Cyclophosphamide

88 interactions 1,015 cited references

Also sold as: Cytoxan® Frindovyx

About Cyclophosphamide

Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that fir… Read the full Cyclophosphamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Varicella Virus Vaccine, Live Yellow Fever Vaccine Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live

9 Contraindicated 47 Major 31 Moderate 1 Minor

All (88) Contraindicated (9) Major (47) Moderate (31) Minor (1)

Contraindicated

Cyclophosphamide Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Cyclophosphamide Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Cyclophosphamide Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Cyclophosphamide Abametapir Increased exposure of CYP2B6 substrates Details Cyclophosphamide Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Amprenavir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Articaine An increased risk of methemoglobinemia Details Cyclophosphamide Atazanavir Reyataz Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Boceprevir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Cannabidiol Epidiolex Altered (increased or reduced) CYP2B6 substrates exposure Details Cyclophosphamide Carbamazepine Carbatrol Increased risk of cycloPHOSphamide toxicity Details Cyclophosphamide Ceritinib Zykadia Decreased cyclophosphamide efficacy Details Cyclophosphamide Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Cyclophosphamide Cobicistat Tybost Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Cyclosporine Atopica Decreased serum cycloSPORINE concentration Details Cyclophosphamide Darunavir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Doxorubicin Adriamycin Increased risk of cardiomyopathy Details Cyclophosphamide Doxorubicin Hydrochloride Liposome Increased risk of cardiomyopathy Details Cyclophosphamide Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Eslicarbazepine Acetate Aptiom Increased exposure of CYP2C19 substrates Details Cyclophosphamide Etanercept Higher incidence of developing non-cutaneous solid malignancies Details Cyclophosphamide Fexinidazole Decreased plasma concentrations of CYP2B6 substrate Details Cyclophosphamide Fosamprenavir Lexiva Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Fosphenytoin Cerebyx Increased plasma concentrations of the active metabolite of cyclophosphamide and an increased risk of toxicity Details Cyclophosphamide Idarubicin Idamycin Increased risk of cardiotoxicity Details Cyclophosphamide Indinavir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Lemborexant Dayvigo Reduced CYP2B6 substrates exposure and reduced efficacy of CYP2B6 substrates Details Cyclophosphamide Lidocaine Akten An increased risk of methemoglobinemia Details Cyclophosphamide Lopinavir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Nelfinavir Viracept Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Nevirapine Viramune Reduced cycloPHOSphamide exposure Details Cyclophosphamide Nilotinib Decreased cyclophosphamide efficacy Details

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