Topotecan
Generic name: Pronounced as (toe'' poe tee' kan)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 10/15/2016
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
Topotecan may cause a decrease in the number of blood cells made by your bone marrow. This increases the risk that you will develop a serious infection. You should not take topotecan if you already have a low number of blood cells. Your doctor will order laboratory tests regularly before and during your treatment to check whether your body has enough blood cells. If you experience any of the following symptoms, call your doctor immediately: sore throat, chills, fever, cough, burning or painful urination, or other signs of infection; stomach pain; unusual bruising or bleeding; excessive tiredness; headache; dizziness; confusion; pale skin; fast heartbeat; or shortness of breath.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to topotecan.
Talk to your doctor about the risks of taking topotecan.
Why is this medication prescribed?
Topotecan is used to treat small cell lung cancer (a type of cancer that begins in the lungs) that was successfully treated with a different chemotherapy medication but has returned no sooner than 45 days after the last dose of the first chemotherapy medication was taken. Topotecan is in a class of medications called topoisomerase I inhibitors. It works by killing cancer cells.
How should this medicine be used?
Topotecan comes as a capsule to take by mouth. It may be taken with or without food. It is usually taken once a day for 5 days in a row every 21 days. Your doctor will decide how many times you should repeat this cycle. Take topotecan at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take topotecan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole with water; do not open, chew, or crush them.
Topotecan capsules come in two different strengths. Your doctor may want you to take a combination of both strengths of capsules to make up your full dose. Be sure that you know what each type of capsule looks like and how many you are to take of each. Ask your doctor or pharmacist if you have any questions.
If any of the capsules are broken or leaking, do not touch them with your bare hands. Carefully dispose of the broken capsules without touching them directly and then wash your hands well with soap and water. If the capsule contents do touch your skin, wash the area well with soap and water right away. If any capsule contents get in your eyes, wash your eyes right away with gently flowing water for at least 15 minutes. Call your doctor if you have any skin reaction or if medication gets in your eyes.
You may vomit after you take the medication. If this happens, let your doctor know right away. Do not take another dose of topotecan on the same day.
Your doctor may need to delay your treatment or adjust your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with topotecan.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking topotecan,
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tell your doctor and pharmacist if you are allergic to topotecan, any other medications, or any of the ingredients in topotecan capsules. Ask your pharmacist for a list of the ingredients.
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tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cyclosporine (Gengraf, Neoral, Sandimmune); ketoconazole (Nizoral); ritonavir (Norvir, in Kaletra); or saquinavir (Fortovase, Invirase). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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tell your doctor if you have or have ever had kidney disease.
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tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking topotecan. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking topotecan, call your doctor immediately. Topotecan may harm the fetus.
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tell your doctor if you are breast-feeding. You should not breast-feed while you are taking topotecan.
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if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking topotecan.
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you should know that topotecan may make you drowsy, tired, or weak. Do not drive a car, use heavy tools, or operate machinery until you know how this medication affects you.
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you should know that topotecan can cause severe diarrhea that may need to be treated in a hospital. Talk to your doctor about how to prevent and treat diarrhea. Call your doctor right away if you have any of the following symptoms: diarrhea with fever, diarrhea 3 or more times a day, or diarrhea with stomach pain or cramps.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Let your doctor know if you miss a dose.
What side effects can this medication cause?
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Topotecan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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nausea
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vomiting
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diarrhea
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loss of appetite
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hair loss
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Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:
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hives
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rash
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itching
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hoarseness
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difficulty breathing or swallowing
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Topotecan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it in the refrigerator and protect it from light.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include:
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sore throat, chills, fever, cough, burning or painful urination, or other signs of infection
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unusual bruising or bleeding
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excessive tiredness
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headache
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dizziness
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confusion
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pale skin
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fast heartbeat
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shortness of breath
What OTHER INFORMATION should I know?
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Leflunomide | Leflunomide The risk or severity of adverse effects can be increased when Topotecan is combined with Leflunomide. |
Atorvastatin | Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Topotecan. |
Aminophylline | Aminophylline The metabolism of Aminophylline can be increased when combined with Topotecan. |
Anagrelide | Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Topotecan. |
Cilostazol | Cilostazol The metabolism of Cilostazol can be decreased when combined with Topotecan. |
Clopidogrel | Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Topotecan. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The serum concentration of Topotecan can be increased when it is combined with Erythromycin. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Fenofibrate | Fenofibrate The metabolism of Fenofibrate can be increased when combined with Topotecan. |
Guanfacine | Guanfacine Guanfacine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Magnesium Hydroxide | Magnesium Hydroxide Topotecan may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. |
Mycophenolate | Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Topotecan. |
Olsalazine | Olsalazine Olsalazine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Paregoric | Paregoric The serum concentration of Topotecan can be increased when it is combined with Morphine. |
Potassium | Potassium Potassium may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Prednisone | Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Topotecan. |
Ranitidine | Ranitidine Ranitidine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Reserpine | Reserpine The serum concentration of Topotecan can be increased when it is combined with Reserpine. |
Rizatriptan | Rizatriptan Rizatriptan may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Sumatriptan | Sumatriptan Sumatriptan may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Tacrolimus | Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Topotecan. |
Tizanidine | Tizanidine Tizanidine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Triamcinolone | Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Topotecan. |
Ampicillin Injection | Ampicillin Injection Ampicillin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Doxycycline Injection | Doxycycline Injection Doxycycline may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Fluconazole Injection | Fluconazole Injection The serum concentration of Topotecan can be increased when it is combined with Fluconazole. |
