Medication interaction hub

What Supplements Interact with Mephobarbital?

Mephobarbital brand name: Mebaral. Every interaction below applies to the brands too.

132 Interactions 7 Major 106 Moderate 19 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Mephobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Mephobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Mephobarbital (Mebaral) is a barbiturate, a powerful sedative used mainly for seizures, and I would treat its supplement list with genuine care. Of the 132 ingredients with an interaction on file, 78 pile extra sedation on top of the drug, and the seven major-rated entries sit almost entirely in that group. Alcohol (beer or wine) and kava stand out, because deep drowsiness on a barbiturate can slow your breathing, not just make you sleepy.

Most of the remaining entries rate moderate, 106 of them, plus 19 minor. Thirty-three work through the liver enzyme CYP2C19 and can shift the levels of other medicines cleared the same way. Activated charcoal earns its major rating differently, soaking up an oral dose before your body absorbs it, so take it well apart from mephobarbital. With a seizure medicine, a lower blood level can mean a breakthrough seizure, which makes that gap worth keeping.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 106 Minor 19 No known interaction 1,320

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Mephobarbital: Top Interactions at a Glance

The Mephobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 132 interacting ingredients — plus 1,320 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Mephobarbital Combinations Today

The Mephobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible German Chamomile + Mephobarbitali

Theoretically, German chamomile might have additive effects when used with CNS depressants.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Mephobarbitali

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Moderate Likelihood Possible Delta-9-tetrahydrocannabinol (thc) + Mephobarbitali

Theoretically, THC might have additive effects if used with other CNS depressants.

Read the full interaction Minor Likelihood Unlikely Eastern Red Cedar + Mephobarbitali

In mice and rats given hexobarbital or pentobarbital, sleep time is reduced and metabolism of the drug is increased when they inhale essential oil vapor from Ea...

Read the full interaction Major Likelihood Likely Beer + Mephobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Mephobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Mephobarbital

All 1,452 ingredients in our database, ranked by severity — 132 with a Mephobarbital interaction on file and 1,320 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Mephobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take German Chamomile with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Mephobarbital answer

Can you take 1,4-butanediol with Mephobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + Mephobarbital answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Mephobarbital answer

Can you take Eastern Red Cedar with Mephobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In mice and rats given hexobarbital or pentobarbital, sleep time is reduced and metabolism of the drug is increased when they inhale essenti...

Full Eastern Red Cedar + Mephobarbital answer

Can you take Beer with Mephobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Beer + Mephobarbital answer

Can you take Wine with Mephobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Wine + Mephobarbital answer

Can you take Activated Charcoal with Mephobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Mephobarbital answer

Can you take Gamma-hydroxybutyrate (ghb) with Mephobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + Mephobarbital answer

Can you take Kava with Mephobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Mephobarbital answer

Can you take L-tryptophan with Mephobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.

Full L-tryptophan + Mephobarbital answer

Can you take Cannabidiol (cbd) with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs metabolized by CYP2C19.

Full Cannabidiol (cbd) + Mephobarbital answer

Can you take Coffee Charcoal with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Mephobarbital answer

Can you take European Mandrake with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Mephobarbital answer

Can you take Ginkgo with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP2C19.

Full Ginkgo + Mephobarbital answer

Can you take Glucomannan with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Mephobarbital answer

Can you take Melatonin with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.

Full Melatonin + Mephobarbital answer

Can you take Schisandra with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.

Full Schisandra + Mephobarbital answer

Can you take Yerba Mansa with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive or prolonged sedative effects.

Full Yerba Mansa + Mephobarbital answer

Can you take 5-htp with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Full 5-htp + Mephobarbital answer

Can you take Adrafinil with Mephobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might increase the levels and clinical effects of CYP2C19 substrates.

Full Adrafinil + Mephobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Mephobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Mephobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Mephobarbital sits in 5 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Mephobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Mephobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Mephobarbital through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Mephobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Mephobarbital through this category.

Related: does Mephobarbital deplete any nutrients?

Mephobarbital has 1 reported nutrient association in the research literature — see the Mephobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Mephobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Mephobarbital.

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Pharmacist Counseling Corner

Mephobarbital & Supplements: Common Questions

What supplements interact with Mephobarbital?
In our interaction database, 132 supplement and herbal ingredients have an interaction with Mephobarbital on file — 7 rated major, 106 moderate, and 19 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Mephobarbital supplement interactions are the most serious?
The 7 major-rated combinations — led by Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb) — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Mephobarbital?
That depends entirely on which supplement. The honest answer for Mephobarbital is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Mebaral have the same supplement interactions as Mephobarbital?
Yes — Mebaral all contain Mephobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Mephobarbital deplete any vitamins or nutrients?
It might — Mephobarbital has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Mephobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Mephobarbital and my other medications?
This page covers Mephobarbital against supplements and herbal ingredients. Checking Mephobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.