. Perrigo Company 9 Publix Super Markets, Inc 9 Lil' Drug Store Products, Inc. 9 Chain Drug Marketing Association 9 Kroger Company 8 Meijer Distribution Inc 8 Lil' Drug Store Products, Inc 8 H E B 7 CVS Health 7 Church & Dwight Co., Inc. 7 A-S Medication Solutions 7 Amazon.com Services LLC 7

…and 16 more on the FDA NDC directory.

RxNorm drug class

Oxymetazoline belongs to the Vasoconstrictor class.

Pharmacologic class Vasoconstrictor
Drug family (ATC) Other dermatologicals, Sympathomimetics, plain, Sympathomimetics used as decongestants

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Dec 11, 2023
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Oxymetazoline.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Oxymetazoline after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
197
NDC products indexed
485
Distinct labelers/manufacturers represented
109
Linked representative label ⓘ
FAMILY DOLLAR (Family Wellness)
Linked label effective
Dec 11, 2023
Composite sections available
11
Linked SPL Set ID
0c006b1c-8ab2-4b9c-8738-e7001c1bb47d
Linked SPL Document ID
3c853555-c557-4b90-bc8f-277c59c65cbe
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 197 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. FAMILY DOLLAR (Family Wellness) is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.