Spotted Geranium Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Spotted Geranium interacts with medications. The heart of this page is the interaction list — every drug Spotted Geranium is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Spotted Geranium is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Spotted Geranium against your medication
Add one medicationDrugs that interact with Spotted Geranium
0 medications have a known interaction with Spotted Geranium, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Spotted Geranium. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Spotted Geranium combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Spotted Geranium: Uses, Safety & Side Effects
Spotted Geranium (Geranium maculatum), also called wild geranium or cranesbill, is a North American woodland plant whose tannin-rich root has long been used in folk medicine as an astringent for diarrhea, minor bleeding, and mouth or throat irritation. Modern human studies are very limited, so its effectiveness is largely unproven. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
- Scientific name
- Geranium maculatum
- Family
- Geraniaceae
- Part used
- Root and rhizome (sometimes the dried leaves)
- Common forms
- Dried root, tea, tincture, powder, capsules
- Diarrhea
- Mouth and throat sores
- Bleeding and wound care
- Hemorrhoids
- Sore throat gargle
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used in small amounts traditionally, but modern safety data are limited.
Insufficient reliable evidence available; avoid using.
Read the full pregnancy detailInsufficient reliable evidence available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Spotted Geranium (Geranium maculatum) is a wildflower native to the woodlands and meadows of eastern North America. It is also known as wild geranium, cranesbill, or alumroot, and it produces pink-purple flowers in spring. It is not the same plant as the scented houseplant geraniums (which belong to the genus Pelargonium).
The part most often used in herbal medicine is the root and rhizome, which is very rich in plant tannins. Native American and early American folk traditions used the dried root as an astringent — something that tightens and dries tissues. It was made into teas, gargles, and washes for diarrhea, sore mouths, and minor wounds.
Today it is mainly found as a dried herb, tincture, or in some herbal blends. It is not a common or well-studied supplement.
Uses & effectiveness
Spotted Geranium has a long history of traditional use, but high-quality human research is lacking. Most of what we know comes from its tannin content and from how similar astringent herbs behave, not from modern clinical trials.
People have traditionally used it for:
- Diarrhea: Tannins can tighten the gut lining, which is the basis for this traditional use, but it has not been proven in good studies.
- Mouth and throat irritation: Used as a gargle or rinse for sore throats, canker sores, and inflamed gums.
- Minor bleeding and wounds: Applied to the skin or used as a wash to help stop minor bleeding and dry weeping skin.
- Hemorrhoids: Used as a soothing, astringent wash.
Overall, the evidence is insufficient to confirm that Spotted Geranium works for any specific condition. Consider it an option with traditional support but little scientific proof.
How it works
The root is high in tannins, a group of plant compounds that bind to proteins. This binding action is thought to tighten and dry out tissues, which is what "astringent" means. By tightening surface tissues, tannins may help reduce minor oozing, bleeding, or fluid loss — for example in diarrhea or on irritated skin.
Tannins may also have mild antimicrobial and anti-inflammatory effects in laboratory settings. However, most of this information comes from test-tube studies of tannins in general, not from studies of Spotted Geranium in people. The exact compounds and how well they work in the human body are not well defined.
Safety & precautions
There is not much modern safety data on Spotted Geranium. In small amounts used traditionally, it has generally been considered fairly safe for short-term use, but this should not be taken as proof that it is safe for everyone.
Because the root is high in tannins, large amounts or long-term use may irritate the stomach and could, in theory, interfere with how the body absorbs some nutrients like iron. People with stomach problems, ulcers, or sensitive digestion should be cautious.
Pregnancy and breastfeeding: There is not enough reliable information to know if Spotted Geranium is safe during pregnancy or while breastfeeding. To be safe, avoid it during these times.
Do not give it to children without medical advice. Always tell your pharmacist or doctor about any herbal products you take, especially if you have a health condition or take other medicines.
Side effects
Reported side effects are not well documented because the plant has not been widely studied. Based on its high tannin content, possible effects include:
- Stomach upset, nausea, or constipation, especially with strong or frequent use
- Mouth dryness or a puckering feeling when used as a gargle
- Possible reduced absorption of certain nutrients with long-term use
Allergic reactions are always possible with any plant product. Stop using it and seek care if you notice a rash, swelling, or trouble breathing.
Dosing
There is no established standard dose for Spotted Geranium. Traditional use involved teas, tinctures, and gargles made from the dried root, but amounts varied widely and were not standardized.
If you choose to use a commercial product, follow the directions on the label and do not exceed them. Because reliable dosing information is lacking, it is best to check with a pharmacist or doctor before starting, and to use it only for short periods.
Spotted Geranium & Pregnancy
Spotted Geranium & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 sources that drive our Spotted Geranium monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
- Herbs at a Glance — NIH NCCIH Source
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Brands that make products with Spotted Geranium
2 brands in our database make a supplement containing Spotted Geranium.
Supplement products with Spotted Geranium
2 products in our database contain Spotted Geranium. Open any to see its full ingredient list and every drug interaction we check.
Spotted Geranium: Common Questions
Does Spotted Geranium interact with prescription medications?
How are Spotted Geranium interactions rated?
Is it safe to take Spotted Geranium with my medications?
Where does this Spotted Geranium interaction information come from?
What is Spotted Geranium used for?
Is Spotted Geranium the same as the geranium houseplant?
Is Spotted Geranium safe to take?
Can I use it during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Spotted Geranium
A rotating sample of real supplements in our database that list Spotted Geranium — open any to see its full ingredients and every drug interaction we check.
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