Drug & supplement interaction

Rauvolfia Vomitoria + Amphetamine

Amphetamine brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Amphetamine falls into 3 drug categories that Rauvolfia Vomitoria can interact with; the most serious is rated major. Theoretically, concomitant use might cause additive effects.

Read the full interaction report
SeverityMajor
LikelihoodProbable
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Rauvolfia Vomitoria and Amphetamine

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Rauvolfia Vomitoria interacts with whole categories of medication. Amphetamine falls into 3 of those categories, so it can interact with Rauvolfia Vomitoria in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Major).

Major

STIMULANT DRUGS

1 of 3

Why this applies to Amphetamine

Amphetamine falls under STIMULANT DRUGS — the group Rauvolfia Vomitoria interacts with.

Theoretically, concomitant use might cause additive effects.
Yohimbine, a constituent of Rauvolfia vomitoria, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking Rauvolfia vomitoria with stimulant drugs can have additive stimulant and hypertensive effects.
Severity Major Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind with this combination: amphetamine is already a powerful stimulant that revs up your nervous system, raising your heart rate and blood pressure. Rauvolfia vomitoria contains a yohimbine-like compound that can also push blood pressure up and add its own stimulant-type push. Stacking the two together could, in theory, pile those effects on top of each other.

In real terms, that might mean a faster or pounding heartbeat, higher blood pressure, jitteriness, anxiety, or trouble sleeping. I'll be honest, this concern is based mostly on how these compounds work on paper rather than strong human studies, so it's more of a theoretical caution. Still, because both can affect your heart and blood pressure, please don't pair them without checking with your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Bharucha AE, Skaar T, Andrews CN, et al Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil. 2008;20(8):891-9. PubMed
Major

MONOAMINE OXIDASE INHIBITORS (MAOIs)

2 of 3

Amphetamine also falls under MONOAMINE OXIDASE INHIBITORS (MAOIs).

Theoretically, concomitant use might cause additive effects.
Yohimbine, a constituent of Rauvolfia vomitoria, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.
Severity Major Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the concern with pairing Rauvolfia vomitoria and your amphetamine. This plant contains yohimbine, which at high doses can act like an MAO inhibitor (it blocks the enzyme that helps break down certain brain chemicals). Amphetamine works by pushing out and building up those same chemicals (norepinephrine and dopamine). Stack the two together and you could get an exaggerated, additive effect.

In real terms, that can mean a spike in blood pressure, a racing or pounding heart, headache, anxiety, sweating, or feeling jittery and overstimulated. This is a theoretical interaction based on how these compounds behave, not hard clinical data, but it's flagged as major for good reason. Please don't combine them without checking with your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Moderate

CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES

3 of 3

Amphetamine also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.

Theoretically, Rauvolfia vomitoria might increase the levels and clinical effects of CYP2D6 substrates.
Rauvolfia vomitoria contains small amounts of the drug yohimbine. In vitro research shows that yohimbine inhibits CYP2D6 enzyme activity.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for anyone combining Rauvolfia vomitoria with amphetamine (Dyanavel XR, Mydayis, and similar). This plant contains a bit of yohimbine, and lab studies suggest yohimbine can slow down a liver enzyme called CYP2D6, which is one of the pathways your body uses to clear amphetamine. If that enzyme is blocked, amphetamine could hang around longer and feel stronger than expected. You might notice more jitteriness, a faster or pounding heartbeat, higher blood pressure, trouble sleeping, or feeling anxious or wired.

I want to be honest about how solid this is: it's theoretical, based only on test-tube work, not real-world cases. Still, both of these affect your heart and nervous system, so please check with your pharmacist or doctor before pairing them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Rauvolfia Vomitoria Also Interacts With Other Medications

Rauvolfia Vomitoria has 229 major, 523 moderate, 87 minor known drug interactions in our database — the Amphetamine one above is among them. If you take anything else, check it against the full list below.

Major 229 Moderate 523 Minor 87 No known interaction 1,991 (incl. Amphetamine)
Taking anything else?

Check Another of Your Medications Against Rauvolfia Vomitoria

Covers the 2,830 medications we’ve checked against Rauvolfia Vomitoria. Pick one to open its full report.

From our Q&A

Questions About Rauvolfia Vomitoria or Amphetamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Rauvolfia Vomitoria or Amphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amphetamine

This page covers Rauvolfia Vomitoria only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amphetamine page lists 130 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 16 major · 97 moderate · 17 minor.

From our pharmacist’s overview on the Amphetamine page

“Amphetamine (Dyanavel XR, Adzenys ER, Mydayis) is a prescription stimulant, usually taken for ADHD, and its interaction list is one to approach with genuine care. Of the 130 supplements and herbal ingredients on file, 16 carry a major rating, and many of those work the same way, either inhibiting monoamine oxidase, as yohimbe does, or…”

Reviewed by 2 · Jul 18, 2026

Open the Amphetamine interaction page

One more smart check

Taking Rauvolfia Vomitoria as Part of a Dietary Supplement Product? Check It for Interactions

We hold 17 real supplement products containing Rauvolfia Vomitoria, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rauvolfia Vomitoria. Your product may carry other ingredients that interact with Amphetamine too, on top of Rauvolfia Vomitoria — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rauvolfia Vomitoria and Amphetamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rauvolfia Vomitoria
Steady interest

#933 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amphetamine
Top 5%

#46 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Rauvolfia Vomitoria

What is Rauvolfia Vomitoria?

  • High blood pressure
  • Anxiety and agitation
  • Sleep problems
  • Mental health symptoms (traditional use)
  • Fever and general ailments

Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for high blood pressure and agitation. Because these compounds can strongly affect blood pressure, mood, and the nervous system, the plant can cause serious side effects and is not a casual supplement. Always talk to a doctor or pharmacist before using it.

Read the full Rauvolfia Vomitoria monograph & all interactions
Medication

About Amphetamine

What Is Amphetamine Used For?

Brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER

Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group.

Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

See full Amphetamine drug information
Keep checking

Other Drugs & Rauvolfia Vomitoria

Browse every other medication we’ve checked against Rauvolfia Vomitoria — both the ones with a known interaction and the ones without. Select any drug for the full detail.

229Major
523Moderate
87Minor
1,990No known interaction
229 Major 523 Moderate 87 Minor 1,990 No interaction
Major

229 interactions

Showing 60 of 229 major interactions — see all 229 on the Rauvolfia Vomitoria page.

Moderate

523 interactions

Showing 60 of 523 moderate interactions — see all 523 on the Rauvolfia Vomitoria page.

Minor

87 interactions

Showing 60 of 87 minor interactions — see all 87 on the Rauvolfia Vomitoria page.

No interaction 1,990 drugs checked — show the list

We also checked Rauvolfia Vomitoria against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,990 medications checked with no known interaction — see the full Rauvolfia Vomitoria list.

See the full Rauvolfia Vomitoria interactions page
See every supplement checked against Amphetamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Rauvolfia Vomitoria monograph › Uses, safety, and every drug interaction in one place Amphetamine supplement interactions › Every supplement checked against Amphetamine, ranked by severity Amphetamine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Rauvolfia Vomitoria and Amphetamine Together: Common Questions

Can you take Rauvolfia Vomitoria with Amphetamine?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Rauvolfia Vomitoria and Amphetamine?
Amphetamine belongs to more than one drug category, and Rauvolfia Vomitoria interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Rauvolfia Vomitoria and Amphetamine interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Amphetamine and Rauvolfia Vomitoria?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.