Topotecan

Generic name: Pronounced as (toe'' poe tee' kan)
Brand names
  • Hycamtin®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 10/15/2016

Topotecan may cause a decrease in the number of blood cells made by your bone marrow. This increases the risk that you will develop a serious infection. You should not take topotecan if you already have a low number of blood cells. Your doctor will order laboratory tests regularly before and during your treatment to check whether your body has enough blood cells. If you experience any of the following symptoms, call your doctor immediately: sore throat, chills, fever, cough, burning or painful urination, or other signs of infection; stomach pain; unusual bruising or bleeding; excessive tiredness; headache; dizziness; confusion; pale skin; fast heartbeat; or shortness of breath.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to topotecan.

Talk to your doctor about the risks of taking topotecan.

Topotecan is used to treat small cell lung cancer (a type of cancer that begins in the lungs) that was successfully treated with a different chemotherapy medication but has returned no sooner than 45 days after the last dose of the first chemotherapy medication was taken. Topotecan is in a class of medications called topoisomerase I inhibitors. It works by killing cancer cells.

Topotecan comes as a capsule to take by mouth. It may be taken with or without food. It is usually taken once a day for 5 days in a row every 21 days. Your doctor will decide how many times you should repeat this cycle. Take topotecan at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take topotecan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with water; do not open, chew, or crush them.

Topotecan capsules come in two different strengths. Your doctor may want you to take a combination of both strengths of capsules to make up your full dose. Be sure that you know what each type of capsule looks like and how many you are to take of each. Ask your doctor or pharmacist if you have any questions.

If any of the capsules are broken or leaking, do not touch them with your bare hands. Carefully dispose of the broken capsules without touching them directly and then wash your hands well with soap and water. If the capsule contents do touch your skin, wash the area well with soap and water right away. If any capsule contents get in your eyes, wash your eyes right away with gently flowing water for at least 15 minutes. Call your doctor if you have any skin reaction or if medication gets in your eyes.

You may vomit after you take the medication. If this happens, let your doctor know right away. Do not take another dose of topotecan on the same day.

Your doctor may need to delay your treatment or adjust your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with topotecan.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking topotecan,

  • tell your doctor and pharmacist if you are allergic to topotecan, any other medications, or any of the ingredients in topotecan capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cyclosporine (Gengraf, Neoral, Sandimmune); ketoconazole (Nizoral); ritonavir (Norvir, in Kaletra); or saquinavir (Fortovase, Invirase). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking topotecan. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking topotecan, call your doctor immediately. Topotecan may harm the fetus.

  • tell your doctor if you are breast-feeding. You should not breast-feed while you are taking topotecan.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking topotecan.

  • you should know that topotecan may make you drowsy, tired, or weak. Do not drive a car, use heavy tools, or operate machinery until you know how this medication affects you.

  • you should know that topotecan can cause severe diarrhea that may need to be treated in a hospital. Talk to your doctor about how to prevent and treat diarrhea. Call your doctor right away if you have any of the following symptoms: diarrhea with fever, diarrhea 3 or more times a day, or diarrhea with stomach pain or cramps.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Let your doctor know if you miss a dose.

  • Topotecan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • loss of appetite

    • hair loss

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:

    • hives

    • rash

    • itching

    • hoarseness

    • difficulty breathing or swallowing

  • Topotecan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it in the refrigerator and protect it from light.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • sore throat, chills, fever, cough, burning or painful urination, or other signs of infection

