Acetaminophen / Aspirin (Nsaid) / Caffeine
Acetaminophen / aspirin / caffeine is a combination pain reliever sold over the counter, used for minor aches and pains (like headache, muscle aches, arthritis pain, toothache and menstrual cramps) and, in migraine-labeled products, for migraine.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 175 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Acetaminophen, aspirin and caffeine (best known as Excedrin) is a familiar over-the-counter combination for headache, minor aches and, in migraine-labeled products, migraine, with the caffeine boosting the two pain relievers; it has been on the market since the early 1990s and is available as a generic. Occasional use is usually well tolerated, though the caffeine (about a cup of coffee per dose) can bring jitters or trouble sleeping. The real risks are liver damage from too much acetaminophen and stomach bleeding from the aspirin, so stop and get help for black or bloody stools, vomiting blood, hives, facial swelling or a blistering rash.
Clinical pearls
- Check cold, flu and nighttime products for acetaminophen, since doubling up with this combination is a common route to liver damage.
- Don't pair it with ibuprofen or naproxen, and ask first if you take warfarin or another blood thinner.
- Children or teens with or recovering from flu or chickenpox should not take it, since aspirin can trigger Reye's syndrome.
- For migraine, if the first dose does not help or the headache worsens, stop and see a doctor instead of repeating.
Patient information guide A plain-language walkthrough of Acetaminophen / Aspirin (Nsaid) / Caffeine, written from its FDA label.
What Acetaminophen / Aspirin (Nsaid) / Caffeine is used for
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This combination is used for temporary relief of minor pain, and some products are labeled for migraine.
- Headache
- Common cold aches
- Sinusitis (Extra Strength Headache Relief and Headache Relief tablets)
- Toothache
- Muscular aches
- Arthritis pain
- Premenstrual and menstrual cramps
- Backache (Exaprin Plus and Goodys)
- Fever reduction (Exaprin Plus and Extra Strength Pain Reliever capsules)
- Migraine (migraine-labeled products such as Excedrin Migraine, Amazon Basic Care Migraine Relief and Equaline migraine formula)
Acetaminophen / Aspirin (Nsaid) / Caffeine dosage
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These products are taken by mouth with a full glass of water. Directions differ by product, so follow your label.
- Migraine-labeled products (such as Excedrin Migraine and Amazon Basic Care Migraine Relief): adults take 2 caplets or tablets, with no more than 2 in 24 hours unless a doctor directs. Under 18, ask a doctor.
- Pain-relief products (such as Excedrin Extra Strength Headache and Headache Relief tablets): adults and children 12 and over take 2 every 6 hours, with a daily limit stated on the label (6 or 8 depending on product). Under 12, ask a doctor.
If symptoms continue or get worse, ask your doctor.
Dosing details from the FDA-approved label
From the Acetaminophen / Aspirin (Nsaid) / Caffeine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Adults (migraine formula: Excedrin Migraine and store-brand migraine relief caplets)
- Take 2 caplets with a glass of water
- Do not use more than directed
- If symptoms persist or worsen, ask your doctor
- Maximum: do not take more than 2 caplets in 24 hours, unless directed by a doctor
- Under 18 years of age (migraine formula)
- Ask a doctor
- Adults (topcare migraine relief)
- Take 2 geltabs with a glass of water
- If symptoms persist or worsen, ask your doctor
- Maximum: do not take more than 2 geltabs in 24 hours, unless directed by a doctor
- Adults (Amazon Basic Care Migraine Relief and Acetaminophen Aspirin And Caffeine tablets)
- Take 2 tablets with a glass of water
- If symptoms persist or worsen, ask your doctor
- Maximum: do not take more than 2 tablets in 24 hours, unless directed by a doctor
- Adults and children 12 years of age and over (Extra Strength Headache caplets)
- Take 2 caplets every 6 hours
- Drink a full glass of water with each dose
- Maximum: not more than 8 caplets in 24 hours
- Children under 12 years (Extra Strength Headache)
- Ask a doctor
- Adults and children 12 years and over (Headache Relief tablets)
- Take 2 tablets every 6 hours
- Drink a full glass of water with each dose
- Maximum: Do not take more than 8 tablets in 24 hours
- Do not exceed recommended dosage
- Adults and children 12 years and over (Excedrin/Excedrin Tension Headache caplets, first directions)
- Take 2 caplets every 6 hours
- Maximum: not more than 6 caplets in 24 hours
Read the label’s full dosing text
Directions do not use more than directed adults and children 12 years and over: take 2 caplets every 6 hours; not more than 6 caplets in 24 hours children under 12 years: ask a doctor
Directions do not use more than directed drink a full glass of water with each dose adults and children 12 years and over: take 2 caplets every 6 hours; not more than 8 caplets in 24 hours children under 12 years: ask a doctor
Read the full Dosage and Administration section on DailyMed →
Acetaminophen / Aspirin (Nsaid) / Caffeine side effects
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The label mainly points to effects from the caffeine.
