Herb & supplement monograph

German Ipecac Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with German Ipecac

0 medications have a known interaction with German Ipecac, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for German Ipecac. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact German Ipecac combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

German Ipecac: Uses, Safety & Side Effects

The bottom line

"German Ipecac" is an uncommon name, and the source plant is not clearly established, so be very cautious about any product sold under this name. True ipecac is a powerful emetic that is no longer recommended for treating poisoning and can be dangerous if misused. Talk to a pharmacist or doctor before using any product labeled as ipecac.

Part used
Root and rhizome
Common forms
Tincture, syrup, homeopathic preparations, dried root
People commonly use it for
  • To cause vomiting (emetic)
  • Loosening chest congestion
  • Nausea (in homeopathic dilutions)
  • Cough and bronchial complaints

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Ipecac-type preparations can cause forceful vomiting and have a narrow margin of safety.

PregnancyPossibly Unsafe

When used orally; avoid using.

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

When used orally; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

German Ipecac is an uncommon name with no widely recognized, well-documented source plant on record. The familiar herb called ipecac comes from the root of a South American shrub (commonly known as ipecacuanha) and has long been used to make people vomit and to loosen mucus in the chest.

The word "German" in the name may refer to a regional or traditional preparation, but reliable information tying it to a specific plant is lacking. Because of this uncertainty, you should treat any product sold as "German Ipecac" with extra care and verify exactly what is in it before using it.

Historically, ipecac products have been sold as syrups, tinctures, and homeopathic remedies. In conventional medicine, ipecac syrup was once kept at home to cause vomiting after poisoning, but this practice has largely been abandoned.

How it works

True ipecac root contains alkaloids, mainly emetine and cephaeline. These compounds are thought to trigger vomiting in two ways: by irritating the lining of the stomach and by acting on the part of the brain that controls the vomiting reflex.

In larger or repeated amounts, emetine can be toxic to the heart and muscles. This is one reason ipecac is considered risky and why misuse, including by people with eating disorders, can be dangerous.

Most of what is known comes from older pharmacology and case reports rather than modern controlled studies. The active makeup of a product specifically labeled "German Ipecac" is not clearly established.

Effectiveness

Does German Ipecac work?

Evidence overview · 2 uses evaluated
2 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For German Ipecac, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Bruises
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical German ipecac for bruises, there is insufficient reliable information about the clinical effects of German ipecac for this purpose.

Insufficient Reliable Evidence To Rate Dysmenorrhea
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral German ipecac for dysmenorrhea, there is insufficient reliable information about the clinical effects of German ipecac for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Ipecac-type products should be used only with professional guidance, if at all. Because they cause forceful vomiting, they can lead to dehydration, electrolyte problems, and tears in the esophagus. Repeated use can damage the heart muscle.

Do not use ipecac to treat poisoning at home. If you suspect a poisoning, call your local poison control center or emergency services right away.

People with heart disease, eating disorders, swallowing problems, or those who are weak, elderly, or very young should be especially cautious. During pregnancy and breastfeeding, avoid these products because of the risk of vomiting and the lack of safety data. Always check with a pharmacist or doctor before using anything labeled as ipecac.

Side effects

The most expected effect is vomiting, often along with nausea, drooling, stomach cramps, and diarrhea.

More serious problems can occur, especially with overuse or high doses. These include dehydration, abnormal heart rhythms, low blood pressure, muscle weakness, and heart muscle damage, which can be life-threatening. Forceful or repeated vomiting can also injure the throat and esophagus.

Seek medical help right away if you notice chest pain, irregular heartbeat, severe weakness, fainting, or signs of bleeding.

German Ipecac: Reported Adverse Effects

Documented safety reports on German Ipecac from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, high doses of German ipecac may cause vomiting, apnea, and cardiac arrest. Seed extracts may cause advancing paralysis of the central nervous system.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established, standardized dose for a product called "German Ipecac," and reliable dosing information for this specific name does not exist. Because ipecac-type preparations have a narrow margin between a typical dose and a harmful one, self-dosing is not advised.

If you are considering any product labeled as ipecac, follow the product label exactly and speak with a pharmacist or doctor first. Never increase the dose or repeat it on your own. Keep all such products out of reach of children.

Pregnancy & Breastfeeding

German Ipecac & Pregnancy

Possibly Unsafe

When used orally; avoid using.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

German Ipecac & Breastfeeding

Possibly Unsafe

When used orally; avoid using.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our German Ipecac monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

German Ipecac: Common Questions

What is German Ipecac used for, and does it work?
People use German Ipecac for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does German Ipecac interact with prescription medications?
We do not currently list any known drug interactions for German Ipecac. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are German Ipecac interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take German Ipecac with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this German Ipecac interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is German Ipecac used for?
It is associated with traditional ipecac, which people used to cause vomiting and to loosen chest congestion. There is little reliable evidence that products under this name are effective for any condition.
Is German Ipecac safe to take?
It should be approached with caution because ipecac-type products can cause forceful vomiting and, with misuse, heart damage. Talk to a pharmacist or doctor before using any product labeled as ipecac.
Can I use ipecac to treat poisoning at home?
No. Health authorities no longer recommend ipecac for home treatment of poisoning. Call your local poison control center or emergency services instead.
Is it safe during pregnancy or breastfeeding?
No, it is best avoided during pregnancy and breastfeeding because of the risk of vomiting and the lack of safety data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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