Medication interaction hub

What Supplements Interact with Hexobarbital?

Hexobarbital brand names: Hexobarbital, Sombulex. Every interaction below applies to the brands too.

125 Interactions 7 Major 100 Moderate 18 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hexobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hexobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A person taking hexobarbital (Sombulex), a barbiturate sedative, is already on a drug designed to slow the brain, and this supplement list deserves genuine care. Of the 125 ingredients listed, 78 are sedating in their own right, and stacking them on a barbiturate can push ordinary drowsiness toward dangerous sedation. Alcohol, whether beer or wine, is a major-rated pairing, and kava sits in that same top tier.

Seven interactions rate major, alongside 100 moderate and 18 minor, and those seven are the ones to understand first. A second group of 33 ingredients, CBD and melatonin among them, works on CYP2C19, the liver enzyme that clears hexobarbital, which can raise or lower how much drug stays in the blood. A smaller set, led by activated charcoal, can stop the pill from being absorbed, and a sleep medicine that never reaches the blood fails in its own way.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 100 Minor 18 No known interaction 1,327

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hexobarbital: Top Interactions at a Glance

The Hexobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 125 interacting ingredients — plus 1,327 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hexobarbital Combinations Today

The Hexobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Calendula + Hexobarbitali

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.

Read the full interaction Moderate Likelihood Possible Lentinan + Hexobarbitali

Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2C19 (CYP2C19).

Read the full interaction Minor Likelihood Possible Karaya Gum + Hexobarbitali

Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.

Read the full interaction Moderate Likelihood Possible Jamaican Dogwood + Hexobarbitali

Jamaican dogwood may potentiate sedative effects.

Read the full interaction Moderate Likelihood Probable Yerba Mansa + Hexobarbitali

Theoretically, concomitant use might cause additive or prolonged sedative effects.

Read the full interaction Minor Likelihood Possible Algin + Hexobarbitali

Theoretically, algin can alter the absorption of oral drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Hexobarbital

All 1,452 ingredients in our database, ranked by severity — 125 with a Hexobarbital interaction on file and 1,327 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hexobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calendula with Hexobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.

Full Calendula + Hexobarbital answer

Can you take Lentinan with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2C19 (CYP2C19).

Full Lentinan + Hexobarbital answer

Can you take Karaya Gum with Hexobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Hexobarbital answer

Can you take Jamaican Dogwood with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Jamaican dogwood may potentiate sedative effects.

Full Jamaican Dogwood + Hexobarbital answer

Can you take Yerba Mansa with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive or prolonged sedative effects.

Full Yerba Mansa + Hexobarbital answer

Can you take Adrafinil with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might increase the levels and clinical effects of CYP2C19 substrates.

Full Adrafinil + Hexobarbital answer

Can you take Adrue with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold comp...

Full Adrue + Hexobarbital answer

Can you take Albizia Julibrissin with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mi...

Full Albizia Julibrissin + Hexobarbital answer

Can you take Artichoke with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.

Full Artichoke + Hexobarbital answer

Can you take Ashwagandha with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Hexobarbital answer

Can you take Atractylodes with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking atractylodes may prolong the therapeutic and adverse effects of hexobarbital.

Full Atractylodes + Hexobarbital answer

Can you take Bacopa with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.

Full Bacopa + Hexobarbital answer

Can you take Baikal Skullcap with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap might increase levels of drugs metabolized by CYP2C19 enzymes.

Full Baikal Skullcap + Hexobarbital answer

Can you take Bay Leaf with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Hexobarbital answer

Can you take Berberine with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Hexobarbital answer

Can you take Bitter Almond with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.

Full Bitter Almond + Hexobarbital answer

Can you take Black Seed with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Hexobarbital answer

Can you take Boswellia Serrata with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.

Full Boswellia Serrata + Hexobarbital answer

Can you take Calamus with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.

Full Calamus + Hexobarbital answer

Can you take California Poppy with Hexobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.

Full California Poppy + Hexobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hexobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hexobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hexobarbital sits in 5 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Hexobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Hexobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hexobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hexobarbital through this category.

Hexobarbital 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Hexobarbital through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hexobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hexobarbital.

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Pharmacist Counseling Corner

Hexobarbital & Supplements: Common Questions

What supplements interact with Hexobarbital?
Our database currently documents 125 ingredients with a known Hexobarbital interaction (7 major, 100 moderate, 18 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 125. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Hexobarbital supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hexobarbital?
Plenty of supplements coexist fine with Hexobarbital; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Hexobarbital have the same supplement interactions as Hexobarbital?
Yes — Hexobarbital, Sombulex all contain Hexobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Hexobarbital and my other medications?
This page covers Hexobarbital against supplements and herbal ingredients. Checking Hexobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.