Medication interaction hub

What Supplements Interact with Hexobarbitone?

Hexobarbitone brand names: Cyclonal, Evipan. Every interaction below applies to the brands too.

6 Interactions 5 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hexobarbitone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hexobarbitone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hexobarbitone (Cyclonal, Evipan) is a barbiturate, a sedative that slows the brain, so the real question with any add-on is whether it deepens or drags out that sedation. Five of the six supplement and herbal ingredients on file do exactly that, and none of the six rates above moderate. For most people these combinations are workable; what the list buys you is knowing which ones can amplify drowsiness so you notice it early. Cannabis may raise barbiturate levels and lengthen how long the drug stays in the body, and selenium, an ordinary mineral supplement, may slow its breakdown in the liver.

Most of this evidence comes from animal or laboratory research rather than human trials, which fits the ratings of five moderate entries and one minor. That lone minor, Eastern red cedar, points the other way, possibly speeding the drug's metabolism and shortening its effect. Unusual grogginess is the main signal worth reporting.

— , Clinical Pharmacist · July 18, 2026

Moderate 5 Minor 1 No known interaction 1,446

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Hexobarbitone: Top Interactions at a Glance

The most significant Hexobarbitone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 6 highest-ranked of 6 interacting ingredients — plus 1,446 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Hexobarbitone + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible Adrue + Hexobarbitonei

Animal research suggests that taking adrue in combination with sodium thiopental increases total sleep time three-fold compared to the effects of sodium thiopen...

Read the full interaction Moderate Likelihood Possible Cannabis + Hexobarbitonei

Theoretically, cannabis might increase the levels and adverse effects of barbiturates.

Read the full interaction Moderate Likelihood Possible Delta-9-tetrahydrocannabinol (thc) + Hexobarbitonei

Theoretically, THC might increase the levels and adverse effects of barbiturates.

Read the full interaction Moderate Likelihood Possible Pinellia Ternata + Hexobarbitonei

Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Read the full interaction Moderate Likelihood Possible Selenium + Hexobarbitonei

Theoretically, selenium might prolong the sedating effects of barbiturates.

Read the full interaction
The complete list

Every Supplement Checked Against Hexobarbitone

All 1,452 ingredients in our database, ranked by severity — 6 with a Hexobarbitone interaction on file and 1,446 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hexobarbitone?

One-line answers, one card per combination — scroll through today’s 10 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Delta-9-tetrahydrocannabinol (thc) with Hexobarbitone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might increase the levels and adverse effects of barbiturates.

Full Delta-9-tetrahydrocannabinol (thc) + Hexobarbitone answer

Can you take Pinellia Ternata with Hexobarbitone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Hexobarbitone answer

Can you take Selenium with Hexobarbitone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, selenium might prolong the sedating effects of barbiturates.

Full Selenium + Hexobarbitone answer

Can you take Eastern Red Cedar with Hexobarbitone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In mice and rats given hexobarbital or pentobarbital, sleep time is reduced and metabolism of the drug is increased when they inhale essenti...

Full Eastern Red Cedar + Hexobarbitone answer

Can you take Adrue with Hexobarbitone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that taking adrue in combination with sodium thiopental increases total sleep time three-fold compared to the effec...

Full Adrue + Hexobarbitone answer

Can you take Cannabis with Hexobarbitone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might increase the levels and adverse effects of barbiturates.

Full Cannabis + Hexobarbitone answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Hexobarbitone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might increase the levels and adverse effects of barbiturates.

Full Delta-9-tetrahydrocannabinol (thc) + Hexobarbitone answer

Can you take Pinellia Ternata with Hexobarbitone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Hexobarbitone answer

Can you take Selenium with Hexobarbitone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, selenium might prolong the sedating effects of barbiturates.

Full Selenium + Hexobarbitone answer

Can you take Eastern Red Cedar with Hexobarbitone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In mice and rats given hexobarbital or pentobarbital, sleep time is reduced and metabolism of the drug is increased when they inhale essenti...

Full Eastern Red Cedar + Hexobarbitone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hexobarbitone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hexobarbitone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hexobarbitone sits in 1 interaction category. Open any one to see what the group means:

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hexobarbitone through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hexobarbitone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hexobarbitone.

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Pharmacist Counseling Corner

Hexobarbitone & Supplements: Common Questions

What supplements interact with Hexobarbitone?
In our interaction database, 6 supplement and herbal ingredients have an interaction with Hexobarbitone on file — 0 rated major, 5 moderate, and 1 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Adrue, Cannabis, Delta-9-tetrahydrocannabinol (thc).
Which Hexobarbitone supplement interactions are the most serious?
None of the Hexobarbitone supplement interactions on file are currently rated major. The most significant are the 5 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Hexobarbitone?
That depends entirely on which supplement. The honest answer for Hexobarbitone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Cyclonal have the same supplement interactions as Hexobarbitone?
Yes — Cyclonal, Evipan all contain Hexobarbitone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Hexobarbitone and my other medications?
This page covers Hexobarbitone against supplements and herbal ingredients. Checking Hexobarbitone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.