Common side effects
- Nervousness
- Irritability
- Trouble sleeping
- Occasional rapid heartbeat (from caffeine)
When to get medical help
- Stop and get medical help right away if you have a skin reaction such as reddening, blisters or rash.
- Get help right away for hives, facial swelling, wheezing or shock, which can be signs of a severe allergic reaction.
- Stop and call your doctor if you feel faint, vomit blood, or have bloody or black stools.
- Stop and call your doctor if you have stomach pain that doesn't get better.
- Stop and call your doctor if you notice ringing in the ears or hearing loss.
- Call your doctor if pain gets worse or lasts more than 10 days, or fever gets worse or lasts more than 3 days.
- If your migraine isn't relieved or gets worse after the first dose, stop and ask a doctor.
- In children and teens, changes in behavior with nausea and vomiting can be an early sign of Reye's syndrome, so call a doctor.
Serious reactions include severe skin reactions, severe allergic reactions, signs of stomach bleeding and liver damage. Stop use and get medical help if these occur.
Acetaminophen / Aspirin (Nsaid) / Caffeine warnings and precautions
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- Liver damage: exceeding the daily maximum, combining with other acetaminophen products, or having 3 or more alcoholic drinks daily raises the risk.
- Stomach bleeding: the aspirin (an NSAID) can cause it, especially at age 60 or older, with ulcers or bleeding problems, or with blood thinners, steroids or other NSAIDs.
- Allergic reactions: acetaminophen may cause severe skin reactions. Aspirin may cause hives, facial swelling, wheezing or shock.
- Reye's syndrome: children and teens with chicken pox or flu-like symptoms should not use it.
- Caffeine: each dose has about as much as a cup of coffee.
- Pregnancy: avoid aspirin in the last three months unless a doctor directs.
Acetaminophen / Aspirin (Nsaid) / Caffeine interactions
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Check with your pharmacist about these before use.
- Other acetaminophen products: raises the risk of liver damage.
- Other NSAIDs (aspirin, ibuprofen, naproxen): raises the risk of stomach bleeding.
- Blood thinners, including warfarin, and steroids: raises bleeding risk or needs a pharmacist's check.
- Alcohol (3 or more drinks daily): raises liver and stomach bleeding risk.
- Prescription drugs for diabetes, gout or arthritis, and diuretics: ask first.
- Other caffeine sources: may cause nervousness, sleeplessness and rapid heartbeat.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Acetaminophen / Aspirin (Nsaid) / Caffeine
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- Don't use if you're allergic to acetaminophen, aspirin or similar pain relievers/fever reducers.
- Ask a doctor first if you have liver disease or cirrhosis.
- Ask first if you have kidney disease, heart disease, high blood pressure or asthma.
- Ask first if you have a history of stomach problems like heartburn, ulcers or bleeding.
- Ask a health professional first if pregnant or breast-feeding.
- Children and teens recovering from chicken pox or flu-like symptoms should not use it.
- Migraine-labeled products: under 18, ask a doctor.
Acetaminophen / Aspirin (Nsaid) / Caffeine overdose
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In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults and children, even if you don't notice any signs or symptoms.
How to store Acetaminophen / Aspirin (Nsaid) / Caffeine
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store at controlled room temperature 20°-25°C (68°-77°F) • close cap tightly after use • read all product information before using.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Acetaminophen / Aspirin (Nsaid) / Caffeine: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Acetaminophen / Aspirin (Nsaid) / Caffeine — the kind of thing our pharmacy team would talk through with you at the counter.
What is this medicine used for?
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How should I take it?
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What side effects might I notice?
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When should I stop it and call someone?
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Can I take it with other pain relievers or alcohol?
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Is it safe in pregnancy or for kids?
