Topotecan drug information | HelloPharmacist

Why is this medication prescribed?
How should this medicine be used?
Other uses for this medicine
What special precautions should I follow?
What special dietary instructions should I follow?
What should I do if I forget a dose?
What side effects can this medication cause?
What should I know about STORAGE and DISPOSAL of this medication?
What should I do in case of OVERDOSE?
What OTHER INFORMATION should I know?
Drug interactions

IMPORTANT WARNING

Topotecan may cause a decrease in the number of blood cells made by your bone marrow. This increases the risk that you will develop a serious infection. You should not take topotecan if you already have a low number of blood cells. Your doctor will order laboratory tests regularly before and during your treatment to check whether your body has enough blood cells. If you experience any of the following symptoms, call your doctor immediately: sore throat, chills, fever, cough, burning or painful urination, or other signs of infection; stomach pain; unusual bruising or bleeding; excessive tiredness; headache; dizziness; confusion; pale skin; fast heartbeat; or shortness of breath.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to topotecan.

Talk to your doctor about the risks of taking topotecan.

Why is this medication prescribed?

Topotecan is used to treat small cell lung cancer (a type of cancer that begins in the lungs) that was successfully treated with a different chemotherapy medication but has returned no sooner than 45 days after the last dose of the first chemotherapy medication was taken. Topotecan is in a class of medications called topoisomerase I inhibitors. It works by killing cancer cells.

How should this medicine be used?

Topotecan comes as a capsule to take by mouth. It may be taken with or without food. It is usually taken once a day for 5 days in a row every 21 days. Your doctor will decide how many times you should repeat this cycle. Take topotecan at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take topotecan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with water; do not open, chew, or crush them.

Topotecan capsules come in two different strengths. Your doctor may want you to take a combination of both strengths of capsules to make up your full dose. Be sure that you know what each type of capsule looks like and how many you are to take of each. Ask your doctor or pharmacist if you have any questions.

If any of the capsules are broken or leaking, do not touch them with your bare hands. Carefully dispose of the broken capsules without touching them directly and then wash your hands well with soap and water. If the capsule contents do touch your skin, wash the area well with soap and water right away. If any capsule contents get in your eyes, wash your eyes right away with gently flowing water for at least 15 minutes. Call your doctor if you have any skin reaction or if medication gets in your eyes.

You may vomit after you take the medication. If this happens, let your doctor know right away. Do not take another dose of topotecan on the same day.

Your doctor may need to delay your treatment or adjust your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with topotecan.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking topotecan,

tell your doctor and pharmacist if you are allergic to topotecan, any other medications, or any of the ingredients in topotecan capsules. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cyclosporine (Gengraf, Neoral, Sandimmune); ketoconazole (Nizoral); ritonavir (Norvir, in Kaletra); or saquinavir (Fortovase, Invirase). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had kidney disease.

tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking topotecan. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking topotecan, call your doctor immediately. Topotecan may harm the fetus.

tell your doctor if you are breast-feeding. You should not breast-feed while you are taking topotecan.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking topotecan.

you should know that topotecan may make you drowsy, tired, or weak. Do not drive a car, use heavy tools, or operate machinery until you know how this medication affects you.

you should know that topotecan can cause severe diarrhea that may need to be treated in a hospital. Talk to your doctor about how to prevent and treat diarrhea. Call your doctor right away if you have any of the following symptoms: diarrhea with fever, diarrhea 3 or more times a day, or diarrhea with stomach pain or cramps.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Let your doctor know if you miss a dose.

What side effects can this medication cause?

Topotecan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea
- vomiting
- diarrhea
- loss of appetite
- hair loss

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:
- hives
- rash
- itching
- hoarseness
- difficulty breathing or swallowing
Topotecan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it in the refrigerator and protect it from light.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

sore throat, chills, fever, cough, burning or painful urination, or other signs of infection
unusual bruising or bleeding
excessive tiredness
headache
dizziness
confusion
pale skin
fast heartbeat
shortness of breath

What OTHER INFORMATION should I know?

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug interactions

Drug	Interaction
Leflunomide	Leflunomide The risk or severity of adverse effects can be increased when Topotecan is combined with Leflunomide.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Topotecan.
Aminophylline	Aminophylline The metabolism of Aminophylline can be increased when combined with Topotecan.
Anagrelide	Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Topotecan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Topotecan.
Clopidogrel	Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Topotecan.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The serum concentration of Topotecan can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be increased when combined with Topotecan.
Guanfacine	Guanfacine Guanfacine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Magnesium Hydroxide	Magnesium Hydroxide Topotecan may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate	Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Topotecan.
Olsalazine	Olsalazine Olsalazine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Paregoric	Paregoric The serum concentration of Topotecan can be increased when it is combined with Morphine.
Potassium	Potassium Potassium may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Topotecan.
Ranitidine	Ranitidine Ranitidine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Reserpine	Reserpine The serum concentration of Topotecan can be increased when it is combined with Reserpine.
Rizatriptan	Rizatriptan Rizatriptan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sumatriptan	Sumatriptan Sumatriptan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Topotecan.
Tizanidine	Tizanidine Tizanidine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Triamcinolone	Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Topotecan.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Doxycycline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fluconazole Injection	Fluconazole Injection The serum concentration of Topotecan can be increased when it is combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Topotecan which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection Hydromorphone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Topotecan.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Topotecan.
Levofloxacin Injection	Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Topotecan.
Meperidine Injection	Meperidine Injection The metabolism of Topotecan can be increased when combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Topotecan.
Metoclopramide Injection	Metoclopramide Injection Topotecan may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Morphine Injection	Morphine Injection The serum concentration of Topotecan can be increased when it is combined with Morphine.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Topotecan may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Topotecan.
Altretamine	Altretamine Amphetamine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cyclosporine	Cyclosporine Topotecan may increase the immunosuppressive activities of Cyclosporine.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Topotecan.
Torsemide	Torsemide Torasemide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Dofetilide	Dofetilide The metabolism of Dofetilide can be increased when combined with Topotecan.
Hydroxychloroquine	Hydroxychloroquine The risk or severity of adverse effects can be increased when Topotecan is combined with Hydroxychloroquine.
Meloxicam	Meloxicam Meloxicam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Oxcarbazepine	Oxcarbazepine Oxcarbazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Telmisartan	Telmisartan Telmisartan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Temozolomide	Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Topotecan.
Zaleplon	Zaleplon Zaleplon may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Anakinra	Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Topotecan.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Topotecan.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Topotecan.
Etanercept Injection	Etanercept Injection The risk or severity of adverse effects can be increased when Etanercept is combined with Topotecan.
Perindopril	Perindopril Perindopril may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tenofovir	Tenofovir The metabolism of Tenofovir can be decreased when combined with Topotecan.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sirolimus	Sirolimus The metabolism of Sirolimus can be increased when combined with Topotecan.
Epirubicin	Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Topotecan.
Eplerenone	Eplerenone Eplerenone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Zonisamide	Zonisamide The serum concentration of Topotecan can be increased when it is combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The risk or severity of adverse effects can be increased when Adalimumab is combined with Topotecan.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be increased when combined with Topotecan.
Atomoxetine	Atomoxetine Atomoxetine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Glatiramer Injection	Glatiramer Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Glatiramer.
Atazanavir	Atazanavir The metabolism of Atazanavir can be increased when combined with Topotecan.
Almotriptan	Almotriptan Almotriptan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Topotecan.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Topotecan.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Topotecan.
Emtricitabine	Emtricitabine The excretion of Emtricitabine can be decreased when combined with Topotecan.
Memantine	Memantine Topotecan may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod	Tegaserod The serum concentration of Topotecan can be increased when it is combined with Tegaserod.
Tadalafil	Tadalafil Tadalafil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Progesterone	Progesterone Progesterone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Darbepoetin Alfa Injection	Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Topotecan.
Infliximab Injection	Infliximab Injection The risk or severity of adverse effects can be increased when Infliximab is combined with Topotecan.
Duloxetine	Duloxetine The metabolism of Duloxetine can be decreased when combined with Topotecan.
Norethindrone	Norethindrone The metabolism of Norethisterone can be increased when combined with Topotecan.
Tinidazole	Tinidazole Tinidazole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefditoren	Cefditoren Cefdinir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Natalizumab Injection	Natalizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Natalizumab.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Erlotinib	Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Topotecan.
Eszopiclone	Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Topotecan.
Ganciclovir	Ganciclovir The excretion of Topotecan can be decreased when combined with Ganciclovir.
Palifermin	Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Topotecan.
Ribavirin	Ribavirin Ribavirin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Valganciclovir	Valganciclovir Topotecan may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine Amphetamine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Topotecan.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Topotecan.
Ramelteon	Ramelteon Ramelteon may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Topotecan.
Pregabalin	Pregabalin Pregabalin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Tipranavir	Tipranavir The serum concentration of Topotecan can be increased when it is combined with Tipranavir.
Felbamate	Felbamate Felbamate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Ranolazine	Ranolazine The metabolism of Topotecan can be increased when combined with Ranolazine.
Abatacept Injection	Abatacept Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Abatacept.
Rasagiline	Rasagiline Topotecan may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib	Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Topotecan.
Sitagliptin	Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Topotecan.
Varenicline	Varenicline Topotecan may decrease the excretion rate of Varenicline which could result in a higher serum level.
Bevacizumab Injection	Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Topotecan.
Gefitinib	Gefitinib Gefitinib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Albuterol	Albuterol Salbutamol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Paliperidone	Paliperidone The serum concentration of Topotecan can be increased when it is combined with Paliperidone.
Bortezomib	Bortezomib The metabolism of Topotecan can be increased when combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Topotecan.
Hepatitis B Vaccine	Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Topotecan.
Influenza Vaccine, Inactivated or Recombinant	Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Topotecan.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Topotecan.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Topotecan.
Lubiprostone	Lubiprostone Topotecan may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Topotecan.
Posaconazole	Posaconazole The serum concentration of Topotecan can be increased when it is combined with Posaconazole.
Rituximab Injection	Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Topotecan.
Pemetrexed Injection	Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Topotecan.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Topotecan.
Vorinostat	Vorinostat The risk or severity of adverse effects can be increased when Topotecan is combined with Vorinostat.
Sorafenib	Sorafenib The serum concentration of Topotecan can be increased when it is combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Topotecan can be increased when combined with Sunitinib.
Dronabinol	Dronabinol Dronabinol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Lapatinib	Lapatinib The serum concentration of Topotecan can be increased when it is combined with Lapatinib.
Levocetirizine	Levocetirizine Topotecan may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection	Pegaptanib Injection Topotecan may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Pegfilgrastim Injection	Pegfilgrastim Injection The risk or severity of neutropenia can be increased when Pegfilgrastim is combined with Topotecan.
Dasatinib	Dasatinib The metabolism of Topotecan can be increased when combined with Dasatinib.
Azacitidine Injection	Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Topotecan.
Temsirolimus	Temsirolimus The serum concentration of Topotecan can be increased when it is combined with Temsirolimus.
Nelarabine Injection	Nelarabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Nelarabine.
Lenalidomide	Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Topotecan.
Nilotinib	Nilotinib The serum concentration of Topotecan can be increased when it is combined with Nilotinib.
Toremifene	Toremifene The serum concentration of Topotecan can be increased when it is combined with Toremifene.
Bexarotene	Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Topotecan.
Budesonide	Budesonide The risk or severity of adverse effects can be increased when Topotecan is combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Topotecan.
Decitabine Injection	Decitabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Decitabine.
Desmopressin	Desmopressin Desmopressin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Doripenem Injection	Doripenem Injection Topotecan may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine	Etravirine The serum concentration of Topotecan can be decreased when it is combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Arsenic trioxide.
Mitoxantrone Injection	Mitoxantrone Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Mitoxantrone.
Desvenlafaxine	Desvenlafaxine Topotecan may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline	Cevimeline Cevimeline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tretinoin	Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Topotecan.
Bendamustine Injection	Bendamustine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Bendamustine.
Flecainide	Flecainide The excretion of Topotecan can be decreased when combined with Flecainide.
Certolizumab Injection	Certolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Topotecan.
Irinotecan Injection	Irinotecan Injection The metabolism of Topotecan can be increased when combined with Irinotecan.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Estramustine	Estramustine The risk or severity of adverse effects can be increased when Topotecan is combined with Estramustine.
Methylnaltrexone Injection	Methylnaltrexone Injection Topotecan may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Topotecan.
Rufinamide	Rufinamide Topotecan may increase the excretion rate of Rufinamide which could result in a lower serum level and potentially a reduction in efficacy.
Silodosin	Silodosin The serum concentration of Topotecan can be increased when it is combined with Silodosin.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Topotecan.
Dexrazoxane Injection	Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Topotecan.
Eltrombopag	Eltrombopag Eltrombopag may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ibritumomab Injection	Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Topotecan.
Milnacipran	Milnacipran The metabolism of Milnacipran can be increased when combined with Topotecan.
Plerixafor Injection	Plerixafor Injection Topotecan may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine	Fesoterodine Topotecan may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Topotecan.
Prasugrel	Prasugrel Topotecan may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide	Lacosamide Topotecan may increase the excretion rate of Lacosamide which could result in a lower serum level and potentially a reduction in efficacy.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Topotecan.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Topotecan can be increased when combined with Tolvaptan.
Dronedarone	Dronedarone The serum concentration of Topotecan can be increased when it is combined with Dronedarone.
Pralatrexate Injection	Pralatrexate Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Pralatrexate.
Palonosetron Injection	Palonosetron Injection Palonosetron may decrease the excretion rate of Topotecan which could result in a higher serum level.
Saxagliptin	Saxagliptin Topotecan may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection	Telavancin Injection Topotecan may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection	Romidepsin Injection The metabolism of Topotecan can be increased when combined with Romidepsin.
Golimumab Injection	Golimumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Pazopanib can be increased when combined with Topotecan.
Vigabatrin	Vigabatrin Vigabatrin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Albendazole	Albendazole The metabolism of Albendazole can be increased when combined with Topotecan.
Ulipristal	Ulipristal The metabolism of Ulipristal can be increased when combined with Topotecan.
Levonorgestrel	Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Topotecan.
Denosumab Injection	Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Topotecan.
Dabigatran	Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Topotecan.
Tocilizumab Injection	Tocilizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Tocilizumab.
Dalfampridine	Dalfampridine Topotecan may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Fingolimod	Fingolimod Topotecan may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Eribulin.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Topotecan can be increased when combined with Cabazitaxel.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Acetaminophen Injection	Acetaminophen Injection Acetaminophen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ipilimumab Injection	Ipilimumab Injection Topotecan may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Topotecan.
Sipuleucel-T Injection	Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Topotecan.
Terbutaline Injection	Terbutaline Injection Terbutaline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Belimumab Injection	Belimumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belimumab.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be increased when combined with Topotecan.
Roflumilast	Roflumilast Roflumilast may increase the immunosuppressive activities of Topotecan.
Linagliptin	Linagliptin The serum concentration of Topotecan can be increased when it is combined with Linagliptin.
Rilpivirine	Rilpivirine Rilpivirine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Telaprevir	Telaprevir The serum concentration of Topotecan can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Topotecan can be increased when combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Topotecan.
Ticagrelor	Ticagrelor The serum concentration of Topotecan can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Topotecan.
Ruxolitinib	Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Topotecan.
Vandetanib	Vandetanib The serum concentration of Topotecan can be increased when it is combined with Vandetanib.
Clobazam	Clobazam Clobazam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Vemurafenib	Vemurafenib The serum concentration of Topotecan can be increased when it is combined with Vemurafenib.
Vismodegib	Vismodegib Vismodegib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Belatacept Injection	Belatacept Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belatacept.
Ivacaftor	Ivacaftor The serum concentration of Topotecan can be increased when it is combined with Ivacaftor.
Basiliximab Injection	Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Topotecan.
Deferiprone	Deferiprone Topotecan may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be increased when combined with Topotecan.
Crizotinib	Crizotinib The serum concentration of Topotecan can be increased when it is combined with Crizotinib.
Melphalan Injection	Melphalan Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Melphalan.
Cabergoline	Cabergoline The metabolism of Cabergoline can be increased when combined with Topotecan.
Naloxone Injection	Naloxone Injection Topotecan may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan	Ambrisentan The serum concentration of Topotecan can be increased when it is combined with Ambrisentan.
Eculizumab Injection	Eculizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Eculizumab.
Fondaparinux Injection	Fondaparinux Injection Fondaparinux may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ezogabine	Ezogabine Tiagabine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Carfilzomib Injection	Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Topotecan.
Iloprost	Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Topotecan.
Enzalutamide	Enzalutamide The serum concentration of Topotecan can be increased when it is combined with Enzalutamide.
Mirabegron	Mirabegron The serum concentration of Topotecan can be increased when it is combined with Mirabegron.
Regorafenib	Regorafenib The serum concentration of Topotecan can be increased when it is combined with Regorafenib.
Bosutinib	Bosutinib The metabolism of Bosutinib can be increased when combined with Topotecan.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Corticotropin.
Teriflunomide	Teriflunomide The risk or severity of adverse effects can be increased when Topotecan is combined with Teriflunomide.
Teduglutide Injection	Teduglutide Injection Topotecan may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl	Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Topotecan.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Topotecan.
Alogliptin	Alogliptin Topotecan may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Dimethyl Fumarate	Dimethyl Fumarate The risk or severity of adverse effects can be increased when Topotecan is combined with Dimethyl fumarate.
Ponatinib	Ponatinib The serum concentration of Topotecan can be increased when it is combined with Ponatinib.
Pomalidomide	Pomalidomide The metabolism of Pomalidomide can be increased when combined with Topotecan.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Topotecan.
Apixaban	Apixaban The serum concentration of Topotecan can be increased when it is combined with Apixaban.
Canagliflozin	Canagliflozin The serum concentration of Topotecan can be increased when it is combined with Canagliflozin.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib	Dabrafenib The metabolism of Topotecan can be increased when combined with Dabrafenib.
Trametinib	Trametinib Topotecan may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir	Dolutegravir The serum concentration of Topotecan can be increased when it is combined with Dolutegravir.
Afatinib	Afatinib The serum concentration of Topotecan can be increased when it is combined with Afatinib.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Topotecan.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Topotecan which could result in a higher serum level.
Vortioxetine	Vortioxetine Topotecan may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Perampanel	Perampanel The metabolism of Perampanel can be increased when combined with Topotecan.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Topotecan.
Lomitapide	Lomitapide The serum concentration of Topotecan can be increased when it is combined with Lomitapide.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Obinutuzumab.
Simeprevir	Simeprevir The serum concentration of Topotecan can be increased when it is combined with Simeprevir.
Sofosbuvir	Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Topotecan.
Dapagliflozin	Dapagliflozin Dapagliflozin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast	Apremilast The risk or severity of adverse effects can be increased when Topotecan is combined with Apremilast.
Droxidopa	Droxidopa Topotecan may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib	Ceritinib The metabolism of Ceritinib can be increased when combined with Topotecan.
Siltuximab Injection	Siltuximab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine Eslicarbazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Vedolizumab Injection	Vedolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Vedolizumab.
Belinostat Injection	Belinostat Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belinostat.
Idelalisib	Idelalisib The metabolism of Idelalisib can be increased when combined with Topotecan.
Testosterone Injection	Testosterone Injection Testosterone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Vorapaxar	Vorapaxar The serum concentration of Topotecan can be increased when it is combined with Vorapaxar.
Suvorexant	Suvorexant The serum concentration of Topotecan can be increased when it is combined with Suvorexant.
Edoxaban	Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Topotecan.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Olaparib can be increased when combined with Topotecan.
Blinatumomab Injection	Blinatumomab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Blinatumomab.
Methamphetamine	Methamphetamine Topotecan may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon	Tasimelteon The metabolism of Tasimelteon can be increased when combined with Topotecan.
Pirfenidone	Pirfenidone The risk or severity of adverse effects can be increased when Topotecan is combined with Pirfenidone.
Nintedanib	Nintedanib The metabolism of Nintedanib can be decreased when combined with Topotecan.
Secukinumab Injection	Secukinumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Secukinumab.
Palbociclib	Palbociclib The serum concentration of Topotecan can be increased when it is combined with Palbociclib.
Lenvatinib	Lenvatinib The serum concentration of Topotecan can be increased when it is combined with Lenvatinib.
Panobinostat	Panobinostat The metabolism of Panobinostat can be increased when combined with Topotecan.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Dinutuximab.
Haloperidol Injection	Haloperidol Injection The serum concentration of Topotecan can be increased when it is combined with Haloperidol.
Amiloride	Amiloride Amiloride may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection	Isavuconazonium Injection The serum concentration of Topotecan can be increased when it is combined with Isavuconazonium.
Macitentan	Macitentan Topotecan may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib	Sonidegib The metabolism of Sonidegib can be increased when combined with Topotecan.
Flibanserin	Flibanserin The serum concentration of Topotecan can be increased when it is combined with Flibanserin.
Rolapitant	Rolapitant The serum concentration of Topotecan can be increased when it is combined with Rolapitant.
Prednisolone	Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Topotecan.
Daclatasvir	Daclatasvir The serum concentration of Topotecan can be increased when it is combined with Daclatasvir.
Ziprasidone Injection	Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Topotecan.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Topotecan may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be increased when combined with Topotecan.
Mepolizumab Injection	Mepolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Mepolizumab.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Topotecan.
Osimertinib	Osimertinib The metabolism of Osimertinib can be increased when combined with Topotecan.
Alectinib	Alectinib The metabolism of Topotecan can be increased when combined with Alectinib.
Ixazomib	Ixazomib The metabolism of Ixazomib can be increased when combined with Topotecan.
Lesinurad	Lesinurad Topotecan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dexamethasone Injection	Dexamethasone Injection The risk or severity of adverse effects can be increased when Dexamethasone is combined with Topotecan.
Defibrotide Injection	Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Topotecan.
Ixekizumab Injection	Ixekizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Ixekizumab.
Brivaracetam Injection	Brivaracetam Injection Topotecan may increase the excretion rate of Brivaracetam which could result in a lower serum level and potentially a reduction in efficacy.
Venetoclax	Venetoclax The serum concentration of Topotecan can be increased when it is combined with Venetoclax.
Cobicistat	Cobicistat The serum concentration of Topotecan can be increased when it is combined with Cobicistat.
Selexipag	Selexipag The serum concentration of Topotecan can be increased when it is combined with Selexipag.
Furosemide Injection	Furosemide Injection Furosemide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib	Rucaparib The serum concentration of Topotecan can be increased when it is combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection Topotecan may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib	Ribociclib The metabolism of Ribociclib can be increased when combined with Topotecan.
Brodalumab Injection	Brodalumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Brodalumab.
Brigatinib	Brigatinib The metabolism of Topotecan can be increased when combined with Brigatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) Topotecan may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine	Deutetrabenazine Topotecan may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine	Valbenazine Topotecan may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort	Deflazacort The risk or severity of adverse effects can be increased when Topotecan is combined with Deflazacort.
Safinamide	Safinamide Safinamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ocrelizumab Injection	Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Topotecan.
Naldemedine	Naldemedine Topotecan may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection	Sarilumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Midostaurin can be increased when combined with Topotecan.
Neratinib	Neratinib The serum concentration of Topotecan can be increased when it is combined with Neratinib.
Guselkumab Injection	Guselkumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Guselkumab.
Enasidenib	Enasidenib The serum concentration of Topotecan can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Topotecan can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Topotecan.
Benznidazole	Benznidazole Topotecan may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Topotecan can be increased when combined with Copanlisib.
Delafloxacin	Delafloxacin Topotecan may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib	Abemaciclib The metabolism of Topotecan can be increased when combined with Abemaciclib.
Betrixaban	Betrixaban The serum concentration of Topotecan can be increased when it is combined with Betrixaban.
Acalabrutinib	Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Topotecan.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Topotecan.
Letermovir	Letermovir Letermovir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ertugliflozin	Ertugliflozin Ertugliflozin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection	Buprenorphine Injection Buprenorphine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Apalutamide	Apalutamide The serum concentration of Topotecan can be decreased when it is combined with Apalutamide.
Penicillamine	Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Topotecan.
Fostamatinib	Fostamatinib Fostamatinib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Avatrombopag	Avatrombopag Avatrombopag may decrease the excretion rate of Topotecan which could result in a higher serum level.
Baricitinib	Baricitinib The metabolism of Topotecan can be increased when combined with Baricitinib.
Lofexidine	Lofexidine The excretion of Topotecan can be decreased when combined with Lofexidine.
Plazomicin Injection	Plazomicin Injection The excretion of Topotecan can be decreased when combined with Plazomicin.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Topotecan.
Ivosidenib	Ivosidenib The serum concentration of Topotecan can be increased when it is combined with Ivosidenib.
Lusutrombopag	Lusutrombopag The serum concentration of Topotecan can be increased when it is combined with Lusutrombopag.
Elagolix	Elagolix The serum concentration of Topotecan can be increased when it is combined with Elagolix.
Tafenoquine	Tafenoquine The excretion of Topotecan can be decreased when combined with Tafenoquine.
Cannabidiol	Cannabidiol Cannabidiol may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Dacomitinib	Dacomitinib The serum concentration of Topotecan can be increased when it is combined with Dacomitinib.
Duvelisib	Duvelisib The metabolism of Duvelisib can be decreased when combined with Topotecan.
Omadacycline	Omadacycline The serum concentration of Topotecan can be increased when it is combined with Omadacycline.
Sarecycline	Sarecycline The serum concentration of Topotecan can be increased when it is combined with Sarecycline.
Stiripentol	Stiripentol Topotecan may increase the excretion rate of Stiripentol which could result in a lower serum level and potentially a reduction in efficacy.
Talazoparib	Talazoparib The serum concentration of Topotecan can be increased when it is combined with Talazoparib.
Gilteritinib	Gilteritinib The excretion of Topotecan can be decreased when combined with Gilteritinib.
Glasdegib	Glasdegib The serum concentration of Topotecan can be increased when it is combined with Glasdegib.
Larotrectinib	Larotrectinib The serum concentration of Topotecan can be increased when it is combined with Larotrectinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection	Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Topotecan.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Topotecan.
Rifamycin	Rifamycin The serum concentration of Topotecan can be increased when it is combined with Rifamycin.
Prucalopride	Prucalopride The metabolism of Prucalopride can be decreased when combined with Topotecan.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Ravulizumab.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be increased when combined with Topotecan.
Acyclovir Ophthalmic	Acyclovir Ophthalmic The excretion of Topotecan can be decreased when combined with Acyclovir.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Topotecan.
Erdafitinib	Erdafitinib The serum concentration of Topotecan can be increased when it is combined with Erdafitinib.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Risankizumab.
Alpelisib	Alpelisib The metabolism of Alpelisib can be increased when combined with Topotecan.
Brexanolone Injection	Brexanolone Injection Brexanolone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Cladribine	Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Topotecan.
Solriamfetol	Solriamfetol The excretion of Topotecan can be decreased when combined with Solriamfetol.
Darolutamide	Darolutamide The serum concentration of Topotecan can be increased when it is combined with Darolutamide.
Entrectinib	Entrectinib The metabolism of Entrectinib can be increased when combined with Topotecan.
Pexidartinib	Pexidartinib The metabolism of Topotecan can be increased when combined with Pexidartinib.
Istradefylline	Istradefylline The serum concentration of Topotecan can be increased when it is combined with Istradefylline.
Pitolisant	Pitolisant Topotecan may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Fedratinib	Fedratinib The serum concentration of Topotecan can be increased when it is combined with Fedratinib.
Lefamulin	Lefamulin The metabolism of Lefamulin can be increased when combined with Topotecan.
Phenytoin Injection	Phenytoin Injection Phenytoin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Fosphenytoin Injection	Fosphenytoin Injection Fosphenytoin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Enfortumab vedotin-ejfv Injection	Enfortumab vedotin-ejfv Injection The serum concentration of Topotecan can be increased when it is combined with Enfortumab vedotin.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Topotecan.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Topotecan.
Lumateperone	Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Topotecan.
Lasmiditan	Lasmiditan The serum concentration of Topotecan can be increased when it is combined with Lasmiditan.
Ubrogepant	Ubrogepant The serum concentration of Topotecan can be increased when it is combined with Ubrogepant.
Tazemetostat	Tazemetostat The excretion of Topotecan can be decreased when combined with Tazemetostat.
Cenobamate	Cenobamate Cenobamate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Ozanimod	Ozanimod The risk or severity of adverse effects can be increased when Topotecan is combined with Ozanimod.
Selumetinib	Selumetinib The serum concentration of Topotecan can be increased when it is combined with Selumetinib.
Rimegepant	Rimegepant The metabolism of Rimegepant can be increased when combined with Topotecan.
Tucatinib	Tucatinib The excretion of Topotecan can be decreased when combined with Tucatinib.
Remdesivir Injection	Remdesivir Injection The excretion of Topotecan can be decreased when combined with Remdesivir.
Ripretinib	Ripretinib The serum concentration of Topotecan can be increased when it is combined with Ripretinib.
Selpercatinib	Selpercatinib The serum concentration of Topotecan can be decreased when it is combined with Selpercatinib.
Capmatinib	Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Topotecan.
Lemborexant	Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Topotecan.
Fostemsavir	Fostemsavir Fostemsavir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The serum concentration of Topotecan can be increased when it is combined with Belantamab mafodotin.
Pralsetinib	Pralsetinib The serum concentration of Topotecan can be increased when it is combined with Pralsetinib.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Topotecan.
Viloxazine	Viloxazine Topotecan may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be increased when combined with Topotecan.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Indomethacin	Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Topotecan.
Mefenamic Acid	Mefenamic Acid Mefenamic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Naproxen	Naproxen Naproxen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Trazodone	Trazodone The serum concentration of Topotecan can be decreased when it is combined with Trazodone.
Isotretinoin	Isotretinoin Isotretinoin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Hydroxyurea	Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Topotecan.
Floxuridine	Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Topotecan.
Phenobarbital	Phenobarbital Phenobarbital may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Metaxalone	Metaxalone Metaxalone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Methotrexate Injection	Methotrexate Injection The metabolism of Topotecan can be decreased when combined with Methotrexate.
Primidone	Primidone Primidone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Methsuximide	Methsuximide Methsuximide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Chlorpromazine	Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Topotecan.
Diazepam	Diazepam Diazepam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Oxazepam	Oxazepam Oxazepam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Flurazepam	Flurazepam Flurazepam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Clorazepate	Clorazepate Clorazepic acid may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Lorazepam	Lorazepam Lorazepam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Carmustine	Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Topotecan.
Amantadine	Amantadine Amantadine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Codeine	Codeine Codeine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Phenelzine	Phenelzine Phenelzine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Topotecan is combined with Procarbazine.
Tetracycline	Tetracycline Tetracycline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Thioguanine	Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Topotecan.
Prochlorperazine	Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Topotecan.
Bleomycin	Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Topotecan.
Sulfadiazine	Sulfadiazine Sulfadiazine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Methadone	Methadone Methadone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Benztropine	Benztropine Benzatropine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Maprotiline	Maprotiline Maprotiline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ibuprofen	Ibuprofen Ibuprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Azathioprine	Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Topotecan.
Phentermine	Phentermine The metabolism of Phentermine can be increased when combined with Topotecan.
Methylphenidate	Methylphenidate Methylphenidate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Topotecan.
Lomustine	Lomustine The risk or severity of adverse effects can be increased when Topotecan is combined with Lomustine.
Doxorubicin	Doxorubicin The metabolism of Topotecan can be increased when combined with Doxorubicin.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Topotecan.
Mechlorethamine	Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Topotecan.
Dactinomycin	Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Topotecan.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Carbamazepine	Carbamazepine Carbamazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Methyldopa	Methyldopa Methyldopa may decrease the excretion rate of Topotecan which could result in a higher serum level.
Clonidine	Clonidine The metabolism of Clonidine can be increased when combined with Topotecan.
Hydralazine	Hydralazine Topotecan may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine	Cimetidine The excretion of Topotecan can be decreased when combined with Cimetidine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Warfarin	Warfarin The metabolism of Warfarin can be increased when combined with Topotecan.
Clonazepam	Clonazepam The metabolism of Clonazepam can be increased when combined with Topotecan.
Loperamide	Loperamide The serum concentration of Topotecan can be increased when it is combined with Loperamide.
Promethazine	Promethazine Topotecan may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Daunorubicin	Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Topotecan.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Digoxin	Digoxin Topotecan may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine	Loxapine The serum concentration of Topotecan can be increased when it is combined with Loxapine.
Chloroquine	Chloroquine Chloroquine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Quinine	Quinine The serum concentration of Topotecan can be increased when it is combined with Quinine.
Ethosuximide	Ethosuximide Topotecan may increase the excretion rate of Ethosuximide which could result in a lower serum level and potentially a reduction in efficacy.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sulfinpyrazone	Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Topotecan.
Chlorothiazide	Chlorothiazide Chlorothiazide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Metolazone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide The metabolism of Isosorbide can be increased when combined with Topotecan.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Topotecan.
Secobarbital	Secobarbital Secobarbital may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Desipramine	Desipramine Topotecan may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline	Amitriptyline Amitriptyline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Imipramine	Imipramine Imipramine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Probenecid	Probenecid Topotecan may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine	Quinidine The serum concentration of Topotecan can be increased when it is combined with Quinidine.
Procainamide	Procainamide The excretion of Procainamide can be decreased when combined with Topotecan.
Isoniazid	Isoniazid Isoniazid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Rifampin	Rifampin The serum concentration of Topotecan can be decreased when it is combined with Rifampicin.
Disopyramide	Disopyramide Disopyramide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Valproic Acid	Valproic Acid Valproic acid may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Tamoxifen	Tamoxifen The serum concentration of Topotecan can be increased when it is combined with Tamoxifen.
Mitomycin	Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Topotecan.
Butabarbital	Butabarbital Butabarbital may decrease the excretion rate of Topotecan which could result in a higher serum level.
Levothyroxine	Levothyroxine The serum concentration of Topotecan can be decreased when it is combined with Levothyroxine.
Liothyronine	Liothyronine Liothyronine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Methimazole	Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Topotecan.
Propylthiouracil	Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Topotecan.
Chlorpropamide	Chlorpropamide Chlorpropamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tolbutamide	Tolbutamide Topotecan may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide	Tolazamide Tolazamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Baclofen	Baclofen Baclofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Methyclothiazide	Methyclothiazide Methyclothiazide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide	Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Chlorzoxazone	Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nortriptyline	Nortriptyline The metabolism of Nortriptyline can be increased when combined with Topotecan.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Topotecan which could result in a higher serum level.
Mercaptopurine	Mercaptopurine The risk or severity of adverse effects can be increased when Topotecan is combined with Mercaptopurine.
Phytonadione	Phytonadione Phylloquinone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nadolol	Nadolol The excretion of Nadolol can be decreased when combined with Topotecan.
Allopurinol	Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Topotecan.
Clomiphene	Clomiphene The serum concentration of Topotecan can be increased when it is combined with Clomifene.
Flavoxate	Flavoxate Topotecan may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Topotecan.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Topotecan.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cephalexin	Cephalexin The excretion of Topotecan can be decreased when combined with Cephalexin.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dacarbazine	Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Topotecan.
Acetazolamide	Acetazolamide Acetazolamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Topotecan.
Ketoconazole	Ketoconazole The serum concentration of Topotecan can be increased when it is combined with Ketoconazole.
Pyrantel	Pyrantel Topotecan may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection	Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Topotecan.
Vincristine Injection	Vincristine Injection The metabolism of Topotecan can be increased when combined with Vincristine.
Dipyridamole	Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Topotecan.
Vinblastine	Vinblastine The metabolism of Topotecan can be increased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Topotecan.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Salsalate	Salsalate Salsalate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Chlorambucil	Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Topotecan.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Topotecan.
Temazepam	Temazepam Temazepam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Triazolam	Triazolam Triazolam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dicyclomine	Dicyclomine Dicyclomine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Propantheline	Propantheline Propantheline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Trimethoprim	Trimethoprim Trimethoprim may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nifedipine	Nifedipine Topotecan may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol	Timolol Timolol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Verapamil	Verapamil The serum concentration of Topotecan can be increased when it is combined with Verapamil.
Pindolol	Pindolol Pindolol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cisplatin Injection	Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Topotecan.
Diflunisal	Diflunisal Diflunisal may decrease the excretion rate of Topotecan which could result in a higher serum level.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Bumetanide	Bumetanide Bumetanide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin	Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Topotecan.
Etoposide	Etoposide The metabolism of Topotecan can be increased when combined with Etoposide.
Glipizide	Glipizide Topotecan may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide	Indapamide Indapamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Topotecan may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection	Oxacillin Injection Oxacillin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pentoxifylline	Pentoxifylline Pentoxifylline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pentamidine Injection	Pentamidine Injection Pentamidine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Labetalol	Labetalol Labetalol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Auranofin	Auranofin Auranofin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Gemfibrozil	Gemfibrozil Topotecan may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ketoprofen	Ketoprofen Ketoprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Pimozide can be increased when combined with Topotecan.
Flurbiprofen	Flurbiprofen Flurbiprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Amiodarone	Amiodarone The serum concentration of Topotecan can be increased when it is combined with Amiodarone.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Buspirone	Buspirone Buspirone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Topotecan.
Ciprofloxacin	Ciprofloxacin The excretion of Topotecan can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Diclofenac	Diclofenac Diclofenac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Topotecan.
Clozapine	Clozapine The risk or severity of neutropenia can be increased when Topotecan is combined with Clozapine.
Estazolam	Estazolam Topotecan may increase the excretion rate of Estazolam which could result in a lower serum level and potentially a reduction in efficacy.
Idarubicin	Idarubicin The risk or severity of adverse effects can be increased when Topotecan is combined with Idarubicin.
Didanosine	Didanosine Didanosine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fludarabine Injection	Fludarabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Fludarabine.
Pentostatin Injection	Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Topotecan.
Clarithromycin	Clarithromycin The serum concentration of Topotecan can be increased when it is combined with Clarithromycin.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fosinopril	Fosinopril Fosinopril may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nabumetone	Nabumetone Nabumetone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pravastatin	Pravastatin Pravastatin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Simvastatin	Simvastatin The serum concentration of Topotecan can be increased when it is combined with Simvastatin.
Filgrastim Injection	Filgrastim Injection The risk or severity of neutropenia can be increased when Filgrastim is combined with Topotecan.
Epoetin Alfa, Injection	Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Topotecan.
Amlodipine	Amlodipine The metabolism of Amlodipine can be increased when combined with Topotecan.
Teniposide Injection	Teniposide Injection The metabolism of Topotecan can be increased when combined with Teniposide.
Itraconazole	Itraconazole The serum concentration of Topotecan can be increased when it is combined with Itraconazole.
Lisinopril	Lisinopril Lisinopril may decrease the excretion rate of Topotecan which could result in a higher serum level.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Bisoprolol	Bisoprolol The serum concentration of Topotecan can be increased when it is combined with Bisoprolol.
Zolpidem	Zolpidem The metabolism of Zolpidem can be increased when combined with Topotecan.
Doxazosin	Doxazosin The metabolism of Doxazosin can be increased when combined with Topotecan.
Isradipine	Isradipine Isradipine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Omeprazole	Omeprazole Omeprazole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cisapride	Cisapride The metabolism of Cisapride can be increased when combined with Topotecan.
Gabapentin	Gabapentin Gabapentin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Venlafaxine	Venlafaxine Venlafaxine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Famciclovir	Famciclovir The metabolism of Famciclovir can be increased when combined with Topotecan.
Fluvoxamine	Fluvoxamine Fluvoxamine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nefazodone	Nefazodone Topotecan may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Lamotrigine	Lamotrigine Lamotrigine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tramadol	Tramadol The metabolism of Topotecan can be decreased when combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Topotecan can be increased when combined with Vinorelbine.
Carboplatin Injection	Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Topotecan.
Lansoprazole	Lansoprazole Lansoprazole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Topotecan.
Pegaspargase Injection	Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Topotecan.
Bupropion	Bupropion Topotecan may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine	Ticlopidine The metabolism of Topotecan can be increased when combined with Ticlopidine.
Saquinavir	Saquinavir The serum concentration of Topotecan can be increased when it is combined with Saquinavir.
Metformin	Metformin The excretion of Topotecan can be decreased when combined with Metformin.
Dalteparin Injection	Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Topotecan.
Nisoldipine	Nisoldipine Nisoldipine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Lamivudine	Lamivudine Lamivudine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Riluzole	Riluzole Riluzole may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Acarbose	Acarbose Acarbose may decrease the excretion rate of Topotecan which could result in a higher serum level.
Gemcitabine Injection	Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Topotecan.
Ritonavir	Ritonavir The serum concentration of Topotecan can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Topotecan.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may decrease the excretion rate of Topotecan which could result in a higher serum level.
Clomipramine	Clomipramine The metabolism of Clomipramine can be increased when combined with Topotecan.
Zafirlukast	Zafirlukast The metabolism of Zafirlukast can be increased when combined with Topotecan.
Fosfomycin	Fosfomycin Fosfomycin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Topiramate	Topiramate Topiramate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Pramipexole	Pramipexole Pramipexole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nelfinavir	Nelfinavir Nelfinavir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fexofenadine	Fexofenadine The serum concentration of Topotecan can be increased when it is combined with Fexofenadine.
Azithromycin	Azithromycin The metabolism of Azithromycin can be increased when combined with Topotecan.
Carvedilol	Carvedilol The serum concentration of Topotecan can be increased when it is combined with Carvedilol.
Nilutamide	Nilutamide Nilutamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Flutamide	Flutamide Flutamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Bicalutamide	Bicalutamide The metabolism of Bicalutamide can be increased when combined with Topotecan.
Propafenone	Propafenone The serum concentration of Topotecan can be increased when it is combined with Propafenone.
Tamsulosin	Tamsulosin Tamsulosin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Quetiapine	Quetiapine Topotecan may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cetirizine	Cetirizine Cetirizine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tolcapone	Tolcapone Tolcapone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Capecitabine	Capecitabine The risk or severity of adverse effects can be increased when Topotecan is combined with Capecitabine.
Abacavir	Abacavir Topotecan may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil	Sildenafil The serum concentration of Topotecan can be increased when it is combined with Sildenafil.
Trastuzumab Injection	Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Topotecan.
Celecoxib	Celecoxib Celecoxib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Rosiglitazone	Rosiglitazone Rosiglitazone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tolterodine	Tolterodine Topotecan may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide	Thalidomide The risk or severity of adverse effects can be increased when Topotecan is combined with Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nateglinide	Nateglinide Nateglinide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Levetiracetam	Levetiracetam Topotecan may increase the excretion rate of Levetiracetam which could result in a lower serum level and potentially a reduction in efficacy.
Rabeprazole	Rabeprazole Rabeprazole may decrease the excretion rate of Topotecan which could result in a higher serum level.

Topotecan

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