Dipyridamole
Dipyridamole is a platelet-active heart medicine: the tablets help prevent blood clots after cardiac valve replacement, and the injection is used as part of a heart imaging stress test for coronary artery disease.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 5 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Dipyridamole is an older standby, around since the late 1970s and available as a generic, that raises adenosine (a natural chemical) so platelets clump less and blood vessels widen; the tablets are an add-on to warfarin after heart valve replacement, and the injection replaces exercise in a heart stress scan when you cannot exercise enough. Side effects mostly come with the injection, mainly headache, flushing, dizziness, nausea and chest discomfort that usually fade soon after the test. With the tablets, the label says aspirin should not be taken alongside warfarin, so tell every prescriber about your blood thinners and check before taking any aspirin.
Clinical pearls
- The tablets are taken several times a day together with your warfarin, never as a replacement for it.
- Rare serious injection reactions include heart attack and bronchospasm, so tell the testing team about asthma or unstable angina.
- Before a regadenoson stress test, mention dipyridamole, since it strengthens regadenoson's heart effects and should ideally be held 48 hours beforehand.
- If you have myasthenia gravis and take a cholinesterase inhibitor, dipyridamole may work against it and worsen your symptoms.
Patient information guide A plain-language walkthrough of Dipyridamole, written from its FDA label.
What Dipyridamole is used for
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Dipyridamole is used in two different ways depending on the product.
- Dipyridamole tablets: added to coumarin anticoagulants (such as warfarin) to help prevent clot complications after cardiac valve replacement.
- Dipyridamole Injection (intravenous): an alternative to exercise in thallium myocardial perfusion imaging to evaluate coronary artery disease in people who cannot exercise adequately.
How Dipyridamole works
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Dipyridamole blocks the uptake of adenosine into platelets, blood vessel lining cells and red blood cells. That leaves more adenosine nearby, which raises a signal (cAMP) inside platelets and makes them less likely to clump.
It also blocks an enzyme called phosphodiesterase, which boosts the effects of nitric oxide, a natural vessel relaxer.
Dipyridamole dosage
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The tablets are taken by mouth, generally four times a day, along with your usual warfarin. Follow your prescriber’s directions and the label.
The injection is a different regimen. A healthcare professional gives it as a 4-minute infusion into a vein, based on body weight, before thallium imaging.
Dosing details from the FDA-approved label
From the Dipyridamole prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Adjunct to thallium myocardial perfusion imaging (intravenous injection)
- 0.142 mg/kg/min (0.57 mg/kg total) infused over 4 minutes
- Dose adjusted according to the weight of the patient
- Dilute in at least a 1:2 ratio with sodium chloride injection 0.45%, sodium chloride injection 0.9% or dextrose injection 5% for a total volume of approximately 20 to 50 mL. Thallium-201 should be injected within 5 minutes following the 4-minute i
- Maximum: Maximum tolerated dose has not been determined; clinical experience suggests a total dose beyond 60 mg is not needed for any patient
- Dose adjusted according to patient weight; do not mix with other drugs in the same syringe or infusion container
- Adjunctive use in prophylaxis of thromboembolism after cardiac valve replacement (oral tablet)
- 75 mg to 100 mg four times daily as an adjunct to the usual warfarin therapy
- Aspirin is not to be administered concomitantly with coumarin anticoagulants
- Adjunctive use in prophylaxis of thromboembolism after cardiac valve replacement (oral film-coated tablet)
- 75 to 100 mg four times daily as an adjunct to the usual warfarin therapy
- Aspirin is not to be administered concomitantly with coumarin anticoagulants
Read the label’s full dosing text
DOSAGE AND ADMINISTRATION Adjunctive Use in Prophylaxis of Thromboembolism after Cardiac Valve Replacement. The recommended dose is 75 mg to 100 mg four times daily as an adjunct to the usual warfarin therapy. Please note that aspirin is not to be administered concomitantly with coumarin anticoagulants.
Read the full Dosage and Administration section on DailyMed →
Dipyridamole side effects
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The side effect data on the label come from the injection used in imaging studies. The most common were:
Common side effects
- Chest pain or angina (with the injection)
- Headache (with the injection)
- Dizziness (with the injection)
- Changes on the heart tracing (ECG) (with the injection)
- Low blood pressure (with the injection)
- Nausea (with the injection)
- Flushing (with the injection)
When to get medical help
- Get emergency help for severe chest pain, a possible heart attack, or a fast or irregular heartbeat.
- Get emergency help for wheezing, trouble breathing or severe shortness of breath.
- Get emergency help for signs of a serious allergic reaction, such as swelling of the face, lips or throat, or trouble breathing.
- Seek help right away for symptoms of stroke or a mini-stroke, or for a seizure.
- Tell your care team right away about severe dizziness, fainting or a big drop in blood pressure.
Dipyridamole warnings and precautions
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- Injection risks: heart attack, dangerous rhythms, stroke, seizures, severe low blood pressure, severe allergic reactions and bronchospasm have been reported.
- Higher risk: people with asthma, unstable angina, severe coronary artery disease or heart conduction problems.
- Monitoring: vital signs and an ECG are checked during and for 10–15 minutes after the infusion, and aminophylline is kept available.
- Do not combine aspirin with coumarin anticoagulants.
Dipyridamole interactions
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These are the key interactions on the label.
- Adenosine: dipyridamole raises its levels and heart effects, so dose changes may be needed.
- Regadenoson: its heart effects are increased.
- Cholinesterase inhibitors: dipyridamole may counteract them and worsen myasthenia gravis.
Interactions listed in the FDA-approved label
From the Dipyridamole prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Adenosinergic agents (e.g., adenosine): Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary.
- Regadenoson (adenosine A2A-receptor agonist): Dipyridamole increases the cardiovascular effects of regadenoson; the risk of cardiovascular side effects with intravenous adenosinergic agents may be increased during the testing period when dipyridamole is not held 48 hours prior to stress testing.
- Cholinesterase inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.
Read the label’s full interactions text
Drug Interactions No pharmacokinetic drug-drug interaction studies were conducted with dipyridamole tablets. The following information was obtained from the literature. Adenosinergic agents (e.g., adenosine, regadenoson): Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary. Dipyridamole also increases the cardiovascular effects of regadenoson, an adenosine A 2A -receptor agonist. The potential risk of cardiovascular side effects with intravenous adenosinergic agents may be increased during the testing period when dipyridamole is not held 48 hours prior to stress testing. Cholinesterase Inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Dipyridamole
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- Do not use if allergic to dipyridamole or any ingredient.
- Tell your doctor about asthma, unstable angina, severe coronary artery disease or rhythm problems.
- Tell your doctor if you have myasthenia gravis.
- Share a full list of your medicines, especially warfarin and aspirin.
Dipyridamole overdose
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Too much dipyridamole may cause a warm feeling, flushing, sweating, restlessness, weakness, dizziness, low blood pressure and a fast heartbeat. Seek medical attention or call Poison Control right away. Treatment is symptom-based, and aminophylline may reverse the effects. Dialysis is unlikely to help.
What Dipyridamole does in the body
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Dipyridamole lengthens abnormally short platelet survival time, which is linked to clots with prosthetic heart valves. In studies, tablets plus warfarin cut clot events by 62% to 91% compared with warfarin alone. It does not change prothrombin time with warfarin. It also widens blood vessels, lowers blood pressure and increases coronary blood flow.
How your body processes Dipyridamole
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After a tablet is swallowed, blood levels peak in about 75 minutes. Levels fall in two phases, with half-lives of about 40 minutes and then about 10 hours. Dipyridamole is highly bound to proteins in the blood. The liver processes it, and it leaves the body through bile.
How to store Dipyridamole
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Store at 20°C to 25°C (68°F to 77°F) . Keep out of reach of children. Dispense in a tight, light-resistant container.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Dipyridamole
219 supplements and herbal products have documented interactions with Dipyridamole in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 4
- Moderate · 190
- Minor · 25
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Dipyridamole: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Dipyridamole — the kind of thing our pharmacy team would talk through with you at the counter.
What is dipyridamole for?
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How do I take the tablets?
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Can I take aspirin with it?
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What side effects should I expect?
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Are there medicines that don’t mix well with it?
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Who needs to be extra careful with the injection?
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Is Dipyridamole available over the counter?
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When was Dipyridamole first available?
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Who makes Dipyridamole?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Dipyridamole on HelloPharmacist
Dipyridamole forms and strengths (how it comes)
Dipyridamole is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Dipyridamole tablets are used with coumarin anticoagulants to help prevent clot complications after cardiac valve replacement.
- Dipyridamole tablets are taken by mouth, generally four times daily, with usual warfarin therapy.
- Dipyridamole tablets should not be combined with aspirin while you take a coumarin anticoagulant.
Injection
How this form is used
- Dipyridamole Injection is used as an alternative to exercise in thallium heart imaging to evaluate coronary artery disease in people who cannot exercise adequately.
- Dipyridamole Injection is diluted before it is given into a vein.
- Dipyridamole Injection is infused over 4 minutes, with the dose based on body weight.
- Dipyridamole Injection is followed by thallium-201 within 5 minutes after the infusion.
- Dipyridamole Injection should not be mixed with other drugs in the same syringe or container.
Dipyridamole on the U.S. market: products, makers and brands
How Dipyridamole appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
8 companies list 16 Dipyridamole product records with the FDA, mostly as tablet, injection; the earliest marketing or approval year on record is 1961. Brand names on the directory include Persantine, Permole; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (6) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Dipyridamole is used (Medicaid data)
A general measure of how commonly Dipyridamole is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Dipyridamole is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Dipyridamole prescribed? Of the 1,601 medications we measure, Dipyridamole ranks #1,233 by Medicaid prescriptions — more than 23% of them.
Utilization by Dipyridamole product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
10 ML dipyridamole 5 MG/ML Injection Most dispensed
Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309953
dipyridamole 75 MG Oral Tablet
Summed across the 2 of 24 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309955
dipyridamole 50 MG Oral Tablet
Summed across the 2 of 26 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197622
dipyridamole 25 MG Oral Tablet
Summed across the 2 of 24 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309952
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Dipyridamole, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 7 of 78 listed Dipyridamole NDCs with Medicaid activity.
Compare Dipyridamole products
A representative set of FDA-listed product records for Dipyridamole — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Injection | ||||
| 5 mg/mL | Intravenous | Henry Schein, Inc. | ANDA | View NDC → |
| 5 mg/mL | Intravenous | HF Acquisition Co LLC, DBA HealthFirst | ANDA | View NDC → |
| 5 mg/mL | Intravenous | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 💊Tablet | ||||
| 25 mg | Oral | Amneal Pharmaceuticals of New York LLC | ANDA | View NDC → |
| 50 mg | Oral | Amneal Pharmaceuticals of New York LLC | ANDA | View NDC → |
| 75 mg | Oral | Amneal Pharmaceuticals of New York LLC | ANDA | View NDC → |
| 25 mg | Oral | Oxford Pharmaceuticals, LLC | ANDA | View NDC → |
| 50 mg | Oral | Oxford Pharmaceuticals, LLC | ANDA | View NDC → |
| 75 mg | Oral | Oxford Pharmaceuticals, LLC | ANDA | View NDC → |
| 50 mg | Oral | Remedyrepack Inc. | ANDA | View NDC → |
| 25 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 50 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 75 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 25 mg | Oral | Zydus Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 50 mg | Oral | Zydus Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 75 mg | Oral | Zydus Pharmaceuticals USA Inc. | ANDA | View NDC → |
Showing 16 of 16 products — FDA National Drug Code Directory. See every product, package size and price: browse all 16 Dipyridamole NDCs →
Dipyridamole side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Dipyridamole — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Dipyridamole in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Dipyridamole FDA approval history
How Dipyridamole went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Dipyridamole recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Dipyridamole recalls since July 2021.
✅No Dipyridamole recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 3521 4 dose forms · 7 strengths
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Dose form (SCDF) Extended Release Oral Capsule RxCUI 371916No current FDA listingClinical drug / strength (SCD) 12 HR dipyridamole 200 MGRxCUI 411653 -
Dose form (SCDF) Injection RxCUI 1812189In current FDA listingsClinical drug / strength (SCD) 10 ML dipyridamole 5 MG/MLRxCUI 309953 -
Dose form (SCDF) Oral Suspension RxCUI 393522No current FDA listingClinical drug / strength (SCD) 10 MG/MLRxCUI 392451 -
Dose form (SCDF) Oral Tablet RxCUI 371917In current FDA listings
Look up RxCUI 3521 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Dipyridamole supply and shortage status
Whether Dipyridamole is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Dipyridamole costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet · Oral | 25 mg | $0.136 per tablet | NDC details & price history |
| Tablet · Oral | 50 mg | $0.357 per tablet | NDC details & price history |
| Tablet · Oral | 75 mg | $0.236 per tablet | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Dipyridamole brand names
Dipyridamole is sold under 2 brand names in the FDA directory — Persantine, Permole. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Dipyridamole: manufacturers and labelers
8 companies list Dipyridamole products with the FDA. By number of product records, the largest are Amneal Pharmaceuticals of New York LLC, Oxford Pharmaceuticals, LLC, Zydus Lifesciences Limited. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Dipyridamole drug class (RxNorm)
Dipyridamole belongs to the Platelet Aggregation Inhibitor class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Dipyridamole page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Oxford Pharmaceuticals, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →