Drug & supplement interaction

Rauvolfia Vomitoria + Hexobarbitone

Hexobarbitone brand names: Cyclonal, Evipan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rauvolfia Vomitoria and Hexobarbitone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Rauvolfia Vomitoria and Hexobarbitone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hexobarbitone and Rauvolfia Vomitoria in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rauvolfia Vomitoria safety at a glance

Rauvolfia Vomitori... overall Use caution It contains potent alkaloids that can cause low blood pressure, depression, and other significant effects.
Pregnancy Possibly Unsafe When used orally. Animal research suggests that Rauvolfia vomitoria has teratogenic effects. Read the full pregnancy detail
Breastfeeding Avoid Avoid while breastfeeding because alkaloids may pass into milk and safety is unknown.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hexobarbitone and Rauvolfia Vomitoria? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Hexobarbitone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Hexobarbitone is filed under a single classification — barbiturates. Rauvolfia Vomitoria has documented interactions with 11 drug classes — the most serious being antipsychotic drugs (major), levodopa (major) and monoamine oxidase inhibitors (maois) (major) — and none of Hexobarbitone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rauvolfia Vomitoria Does Interact With Other Medications

Rauvolfia Vomitoria has 230 major, 523 moderate, 87 minor known drug interactions in our database — Hexobarbitone isn’t one of them. If you take anything else, check it against the full list below.

Major 230 Moderate 523 Minor 87 No known interaction 1,990 (incl. Hexobarbitone)
Taking anything else?

Check Another of Your Medications Against Rauvolfia Vomitoria

Covers the 2,830 medications we’ve checked against Rauvolfia Vomitoria. Pick one to open its full report.

What to actually watch for

What Rauvolfia Vomitoria Itself Has Been Linked To

This is not an interaction — nothing below involves Hexobarbitone. It is the side-effect record for Rauvolfia Vomitoria on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Rauvolfia Vomitoria, this list is the first place to look. 5 entries are worth acting on rather than waiting out — marked below.

  • A heart attack / An irregular heartbeat / Chest pain / Raised blood pressure Worth acting on Additional detail

    “Orally, drinking a beverage made by boiling Rauvolfia vomitoria foliage with bitter orange fruit can reduce levels of high-density lipoprotein (HDL) cholesterol in patients with diabetes. The effect of Rauvolfia vomitoria alone is unclear.

    Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might also cause some of the adverse effects associated with these constituents.”

    Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in angina.

    6 sources cited
    1. 35751. Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic ef
    2. 94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.
    3. 17645. Chapotin SM, Razanameharizaka JH, Holbrook NM. A biomechanical perspective on the role of large stem volume and high water content in baobab trees (Adansonia spp.; Bombacaceae). Am J Bot 2006;93:1251-64.
    4. 86801. Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
    5. 91521. Ruck B, Shih RD, Marcus SM. Hypertensive crisis from herbal treatment of impotence. Am J Emerg Med. 1999;17:317-318. PubMed
    6. 3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
  • Hallucinations / Low mood Worth acting on Additional detail

    “In one clinical study, Rauvolfia vomitoria dried root 300-800 mg orally daily for 6 weeks was not associated with reports of depression or thoughts of suicide in patients with psychosis. However, since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might cause some of the adverse effects associated with these constituents.”

    Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 95991. Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.
    2. 3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
    3. 3970. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
    4. 3971. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
    5. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    6. 86786. Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
  • Fainting / Seizures Worth acting on Additional detail

    “Orally, Rauvolfia vomitoria has been associated with the development of extrapyramidal symptoms in some patients. In one clinical study, 4 out of 10 patients who were taking Rauvolfia vomitoria dried root 300-800 mg daily developed extrapyramidal symptoms, including tremor, akathisia, hypokinesia, and dystonia.”

    Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 95991. Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.
    2. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    3. 94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.
    4. 94332. Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed
    5. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
    6. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Wheezing Worth acting on Additional detail

    “Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might cause some of the adverse effects associated with these constituents. Orally, reserpine may cause nasal congestion or bronchospasm (15,94328). Allergic reactions may also occur; while these events are rare, they may precipitate asthma (15,94328).”

    Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in asthma.

    6 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.
    3. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    4. 86825. Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed
    5. 86850. Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.
    6. 94112. Wylie KR. Yohimbine and sinusitis. Br J Psychiatry. 1996;169(3):384-5. PubMed
  • Kidney problems Worth acting on Additional detail

    “Since Rauvolfia vomitoria contains small amounts of yohimbine, theoretically it might cause some of the adverse effects associated with this constituent. A case of acute kidney failure related to yohimbine-induced systemic lupus erythematosus has been reported.”

    Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in kidney failure.

    1 source cited
    1. 6169. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed

    “Since Rauvolfia vomitoria contains small amounts of yohimbine, theoretically it might cause some of the adverse effects associated with this constituent. There is one report of a hypersensitivity reaction including fever; chills; malaise; itchy, scaly skin; progressive renal failure; and lupus-like syndrome associated with ingestion of a one-day dose of yohimbine.”

    Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in kidney failure.

    1 source cited
    1. 6169. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed

Showing the 10 most notable of 34 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Rauvolfia Vomitoria — expand a row for the licensed statement it rests on. We haven’t matched Hexobarbitone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Hexobarbitone.

Special populations

Rauvolfia Vomitoria in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Animal research suggests that Rauvolfia vomitoria has teratogenic effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Hexobarbitone

This page covers Rauvolfia Vomitoria only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hexobarbitone page lists 6 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Adrue (moderate), Cannabis (moderate), Delta-9-tetrahydrocannabinol (thc) (moderate), Pinellia Ternata (moderate) and Selenium (moderate).

By severity: 5 moderate · 1 minor.

From our pharmacist’s overview on the Hexobarbitone page

“Hexobarbitone (Cyclonal, Evipan) is a barbiturate, a sedative that slows the brain, so the real question with any add-on is whether it deepens or drags out that sedation. Five of the six supplement and herbal ingredients on file do exactly that, and none of the six rates above moderate.”

Reviewed by 2 · Jul 18, 2026

Open the Hexobarbitone interaction page

One more smart check

Taking Rauvolfia Vomitoria as Part of a Dietary Supplement Product? Check It for Interactions

We hold 17 real supplement products containing Rauvolfia Vomitoria, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rauvolfia Vomitoria. Even though Rauvolfia Vomitoria itself has no known interaction with Hexobarbitone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rauvolfia Vomitoria and Hexobarbitone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rauvolfia Vomitoria
Steady interest

#933 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hexobarbitone
Top 10%

#225 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rauvolfia Vomitoria reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rauvolfia Vomitoria and Hexobarbitone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rauvolfia Vomitoria

What is Rauvolfia Vomitoria?

  • High blood pressure
  • Anxiety and agitation
  • Sleep problems
  • Mental health symptoms (traditional use)
  • Fever and general ailments

Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for high blood pressure and agitation. Because these compounds can strongly affect blood pressure, mood, and the nervous system, the plant can cause serious side effects and is not a casual supplement. Always talk to a doctor or pharmacist before using it.

Rauvolfia vomitoria · Apocynaceae · Root and root bark (sometimes leaves and stem bark) · Dried root powder, capsules, tinctures, decoctions (traditional preparations)

An interaction check asks whether these two react with each other — it does not ask whether Rauvolfia Vomitoria is a good idea for someone in your situation. Here is what our Rauvolfia Vomitoria record says about it on its own.

Rauvolfia Vomitoria: dosing

There is no well-established safe supplement dose for Rauvolfia vomitoria. Traditional preparations vary widely, and the amount of active alkaloid in a given product is often unknown.Because the active compounds are powerful and the line between a calming dose and a harmful one can be narrow, you should not guess at a dose on your own. They can help you decide whether it is appropriate and watch for problems.

From our Rauvolfia Vomitoria monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rauvolfia Vomitoria monograph & all interactions
Keep checking

Other Drugs & Rauvolfia Vomitoria

Browse every other medication we’ve checked against Rauvolfia Vomitoria — both the ones with a known interaction and the ones without. Select any drug for the full detail.

230Major
523Moderate
87Minor
1,989No known interaction
230 Major 523 Moderate 87 Minor 1,989 No interaction
Major

230 interactions

Showing 60 of 230 major interactions — see all 230 on the Rauvolfia Vomitoria page.

Moderate

523 interactions

Showing 60 of 523 moderate interactions — see all 523 on the Rauvolfia Vomitoria page.

Minor

87 interactions

Showing 60 of 87 minor interactions — see all 87 on the Rauvolfia Vomitoria page.

No interaction 1,989 drugs checked — show the list

We also checked Rauvolfia Vomitoria against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,989 medications checked with no known interaction — see the full Rauvolfia Vomitoria list.

See the full Rauvolfia Vomitoria interactions page
See every supplement checked against Hexobarbitone, ranked by severity
Evidence & sources

Rauvolfia Vomitoria References

The 46 references that drive our Rauvolfia Vomitoria monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  5. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  6. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  7. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
  8. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
  9. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
  10. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
  11. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
  12. Chapotin SM, Razanameharizaka JH, Holbrook NM. A biomechanical perspective on the role of large stem volume and high water content in baobab trees (Adansonia spp.; Bombacaceae). Am J Bot 2006;93:1251-64.
  13. VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
  14. Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic ef
  15. Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rauvolfia Vomitoria and Hexobarbitone Together: Common Questions

Is it safe to take Rauvolfia Vomitoria with Hexobarbitone?
We do not list a known interaction between Rauvolfia Vomitoria and Hexobarbitone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Rauvolfia Vomitoria and Hexobarbitone combination checked?
Interactions in our licensed database are recorded against drug classes. Hexobarbitone is filed under 1 classification, and Rauvolfia Vomitoria has documented interactions with 11 drug classes — none of Hexobarbitone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rauvolfia Vomitoria interact with any other medications?
Yes. Rauvolfia Vomitoria has 840 documented drug interactions in our database — Hexobarbitone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Hexobarbitone interact with any supplements?
Yes. Hexobarbitone has documented interactions with 6 supplements in our database — Rauvolfia Vomitoria is not one of them. The Hexobarbitone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rauvolfia Vomitoria monograph Uses, safety profile, and every drug interaction in one place Hexobarbitone supplement interactions Every supplement checked against Hexobarbitone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 46 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hexobarbitone and Rauvolfia Vomitoria?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.