Acetaminophen / Aspirin / Caffeine

Acetaminophen, aspirin, and caffeine together are used across many OTC products to relieve pain, headache, migraine, and other common discomforts. Specific approvals vary by product:

• Headache (all supported products)
• Muscular aches (all supported products)
• Arthritis pain (most products)
• Common cold symptoms (most products)
• Toothache (most products)
• Premenstrual and menstrual cramps (most products)
• Sinusitis — listed by Extra Strength Headache Relief capsules and some headache relief tablets
• Backache — listed by Exaprin Plus tablets and Goodys oral powder
• Migraine — Amazon Basic Care Migraine Relief, Acetaminophen Aspirin And Caffeine, Excedrin Migraine, Equaline migraine formula, and other migraine-labeled tablets
• Temporary fever reduction — Exaprin Plus tablets and Extra Strength Pain Reliever capsules
• Menstrual bloating — Dolex Forte tablets

All products in this combination are taken by mouth. Dosing frequency and daily limits differ by product — always follow the directions on your specific label.

• Migraine-labeled tablets (such as Excedrin Migraine, Amazon Basic Care Migraine Relief, Equaline migraine formula): generally taken as a single dose of 2 tablets with a full glass of water; do not take more than 2 tablets in 24 hours unless directed by a doctor
• Extra-strength headache products (such as Excedrin Extra Strength Headache and headache-labeled tablets): typically 2 caplets or tablets every 6 hours with a full glass of water; no more than 8 in 24 hours
• Exaprin Plus and similar products: follow the specific label directions for frequency and daily limit
• If you miss a dose, take it when you remember, but never double up to make up for a missed one — and never exceed your product's daily maximum

The caffeine in this combination is the source of many common side effects, while aspirin contributes stomach-related ones:

• Nervousness or irritability
• Trouble sleeping
• Rapid heartbeat
• Stomach upset or pain
• Nausea
• Ringing in the ears (tinnitus)

Stop use and get medical help right away if you develop skin redness, blistering, or a rash — this can be a rare but serious skin reaction to acetaminophen. Also seek care immediately if you notice signs of stomach bleeding, such as feeling faint, vomiting blood, or having black or bloody stools.

• Liver damage risk: Acetaminophen can cause serious liver damage if you exceed the daily maximum, combine this product with other acetaminophen-containing medicines, or drink 3 or more alcoholic drinks per day while using it.
• Stomach bleeding: Aspirin is an NSAID and can cause severe stomach bleeding. Risk is higher if you're 60 or older, have had ulcers, take blood thinners or steroids, use other NSAIDs, or drink heavily.
• Reye's syndrome: Children and teenagers with or recovering from chicken pox or flu-like illness must NOT use aspirin-containing products. Reye's syndrome is a rare but serious condition.
• Severe allergic reactions: Acetaminophen can rarely cause serious skin reactions. Aspirin can trigger hives, facial swelling, wheezing (asthma), or shock in people with aspirin sensitivity. Stop use and seek emergency help if either occurs.
• Caffeine overload: This product contains roughly as much caffeine as a cup of coffee. Combining it with other caffeine sources can cause nervousness, irritability, sleeplessness, or a rapid heartbeat.
• Pregnancy: Avoid aspirin — especially in the last three months of pregnancy — unless your doctor specifically tells you to use it.

This combination can interact with several common drugs, foods, and substances — always check before combining it with anything else:

• Warfarin (blood thinner) — both aspirin and acetaminophen can increase bleeding risk; ask your doctor or pharmacist before use
• Other acetaminophen-containing products — doubling up raises serious liver damage risk; read every label
• NSAIDs (ibuprofen, naproxen, other aspirin products) — combining increases stomach bleeding risk
• Steroid drugs — raise stomach bleeding risk when used with aspirin
• Prescription drugs for diabetes, gout, or arthritis — aspirin may interfere with these; ask your pharmacist
• Diuretics (water pills) — ask a doctor before combining with this product
• Alcohol — 3 or more drinks a day significantly raises risk of liver damage and stomach bleeding
• Caffeine from food, drinks, or other medicines — too much total caffeine can cause nervousness, trouble sleeping, or rapid heartbeat

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

• Tell your doctor if you have liver disease — acetaminophen can be harmful
• Ask a doctor if you have stomach ulcers, a history of stomach bleeding, or frequent heartburn
• Ask a doctor if you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
• Ask a doctor if you have asthma — aspirin can trigger breathing problems in some people
• Children and teenagers with chicken pox or flu-like illness must not use this product (aspirin and Reye's syndrome risk)
• Children under 12 should not use most formulations without a doctor's guidance
• Adults 60 and older are at higher risk for stomach bleeding from aspirin
• Pregnant or breastfeeding? Ask a health professional before use; avoid aspirin in the last three months of pregnancy unless a doctor directs it
• If you are not sure whether another drug you take contains acetaminophen, ask your pharmacist before taking this product

In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for both adults and children — even if no symptoms are present yet, because acetaminophen overdose can cause severe liver damage that may not be immediately obvious.

store at controlled room temperature 20°-25°C (68°-77°F) • close cap tightly after use • read all product information before using.