Drug & supplement interaction

Kudzu + Cyclophosphamide

Cyclophosphamide brand names: Cytoxan, Neosar.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Kudzu has a moderate interaction with Cyclophosphamide. Theoretically, concomitant use might have additive hepatotoxic effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Kudzu and Cyclophosphamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

HEPATOTOXIC DRUGS

Why this applies to Cyclophosphamide

Cyclophosphamide falls under HEPATOTOXIC DRUGS — the group Kudzu interacts with.

Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Cyclophosphamide (Cytoxan, Neosar) and kudzu. This is a strong chemotherapy drug, and one of the things doctors watch during treatment is your liver. Kudzu, on its own, has raised some questions about being hard on the liver too. So the worry here is simple: putting two liver stressors together could, in theory, add up and put more strain on that organ.

I want to be honest about how solid this is. The concern is theoretical, based on how each one behaves, not on real cases of people getting hurt by combining them. It's not about kudzu changing how well your chemo works. Still, because cyclophosphamide is serious medicine and your care team is already tracking your liver, please loop in your oncologist or pharmacist before adding kudzu so they can decide what's safe for you.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kim HJ, Kim H, Ahn JH, Suk JH. Liver injury induced by herbal extracts containing mistletoe and kudzu. J Altern Complement Med 2015;21(3):180-5. PubMed
  2. Santosh N, Mohan K, Royana S, Yamini TB. Hepatotoxicity of tubers of Indian Kudzu (Pueraria tuberosa) in rats. Food Chem Toxicol. 2010 Apr;48(4):1066-71. PubMed
  3. Teschke R, Zhang L, Long H, Schwarzenboeck A, Schmidt-Taenzer W, Genthner A, Wolff A, Frenzel C, Schulze J, Eickhoff A. Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases. Ann Hepatol. 2015 Jan-Feb;14(1):7-19. DOI
  4. Wang D, Qiu L, Wu X, Wei H, Xu F. Evaluation of kudzu root extract-induced hepatotoxicity. J Ethnopharmacol. 2015 Dec 24;176:321-6. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Kudzu Also Interacts With Other Medications

Kudzu has 513 moderate, 72 minor known drug interactions in our database — the Cyclophosphamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 513 Minor 72 No known interaction 2,245 (incl. Cyclophosphamide)
Taking anything else?

Check Another of Your Medications Against Kudzu

Covers the 2,830 medications we’ve checked against Kudzu. Pick one to open its full report.

From our Q&A

Questions About Kudzu or Cyclophosphamide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Kudzu or Cyclophosphamide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Cyclophosphamide

This page covers Kudzu only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cyclophosphamide page lists 220 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 176 moderate · 38 minor.

Open the Cyclophosphamide interaction page

One more smart check

Taking Kudzu as Part of a Dietary Supplement Product? Check It for Interactions

We hold 536 real supplement products containing Kudzu, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kudzu. Your product may carry other ingredients that interact with Cyclophosphamide too, on top of Kudzu — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Kudzu and Cyclophosphamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kudzu
Top 25%

#272 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cyclophosphamide
Steady interest

#1,534 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Kudzu

What is Kudzu?

Kudzu
  • Alcohol cravings and reduction
  • Menopausal symptoms
  • Heart and blood vessel health
  • Hangover relief
  • Traditional Chinese medicine (Ge Gen)

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back on drinking, but evidence for most other uses is weak. Talk with your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Read the full Kudzu monograph & all interactions
Medication

About Cyclophosphamide

What Is Cyclophosphamide Used For?

Brand names: Cytoxan, Neosar

Cyclophosphamide is used mainly to treat cancers in adults and, for most products, in children. These include malignant lymphomas (including Hodgkin's disease and Burkitt's lymphoma), multiple myeloma, leukemias, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma and breast cancer. It is often used with other cancer drugs.

Some products are also approved for children with biopsy-proven minimal change nephrotic syndrome (a kidney condition) who did not respond to steroids or cannot tolerate them. This use appears on the Cyclophosphamide capsule, tablet and some injection powder labels. It is not listed for Frindovyx or for Cyclophosphamide Injection solution products. One Cyclophosphamide Injection concentrate is for adults only, because of its alcohol and propylene glycol content.

See full Cyclophosphamide drug information
Keep checking

Other Drugs & Kudzu

Browse every other medication we’ve checked against Kudzu — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
513Moderate
72Minor
2,244No known interaction
513 Moderate 72 Minor 2,244 No interaction
Moderate

513 interactions

Showing 60 of 513 moderate interactions — see all 513 on the Kudzu page.

Minor

72 interactions

Showing 60 of 72 minor interactions — see all 72 on the Kudzu page.

No interaction 2,244 drugs checked — show the list

We also checked Kudzu against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,244 medications checked with no known interaction — see the full Kudzu list.

See the full Kudzu interactions page
See every supplement checked against Cyclophosphamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Kudzu monograph › Uses, safety, and every drug interaction in one place Cyclophosphamide supplement interactions › Every supplement checked against Cyclophosphamide, ranked by severity Cyclophosphamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Kudzu and Cyclophosphamide Together: Common Questions

Can you take Kudzu with Cyclophosphamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Kudzu and Cyclophosphamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Cyclophosphamide and Kudzu?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.