  • unusual bruising or bleeding

  • excessive tiredness

  • headache

  • dizziness

  • confusion

  • pale skin

  • fast heartbeat

  • shortness of breath

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Topotecan is combined with Leflunomide.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Topotecan.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Topotecan.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Topotecan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Topotecan.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Topotecan.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Topotecan can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Topotecan.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Topotecan may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Topotecan.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Paregoric Paregoric The serum concentration of Topotecan can be increased when it is combined with Morphine.
Potassium Potassium Potassium may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Topotecan.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Reserpine Reserpine The serum concentration of Topotecan can be increased when it is combined with Reserpine.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Topotecan.
Tizanidine Tizanidine Tizanidine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Triamcinolone Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Topotecan.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The serum concentration of Topotecan can be increased when it is combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Topotecan which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Topotecan.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Topotecan.
Levofloxacin Injection Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Topotecan.
Meperidine Injection Meperidine Injection The metabolism of Topotecan can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Topotecan.
Metoclopramide Injection Metoclopramide Injection Topotecan may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Morphine Injection Morphine Injection The serum concentration of Topotecan can be increased when it is combined with Morphine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Topotecan may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Topotecan.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cyclosporine Cyclosporine Topotecan may increase the immunosuppressive activities of Cyclosporine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Topotecan.
Torsemide Torsemide Torasemide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Topotecan.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Topotecan is combined with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Oxcarbazepine Oxcarbazepine Oxcarbazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Topotecan.
Zaleplon Zaleplon Zaleplon may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Anakinra Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Topotecan.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Topotecan.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Topotecan.
Etanercept Injection Etanercept Injection The risk or severity of adverse effects can be increased when Etanercept is combined with Topotecan.
Perindopril Perindopril Perindopril may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Topotecan.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Topotecan.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Topotecan.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Zonisamide Zonisamide The serum concentration of Topotecan can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The risk or severity of adverse effects can be increased when Adalimumab is combined with Topotecan.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Topotecan.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Glatiramer.
Atazanavir Atazanavir The metabolism of Atazanavir can be increased when combined with Topotecan.
Almotriptan Almotriptan Almotriptan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Topotecan.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Topotecan.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Topotecan.
Emtricitabine Emtricitabine The excretion of Emtricitabine can be decreased when combined with Topotecan.
Memantine Memantine Topotecan may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The serum concentration of Topotecan can be increased when it is combined with Tegaserod.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Progesterone Progesterone Progesterone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Topotecan.
Infliximab Injection Infliximab Injection The risk or severity of adverse effects can be increased when Infliximab is combined with Topotecan.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Topotecan.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Topotecan.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Natalizumab.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Topotecan.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Topotecan.
Ganciclovir Ganciclovir The excretion of Topotecan can be decreased when combined with Ganciclovir.
Palifermin Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Topotecan.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Valganciclovir Valganciclovir Topotecan may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Topotecan.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Topotecan.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Topotecan.
Pregabalin Pregabalin Pregabalin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Tipranavir Tipranavir The serum concentration of Topotecan can be increased when it is combined with Tipranavir.
Felbamate Felbamate Felbamate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Ranolazine Ranolazine The metabolism of Topotecan can be increased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Abatacept.
Rasagiline Rasagiline Topotecan may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Topotecan.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Topotecan.
Varenicline Varenicline Topotecan may decrease the excretion rate of Varenicline which could result in a higher serum level.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Topotecan.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Topotecan can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Topotecan can be increased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Topotecan.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Topotecan.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Topotecan.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Topotecan.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Topotecan.
Lubiprostone Lubiprostone Topotecan may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Topotecan.
Posaconazole Posaconazole The serum concentration of Topotecan can be increased when it is combined with Posaconazole.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Topotecan.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Topotecan.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Topotecan.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Topotecan is combined with Vorinostat.
Sorafenib Sorafenib The serum concentration of Topotecan can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Topotecan can be increased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Lapatinib Lapatinib The serum concentration of Topotecan can be increased when it is combined with Lapatinib.
Levocetirizine Levocetirizine Topotecan may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Topotecan may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Pegfilgrastim Injection Pegfilgrastim Injection The risk or severity of neutropenia can be increased when Pegfilgrastim is combined with Topotecan.
Dasatinib Dasatinib The metabolism of Topotecan can be increased when combined with Dasatinib.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Topotecan.
