Can I Take Mushroom Gummies With Propranolol and Sumatriptan?
A reader asks about an interaction between Ankhway mushroom gummies, propranolol, and sumatriptan.
Can I take Ankhway mushroom gummies with propranolol? I take the propranolol for migraines, not high blood pressure. I'm not on any other medication, other than sumatriptan when I do get a migraine. I also drink a cup or two of sage tea every day.
Jul 21, 2026- The mushrooms in these gummies, including reishi, lion's mane, and cordyceps, don't have documented interactions with propranolol or sumatriptan. Since reishi may have mild blood pressure lowering effects and propranolol also lowers blood pressure, you should monitor yourself for lightheadedness or dizziness when starting the gummies. Drinking a cup or two of sage tea daily is generally safe with these medications, though very high amounts of sage taken over long periods could be a concern.
Hello, and thank you for trusting HelloPharmacist with this one!
The good news is that the mushrooms found in Ankhway's gummies don't have any well-documented interactions with propranolol or sumatriptan, and a cup or two of sage tea a day isn't expected to cause a problem either.
That said, there are a few small details worth understanding, which I discuss in the sections below.
The Mushrooms in the Gummies and Propranolol
Ankhway's mushroom gummies are a multi-mushroom blend that typically includes lion's mane, reishi, cordyceps, chaga, turkey tail, maitake, and shiitake, among others.
None of these mushrooms is known to interact directly with propranolol or sumatriptan. The one I'd single out for a brief mention, though, is reishi.
In larger, concentrated doses, reishi may have mild blood pressure lowering effects and could slightly slow blood clotting, though the evidence for both is thin and the amounts in a gummy blend are generally small.
Since propranolol is a beta-blocker that lowers heart rate and blood pressure even when it's prescribed for migraine prevention rather than hypertension, it's simply worth paying attention to how you feel when you start the gummies.
If you notice new lightheadedness or dizziness, especially when standing up quickly, bring it up with your doctor or pharmacist.
Sumatriptan and Your Daily Sage Tea
Sumatriptan, which you only take as needed during a migraine attack, has no known interactions with medicinal mushrooms or with sage.
As for the sage tea, drinking a cup or two daily is generally considered fine. Very high amounts of sage (think concentrated oils or strong extracts taken over long periods) contain a compound called thujone that can be a concern in excess, but ordinary tea drinking doesn't come close to those levels.
Sage may also have mild blood sugar lowering effects, and there is one small point worth knowing here: beta-blockers like propranolol can blunt some of the early warning signs of low blood sugar. This mostly matters for people with diabetes, which doesn't sound like your situation, but it's a useful thing to be aware of when you're combining these every day.
Final Words
Overall, there's no known interaction to worry about between mushroom gummies, propranolol, sumatriptan, and moderate sage tea.
My advice is to double-check the ingredient label on your specific bottle, let your doctor or pharmacist know you're adding the gummies, and pay attention to how you feel over the first couple of weeks.
Thanks for reaching out!
References & sources
- DailyMed. Propranolol prescribing information — DailyMed
- Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Nanogel in a Complete Freund's Adjuvant-Induced Rheumatoid Arthritis Rat Model: Anti-Arthritic, Anti-Inflammatory, and Antioxidative Activity — PubMed
- Reishi Mushroom (Ganoderma lucidum): pharmacology of a potent healer in traditional Chinese medicine — PubMed
Glossary — Terms in This Answer
- Propranolol
- A beta-blocker medication that lowers heart rate and blood pressure, often prescribed for migraine prevention.
- Sumatriptan
- A medication taken as needed during a migraine attack to relieve migraine symptoms.
- Beta-blocker
- A class of medication that reduces heart rate and blood pressure by blocking certain nerve signals.
- Reishi
- A type of mushroom that in large concentrated doses may have mild blood pressure lowering effects.
- Thujone
- A compound found in concentrated sage oils or extracts that can be a concern in excess amounts.
- Blood clotting
- The process by which blood thickens to form a clot and stop bleeding.
- Hypertension
- High blood pressure, a condition that propranolol can be prescribed to treat.
- Medicinal mushrooms
- Mushroom varieties used for health and wellness purposes rather than culinary reasons.