Foscarnet Injection | Foscarnet Injection Foscarnet may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Hydromorphone Injection | Hydromorphone Injection Hydromorphone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Interferon Beta-1b Injection | Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Topotecan. |
Interferon Gamma-1b Injection | Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Topotecan. |
Levofloxacin Injection | Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Topotecan. |
Meperidine Injection | Meperidine Injection The metabolism of Topotecan can be increased when combined with Meperidine. |
Methylprednisolone Injection | Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Topotecan. |
Metoclopramide Injection | Metoclopramide Injection Topotecan may decrease the excretion rate of Metoclopramide which could result in a higher serum level. |
Morphine Injection | Morphine Injection The serum concentration of Topotecan can be increased when it is combined with Morphine. |
Pamidronate Injection | Pamidronate Injection Pamidronic acid may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Vancomycin Injection | Vancomycin Injection Topotecan may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
Zidovudine Injection | Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Topotecan. |
Altretamine | Altretamine Amphetamine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cefuroxime | Cefuroxime Cefuroxime may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cyclosporine | Cyclosporine Topotecan may increase the immunosuppressive activities of Cyclosporine. |
Enoxaparin Injection | Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Topotecan. |
Torsemide | Torsemide Torasemide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Dofetilide | Dofetilide The metabolism of Dofetilide can be increased when combined with Topotecan. |
Hydroxychloroquine | Hydroxychloroquine The risk or severity of adverse effects can be increased when Topotecan is combined with Hydroxychloroquine. |
Meloxicam | Meloxicam Meloxicam may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Oxcarbazepine | Oxcarbazepine Oxcarbazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Pantoprazole | Pantoprazole Pantoprazole may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Telmisartan | Telmisartan Telmisartan may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Temozolomide | Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Topotecan. |
Zaleplon | Zaleplon Zaleplon may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Anakinra | Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Topotecan. |
Linezolid | Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Topotecan. |
Pentosan Polysulfate | Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Topotecan. |
Etanercept Injection | Etanercept Injection The risk or severity of adverse effects can be increased when Etanercept is combined with Topotecan. |
Perindopril | Perindopril Perindopril may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Tenofovir | Tenofovir The metabolism of Tenofovir can be decreased when combined with Topotecan. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Sirolimus | Sirolimus The metabolism of Sirolimus can be increased when combined with Topotecan. |
Epirubicin | Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Topotecan. |
Eplerenone | Eplerenone Eplerenone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Zonisamide | Zonisamide The serum concentration of Topotecan can be increased when it is combined with Zonisamide. |
Adalimumab Injection | Adalimumab Injection The risk or severity of adverse effects can be increased when Adalimumab is combined with Topotecan. |
Aripiprazole | Aripiprazole The metabolism of Aripiprazole can be increased when combined with Topotecan. |
Atomoxetine | Atomoxetine Atomoxetine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Glatiramer Injection | Glatiramer Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Glatiramer. |
Atazanavir | Atazanavir The metabolism of Atazanavir can be increased when combined with Topotecan. |
Almotriptan | Almotriptan Almotriptan may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Rosuvastatin | Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Topotecan. |
Vardenafil | Vardenafil The metabolism of Vardenafil can be decreased when combined with Topotecan. |
Alfuzosin | Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Topotecan. |
Emtricitabine | Emtricitabine The excretion of Emtricitabine can be decreased when combined with Topotecan. |
Memantine | Memantine Topotecan may decrease the excretion rate of Memantine which could result in a higher serum level. |
Tegaserod | Tegaserod The serum concentration of Topotecan can be increased when it is combined with Tegaserod. |
Tadalafil | Tadalafil Tadalafil may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Progesterone | Progesterone Progesterone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Darbepoetin Alfa Injection | Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Topotecan. |
Infliximab Injection | Infliximab Injection The risk or severity of adverse effects can be increased when Infliximab is combined with Topotecan. |
Duloxetine | Duloxetine The metabolism of Duloxetine can be decreased when combined with Topotecan. |
Norethindrone | Norethindrone The metabolism of Norethisterone can be increased when combined with Topotecan. |
Tinidazole | Tinidazole Tinidazole may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cefditoren | Cefditoren Cefdinir may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Natalizumab Injection | Natalizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Natalizumab. |
Cyanocobalamin Injection | Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Erlotinib | Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Topotecan. |
Eszopiclone | Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Topotecan. |
Ganciclovir | Ganciclovir The excretion of Topotecan can be decreased when combined with Ganciclovir. |
Palifermin | Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Topotecan. |
Ribavirin | Ribavirin Ribavirin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Valganciclovir | Valganciclovir Topotecan may decrease the excretion rate of Valganciclovir which could result in a higher serum level. |
Adefovir | Adefovir Adefovir may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Dextroamphetamine | Dextroamphetamine Amphetamine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Peginterferon Alfa-2a Injection | Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Topotecan. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Topotecan. |
Ramelteon | Ramelteon Ramelteon may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Fentanyl | Fentanyl The metabolism of Fentanyl can be decreased when combined with Topotecan. |
Pregabalin | Pregabalin Pregabalin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Tipranavir | Tipranavir The serum concentration of Topotecan can be increased when it is combined with Tipranavir. |
Felbamate | Felbamate Felbamate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Ranolazine | Ranolazine The metabolism of Topotecan can be increased when combined with Ranolazine. |
Abatacept Injection | Abatacept Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Abatacept. |
Rasagiline | Rasagiline Topotecan may decrease the excretion rate of Rasagiline which could result in a higher serum level. |
Imatinib | Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Topotecan. |
Sitagliptin | Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Topotecan. |
Varenicline | Varenicline Topotecan may decrease the excretion rate of Varenicline which could result in a higher serum level. |
Bevacizumab Injection | Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Topotecan. |
Gefitinib | Gefitinib Gefitinib may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Albuterol | Albuterol Salbutamol may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Paliperidone | Paliperidone The serum concentration of Topotecan can be increased when it is combined with Paliperidone. |
Bortezomib | Bortezomib The metabolism of Topotecan can be increased when combined with Bortezomib. |
Clofarabine Injection | Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Topotecan. |
Hepatitis B Vaccine | Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Topotecan. |
Influenza Vaccine, Inactivated or Recombinant | Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Topotecan. |
Influenza Vaccine, Live Intranasal | Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Topotecan. |
Live Shingles (Zoster) Vaccine (ZVL) | Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Topotecan. |
Lubiprostone | Lubiprostone Topotecan may decrease the excretion rate of Lubiprostone which could result in a higher serum level. |
Oxaliplatin Injection | Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Topotecan. |
Posaconazole | Posaconazole The serum concentration of Topotecan can be increased when it is combined with Posaconazole. |
Rituximab Injection | Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Topotecan. |
Pemetrexed Injection | Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Topotecan. |
Retapamulin | Retapamulin The metabolism of Retapamulin can be decreased when combined with Topotecan. |
Vorinostat | Vorinostat The risk or severity of adverse effects can be increased when Topotecan is combined with Vorinostat. |
Sorafenib | Sorafenib The serum concentration of Topotecan can be increased when it is combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Topotecan can be increased when combined with Sunitinib. |
Dronabinol | Dronabinol Dronabinol may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Lapatinib | Lapatinib The serum concentration of Topotecan can be increased when it is combined with Lapatinib. |
Levocetirizine | Levocetirizine Topotecan may decrease the excretion rate of Levocetirizine which could result in a higher serum level. |
Pegaptanib Injection | Pegaptanib Injection Topotecan may decrease the excretion rate of Pegaptanib which could result in a higher serum level. |
Pegfilgrastim Injection | Pegfilgrastim Injection The risk or severity of neutropenia can be increased when Pegfilgrastim is combined with Topotecan. |
Dasatinib | Dasatinib The metabolism of Topotecan can be increased when combined with Dasatinib. |
Azacitidine Injection | Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Topotecan. |
Temsirolimus | Temsirolimus The serum concentration of Topotecan can be increased when it is combined with Temsirolimus. |
Nelarabine Injection | Nelarabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Nelarabine. |
Lenalidomide | Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Topotecan. |
Nilotinib | Nilotinib The serum concentration of Topotecan can be increased when it is combined with Nilotinib. |
Toremifene | Toremifene The serum concentration of Topotecan can be increased when it is combined with Toremifene. |
Bexarotene | Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Topotecan. |
Budesonide | Budesonide The risk or severity of adverse effects can be increased when Topotecan is combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Topotecan. |
Decitabine Injection | Decitabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Decitabine. |
Desmopressin | Desmopressin Desmopressin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Doripenem Injection | Doripenem Injection Topotecan may decrease the excretion rate of Doripenem which could result in a higher serum level. |
Etravirine | Etravirine The serum concentration of Topotecan can be decreased when it is combined with Etravirine. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Arsenic trioxide. |
Mitoxantrone Injection | Mitoxantrone Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Mitoxantrone. |
Desvenlafaxine | Desvenlafaxine Topotecan may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level. |
Cevimeline | Cevimeline Cevimeline may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Tretinoin | Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Topotecan. |
Bendamustine Injection | Bendamustine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Bendamustine. |
Flecainide | Flecainide The excretion of Topotecan can be decreased when combined with Flecainide. |
Certolizumab Injection | Certolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Certolizumab pegol. |
Ixabepilone Injection | Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Topotecan. |
Irinotecan Injection | Irinotecan Injection The metabolism of Topotecan can be increased when combined with Irinotecan. |
Daptomycin Injection | Daptomycin Injection Daptomycin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Estramustine | Estramustine The risk or severity of adverse effects can be increased when Topotecan is combined with Estramustine. |
Methylnaltrexone Injection | Methylnaltrexone Injection Topotecan may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. |
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) | Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Topotecan. |
Rufinamide | Rufinamide Topotecan may increase the excretion rate of Rufinamide which could result in a lower serum level and potentially a reduction in efficacy. |
Silodosin | Silodosin The serum concentration of Topotecan can be increased when it is combined with Silodosin. |
Midazolam | Midazolam The serum concentration of Midazolam can be increased when it is combined with Topotecan. |
Dexrazoxane Injection | Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Topotecan. |
Eltrombopag | Eltrombopag Eltrombopag may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ibritumomab Injection | Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Topotecan. |
Milnacipran | Milnacipran The metabolism of Milnacipran can be increased when combined with Topotecan. |
Plerixafor Injection | Plerixafor Injection Topotecan may decrease the excretion rate of Plerixafor which could result in a higher serum level. |
Fesoterodine | Fesoterodine Topotecan may decrease the excretion rate of Fesoterodine which could result in a higher serum level. |
Iloperidone | Iloperidone The metabolism of Iloperidone can be decreased when combined with Topotecan. |
Prasugrel | Prasugrel Topotecan may decrease the excretion rate of Prasugrel which could result in a higher serum level. |
Lacosamide | Lacosamide Topotecan may increase the excretion rate of Lacosamide which could result in a lower serum level and potentially a reduction in efficacy. |
Everolimus | Everolimus The metabolism of Everolimus can be decreased when combined with Topotecan. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The metabolism of Topotecan can be increased when combined with Tolvaptan. |
Dronedarone | Dronedarone The serum concentration of Topotecan can be increased when it is combined with Dronedarone. |
Pralatrexate Injection | Pralatrexate Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Pralatrexate. |
Palonosetron Injection | Palonosetron Injection Palonosetron may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Saxagliptin | Saxagliptin Topotecan may decrease the excretion rate of Saxagliptin which could result in a higher serum level. |
Telavancin Injection | Telavancin Injection Topotecan may decrease the excretion rate of Telavancin which could result in a higher serum level. |
Romidepsin Injection | Romidepsin Injection The metabolism of Topotecan can be increased when combined with Romidepsin. |
Golimumab Injection | Golimumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Golimumab. |
Pazopanib | Pazopanib The metabolism of Pazopanib can be increased when combined with Topotecan. |
Vigabatrin | Vigabatrin Vigabatrin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Albendazole | Albendazole The metabolism of Albendazole can be increased when combined with Topotecan. |
Ulipristal | Ulipristal The metabolism of Ulipristal can be increased when combined with Topotecan. |
Levonorgestrel | Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Topotecan. |
Denosumab Injection | Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Topotecan. |
Dabigatran | Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Topotecan. |
Tocilizumab Injection | Tocilizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Tocilizumab. |
Dalfampridine | Dalfampridine Topotecan may decrease the excretion rate of Dalfampridine which could result in a higher serum level. |
Fingolimod | Fingolimod Topotecan may increase the immunosuppressive activities of Fingolimod. |
Eribulin Injection | Eribulin Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Eribulin. |
Cabazitaxel Injection | Cabazitaxel Injection The metabolism of Topotecan can be increased when combined with Cabazitaxel. |
Ceftaroline Injection | Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Acetaminophen Injection | Acetaminophen Injection Acetaminophen may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ipilimumab Injection | Ipilimumab Injection Topotecan may decrease the excretion rate of Ipilimumab which could result in a higher serum level. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Topotecan. |
Sipuleucel-T Injection | Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Topotecan. |
Terbutaline Injection | Terbutaline Injection Terbutaline may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Belimumab Injection | Belimumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belimumab. |
Busulfan Injection | Busulfan Injection The metabolism of Busulfan can be increased when combined with Topotecan. |
Roflumilast | Roflumilast Roflumilast may increase the immunosuppressive activities of Topotecan. |
Linagliptin | Linagliptin The serum concentration of Topotecan can be increased when it is combined with Linagliptin. |
Rilpivirine | Rilpivirine Rilpivirine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Telaprevir | Telaprevir The serum concentration of Topotecan can be increased when it is combined with Glecaprevir. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Topotecan can be increased when combined with Cyclophosphamide. |
Rivaroxaban | Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Topotecan. |
Ticagrelor | Ticagrelor The serum concentration of Topotecan can be increased when it is combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Topotecan. |
Ruxolitinib | Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Topotecan. |
Vandetanib | Vandetanib The serum concentration of Topotecan can be increased when it is combined with Vandetanib. |
Clobazam | Clobazam Clobazam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Vemurafenib | Vemurafenib The serum concentration of Topotecan can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib Vismodegib may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Belatacept Injection | Belatacept Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belatacept. |
Ivacaftor | Ivacaftor The serum concentration of Topotecan can be increased when it is combined with Ivacaftor. |
Basiliximab Injection | Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Topotecan. |
Deferiprone | Deferiprone Topotecan may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
Axitinib | Axitinib The metabolism of Axitinib can be increased when combined with Topotecan. |
Crizotinib | Crizotinib The serum concentration of Topotecan can be increased when it is combined with Crizotinib. |
Melphalan Injection | Melphalan Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Melphalan. |
Cabergoline | Cabergoline The metabolism of Cabergoline can be increased when combined with Topotecan. |
Naloxone Injection | Naloxone Injection Topotecan may decrease the excretion rate of Naloxone which could result in a higher serum level. |
Ambrisentan | Ambrisentan The serum concentration of Topotecan can be increased when it is combined with Ambrisentan. |
Eculizumab Injection | Eculizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Eculizumab. |
Fondaparinux Injection | Fondaparinux Injection Fondaparinux may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ezogabine | Ezogabine Tiagabine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Topotecan. |
Iloprost | Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Topotecan. |
Enzalutamide | Enzalutamide The serum concentration of Topotecan can be increased when it is combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Topotecan can be increased when it is combined with Mirabegron. |
Regorafenib | Regorafenib The serum concentration of Topotecan can be increased when it is combined with Regorafenib. |
Bosutinib | Bosutinib The metabolism of Bosutinib can be increased when combined with Topotecan. |
Corticotropin, Repository Injection | Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Corticotropin. |
Teriflunomide | Teriflunomide The risk or severity of adverse effects can be increased when Topotecan is combined with Teriflunomide. |
Teduglutide Injection | Teduglutide Injection Topotecan may decrease the excretion rate of Teduglutide which could result in a higher serum level. |
Icosapent Ethyl | Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Topotecan. |
Tofacitinib | Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Topotecan. |
Alogliptin | Alogliptin Topotecan may decrease the excretion rate of Alogliptin which could result in a higher serum level. |
Dimethyl Fumarate | Dimethyl Fumarate The risk or severity of adverse effects can be increased when Topotecan is combined with Dimethyl fumarate. |
Ponatinib | Ponatinib The serum concentration of Topotecan can be increased when it is combined with Ponatinib. |
Pomalidomide | Pomalidomide The metabolism of Pomalidomide can be increased when combined with Topotecan. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Topotecan. |
Apixaban | Apixaban The serum concentration of Topotecan can be increased when it is combined with Apixaban. |
Canagliflozin | Canagliflozin The serum concentration of Topotecan can be increased when it is combined with Canagliflozin. |
Methazolamide | Methazolamide Methazolamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Dabrafenib | Dabrafenib The metabolism of Topotecan can be increased when combined with Dabrafenib. |
Trametinib | Trametinib Topotecan may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Dolutegravir | Dolutegravir The serum concentration of Topotecan can be increased when it is combined with Dolutegravir. |
Afatinib | Afatinib The serum concentration of Topotecan can be increased when it is combined with Afatinib. |
Levomilnacipran | Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Topotecan. |
Ertapenem Injection | Ertapenem Injection Ertapenem may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Vortioxetine | Vortioxetine Topotecan may decrease the excretion rate of Vortioxetine which could result in a higher serum level. |
Perampanel | Perampanel The metabolism of Perampanel can be increased when combined with Topotecan. |
Ibrutinib | Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Topotecan. |
Lomitapide | Lomitapide The serum concentration of Topotecan can be increased when it is combined with Lomitapide. |
Ketorolac Injection | Ketorolac Injection Ketorolac may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Obinutuzumab Injection | Obinutuzumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Obinutuzumab. |
Simeprevir | Simeprevir The serum concentration of Topotecan can be increased when it is combined with Simeprevir. |
Sofosbuvir | Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Topotecan. |
Dapagliflozin | Dapagliflozin Dapagliflozin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Apremilast | Apremilast The risk or severity of adverse effects can be increased when Topotecan is combined with Apremilast. |
Droxidopa | Droxidopa Topotecan may decrease the excretion rate of Droxidopa which could result in a higher serum level. |
Ceritinib | Ceritinib The metabolism of Ceritinib can be increased when combined with Topotecan. |
Siltuximab Injection | Siltuximab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine Eslicarbazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Vedolizumab Injection | Vedolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Vedolizumab. |
Belinostat Injection | Belinostat Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belinostat. |
Idelalisib | Idelalisib The metabolism of Idelalisib can be increased when combined with Topotecan. |
Testosterone Injection | Testosterone Injection Testosterone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Vorapaxar | Vorapaxar The serum concentration of Topotecan can be increased when it is combined with Vorapaxar. |
Suvorexant | Suvorexant The serum concentration of Topotecan can be increased when it is combined with Suvorexant. |
Edoxaban | Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Topotecan. |
Peginterferon Beta-1a Injection | Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Peginterferon beta-1a. |
Olaparib | Olaparib The metabolism of Olaparib can be increased when combined with Topotecan. |
Blinatumomab Injection | Blinatumomab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Blinatumomab. |
Methamphetamine | Methamphetamine Topotecan may decrease the excretion rate of Metamfetamine which could result in a higher serum level. |
Tasimelteon | Tasimelteon The metabolism of Tasimelteon can be increased when combined with Topotecan. |
Pirfenidone | Pirfenidone The risk or severity of adverse effects can be increased when Topotecan is combined with Pirfenidone. |
Nintedanib | Nintedanib The metabolism of Nintedanib can be decreased when combined with Topotecan. |
Secukinumab Injection | Secukinumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Secukinumab. |
Palbociclib | Palbociclib The serum concentration of Topotecan can be increased when it is combined with Palbociclib. |
Lenvatinib | Lenvatinib The serum concentration of Topotecan can be increased when it is combined with Lenvatinib. |
Panobinostat | Panobinostat The metabolism of Panobinostat can be increased when combined with Topotecan. |
Dinutuximab Injection | Dinutuximab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Dinutuximab. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Topotecan can be increased when it is combined with Haloperidol. |
Amiloride | Amiloride Amiloride may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Isavuconazonium Injection | Isavuconazonium Injection The serum concentration of Topotecan can be increased when it is combined with Isavuconazonium. |
Macitentan | Macitentan Topotecan may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Sonidegib | Sonidegib The metabolism of Sonidegib can be increased when combined with Topotecan. |
Flibanserin | Flibanserin The serum concentration of Topotecan can be increased when it is combined with Flibanserin. |
Rolapitant | Rolapitant The serum concentration of Topotecan can be increased when it is combined with Rolapitant. |
Prednisolone | Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Topotecan. |
Daclatasvir | Daclatasvir The serum concentration of Topotecan can be increased when it is combined with Daclatasvir. |
Ziprasidone Injection | Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Topotecan. |
Penicillin G Procaine Injection | Penicillin G Procaine Injection Topotecan may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. |
Cobimetinib | Cobimetinib The metabolism of Cobimetinib can be increased when combined with Topotecan. |
Mepolizumab Injection | Mepolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Mepolizumab. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Topotecan. |
Osimertinib | Osimertinib The metabolism of Osimertinib can be increased when combined with Topotecan. |
Alectinib | Alectinib The metabolism of Topotecan can be increased when combined with Alectinib. |
Ixazomib | Ixazomib The metabolism of Ixazomib can be increased when combined with Topotecan. |
Lesinurad | Lesinurad Topotecan may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Dexamethasone Injection | Dexamethasone Injection The risk or severity of adverse effects can be increased when Dexamethasone is combined with Topotecan. |
Defibrotide Injection | Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Topotecan. |
Ixekizumab Injection | Ixekizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Ixekizumab. |
Brivaracetam Injection | Brivaracetam Injection Topotecan may increase the excretion rate of Brivaracetam which could result in a lower serum level and potentially a reduction in efficacy. |
Venetoclax | Venetoclax The serum concentration of Topotecan can be increased when it is combined with Venetoclax. |
Cobicistat | Cobicistat The serum concentration of Topotecan can be increased when it is combined with Cobicistat. |
Selexipag | Selexipag The serum concentration of Topotecan can be increased when it is combined with Selexipag. |
Furosemide Injection | Furosemide Injection Furosemide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Rucaparib | Rucaparib The serum concentration of Topotecan can be increased when it is combined with Rucaparib. |
Lixisenatide Injection | Lixisenatide Injection Topotecan may decrease the excretion rate of Lixisenatide which could result in a higher serum level. |
Ribociclib | Ribociclib The metabolism of Ribociclib can be increased when combined with Topotecan. |
Brodalumab Injection | Brodalumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Brodalumab. |
Brigatinib | Brigatinib The metabolism of Topotecan can be increased when combined with Brigatinib. |
Doxepin (Insomnia) | Doxepin (Insomnia) Topotecan may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Deutetrabenazine | Deutetrabenazine Topotecan may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. |
Valbenazine | Valbenazine Topotecan may decrease the excretion rate of Valbenazine which could result in a higher serum level. |
Deflazacort | Deflazacort The risk or severity of adverse effects can be increased when Topotecan is combined with Deflazacort. |
Safinamide | Safinamide Safinamide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ocrelizumab Injection | Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Topotecan. |
Naldemedine | Naldemedine Topotecan may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
Sarilumab Injection | Sarilumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Sarilumab. |
Midostaurin | Midostaurin The metabolism of Midostaurin can be increased when combined with Topotecan. |
Neratinib | Neratinib The serum concentration of Topotecan can be increased when it is combined with Neratinib. |
Guselkumab Injection | Guselkumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Guselkumab. |
Enasidenib | Enasidenib The serum concentration of Topotecan can be increased when it is combined with Enasidenib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Topotecan can be increased when it is combined with Inotuzumab ozogamicin. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Topotecan. |
Benznidazole | Benznidazole Topotecan may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
Copanlisib Injection | Copanlisib Injection The metabolism of Topotecan can be increased when combined with Copanlisib. |
Delafloxacin | Delafloxacin Topotecan may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
Abemaciclib | Abemaciclib The metabolism of Topotecan can be increased when combined with Abemaciclib. |
Betrixaban | Betrixaban The serum concentration of Topotecan can be increased when it is combined with Betrixaban. |
Acalabrutinib | Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Topotecan. |
Gemtuzumab Ozogamicin Injection | Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Topotecan. |
Letermovir | Letermovir Letermovir may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ertugliflozin | Ertugliflozin Ertugliflozin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Buprenorphine Injection | Buprenorphine Injection Buprenorphine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Apalutamide | Apalutamide The serum concentration of Topotecan can be decreased when it is combined with Apalutamide. |
Penicillamine | Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Topotecan. |
Fostamatinib | Fostamatinib Fostamatinib may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Avatrombopag | Avatrombopag Avatrombopag may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Baricitinib | Baricitinib The metabolism of Topotecan can be increased when combined with Baricitinib. |
Lofexidine | Lofexidine The excretion of Topotecan can be decreased when combined with Lofexidine. |
Plazomicin Injection | Plazomicin Injection The excretion of Topotecan can be decreased when combined with Plazomicin. |
Eliglustat | Eliglustat The metabolism of Eliglustat can be decreased when combined with Topotecan. |
Ivosidenib | Ivosidenib The serum concentration of Topotecan can be increased when it is combined with Ivosidenib. |
Lusutrombopag | Lusutrombopag The serum concentration of Topotecan can be increased when it is combined with Lusutrombopag. |
Elagolix | Elagolix The serum concentration of Topotecan can be increased when it is combined with Elagolix. |
Tafenoquine | Tafenoquine The excretion of Topotecan can be decreased when combined with Tafenoquine. |
Cannabidiol | Cannabidiol Cannabidiol may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Dacomitinib | Dacomitinib The serum concentration of Topotecan can be increased when it is combined with Dacomitinib. |
Duvelisib | Duvelisib The metabolism of Duvelisib can be decreased when combined with Topotecan. |
Omadacycline | Omadacycline The serum concentration of Topotecan can be increased when it is combined with Omadacycline. |
Sarecycline | Sarecycline The serum concentration of Topotecan can be increased when it is combined with Sarecycline. |
Stiripentol | Stiripentol Topotecan may increase the excretion rate of Stiripentol which could result in a lower serum level and potentially a reduction in efficacy. |
Talazoparib | Talazoparib The serum concentration of Topotecan can be increased when it is combined with Talazoparib. |
Gilteritinib | Gilteritinib The excretion of Topotecan can be decreased when combined with Gilteritinib. |
Glasdegib | Glasdegib The serum concentration of Topotecan can be increased when it is combined with Glasdegib. |
Larotrectinib | Larotrectinib The serum concentration of Topotecan can be increased when it is combined with Larotrectinib. |
Methoxy Polyethylene Glycol-Epoetin Beta Injection | Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Topotecan. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Topotecan. |
Rifamycin | Rifamycin The serum concentration of Topotecan can be increased when it is combined with Rifamycin. |
Prucalopride | Prucalopride The metabolism of Prucalopride can be decreased when combined with Topotecan. |
Ravulizumab-cwvz Injection | Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Ravulizumab. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Emapalumab. |
Siponimod | Siponimod The metabolism of Siponimod can be increased when combined with Topotecan. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic The excretion of Topotecan can be decreased when combined with Acyclovir. |
Caplacizumab-yhdp Injection | Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Topotecan. |
Erdafitinib | Erdafitinib The serum concentration of Topotecan can be increased when it is combined with Erdafitinib. |
Risankizumab-rzaa Injection | Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Risankizumab. |
Alpelisib | Alpelisib The metabolism of Alpelisib can be increased when combined with Topotecan. |
Brexanolone Injection | Brexanolone Injection Brexanolone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Cladribine | Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Topotecan. |
Solriamfetol | Solriamfetol The excretion of Topotecan can be decreased when combined with Solriamfetol. |
Darolutamide | Darolutamide The serum concentration of Topotecan can be increased when it is combined with Darolutamide. |
Entrectinib | Entrectinib The metabolism of Entrectinib can be increased when combined with Topotecan. |
Pexidartinib | Pexidartinib The metabolism of Topotecan can be increased when combined with Pexidartinib. |
Istradefylline | Istradefylline The serum concentration of Topotecan can be increased when it is combined with Istradefylline. |
Pitolisant | Pitolisant Topotecan may decrease the excretion rate of Pitolisant which could result in a higher serum level. |
Fedratinib | Fedratinib The serum concentration of Topotecan can be increased when it is combined with Fedratinib. |
Lefamulin | Lefamulin The metabolism of Lefamulin can be increased when combined with Topotecan. |
Phenytoin Injection | Phenytoin Injection Phenytoin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Fosphenytoin Injection | Fosphenytoin Injection Fosphenytoin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Enfortumab vedotin-ejfv Injection | Enfortumab vedotin-ejfv Injection The serum concentration of Topotecan can be increased when it is combined with Enfortumab vedotin. |
Zanubrutinib | Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Topotecan. |
Voxelotor | Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Topotecan. |
Lumateperone | Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Topotecan. |
Lasmiditan | Lasmiditan The serum concentration of Topotecan can be increased when it is combined with Lasmiditan. |
Ubrogepant | Ubrogepant The serum concentration of Topotecan can be increased when it is combined with Ubrogepant. |
Tazemetostat | Tazemetostat The excretion of Topotecan can be decreased when combined with Tazemetostat. |
Cenobamate | Cenobamate Cenobamate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Ozanimod | Ozanimod The risk or severity of adverse effects can be increased when Topotecan is combined with Ozanimod. |
Selumetinib | Selumetinib The serum concentration of Topotecan can be increased when it is combined with Selumetinib. |
Rimegepant | Rimegepant The metabolism of Rimegepant can be increased when combined with Topotecan. |
Tucatinib | Tucatinib The excretion of Topotecan can be decreased when combined with Tucatinib. |
Remdesivir Injection | Remdesivir Injection The excretion of Topotecan can be decreased when combined with Remdesivir. |
Ripretinib | Ripretinib The serum concentration of Topotecan can be increased when it is combined with Ripretinib. |
Selpercatinib | Selpercatinib The serum concentration of Topotecan can be decreased when it is combined with Selpercatinib. |
Capmatinib | Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Topotecan. |
Lemborexant | Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Topotecan. |
Fostemsavir | Fostemsavir Fostemsavir may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Belantamab Mafodotin-blmf Injection | Belantamab Mafodotin-blmf Injection The serum concentration of Topotecan can be increased when it is combined with Belantamab mafodotin. |
Pralsetinib | Pralsetinib The serum concentration of Topotecan can be increased when it is combined with Pralsetinib. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Topotecan. |
Viloxazine | Viloxazine Topotecan may decrease the excretion rate of Viloxazine which could result in a higher serum level. |
Tobramycin Injection | Tobramycin Injection Tobramycin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Theophylline | Theophylline The metabolism of Theophylline can be increased when combined with Topotecan. |
Fenoprofen | Fenoprofen Fenoprofen may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Indomethacin | Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Topotecan. |
Mefenamic Acid | Mefenamic Acid Mefenamic acid may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Naproxen | Naproxen Naproxen may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Tolmetin | Tolmetin Tolmetin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Sulindac | Sulindac Sulindac may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Trazodone | Trazodone The serum concentration of Topotecan can be decreased when it is combined with Trazodone. |
Isotretinoin | Isotretinoin Isotretinoin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Sucralfate | Sucralfate Sucralfate may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Hydroxyurea | Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Topotecan. |
Floxuridine | Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Topotecan. |
Phenobarbital | Phenobarbital Phenobarbital may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Metaxalone | Metaxalone Metaxalone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Methotrexate Injection | Methotrexate Injection The metabolism of Topotecan can be decreased when combined with Methotrexate. |
Primidone | Primidone Primidone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Methsuximide | Methsuximide Methsuximide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Chlorpromazine | Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Topotecan. |
Diazepam | Diazepam Diazepam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Oxazepam | Oxazepam Oxazepam may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Flurazepam | Flurazepam Flurazepam may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Clorazepate | Clorazepate Clorazepic acid may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Lorazepam | Lorazepam Lorazepam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Carmustine | Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Topotecan. |
Amantadine | Amantadine Amantadine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Codeine | Codeine Codeine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Phenelzine | Phenelzine Phenelzine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Procarbazine | Procarbazine The risk or severity of adverse effects can be increased when Topotecan is combined with Procarbazine. |
Tetracycline | Tetracycline Tetracycline may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Thioguanine | Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Topotecan. |
Prochlorperazine | Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Topotecan. |
Bleomycin | Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Topotecan. |
Sulfadiazine | Sulfadiazine Sulfadiazine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Methadone | Methadone Methadone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Benztropine | Benztropine Benzatropine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Maprotiline | Maprotiline Maprotiline may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ibuprofen | Ibuprofen Ibuprofen may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Azathioprine | Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Topotecan. |
Phentermine | Phentermine The metabolism of Phentermine can be increased when combined with Topotecan. |
Methylphenidate | Methylphenidate Methylphenidate may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Sulfasalazine | Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Topotecan. |
Lomustine | Lomustine The risk or severity of adverse effects can be increased when Topotecan is combined with Lomustine. |
Doxorubicin | Doxorubicin The metabolism of Topotecan can be increased when combined with Doxorubicin. |
Cytarabine | Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Topotecan. |
Mechlorethamine | Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Topotecan. |
Dactinomycin | Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Topotecan. |
Phenazopyridine | Phenazopyridine Phenazopyridine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Carbamazepine | Carbamazepine Carbamazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Methyldopa | Methyldopa Methyldopa may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Clonidine | Clonidine The metabolism of Clonidine can be increased when combined with Topotecan. |
Hydralazine | Hydralazine Topotecan may decrease the excretion rate of Hydralazine which could result in a higher serum level. |
Cimetidine | Cimetidine The excretion of Topotecan can be decreased when combined with Cimetidine. |
Gentamicin Injection | Gentamicin Injection Gentamicin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Warfarin | Warfarin The metabolism of Warfarin can be increased when combined with Topotecan. |
Clonazepam | Clonazepam The metabolism of Clonazepam can be increased when combined with Topotecan. |
Loperamide | Loperamide The serum concentration of Topotecan can be increased when it is combined with Loperamide. |
Promethazine | Promethazine Topotecan may decrease the excretion rate of Promethazine which could result in a higher serum level. |
Meclofenamate | Meclofenamate Meclofenamic acid may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Daunorubicin | Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Topotecan. |
Nitrofurantoin | Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Digoxin | Digoxin Topotecan may decrease the excretion rate of Digoxin which could result in a higher serum level. |
Loxapine | Loxapine The serum concentration of Topotecan can be increased when it is combined with Loxapine. |
Chloroquine | Chloroquine Chloroquine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Quinine | Quinine The serum concentration of Topotecan can be increased when it is combined with Quinine. |
Ethosuximide | Ethosuximide Topotecan may increase the excretion rate of Ethosuximide which could result in a lower serum level and potentially a reduction in efficacy. |
Triamterene | Triamterene Triamterene may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Sulfinpyrazone | Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Topotecan. |
Chlorothiazide | Chlorothiazide Chlorothiazide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Chlorthalidone | Chlorthalidone Chlorthalidone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Metolazone | Metolazone Metolazone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Isosorbide | Isosorbide The metabolism of Isosorbide can be increased when combined with Topotecan. |
Clindamycin Injection | Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Topotecan. |
Secobarbital | Secobarbital Secobarbital may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Desipramine | Desipramine Topotecan may decrease the excretion rate of Desipramine which could result in a higher serum level. |
Amitriptyline | Amitriptyline Amitriptyline may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Imipramine | Imipramine Imipramine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Probenecid | Probenecid Topotecan may decrease the excretion rate of Probenecid which could result in a higher serum level. |
Quinidine | Quinidine The serum concentration of Topotecan can be increased when it is combined with Quinidine. |
Procainamide | Procainamide The excretion of Procainamide can be decreased when combined with Topotecan. |
Isoniazid | Isoniazid Isoniazid may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Pyrazinamide | Pyrazinamide Pyrazinamide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Rifampin | Rifampin The serum concentration of Topotecan can be decreased when it is combined with Rifampicin. |
Disopyramide | Disopyramide Disopyramide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Valproic Acid | Valproic Acid Valproic acid may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Tamoxifen | Tamoxifen The serum concentration of Topotecan can be increased when it is combined with Tamoxifen. |
Mitomycin | Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Topotecan. |
Butabarbital | Butabarbital Butabarbital may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Levothyroxine | Levothyroxine The serum concentration of Topotecan can be decreased when it is combined with Levothyroxine. |
Liothyronine | Liothyronine Liothyronine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Methimazole | Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Topotecan. |
Propylthiouracil | Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Topotecan. |
Chlorpropamide | Chlorpropamide Chlorpropamide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Tolbutamide | Tolbutamide Topotecan may decrease the excretion rate of Tolbutamide which could result in a higher serum level. |
Tolazamide | Tolazamide Tolazamide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Baclofen | Baclofen Baclofen may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ethambutol | Ethambutol Ethambutol may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Methyclothiazide | Methyclothiazide Methyclothiazide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Hydrochlorothiazide | Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Chlorzoxazone | Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Pyridoxine | Pyridoxine Pyridoxine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Folic Acid | Folic Acid Folic acid may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Nortriptyline | Nortriptyline The metabolism of Nortriptyline can be increased when combined with Topotecan. |
Spironolactone | Spironolactone Spironolactone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Amphotericin B Injection | Amphotericin B Injection Amphotericin B may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Mercaptopurine | Mercaptopurine The risk or severity of adverse effects can be increased when Topotecan is combined with Mercaptopurine. |
Phytonadione | Phytonadione Phylloquinone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Amikacin Injection | Amikacin Injection Amikacin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Nadolol | Nadolol The excretion of Nadolol can be decreased when combined with Topotecan. |
Allopurinol | Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Topotecan. |
Clomiphene | Clomiphene The serum concentration of Topotecan can be increased when it is combined with Clomifene. |
Flavoxate | Flavoxate Topotecan may decrease the excretion rate of Flavoxate which could result in a higher serum level. |
Fluorouracil Injection | Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Topotecan. |
Colchicine | Colchicine The metabolism of Colchicine can be decreased when combined with Topotecan. |
Cefaclor | Cefaclor Cefaclor may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cefadroxil | Cefadroxil Cefadroxil may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cefazolin Injection | Cefazolin Injection Cefazolin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cephalexin | Cephalexin The excretion of Topotecan can be decreased when combined with Cephalexin. |
Cefoxitin Injection | Cefoxitin Injection Cefoxitin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Dacarbazine | Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Topotecan. |
Acetazolamide | Acetazolamide Acetazolamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Cefotaxime Injection | Cefotaxime Injection Cefotaxime may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Bacillus Calmette-Guerin (BCG) Vaccine | Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Topotecan. |
Ketoconazole | Ketoconazole The serum concentration of Topotecan can be increased when it is combined with Ketoconazole. |
Pyrantel | Pyrantel Topotecan may decrease the excretion rate of Pyrantel which could result in a higher serum level. |
Thiotepa Injection | Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Topotecan. |
Vincristine Injection | Vincristine Injection The metabolism of Topotecan can be increased when combined with Vincristine. |
Dipyridamole | Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Topotecan. |
Vinblastine | Vinblastine The metabolism of Topotecan can be increased when combined with Vinblastine. |
Ethacrynic Acid | Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Colistimethate Injection | Colistimethate Injection Colistimethate may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Metoprolol | Metoprolol The metabolism of Metoprolol can be decreased when combined with Topotecan. |
Aspirin | Aspirin Acetylsalicylic acid may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Salsalate | Salsalate Salsalate may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Chlorambucil | Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Topotecan. |
Alprazolam | Alprazolam The metabolism of Alprazolam can be decreased when combined with Topotecan. |
Temazepam | Temazepam Temazepam may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Triazolam | Triazolam Triazolam may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Dicyclomine | Dicyclomine Dicyclomine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Propantheline | Propantheline Propantheline may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Trimethoprim | Trimethoprim Trimethoprim may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Nifedipine | Nifedipine Topotecan may decrease the excretion rate of Nifedipine which could result in a higher serum level. |
Timolol | Timolol Timolol may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Verapamil | Verapamil The serum concentration of Topotecan can be increased when it is combined with Verapamil. |
Pindolol | Pindolol Pindolol may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cisplatin Injection | Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Topotecan. |
Diflunisal | Diflunisal Diflunisal may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Piroxicam | Piroxicam Piroxicam may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Bumetanide | Bumetanide Bumetanide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Streptozocin | Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Topotecan. |
Etoposide | Etoposide The metabolism of Topotecan can be increased when combined with Etoposide. |
Glipizide | Glipizide Topotecan may decrease the excretion rate of Glipizide which could result in a higher serum level. |
Indapamide | Indapamide Indapamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Amoxicillin | Amoxicillin Topotecan may decrease the excretion rate of Amoxicillin which could result in a higher serum level. |
Oxacillin Injection | Oxacillin Injection Oxacillin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Pentoxifylline | Pentoxifylline Pentoxifylline may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Pentamidine Injection | Pentamidine Injection Pentamidine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ceftriaxone Injection | Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Labetalol | Labetalol Labetalol may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Auranofin | Auranofin Auranofin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Leuprolide Injection | Leuprolide Injection Leuprolide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Gemfibrozil | Gemfibrozil Topotecan may decrease the excretion rate of Gemfibrozil which could result in a higher serum level. |
Dipivefrin Ophthalmic | Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ceftazidime Injection | Ceftazidime Injection Ceftazidime may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ketoprofen | Ketoprofen Ketoprofen may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cefotetan Injection | Cefotetan Injection Cefotetan may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Pimozide | Pimozide The metabolism of Pimozide can be increased when combined with Topotecan. |
Flurbiprofen | Flurbiprofen Flurbiprofen may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Amiodarone | Amiodarone The serum concentration of Topotecan can be increased when it is combined with Amiodarone. |
Aztreonam Injection | Aztreonam Injection Aztreonam may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Buspirone | Buspirone Buspirone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Lovastatin | Lovastatin The metabolism of Lovastatin can be decreased when combined with Topotecan. |
Ciprofloxacin | Ciprofloxacin The excretion of Topotecan can be decreased when combined with Ciprofloxacin. |
Mesalamine | Mesalamine Mesalazine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Diclofenac | Diclofenac Diclofenac may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Interferon Alfa-2b Injection | Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Topotecan. |
Clozapine | Clozapine The risk or severity of neutropenia can be increased when Topotecan is combined with Clozapine. |
Estazolam | Estazolam Topotecan may increase the excretion rate of Estazolam which could result in a lower serum level and potentially a reduction in efficacy. |
Idarubicin | Idarubicin The risk or severity of adverse effects can be increased when Topotecan is combined with Idarubicin. |
Didanosine | Didanosine Didanosine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Fludarabine Injection | Fludarabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Fludarabine. |
Pentostatin Injection | Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Topotecan. |
Clarithromycin | Clarithromycin The serum concentration of Topotecan can be increased when it is combined with Clarithromycin. |
Etodolac | Etodolac Etodolac may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Fosinopril | Fosinopril Fosinopril may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Nabumetone | Nabumetone Nabumetone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Pravastatin | Pravastatin Pravastatin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Simvastatin | Simvastatin The serum concentration of Topotecan can be increased when it is combined with Simvastatin. |
Filgrastim Injection | Filgrastim Injection The risk or severity of neutropenia can be increased when Filgrastim is combined with Topotecan. |
Epoetin Alfa, Injection | Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Topotecan. |
Amlodipine | Amlodipine The metabolism of Amlodipine can be increased when combined with Topotecan. |
Teniposide Injection | Teniposide Injection The metabolism of Topotecan can be increased when combined with Teniposide. |
Itraconazole | Itraconazole The serum concentration of Topotecan can be increased when it is combined with Itraconazole. |
Lisinopril | Lisinopril Lisinopril may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Oxaprozin | Oxaprozin Oxaprozin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Bisoprolol | Bisoprolol The serum concentration of Topotecan can be increased when it is combined with Bisoprolol. |
Zolpidem | Zolpidem The metabolism of Zolpidem can be increased when combined with Topotecan. |
Doxazosin | Doxazosin The metabolism of Doxazosin can be increased when combined with Topotecan. |
Isradipine | Isradipine Isradipine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Omeprazole | Omeprazole Omeprazole may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cisapride | Cisapride The metabolism of Cisapride can be increased when combined with Topotecan. |
Gabapentin | Gabapentin Gabapentin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Venlafaxine | Venlafaxine Venlafaxine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Famciclovir | Famciclovir The metabolism of Famciclovir can be increased when combined with Topotecan. |
Fluvoxamine | Fluvoxamine Fluvoxamine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Nefazodone | Nefazodone Topotecan may decrease the excretion rate of Nefazodone which could result in a higher serum level. |
Lamotrigine | Lamotrigine Lamotrigine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Valacyclovir | Valacyclovir Valaciclovir may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Tramadol | Tramadol The metabolism of Topotecan can be decreased when combined with Tramadol. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Topotecan can be increased when combined with Vinorelbine. |
Carboplatin Injection | Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Topotecan. |
Lansoprazole | Lansoprazole Lansoprazole may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Ifosfamide Injection | Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Topotecan. |
Pegaspargase Injection | Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Topotecan. |
Bupropion | Bupropion Topotecan may decrease the excretion rate of Bupropion which could result in a higher serum level. |
Ticlopidine | Ticlopidine The metabolism of Topotecan can be increased when combined with Ticlopidine. |
Saquinavir | Saquinavir The serum concentration of Topotecan can be increased when it is combined with Saquinavir. |
Metformin | Metformin The excretion of Topotecan can be decreased when combined with Metformin. |
Dalteparin Injection | Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Topotecan. |
Nisoldipine | Nisoldipine Nisoldipine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Lamivudine | Lamivudine Lamivudine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Riluzole | Riluzole Riluzole may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Acarbose | Acarbose Acarbose may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Gemcitabine Injection | Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Topotecan. |
Ritonavir | Ritonavir The serum concentration of Topotecan can be increased when it is combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Topotecan. |
Cidofovir Injection | Cidofovir Injection Cidofovir may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Meropenem Injection | Meropenem Injection Meropenem may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Clomipramine | Clomipramine The metabolism of Clomipramine can be increased when combined with Topotecan. |
Zafirlukast | Zafirlukast The metabolism of Zafirlukast can be increased when combined with Topotecan. |
Fosfomycin | Fosfomycin Fosfomycin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Topiramate | Topiramate Topiramate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
Pramipexole | Pramipexole Pramipexole may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Nelfinavir | Nelfinavir Nelfinavir may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Fexofenadine | Fexofenadine The serum concentration of Topotecan can be increased when it is combined with Fexofenadine. |
Azithromycin | Azithromycin The metabolism of Azithromycin can be increased when combined with Topotecan. |
Carvedilol | Carvedilol The serum concentration of Topotecan can be increased when it is combined with Carvedilol. |
Nilutamide | Nilutamide Nilutamide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Flutamide | Flutamide Flutamide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Bicalutamide | Bicalutamide The metabolism of Bicalutamide can be increased when combined with Topotecan. |
Propafenone | Propafenone The serum concentration of Topotecan can be increased when it is combined with Propafenone. |
Tamsulosin | Tamsulosin Tamsulosin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Quetiapine | Quetiapine Topotecan may decrease the excretion rate of Quetiapine which could result in a higher serum level. |
Cefepime Injection | Cefepime Injection Cefepime may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cefprozil | Cefprozil Cefprozil may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cefpodoxime | Cefpodoxime Cefpodoxime may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Cetirizine | Cetirizine Cetirizine may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Tolcapone | Tolcapone Tolcapone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Capecitabine | Capecitabine The risk or severity of adverse effects can be increased when Topotecan is combined with Capecitabine. |
Abacavir | Abacavir Topotecan may decrease the excretion rate of Abacavir which could result in a higher serum level. |
Sildenafil | Sildenafil The serum concentration of Topotecan can be increased when it is combined with Sildenafil. |
Trastuzumab Injection | Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Topotecan. |
Celecoxib | Celecoxib Celecoxib may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Rosiglitazone | Rosiglitazone Rosiglitazone may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Tolterodine | Tolterodine Topotecan may decrease the excretion rate of Tolterodine which could result in a higher serum level. |
Thalidomide | Thalidomide The risk or severity of adverse effects can be increased when Topotecan is combined with Thalidomide. |
Oseltamivir | Oseltamivir Oseltamivir may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Balsalazide | Balsalazide Balsalazide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Nateglinide | Nateglinide Nateglinide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Levetiracetam | Levetiracetam Topotecan may increase the excretion rate of Levetiracetam which could result in a lower serum level and potentially a reduction in efficacy. |
Rabeprazole | Rabeprazole Rabeprazole may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists