Drug & supplement interaction

Kudzu + Dapagliflozin

Dapagliflozin brand name: Farxiga.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Kudzu has a minor interaction with Dapagliflozin. Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Kudzu and Dapagliflozin

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANTIDIABETES DRUGS

Why this applies to Dapagliflozin

Dapagliflozin falls under ANTIDIABETES DRUGS — the group Kudzu interacts with.

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: kudzu may nudge your blood sugar down a little on its own. Since dapagliflozin (Farxiga) also works to lower blood sugar, putting the two together could, in theory, add up and push your numbers lower than expected. If that happened, you might notice signs of low blood sugar like shakiness, sweating, dizziness, or feeling lightheaded.

I want to be honest about how strong this concern is though. The evidence here is very weak, coming from lab and animal studies rather than real people, and an actual problem is considered unlikely. On its own, dapagliflozin rarely causes serious lows. Still, if you take other diabetes meds too, it's worth a quick chat with your pharmacist or doctor and keeping an eye on your readings before adding kudzu.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lee KT, Sohn IC, Kim DH, et al. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000;23:461-6.
  2. Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 2003;66:788-92. PubMed
  3. Hsu, H. H., Chang, C. K., Su, H. C., Liu, I. M., and Cheng, J. T. Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. Planta Med 2002;68(11):999-1003.
  4. Hou, Q., Ao, X., Li, G., and Zhang, Y. [Puerarin combined with avandia for diabetic nephropathy]. Zhong.Nan.Da.Xue Xue Bao Yi Xue Ban. 2012;37(1):73-77.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Kudzu Also Interacts With Other Medications

Kudzu has 512 moderate, 71 minor known drug interactions in our database — the Dapagliflozin one above is one of them. If you take anything else, check it against the full list below.

Moderate 512 Minor 71 No known interaction 2,247 (incl. Dapagliflozin)
Taking anything else?

Check Another of Your Medications Against Kudzu

Covers the 2,830 medications we’ve checked against Kudzu. Pick one to open its full report.

From our Q&A

Questions About Kudzu or Dapagliflozin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Kudzu or Dapagliflozin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dapagliflozin

This page covers Kudzu only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dapagliflozin page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Dapagliflozin page

“Dapagliflozin (Farxiga) lowers blood sugar through the kidneys, and I ask anyone taking it to treat this supplement list with real care. Of the 256 ingredients on this list, 239 touch blood sugar control, and two rate major: Siberian cocklebur has caused severe hypoglycemia, dangerously low blood sugar, in people who ate it, and activa…”

Reviewed by 2 · Jul 18, 2026

Open the Dapagliflozin interaction page

One more smart check

Taking Kudzu as Part of a Dietary Supplement Product? Check It for Interactions

We hold 536 real supplement products containing Kudzu, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kudzu. Your product may carry other ingredients that interact with Dapagliflozin too, on top of Kudzu — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Kudzu and Dapagliflozin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kudzu
Top 25%

#254 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dapagliflozin
Top 25%

#394 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Kudzu

What is Kudzu?

Kudzu
  • Alcohol cravings and reduction
  • Menopausal symptoms
  • Heart and blood vessel health
  • Hangover relief
  • Traditional Chinese medicine (Ge Gen)

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back on drinking, but evidence for most other uses is weak. Talk with your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Read the full Kudzu monograph & all interactions
Medication

About Dapagliflozin

What Is Dapagliflozin Used For?

Brand name: Farxiga

Dapagliflozin is used for several serious conditions. It helps improve blood sugar control in adults and children aged 10 and older with type 2 diabetes (alongside diet and exercise). It also reduces the risk of hospitalization for heart failure in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors.

Farxiga (dapagliflozin) is additionally approved to reduce the risk of cardiovascular death, hospitalization, and urgent visits due to heart failure in adults with heart failure — and to slow the progression of chronic kidney disease, including reducing the risk of kidney failure and cardiovascular death, in adults with chronic kidney disease at risk of getting worse.

See full Dapagliflozin drug information
Keep checking

Other Drugs & Kudzu

Browse every other medication we’ve checked against Kudzu — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
512Moderate
71Minor
2,246No known interaction
512 Moderate 71 Minor 2,246 No interaction
Moderate

512 interactions

Showing 60 of 512 moderate interactions — see all 512 on the Kudzu page.

Minor

71 interactions

Showing 60 of 71 minor interactions — see all 71 on the Kudzu page.

No interaction 2,246 drugs checked — show the list

We also checked Kudzu against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,246 medications checked with no known interaction — see the full Kudzu list.

See the full Kudzu interactions page
See every supplement checked against Dapagliflozin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Kudzu monograph › Uses, safety, and every drug interaction in one place Dapagliflozin supplement interactions › Every supplement checked against Dapagliflozin, ranked by severity Dapagliflozin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Kudzu and Dapagliflozin Together: Common Questions

Can you take Kudzu with Dapagliflozin?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Kudzu and Dapagliflozin interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dapagliflozin and Kudzu?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.