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Is Acetaminophen / Aspirin (Nsaid) / Caffeine available over the counter?
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When was Acetaminophen / Aspirin (Nsaid) / Caffeine first available?
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Who makes Acetaminophen / Aspirin (Nsaid) / Caffeine?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Acetaminophen / Aspirin (Nsaid) / Caffeine on HelloPharmacist
Acetaminophen / Aspirin (Nsaid) / Caffeine forms and strengths (how it comes)
Acetaminophen / Aspirin (Nsaid) / Caffeine is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Amazon Basic Care Migraine Relief and Equaline migraine formula are used to treat migraine.
- Dolex Forte is used for minor aches and pains from headache, a cold, arthritis, muscle aches, toothache and menstrual cramps.
- Exaprin Plus is used for minor aches and pains and to temporarily reduce fever.
- Amazon Basic Care Migraine Relief: adults take 2 tablets with a glass of water, no more than 2 tablets in 24 hours unless a doctor directs.
- Equaline migraine formula: adults take 2 caplets with a glass of water, no more than 2 caplets in 24 hours unless a doctor directs.
- Amazon Basic Care Migraine Relief and Equaline migraine formula: under 18, ask a doctor.
Oral powder
How this form is used
- Goodys is used for minor aches and pains from headache, minor arthritis pain, muscle aches, a cold, backache, toothache and menstrual cramps.
Capsule
How this form is used
- Pain Terminator is used for minor aches and pains from headache, muscle aches, arthritis pain, a cold, toothache and menstrual cramps.
- Extra Strength Pain Reliever is used to temporarily relieve fever and minor aches and pains from headache, colds, muscle aches, menstrual discomfort, toothaches and minor arthritis pain.
Topical cream, ointment or gel
Acetaminophen / Aspirin (Nsaid) / Caffeine on the U.S. market: products, makers and brands
How Acetaminophen / Aspirin (Nsaid) / Caffeine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
87 companies list 166 Acetaminophen / Aspirin (Nsaid) / Caffeine product records with the FDA, mostly as tablet, oral powder, capsule; the earliest marketing or approval year on record is 1992. Brand names on the directory include Headache Relief, Headache Relief Extra Strength, migraine relief and 13 more; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Kit (2) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Acetaminophen / Aspirin (Nsaid) / Caffeine is used (Medicaid data)
A general measure of how commonly Acetaminophen / Aspirin (Nsaid) / Caffeine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Acetaminophen / Aspirin (Nsaid) / Caffeine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Acetaminophen / Aspirin (Nsaid) / Caffeine prescribed? Of the 1,601 medications we measure, Acetaminophen / Aspirin (Nsaid) / Caffeine ranks #907 by Medicaid prescriptions — more than 43% of them.
Utilization by Acetaminophen / Aspirin (Nsaid) / Caffeine product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet
Summed across the 13 of 574 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 308297
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Acetaminophen / Aspirin (Nsaid) / Caffeine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 13 of 574 listed Acetaminophen / Aspirin (Nsaid) / Caffeine NDCs with Medicaid activity.
Compare Acetaminophen / Aspirin (Nsaid) / Caffeine products
A representative set of FDA-listed product records for Acetaminophen / Aspirin (Nsaid) / Caffeine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Capsule | ||||
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | JHK Inc dba American Safety & First Aid | OTC MONOGRAPH DRUG | View NDC → |
| ASPIRIN 250 mg/1; ACETAMINOPHEN 250 mg/1; CAFFEINE 65 mg | Oral | Softgel Healthcare Pvt Ltd | OTC MONOGRAPH DRUG | View NDC → |
| CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg | Oral | Wildman Business Group | OTC MONOGRAPH DRUG | View NDC → |
| 💊Oral powder | ||||
| CAFFEINE 65 mg/1; ACETAMINOPHEN 325 mg/1; ASPIRIN 500 mg | Oral | Medtech Products Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 260 mg/1; ASPIRIN 520 mg/1; CAFFEINE 32.5 mg | Oral | Medtech Products Inc. × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 325 mg/1; ASPIRIN 500 mg/1; CAFFEINE 65 mg | Oral | Medtech Products Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 500 mg/1; ASPIRIN 500 mg/1; CAFFEINE 130 mg | Oral | Medtech Products Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ASPIRIN 500 mg/1; ACETAMINOPHEN 500 mg/1; CAFFEINE 65 mg | Oral | Medtech Products Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 💊Tablet | ||||
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | A-S Medication Solutions | NDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Aaa Pharmaceutical, Inc. | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Advanced Rx LLC | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Allegiant Health | NDA | View NDC → |
| 250; 250; 65 mg/1; mg/1; mg | Oral | Alva-Amco Pharmacal Companies, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Amazon.com Services LLC × 4 listings | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Amazon.com Services LLC | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | American Sales Company | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Amerisource Bergen | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Amerisource Bergen | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Army And Air Force Exchange Service | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Aurohealth LLC × 2 listings | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Belmora LLC | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Better Living Brands, LLC | ANDA | View NDC → |
| ASPIRIN 250 mg/1; ACETAMINOPHEN 250 mg/1; CAFFEINE 65 mg | Oral | Better Living Brands, Llc | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Bi-Mart | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Cabinet Health P.B.C. | OTC MONOGRAPH DRUG | View NDC → |
| 250; 250; 65 mg/1; mg/1; mg | Oral | Cardinal Health | OTC MONOGRAPH NOT FINAL | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Cardinal Health 110, LLC. dba Leader × 2 listings | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Cardinal Health 110, LLC. DBA Leader | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Chain Drug Marketing Association, Inc. | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Chain Drug Marketing Association, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Chain Drug Marketing Association Inc | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | CVS Pharmacy × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | CVS Pharmacy | ANDA | View NDC → |
| CAFFEINE 65 mg/1; ASPIRIN 250 mg/1; ACETAMINOPHEN 250 mg | Oral | CVS Pharmacy, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Discount Drug Mart | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Dolgencorp, Inc. (DOLLAR GENERAL & REXALL) | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Dolgencorp Inc | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Dolgencorp Inc | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Dollar General | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | DSE Healthcare Solutions, LLC | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | EQUATE (Wal-Mart Stores, Inc.) (see also WAL-MART INC) | OTC MONOGRAPH DRUG | View NDC → |
| ASPIRIN 250 mg/1; CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg | Oral | Family Dollar | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Family Dollar (FAMILY WELLNESS) | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Family Dollar (FAMILY WELLNESS) | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Farmacias De Similares TX LLC | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Fsa Store Inc. | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Genomma Lab USA | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Granules India Ltd | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Harris Teeter | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | H E B | OTC MONOGRAPH DRUG | View NDC → |
| CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg | Oral | Hi-Tech Nutaceuticals, LLC | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | HyVee Inc | OTC MONOGRAPH DRUG | View NDC → |
| CAFFEINE 65 mg/1; ASPIRIN 250 mg/1; ACETAMINOPHEN 250 mg | Oral | Kroger Company | OTC MONOGRAPH DRUG | View NDC → |
| CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg | Oral | Lil' Drug Store Products, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Lil' Drug Store Products, Inc. × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; CAFFEINE 65 mg/1; ASPIRIN 250 mg | Oral | Lil' Drug Store Products, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ASPIRIN 250 mg/1; CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg | Oral | Lil' Drug Store Products, Inc. × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Magno-Humphries, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg | Oral | Nuvicare Llc | OTC MONOGRAPH DRUG | View NDC → |
| CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg | Oral | Opmx Llc | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; CAFFEINE 65 mg/1; ASPIRIN 250 mg | Oral | Opmx Llc × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| ASPIRIN 250 mg/1; CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg | Oral | Opmx Llc | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | P & L Development, LLC | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Pharmadel LLC | OTC MONOGRAPH DRUG | View NDC → |
| CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg | Oral | Pioneer Life Sciences, LLC | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Publix Super Markets Inc | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Rising Pharma Holdings, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Safeway, Inc | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Safeway, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Safrel Pharmaceuticals, LLC. | ANDA | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Strive Pharmaceuticals Inc. × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | TARGET Corporation | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | The Kroger Co. × 3 listings | OTC MONOGRAPH DRUG | View NDC → |
| CAFFEINE 65 mg/1; ASPIRIN 250 mg/1; ACETAMINOPHEN 250 mg | Oral | Walgreens | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | Walgreens × 5 listings | OTC MONOGRAPH DRUG | View NDC → |
| ASPIRIN 250 mg/1; ACETAMINOPHEN 250 mg/1; CAFFEINE 65 mg | Oral | Walgreens | OTC MONOGRAPH DRUG | View NDC → |
| ASPIRIN 250 mg/1; CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg | Oral | Walgreens | OTC MONOGRAPH DRUG | View NDC → |
| ACETAMINOPHEN 250 mg/1; CAFFEINE 65 mg/1; ASPIRIN 250 mg | Oral | Walmart Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 💊Topical cream, ointment or gel | ||||
| ACETAMINOPHEN 250 mg/1; ASPIRIN 250 mg/1; CAFFEINE 65 mg | Oral | P & L Development, LLC | OTC MONOGRAPH DRUG | View NDC → |
| 💊Kits | ||||
| — | — | Haleon US Holdings LLC | OTC MONOGRAPH DRUG | View NDC → |
Showing 97 of 166 products — FDA National Drug Code Directory. See every product, package size and price: browse all 166 Acetaminophen / Aspirin (Nsaid) / Caffeine NDCs →
Acetaminophen / Aspirin (Nsaid) / Caffeine side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Acetaminophen / Aspirin (Nsaid) / Caffeine — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Acetaminophen / Aspirin (Nsaid) / Caffeine in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Acetaminophen / Aspirin (Nsaid) / Caffeine FDA approval history
How Acetaminophen / Aspirin (Nsaid) / Caffeine went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Acetaminophen / Aspirin (Nsaid) / Caffeine recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Acetaminophen / Aspirin / Caffeine recalls since July 2021.
✅No Acetaminophen / Aspirin / Caffeine recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.
RxCUI 466584 3 dose forms · 8 strengths
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Dose form (SCDF) Oral Capsule RxCUI 375995In current FDA listingsClinical drug / strength (SCD) acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MGRxCUI 827318 -
Dose form (SCDF) Oral Powder RxCUI 692835In current FDA listingsClinical drug / strength (SCD) acetaminophen 260 MG / aspirin 520 MG / caffeine 32.5 MGRxCUI 763116acetaminophen 325 MG / aspirin 500 MG / caffeine 65 MGRxCUI 692836acetaminophen 500 MG / aspirin 500 MG / caffeine 130 MGRxCUI 2734143acetaminophen 500 MG / aspirin 500 MG / caffeine 65 MGRxCUI 2360605 -
Dose form (SCDF) Oral Tablet RxCUI 238142In current FDA listingsClinical drug / strength (SCD) acetaminophen 160 MG / aspirin 230 MG / caffeine 33 MGRxCUI 205251acetaminophen 194 MG / aspirin 227 MG / caffeine 33 MGRxCUI 243694acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MGRxCUI 308297
Look up RxCUI 466584 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Acetaminophen / Aspirin (Nsaid) / Caffeine supply and shortage status
Whether Acetaminophen / Aspirin (Nsaid) / Caffeine is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Acetaminophen / Aspirin (Nsaid) / Caffeine costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet, Film Coated · Oral | ASPIRIN 250 mg/1; CAFFEINE 65 mg/1; ACETAMINOPHEN 250 mg | $0.065 per tablet | NDC details & price history |
| Tablet, Film Coated · Oral | ASPIRIN 250 mg/1; ACETAMINOPHEN 250 mg/1; CAFFEINE 65 mg | $0.065 per tablet | NDC details & price history |
| Tablet, Film Coated · Oral | ASPIRIN 250 mg/1; CAFFEINE 250 mg/1; ACETAMINOPHEN 65 mg | $0.065 per tablet | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Acetaminophen / Aspirin (Nsaid) / Caffeine brand names
Acetaminophen / Aspirin (Nsaid) / Caffeine is sold under 16 brand names in the FDA directory — Headache Relief, Headache Relief Extra Strength, migraine relief, Excedrin and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Acetaminophen / Aspirin (Nsaid) / Caffeine: manufacturers and labelers
87 companies list Acetaminophen / Aspirin (Nsaid) / Caffeine products with the FDA. By number of product records, the largest are Lil' Drug Store Products, Inc., Haleon US Holdings LLC, Walgreens. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
…and 63 more on the FDA NDC directory.
Acetaminophen / Aspirin (Nsaid) / Caffeine drug class (RxNorm)
Acetaminophen / Aspirin (Nsaid) / Caffeine belongs to the Platelet Aggregation Inhibitor class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Acetaminophen / Aspirin (Nsaid) / Caffeine page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Lil' Drug Store Products, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →