Herb & supplement monograph

Spotted Geranium Drug Interactions, Uses, Safety & More

Check Spotted Geranium against your medication

Add one medication
Spotted Geranium
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Spotted Geranium

0 medications have a known interaction with Spotted Geranium, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Spotted Geranium. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Spotted Geranium combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Spotted Geranium: Uses, Safety & Side Effects

The bottom line

Spotted Geranium (Geranium maculatum), also called wild geranium or cranesbill, is a North American woodland plant whose tannin-rich root has long been used in folk medicine as an astringent for diarrhea, minor bleeding, and mouth or throat irritation. Modern human studies are very limited, so its effectiveness is largely unproven. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Scientific name
Geranium maculatum
Family
Geraniaceae
Part used
Root and rhizome (sometimes the dried leaves)
Common forms
Dried root, tea, tincture, powder, capsules
People commonly use it for
  • Diarrhea
  • Mouth and throat sores
  • Bleeding and wound care
  • Hemorrhoids
  • Sore throat gargle

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally used in small amounts traditionally, but modern safety data are limited.

PregnancyInsufficient reliable information

Insufficient reliable evidence available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable evidence available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Spotted Geranium (Geranium maculatum) is a wildflower native to the woodlands and meadows of eastern North America. It is also known as wild geranium, cranesbill, or alumroot, and it produces pink-purple flowers in spring. It is not the same plant as the scented houseplant geraniums (which belong to the genus Pelargonium).

The part most often used in herbal medicine is the root and rhizome, which is very rich in plant tannins. Native American and early American folk traditions used the dried root as an astringent — something that tightens and dries tissues. It was made into teas, gargles, and washes for diarrhea, sore mouths, and minor wounds.

Today it is mainly found as a dried herb, tincture, or in some herbal blends. It is not a common or well-studied supplement.

Uses & effectiveness

Spotted Geranium has a long history of traditional use, but high-quality human research is lacking. Most of what we know comes from its tannin content and from how similar astringent herbs behave, not from modern clinical trials.

People have traditionally used it for:

  • Diarrhea: Tannins can tighten the gut lining, which is the basis for this traditional use, but it has not been proven in good studies.
  • Mouth and throat irritation: Used as a gargle or rinse for sore throats, canker sores, and inflamed gums.
  • Minor bleeding and wounds: Applied to the skin or used as a wash to help stop minor bleeding and dry weeping skin.
  • Hemorrhoids: Used as a soothing, astringent wash.

Overall, the evidence is insufficient to confirm that Spotted Geranium works for any specific condition. Consider it an option with traditional support but little scientific proof.

How it works

The root is high in tannins, a group of plant compounds that bind to proteins. This binding action is thought to tighten and dry out tissues, which is what "astringent" means. By tightening surface tissues, tannins may help reduce minor oozing, bleeding, or fluid loss — for example in diarrhea or on irritated skin.

Tannins may also have mild antimicrobial and anti-inflammatory effects in laboratory settings. However, most of this information comes from test-tube studies of tannins in general, not from studies of Spotted Geranium in people. The exact compounds and how well they work in the human body are not well defined.

Safety & precautions

There is not much modern safety data on Spotted Geranium. In small amounts used traditionally, it has generally been considered fairly safe for short-term use, but this should not be taken as proof that it is safe for everyone.

Because the root is high in tannins, large amounts or long-term use may irritate the stomach and could, in theory, interfere with how the body absorbs some nutrients like iron. People with stomach problems, ulcers, or sensitive digestion should be cautious.

Pregnancy and breastfeeding: There is not enough reliable information to know if Spotted Geranium is safe during pregnancy or while breastfeeding. To be safe, avoid it during these times.

Do not give it to children without medical advice. Always tell your pharmacist or doctor about any herbal products you take, especially if you have a health condition or take other medicines.

Side effects

Reported side effects are not well documented because the plant has not been widely studied. Based on its high tannin content, possible effects include:

  • Stomach upset, nausea, or constipation, especially with strong or frequent use
  • Mouth dryness or a puckering feeling when used as a gargle
  • Possible reduced absorption of certain nutrients with long-term use

Allergic reactions are always possible with any plant product. Stop using it and seek care if you notice a rash, swelling, or trouble breathing.

Dosing

There is no established standard dose for Spotted Geranium. Traditional use involved teas, tinctures, and gargles made from the dried root, but amounts varied widely and were not standardized.

If you choose to use a commercial product, follow the directions on the label and do not exceed them. Because reliable dosing information is lacking, it is best to check with a pharmacist or doctor before starting, and to use it only for short periods.

Pregnancy & Breastfeeding

Spotted Geranium & Pregnancy

Insufficient reliable information

Insufficient reliable evidence available; avoid using.

Spotted Geranium & Breastfeeding

Insufficient reliable information

Insufficient reliable evidence available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 sources that drive our Spotted Geranium monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Herbs at a Glance — NIH NCCIH Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Brand directory

Brands that make products with Spotted Geranium

2 brands in our database make a supplement containing Spotted Geranium.

Product directory

Supplement products with Spotted Geranium

2 products in our database contain Spotted Geranium. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Spotted Geranium: Common Questions

Does Spotted Geranium interact with prescription medications?
We do not currently list any known drug interactions for Spotted Geranium. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Spotted Geranium interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Spotted Geranium with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Spotted Geranium interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Spotted Geranium used for?
It has traditionally been used as an astringent for diarrhea, sore throats, mouth sores, hemorrhoids, and minor bleeding or skin irritation. These uses come from folk medicine, and strong scientific proof is lacking.
Is Spotted Geranium the same as the geranium houseplant?
No. Spotted Geranium (Geranium maculatum) is a wild North American plant. The fragrant geraniums grown as houseplants are usually Pelargonium species, which are a different group of plants.
Is Spotted Geranium safe to take?
In small, short-term traditional amounts it has generally been considered fairly safe, but modern safety data are limited. Large or long-term use may irritate the stomach, so check with your pharmacist or doctor first.
Can I use it during pregnancy or breastfeeding?
It is best to avoid it. There is not enough reliable information to know whether Spotted Geranium is safe during pregnancy or breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Spotted Geranium

A rotating sample of real supplements in our database that list Spotted Geranium — open any to see its full ingredients and every drug interaction we check.

Have a question about Spotted Geranium?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist