Drug & supplement interaction

Rauvolfia Vomitoria + Sumatriptan

Sumatriptan brand name: Tosymra.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Rauvolfia Vomitoria and Sumatriptan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rauvolfia Vomitoria and Sumatriptan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sumatriptan and Rauvolfia Vomitoria in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rauvolfia Vomitoria safety at a glance

Rauvolfia Vomitori... overall Use caution It contains potent alkaloids that can cause low blood pressure, depression, and other significant effects.

Pregnancy Possibly Unsafe When used orally. Animal research suggests that Rauvolfia vomitoria has teratogenic effects. Read the full pregnancy detail

Breastfeeding Avoid Avoid while breastfeeding because alkaloids may pass into milk and safety is unknown.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sumatriptan and Rauvolfia Vomitoria? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Sumatriptan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sumatriptan is filed under 4 classifications — including qt interval-prolonging drugs, serotonergic drugs, serotonergic drugs. Rauvolfia Vomitoria has documented interactions with 11 drug classes — the most serious being antipsychotic drugs (major), levodopa (major) and monoamine oxidase inhibitors (maois) (major) — and none of Sumatriptan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rauvolfia Vomitoria Does Interact With Other Medications

Rauvolfia Vomitoria has 230 major, 523 moderate, 87 minor known drug interactions in our database — Sumatriptan isn’t one of them. If you take anything else, check it against the full list below.

Major 230 Moderate 523 Minor 87 No known interaction 1,990 (incl. Sumatriptan)

Taking anything else?

Check Another of Your Medications Against Rauvolfia Vomitoria

Covers the 2,830 medications we’ve checked against Rauvolfia Vomitoria. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Rauvolfia Vomitoria and Sumatriptan May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 4 of them are worth acting on rather than waiting out — marked below.

A heart attack / Chest pain Worth acting on Additional detail
Rauvolfia Vomitoria
“Orally, drinking a beverage made by boiling Rauvolfia vomitoria foliage with bitter orange fruit can reduce levels of high-density lipoprotein (HDL) cholesterol in patients with diabetes. The effect of Rauvolfia vomitoria alone is unclear.

Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might also cause some of the adverse effects associated with these constituents.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in angina.
6 sources cited

35751. Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic ef

94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

17645. Chapotin SM, Razanameharizaka JH, Holbrook NM. A biomechanical perspective on the role of large stem volume and high water content in baobab trees (Adansonia spp.; Bombacaceae). Am J Bot 2006;93:1251-64.

86801. Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed

91521. Ruck B, Shih RD, Marcus SM. Hypertensive crisis from herbal treatment of impotence. Am J Emerg Med. 1999;17:317-318. PubMed

3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
Sumatriptan

Listed in the ADVERSE REACTIONS section of the FDA label for Sumatriptan. Read the label on DailyMed ›
Seizures Worth acting on Additional detail
Rauvolfia Vomitoria
“Orally, Rauvolfia vomitoria has been associated with the development of extrapyramidal symptoms in some patients. In one clinical study, 4 out of 10 patients who were taking Rauvolfia vomitoria dried root 300-800 mg daily developed extrapyramidal symptoms, including tremor, akathisia, hypokinesia, and dystonia.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in cluster headache.
6 sources cited

95991. Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.

15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

94332. Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed

11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Sumatriptan

Listed in the ADVERSE REACTIONS section of the FDA label for Sumatriptan. Read the label on DailyMed ›
An allergic reaction Worth acting on Additional detail
Rauvolfia Vomitoria
“Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might cause some of the adverse effects associated with these constituents. Orally, reserpine may cause nasal congestion or bronchospasm (15,94328). Allergic reactions may also occur; while these events are rare, they may precipitate asthma (15,94328).”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in asthma.
6 sources cited

15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed

86825. Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed

86850. Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.

94112. Wylie KR. Yohimbine and sinusitis. Br J Psychiatry. 1996;169(3):384-5. PubMed
“Since Rauvolfia vomitoria contains small amounts of yohimbine, theoretically it might cause some of the adverse effects associated with this constituent. There is one report of a hypersensitivity reaction including fever; chills; malaise; itchy, scaly skin; progressive renal failure; and lupus-like syndrome associated with ingestion of a one-day dose of yohimbine.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in kidney failure.
1 source cited

6169. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
Sumatriptan

Listed in the ADVERSE REACTIONS section of the FDA label for Sumatriptan. Read the label on DailyMed ›
Flushing Additional detail
Rauvolfia Vomitoria
“Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might also cause some of the adverse effects associated with these constituents. Orally, low amounts of reserpine may cause adverse reactions including facial flushing, skin rash, and itching. Yohimbine may cause rash, erythrodermic skin eruption, and exanthema.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in pruritus.
5 sources cited

94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed

3971. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.

86878. Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16. PubMed

86896. Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26. DOI
Sumatriptan

Listed in the ADVERSE REACTIONS section of the FDA label for Sumatriptan. Read the label on DailyMed ›
Dizziness / Headache Additional detail

Rauvolfia Vomitoria

Recorded for Rauvolfia Vomitoria in the same Natural Medicines adverse-effect record shown under Seizures above.

Sumatriptan

Listed in the ADVERSE REACTIONS section of the FDA label for Sumatriptan. Read the label on DailyMed ›

Reported for Rauvolfia Vomitoria but not commonly for Sumatriptan: stomach upset, fainting, an irregular heartbeat and a stuffy or runny nose.

Effects for Sumatriptan come from the ADVERSE REACTIONS section of its FDA label; effects for Rauvolfia Vomitoria come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Rauvolfia Vomitoria in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Animal research suggests that Rauvolfia vomitoria has teratogenic effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Rauvolfia Vomitoria or Sumatriptan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Rauvolfia Vomitoria or Sumatriptan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sumatriptan

This page covers Rauvolfia Vomitoria only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sumatriptan page lists 50 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 31 moderate · 11 minor.

From our pharmacist’s overview on the Sumatriptan page

“The supplement risk that matters most with sumatriptan (Tosymra) is serotonin overload. This migraine drug works through serotonin receptors, and 20 of the 50 interacting ingredients on file, 5-HTP among them, can push serotonin activity higher still, raising the risk of serotonin syndrome (agitation, racing heart, fever).”

Reviewed by 2 · Jul 18, 2026

Open the Sumatriptan interaction page

One more smart check

Taking Rauvolfia Vomitoria as Part of a Dietary Supplement Product? Check It for Interactions

We hold 17 real supplement products containing Rauvolfia Vomitoria, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rauvolfia Vomitoria. Even though Rauvolfia Vomitoria itself has no known interaction with Sumatriptan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rauvolfia Vomitoria and Sumatriptan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rauvolfia Vomitoria

Steady interest

#933 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Sumatriptan

Top 5%

#37 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rauvolfia Vomitoria reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rauvolfia Vomitoria and Sumatriptan records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Rauvolfia Vomitoria

What is Rauvolfia Vomitoria?

High blood pressure
Anxiety and agitation
Sleep problems
Mental health symptoms (traditional use)
Fever and general ailments

Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for high blood pressure and agitation. Because these compounds can strongly affect blood pressure, mood, and the nervous system, the plant can cause serious side effects and is not a casual supplement. Always talk to a doctor or pharmacist before using it.

Rauvolfia vomitoria · Apocynaceae · Root and root bark (sometimes leaves and stem bark) · Dried root powder, capsules, tinctures, decoctions (traditional preparations)

An interaction check asks whether these two react with each other — it does not ask whether Rauvolfia Vomitoria is a good idea for someone in your situation. Here is what our Rauvolfia Vomitoria record says about it on its own.

Rauvolfia Vomitoria: dosing

There is no well-established safe supplement dose for Rauvolfia vomitoria. Traditional preparations vary widely, and the amount of active alkaloid in a given product is often unknown.Because the active compounds are powerful and the line between a calming dose and a harmful one can be narrow, you should not guess at a dose on your own. They can help you decide whether it is appropriate and watch for problems.

From our Rauvolfia Vomitoria monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rauvolfia Vomitoria monograph & all interactions

Medication

About Sumatriptan

What Is Sumatriptan Used For?

Brand name: Tosymra

Sumatriptan is used to stop a migraine headache once it starts — with or without aura (the visual or sensory warning signs some people get before a migraine). It is available as tablets, nasal sprays, nasal capsules, and subcutaneous (under-the-skin) injections for this purpose.

Sumatriptan subcutaneous injections (brands: Imitrex injection, Sumatriptan Injection, Sumatriptan Succinate Injection) are also approved to treat acute cluster headaches in adults. Sumatriptan is not used to prevent migraines or cluster headaches — it only treats attacks once they begin.

Most-Reported Side Effects for Sumatriptan

From FAERS, the FDA’s public side-effect reporting system (46,096 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 3,911 reports

Nausea 3,510 reports

Migraine 3,445 reports

Fatigue 2,617 reports

Dizziness 2,121 reports

See full Sumatriptan drug information

Keep checking

Other Drugs & Rauvolfia Vomitoria

Browse every other medication we’ve checked against Rauvolfia Vomitoria — both the ones with a known interaction and the ones without. Select any drug for the full detail.

230Major

523Moderate

87Minor

1,989No known interaction

230 Major 523 Moderate 87 Minor 1,989 No interaction

Major

230 interactions

Showing 60 of 230 major interactions — see all 230 on the Rauvolfia Vomitoria page.

Moderate

523 interactions

Showing 60 of 523 moderate interactions — see all 523 on the Rauvolfia Vomitoria page.

Minor

87 interactions

Showing 60 of 87 minor interactions — see all 87 on the Rauvolfia Vomitoria page.

No interaction 1,989 drugs checked — show the list

We also checked Rauvolfia Vomitoria against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,989 medications checked with no known interaction — see the full Rauvolfia Vomitoria list.

See the full Rauvolfia Vomitoria interactions page

See every supplement checked against Sumatriptan, ranked by severity

Evidence & sources

Rauvolfia Vomitoria References

The 46 references that drive our Rauvolfia Vomitoria monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
Chapotin SM, Razanameharizaka JH, Holbrook NM. A biomechanical perspective on the role of large stem volume and high water content in baobab trees (Adansonia spp.; Bombacaceae). Am J Bot 2006;93:1251-64.
VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic ef
Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed
Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
Cimolai, N. and Cimolai, T. Yohimbine use for physical enhancement and its potential toxicity. J Diet.Suppl 2011;8(4):346-354. PubMed
Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed
Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. PubMed
Charney, D. S., Price, L. H., and Heninger, G. R. Desipramine-yohimbine combination treatment of refractory depression. Implications for the beta-adrenergic receptor hypothesis of antidepressant action. Arch.Gen.Psychiatry 1986;43(12):1155-1161. PubMed
Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. PubMed
Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.
Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
Morgan, C. A., III, Southwick, S. M., Grillon, C., Davis, M., Krystal, J. H., and Charney, D. S. Yohimbine-facilitated acoustic startle reflex in humans. Psychopharmacology (Berl) 1993;110(3):342-346. PubMed
Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16. PubMed
Rowland, D. L., Kallan, K., and Slob, A. K. Yohimbine, erectile capacity, and sexual response in men. Arch Sex Behav 1997;26(1):49-62.
Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26. DOI
Ruck B, Shih RD, Marcus SM. Hypertensive crisis from herbal treatment of impotence. Am J Emerg Med. 1999;17:317-318. PubMed
Eluwa MA, Udoaffah MT, Vulley MB, et al. Comparative study of teratogenic potentials of crude ethanolic root bark and leaf extract of Rauwolfia vomitoria (apocynaceae) on the fetal heart. N Am J Med Sci 2010;2:592-5. PubMed
Eluwa MA, Ekanem TB, Udoh PB, et al. Teratogenic effect of crude ethanolic root bark and leaf extracts of Rauwolfia vomitoria (Apocynaceae) on nissl substances of albino wistar rat fetuses. Neurosci J 2013;2013:906731.
Eluwa MA, Ekanem TB, Udoh PB, et al. Teratogenic effect of crude ethanolic root bark and leaf extracts of Rauwolfia vomitoria (Apocynaceae) on the femur of albino wistar rat fetuses. J. Histol 2013;1-5.
Ekong MB, Peter AI, Edagha IA, et al. Rauwolfia vomitoria inhibits olfaction and modifies olfactory bulb cells. Brain Res Bull 2016;124:206-13. PubMed
Amole OO, Yemitan OK, Oshikoya KA. Anticonvulsant activity of Rauvol?a Vomitoria (Afzel). Afr J Pharmacy Pharmacol 2009;3:319-322.
Campbell JI, Mortensen A, Mølgaard P. Tissue lipid lowering-effect of a traditional Nigerian anti-diabetic infusion of Rauwolfia vomitoria foilage and Citrus aurantium fruit. J Ethnopharmacol 2006;104:379-86. PubMed
Wylie KR. Yohimbine and sinusitis. Br J Psychiatry. 1996;169(3):384-5. PubMed
Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.
Sheldon MB, Kotte JH. Effect of Rauwolfia serpentina and reserpine on the blood pressure in essential hypertension; a long-term double-blind study. Circulation. 1957 Aug;16(2):200-6.
Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed
Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.
Bharucha AE, Skaar T, Andrews CN, et al Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil. 2008;20(8):891-9. PubMed
Schmauss M, Laakmann G, Dieterle D. Effects of alpha 2-receptor blockade in addition to tricyclic antidepressants in therapy-resistant depression. J Clin Psychopharmacol. 1988;8(2):108-11.
Wang N, Xie YW, Li MY, et al. Simultaneous determination of five alkaloids from Rauvolfia vomitoria in rat plasma by LC-MS/MS: Application to a comparative pharmacokinetic study in normal and type 2 diabetic rats. J Sep Sci 2021;44(7):1391-1403.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rauvolfia Vomitoria and Sumatriptan Together: Common Questions

Is it safe to take Rauvolfia Vomitoria with Sumatriptan?

We do not list a known interaction between Rauvolfia Vomitoria and Sumatriptan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Rauvolfia Vomitoria and Sumatriptan have any of the same side effects?

Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Rauvolfia Vomitoria and Sumatriptan combination checked?

Interactions in our licensed database are recorded against drug classes. Sumatriptan is filed under 4 classifications, and Rauvolfia Vomitoria has documented interactions with 11 drug classes — none of Sumatriptan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Rauvolfia Vomitoria interact with any other medications?

Yes. Rauvolfia Vomitoria has 840 documented drug interactions in our database — Sumatriptan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Sumatriptan interact with any supplements?

Yes. Sumatriptan has documented interactions with 50 supplements in our database — Rauvolfia Vomitoria is not one of them. The Sumatriptan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Rauvolfia Vomitoria monograph Uses, safety profile, and every drug interaction in one place Sumatriptan drug information The full plain-English guide to this medication Sumatriptan supplement interactions Every supplement checked against Sumatriptan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 46 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.