Temsirolimus Temsirolimus The serum concentration of Topotecan can be increased when it is combined with Temsirolimus.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Nelarabine.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Topotecan.
Nilotinib Nilotinib The serum concentration of Topotecan can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Topotecan can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Topotecan.
Budesonide Budesonide The risk or severity of adverse effects can be increased when Topotecan is combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Topotecan.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Decitabine.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Doripenem Injection Doripenem Injection Topotecan may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The serum concentration of Topotecan can be decreased when it is combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine Topotecan may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Topotecan.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Bendamustine.
Flecainide Flecainide The excretion of Topotecan can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Topotecan.
Irinotecan Injection Irinotecan Injection The metabolism of Topotecan can be increased when combined with Irinotecan.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Topotecan is combined with Estramustine.
Methylnaltrexone Injection Methylnaltrexone Injection Topotecan may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Topotecan.
Rufinamide Rufinamide Topotecan may increase the excretion rate of Rufinamide which could result in a lower serum level and potentially a reduction in efficacy.
Silodosin Silodosin The serum concentration of Topotecan can be increased when it is combined with Silodosin.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Topotecan.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Topotecan.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Topotecan.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Topotecan.
Plerixafor Injection Plerixafor Injection Topotecan may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Topotecan may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Topotecan.
Prasugrel Prasugrel Topotecan may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide Topotecan may increase the excretion rate of Lacosamide which could result in a lower serum level and potentially a reduction in efficacy.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Topotecan.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Topotecan can be increased when combined with Tolvaptan.
Dronedarone Dronedarone The serum concentration of Topotecan can be increased when it is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Pralatrexate.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Topotecan which could result in a higher serum level.
Saxagliptin Saxagliptin Topotecan may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Topotecan may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Topotecan can be increased when combined with Romidepsin.
Golimumab Injection Golimumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Topotecan.
Vigabatrin Vigabatrin Vigabatrin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Topotecan.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Topotecan.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Topotecan.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Topotecan.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Topotecan.
Tocilizumab Injection Tocilizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Tocilizumab.
Dalfampridine Dalfampridine Topotecan may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Fingolimod Fingolimod Topotecan may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Topotecan can be increased when combined with Cabazitaxel.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Topotecan may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Topotecan.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Topotecan.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belimumab.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Topotecan.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Topotecan.
Linagliptin Linagliptin The serum concentration of Topotecan can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Telaprevir Telaprevir The serum concentration of Topotecan can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Topotecan can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Topotecan.
Ticagrelor Ticagrelor The serum concentration of Topotecan can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Topotecan.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Topotecan.
Vandetanib Vandetanib The serum concentration of Topotecan can be increased when it is combined with Vandetanib.
Clobazam Clobazam Clobazam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Vemurafenib Vemurafenib The serum concentration of Topotecan can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belatacept.
Ivacaftor Ivacaftor The serum concentration of Topotecan can be increased when it is combined with Ivacaftor.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Topotecan.
Deferiprone Deferiprone Topotecan may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Topotecan.
Crizotinib Crizotinib The serum concentration of Topotecan can be increased when it is combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Melphalan.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Topotecan.
Naloxone Injection Naloxone Injection Topotecan may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan The serum concentration of Topotecan can be increased when it is combined with Ambrisentan.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Eculizumab.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ezogabine Ezogabine Tiagabine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Topotecan.
Iloprost Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Topotecan.
Enzalutamide Enzalutamide The serum concentration of Topotecan can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Topotecan can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Topotecan can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Topotecan.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Corticotropin.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Topotecan is combined with Teriflunomide.
Teduglutide Injection Teduglutide Injection Topotecan may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Topotecan.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Topotecan.
Alogliptin Alogliptin Topotecan may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Topotecan is combined with Dimethyl fumarate.
Ponatinib Ponatinib The serum concentration of Topotecan can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Topotecan.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Topotecan.
Apixaban Apixaban The serum concentration of Topotecan can be increased when it is combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Topotecan can be increased when it is combined with Canagliflozin.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Topotecan can be increased when combined with Dabrafenib.
Trametinib Trametinib Topotecan may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir Dolutegravir The serum concentration of Topotecan can be increased when it is combined with Dolutegravir.
Afatinib Afatinib The serum concentration of Topotecan can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Topotecan.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Topotecan which could result in a higher serum level.
Vortioxetine Vortioxetine Topotecan may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Topotecan.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Topotecan.
Lomitapide Lomitapide The serum concentration of Topotecan can be increased when it is combined with Lomitapide.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Obinutuzumab.
Simeprevir Simeprevir The serum concentration of Topotecan can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Topotecan.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The risk or severity of adverse effects can be increased when Topotecan is combined with Apremilast.
Droxidopa Droxidopa Topotecan may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Topotecan.
Siltuximab Injection Siltuximab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Siltuximab.
Eslicarbazepine Eslicarbazepine Eslicarbazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Topotecan.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Vorapaxar Vorapaxar The serum concentration of Topotecan can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Topotecan can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Topotecan.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Topotecan.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Blinatumomab.
Methamphetamine Methamphetamine Topotecan may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Topotecan.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Topotecan is combined with Pirfenidone.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Topotecan.
Secukinumab Injection Secukinumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Secukinumab.
Palbociclib Palbociclib The serum concentration of Topotecan can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib The serum concentration of Topotecan can be increased when it is combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Topotecan.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Topotecan can be increased when it is combined with Haloperidol.
Amiloride Amiloride Amiloride may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Topotecan can be increased when it is combined with Isavuconazonium.
Macitentan Macitentan Topotecan may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Topotecan.
Flibanserin Flibanserin The serum concentration of Topotecan can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Topotecan can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Topotecan.
Daclatasvir Daclatasvir The serum concentration of Topotecan can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Topotecan.
Penicillin G Procaine Injection Penicillin G Procaine Injection Topotecan may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Topotecan.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Mepolizumab.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Topotecan.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Topotecan.
Alectinib Alectinib The metabolism of Topotecan can be increased when combined with Alectinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Topotecan.
Lesinurad Lesinurad Topotecan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of adverse effects can be increased when Dexamethasone is combined with Topotecan.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Topotecan.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Ixekizumab.
Brivaracetam Injection Brivaracetam Injection Topotecan may increase the excretion rate of Brivaracetam which could result in a lower serum level and potentially a reduction in efficacy.
Venetoclax Venetoclax The serum concentration of Topotecan can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Topotecan can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Topotecan can be increased when it is combined with Selexipag.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The serum concentration of Topotecan can be increased when it is combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Topotecan may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Topotecan.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Brodalumab.
Brigatinib Brigatinib The metabolism of Topotecan can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) Topotecan may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Topotecan may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Topotecan may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of adverse effects can be increased when Topotecan is combined with Deflazacort.
Safinamide Safinamide Safinamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ocrelizumab Injection Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Topotecan.
Naldemedine Naldemedine Topotecan may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Midostaurin can be increased when combined with Topotecan.
Neratinib Neratinib The serum concentration of Topotecan can be increased when it is combined with Neratinib.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Guselkumab.
Enasidenib Enasidenib The serum concentration of Topotecan can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Topotecan can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Topotecan.
Benznidazole Benznidazole Topotecan may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Topotecan can be increased when combined with Copanlisib.
Delafloxacin Delafloxacin Topotecan may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Topotecan can be increased when combined with Abemaciclib.
Betrixaban Betrixaban The serum concentration of Topotecan can be increased when it is combined with Betrixaban.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Topotecan.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Topotecan.
Letermovir Letermovir Letermovir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Apalutamide Apalutamide The serum concentration of Topotecan can be decreased when it is combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Topotecan.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Topotecan which could result in a higher serum level.
Baricitinib Baricitinib The metabolism of Topotecan can be increased when combined with Baricitinib.
Lofexidine Lofexidine The excretion of Topotecan can be decreased when combined with Lofexidine.
Plazomicin Injection Plazomicin Injection The excretion of Topotecan can be decreased when combined with Plazomicin.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Topotecan.
Ivosidenib Ivosidenib The serum concentration of Topotecan can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Topotecan can be increased when it is combined with Lusutrombopag.
Elagolix Elagolix The serum concentration of Topotecan can be increased when it is combined with Elagolix.
Tafenoquine Tafenoquine The excretion of Topotecan can be decreased when combined with Tafenoquine.
Cannabidiol Cannabidiol Cannabidiol may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Dacomitinib Dacomitinib The serum concentration of Topotecan can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Topotecan.
Omadacycline Omadacycline The serum concentration of Topotecan can be increased when it is combined with Omadacycline.
Sarecycline Sarecycline The serum concentration of Topotecan can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol Topotecan may increase the excretion rate of Stiripentol which could result in a lower serum level and potentially a reduction in efficacy.
Talazoparib Talazoparib The serum concentration of Topotecan can be increased when it is combined with Talazoparib.
Gilteritinib Gilteritinib The excretion of Topotecan can be decreased when combined with Gilteritinib.
Glasdegib Glasdegib The serum concentration of Topotecan can be increased when it is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Topotecan can be increased when it is combined with Larotrectinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Topotecan.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Topotecan.
Rifamycin Rifamycin The serum concentration of Topotecan can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Topotecan.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Topotecan.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Topotecan can be decreased when combined with Acyclovir.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Topotecan.
Erdafitinib Erdafitinib The serum concentration of Topotecan can be increased when it is combined with Erdafitinib.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Risankizumab.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Topotecan.
Brexanolone Injection Brexanolone Injection Brexanolone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Topotecan.
Solriamfetol Solriamfetol The excretion of Topotecan can be decreased when combined with Solriamfetol.
Darolutamide Darolutamide The serum concentration of Topotecan can be increased when it is combined with Darolutamide.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Topotecan.
Pexidartinib Pexidartinib The metabolism of Topotecan can be increased when combined with Pexidartinib.
Istradefylline Istradefylline The serum concentration of Topotecan can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant Topotecan may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Fedratinib Fedratinib The serum concentration of Topotecan can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Topotecan.
Phenytoin Injection Phenytoin Injection Phenytoin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Fosphenytoin Injection Fosphenytoin Injection Fosphenytoin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Topotecan can be increased when it is combined with Enfortumab vedotin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Topotecan.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Topotecan.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Topotecan.
Lasmiditan Lasmiditan The serum concentration of Topotecan can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Topotecan can be increased when it is combined with Ubrogepant.
Tazemetostat Tazemetostat The excretion of Topotecan can be decreased when combined with Tazemetostat.
Cenobamate Cenobamate Cenobamate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Topotecan is combined with Ozanimod.
Selumetinib Selumetinib The serum concentration of Topotecan can be increased when it is combined with Selumetinib.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Topotecan.
Tucatinib Tucatinib The excretion of Topotecan can be decreased when combined with Tucatinib.
Remdesivir Injection Remdesivir Injection The excretion of Topotecan can be decreased when combined with Remdesivir.
Ripretinib Ripretinib The serum concentration of Topotecan can be increased when it is combined with Ripretinib.
Selpercatinib Selpercatinib The serum concentration of Topotecan can be decreased when it is combined with Selpercatinib.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Topotecan.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Topotecan.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Topotecan can be increased when it is combined with Belantamab mafodotin.
Pralsetinib Pralsetinib The serum concentration of Topotecan can be increased when it is combined with Pralsetinib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Topotecan.
Viloxazine Viloxazine Topotecan may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Topotecan.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Topotecan.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Trazodone Trazodone The serum concentration of Topotecan can be decreased when it is combined with Trazodone.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Topotecan.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Topotecan.
Phenobarbital Phenobarbital Phenobarbital may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The metabolism of Topotecan can be decreased when combined with Methotrexate.
Primidone Primidone Primidone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Methsuximide Methsuximide Methsuximide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Topotecan.
Diazepam Diazepam Diazepam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Lorazepam Lorazepam Lorazepam may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Topotecan.
Amantadine Amantadine Amantadine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Topotecan is combined with Procarbazine.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Topotecan.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Topotecan.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Topotecan.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Methadone Methadone Methadone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Topotecan.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Topotecan.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Topotecan.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Topotecan is combined with Lomustine.
Doxorubicin Doxorubicin The metabolism of Topotecan can be increased when combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Topotecan.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Topotecan.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Topotecan.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Carbamazepine Carbamazepine Carbamazepine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Topotecan which could result in a higher serum level.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Topotecan.
Hydralazine Hydralazine Topotecan may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The excretion of Topotecan can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Topotecan.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Topotecan.
Loperamide Loperamide The serum concentration of Topotecan can be increased when it is combined with Loperamide.
Promethazine Promethazine Topotecan may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Daunorubicin Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Topotecan.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Digoxin Digoxin Topotecan may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The serum concentration of Topotecan can be increased when it is combined with Loxapine.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Quinine Quinine The serum concentration of Topotecan can be increased when it is combined with Quinine.
Ethosuximide Ethosuximide Topotecan may increase the excretion rate of Ethosuximide which could result in a lower serum level and potentially a reduction in efficacy.
Triamterene Triamterene Triamterene may decrease the excretion rate of Topotecan which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Topotecan.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Topotecan.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Topotecan.
Secobarbital Secobarbital Secobarbital may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Desipramine Desipramine Topotecan may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Probenecid Probenecid Topotecan may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine Quinidine The serum concentration of Topotecan can be increased when it is combined with Quinidine.
Procainamide Procainamide The excretion of Procainamide can be decreased when combined with Topotecan.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Rifampin Rifampin The serum concentration of Topotecan can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide Disopyramide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Valproic Acid Valproic Acid Valproic acid may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Tamoxifen Tamoxifen The serum concentration of Topotecan can be increased when it is combined with Tamoxifen.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Topotecan.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Topotecan which could result in a higher serum level.
Levothyroxine Levothyroxine The serum concentration of Topotecan can be decreased when it is combined with Levothyroxine.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Methimazole Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Topotecan.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Topotecan.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tolbutamide Tolbutamide Topotecan may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Baclofen Baclofen Baclofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Topotecan.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Topotecan which could result in a higher serum level.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Topotecan is combined with Mercaptopurine.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nadolol Nadolol The excretion of Nadolol can be decreased when combined with Topotecan.
Allopurinol Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Topotecan.
Clomiphene Clomiphene The serum concentration of Topotecan can be increased when it is combined with Clomifene.
Flavoxate Flavoxate Topotecan may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Topotecan.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Topotecan.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cephalexin Cephalexin The excretion of Topotecan can be decreased when combined with Cephalexin.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Topotecan.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Topotecan.
Ketoconazole Ketoconazole The serum concentration of Topotecan can be increased when it is combined with Ketoconazole.
Pyrantel Pyrantel Topotecan may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Topotecan.
Vincristine Injection Vincristine Injection The metabolism of Topotecan can be increased when combined with Vincristine.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Topotecan.
Vinblastine Vinblastine The metabolism of Topotecan can be increased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Topotecan.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Topotecan which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Topotecan.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Topotecan.
Temazepam Temazepam Temazepam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nifedipine Nifedipine Topotecan may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Verapamil Verapamil The serum concentration of Topotecan can be increased when it is combined with Verapamil.
Pindolol Pindolol Pindolol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Topotecan.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Topotecan which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Topotecan.
Etoposide Etoposide The metabolism of Topotecan can be increased when combined with Etoposide.
Glipizide Glipizide Topotecan may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Indapamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Topotecan may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Topotecan which could result in a higher serum level.
Auranofin Auranofin Auranofin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Gemfibrozil Gemfibrozil Topotecan may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Topotecan.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Amiodarone Amiodarone The serum concentration of Topotecan can be increased when it is combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Topotecan.
Ciprofloxacin Ciprofloxacin The excretion of Topotecan can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Topotecan.
Clozapine Clozapine The risk or severity of neutropenia can be increased when Topotecan is combined with Clozapine.
Estazolam Estazolam Topotecan may increase the excretion rate of Estazolam which could result in a lower serum level and potentially a reduction in efficacy.
Idarubicin Idarubicin The risk or severity of adverse effects can be increased when Topotecan is combined with Idarubicin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Topotecan is combined with Fludarabine.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Topotecan.
Clarithromycin Clarithromycin The serum concentration of Topotecan can be increased when it is combined with Clarithromycin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Topotecan can be increased when it is combined with Simvastatin.
Filgrastim Injection Filgrastim Injection The risk or severity of neutropenia can be increased when Filgrastim is combined with Topotecan.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Topotecan.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Topotecan.
Teniposide Injection Teniposide Injection The metabolism of Topotecan can be increased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Topotecan can be increased when it is combined with Itraconazole.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Topotecan which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Bisoprolol Bisoprolol The serum concentration of Topotecan can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Topotecan.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Topotecan.
Isradipine Isradipine Isradipine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Topotecan.
Gabapentin Gabapentin Gabapentin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Topotecan.
Fluvoxamine Fluvoxamine Fluvoxamine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nefazodone Nefazodone Topotecan may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Lamotrigine Lamotrigine Lamotrigine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tramadol Tramadol The metabolism of Topotecan can be decreased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Topotecan can be increased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Topotecan.
Lansoprazole Lansoprazole Lansoprazole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Topotecan.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Topotecan.
Bupropion Bupropion Topotecan may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine The metabolism of Topotecan can be increased when combined with Ticlopidine.
Saquinavir Saquinavir The serum concentration of Topotecan can be increased when it is combined with Saquinavir.
Metformin Metformin The excretion of Topotecan can be decreased when combined with Metformin.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Topotecan.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Riluzole Riluzole Riluzole may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Acarbose Acarbose Acarbose may decrease the excretion rate of Topotecan which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Topotecan.
Ritonavir Ritonavir The serum concentration of Topotecan can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Topotecan.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Topotecan which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Topotecan.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be increased when combined with Topotecan.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Topiramate Topiramate Topiramate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Fexofenadine Fexofenadine The serum concentration of Topotecan can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Topotecan.
Carvedilol Carvedilol The serum concentration of Topotecan can be increased when it is combined with Carvedilol.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Topotecan.
Propafenone Propafenone The serum concentration of Topotecan can be increased when it is combined with Propafenone.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Quetiapine Quetiapine Topotecan may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Topotecan which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Topotecan is combined with Capecitabine.
Abacavir Abacavir Topotecan may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The serum concentration of Topotecan can be increased when it is combined with Sildenafil.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Topotecan.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tolterodine Tolterodine Topotecan may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Topotecan is combined with Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Topotecan which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Levetiracetam Levetiracetam Topotecan may increase the excretion rate of Levetiracetam which could result in a lower serum level and potentially a reduction in efficacy.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Topotecan which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists