Medication interaction hub

What Supplements Interact with Secobarbital Sodium?

Secobarbital Sodium brand name: Seconal. Every interaction below applies to the brands too.

111 Interactions 7 Major 86 Moderate 18 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Secobarbital Sodium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Secobarbital Sodium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Secobarbital (Seconal) is an old and unusually powerful barbiturate sleep medication, and the risk across most of this page points the same way, toward deeper sedation. Seventy-eight of the interacting supplements add their own drowsiness on top of secobarbital's, with alcohol (beer and wine) and kava at the top, combinations that can depress breathing rather than just deepen sleep. With a drug this potent, I would treat any unfamiliar supplement as risky until you have checked it.

A smaller cluster, activated charcoal and bulky fibers like glucomannan among them, can keep an oral dose from being fully absorbed, so those should be spaced well apart from the medication. A third group acts on the liver enzyme CYP2B6, which can shift the drug's levels up or down. Of the 111 entries here, 86 are moderate and 18 minor, but the seven rated major, nearly all sedatives or alcohol, are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 86 Minor 18 No known interaction 1,341

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Secobarbital Sodium: Top Interactions at a Glance

The most significant Secobarbital Sodium supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 111 interacting ingredients — plus 1,341 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Secobarbital Sodium + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Secobarbital Sodiumi

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Secobarbital Sodiumi

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Secobarbital Sodiumi

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Secobarbital Sodiumi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Secobarbital Sodiumi

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Secobarbital Sodiumi

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Secobarbital Sodium

All 1,452 ingredients in our database, ranked by severity — 111 with a Secobarbital Sodium interaction on file and 1,341 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Secobarbital Sodium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Adrafinil with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the levels and clinical effects of CYP2B6 substrates.

Full Adrafinil + Secobarbital Sodium answer

Can you take Adrue with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold comp...

Full Adrue + Secobarbital Sodium answer

Can you take African Wild Potato with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits cytochrome P450 2B6 (CYP2B6).

Full African Wild Potato + Secobarbital Sodium answer

Can you take Albizia Julibrissin with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mi...

Full Albizia Julibrissin + Secobarbital Sodium answer

Can you take Artichoke with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.

Full Artichoke + Secobarbital Sodium answer

Can you take Ashwagandha with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Secobarbital Sodium answer

Can you take Astaxanthin with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.

Full Astaxanthin + Secobarbital Sodium answer

Can you take Bay Leaf with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Secobarbital Sodium answer

Can you take Berberine with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Secobarbital Sodium answer

Can you take Bitter Almond with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.

Full Bitter Almond + Secobarbital Sodium answer

Can you take Black Seed with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Secobarbital Sodium answer

Can you take Calamus with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.

Full Calamus + Secobarbital Sodium answer

Can you take California Poppy with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.

Full California Poppy + Secobarbital Sodium answer

Can you take Cannabichromene (cbc) with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.

Full Cannabichromene (cbc) + Secobarbital Sodium answer

Can you take Cannabidiol (cbd) with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might have additive effects if used with other CNS depressants.

Full Cannabidiol (cbd) + Secobarbital Sodium answer

Can you take Cannabinol (cbn) with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabinol might increase the levels and clinical effects of CYP2B6 substrates.

Full Cannabinol (cbn) + Secobarbital Sodium answer

Can you take Cannabis with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Secobarbital Sodium answer

Can you take Caraway with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caraway might increase the effects and adverse effects of CNS depressants.

Full Caraway + Secobarbital Sodium answer

Can you take Catnip with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Catnip + Secobarbital Sodium answer

Can you take Ceylon Leadwort with Secobarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2B6 (CYP2B6) in vitro.

Full Ceylon Leadwort + Secobarbital Sodium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Secobarbital Sodium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Secobarbital Sodium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Secobarbital Sodium sits in 4 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Secobarbital Sodium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Secobarbital Sodium through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Secobarbital Sodium through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Secobarbital Sodium through this category.

About Secobarbital Sodium

Secobarbital Sodium is a prescription medication also sold under the brand name Seconal. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Secobarbital Sodium  ·  Brand name: Seconal.

See the full Secobarbital drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Secobarbital Sodium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Secobarbital Sodium.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Secobarbital Sodium & Supplements: Common Questions

What supplements interact with Secobarbital Sodium?
Our database currently documents 111 ingredients with a known Secobarbital Sodium interaction (7 major, 86 moderate, 18 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 111. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Secobarbital Sodium supplement interactions are the most serious?
The 7 major-rated combinations — led by Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb) — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Secobarbital Sodium?
Plenty of supplements coexist fine with Secobarbital Sodium; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Seconal have the same supplement interactions as Secobarbital Sodium?
Yes — Seconal all contain Secobarbital Sodium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Secobarbital Sodium and my other medications?
This page covers Secobarbital Sodium against supplements and herbal ingredients. Checking Secobarbital Sodium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Secobarbital drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.