Oxymetazoline

Name: Oxymetazoline Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions 1 explained in plain English

Also sold as: Afrin Allerest 12 Hour Nasal Spray Dristan 12-Hour Nasal Spray Duramist Plus Neo-Synephrine 12 Hour Nostrilla Qlearquil Nasal Decongestant Rhofade Sinex Long-Acting Sinufrin Plus Sudafed OM Upneeq Zicam Sinus Relief

Read the full Oxymetazoline drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Fentanyl Transdermal Patch Labetalol Levobunolol Ophthalmic Linezolid Injection Nadolol

8 Major

All (8) Major (8)

Major

Oxymetazoline Amitriptyline Elavil Explained Increased blood pressure Details Oxymetazoline Fentanyl Transdermal Patch Duragesic® Reduced analgesic effect Details Oxymetazoline Labetalol Normodyne® Increased blood pressure Details Oxymetazoline Levobunolol Ophthalmic AKBeta® Increased blood pressure Details Oxymetazoline Linezolid Injection Zyvox Increased blood pressure Details Oxymetazoline Nadolol Corgard Increased blood pressure Details Oxymetazoline Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Oxymetazoline Penbutolol Levatol® Increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.