Herb & supplement monograph

Cannabichromene (cbc) Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how Cannabichromene (cbc) interacts with medications. The heart of this page is the interaction list — every drug Cannabichromene (cbc) is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Cannabichromene (cbc) is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Cannabichromene (cbc) Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Cannabichromene (cbc) drug interaction appears low for most people, though sedating medications deserve some caution. None of the listed interactions are rated major, and the concern behind them rests on animal research rather than well-documented human studies.

Interactions deserving the most attention

The one theme running through this profile is added sedation. Combining CBC with CNS depressants, meaning medicines that cause drowsiness such as sedatives and certain sleep or anxiety drugs, could in theory increase their sedative effects. Animal studies found that a single dose of CBC boosted the response to several sedative drugs, but interestingly this effect faded when CBC was given continuously. So while extra drowsiness is worth watching for, the effect has not been confirmed in people.

What the rest of the list means

Although CBC is linked to a long list of medications, nearly all of them fall under this single sedation concern rather than many separate problems. The evidence is graded as possible, based on animal research only, so most of these predicted interactions remain theoretical and have not been shown to cause meaningful changes in people.

Check your medications against Cannabichromene (cbc)

Based on HelloPharmacist’s Cannabichromene (cbc) interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Cannabichromene (cbc)

248 medications have a known interaction with Cannabichromene (cbc), graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Cannabichromene (cbc) using our pharmacist-reviewed interaction data.

AI summaries are generated from our Cannabichromene (cbc) interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Cannabichromene (cbc) combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Cannabichromene (cbc) affects

Every type of medication (drug category) Cannabichromene (cbc) is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Cannabichromene (cbc) interacts with

Cns Depressants

Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.
Animal research shows that cannabichromene, given as a single dose intraperitoneally, increases the sedative response to the drugs hexobarbital, barbital, and zoxazolamine. However, this effect was not maintained when cannabichromene was given continuously. After receiving cannabichromene daily for 7 days, the sedative effect of these drugs was reduced when compared with a control group or a single dose of cannabichromene.

Likelihood Possible Evidence D

Monograph

Cannabichromene (cbc): Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

Cannabichromene (CBC) is a non-intoxicating cannabinoid found in the cannabis plant that is being studied for possible pain, anti-inflammatory, and nervous-system effects. Almost all current evidence comes from laboratory and animal research, so we do not yet know how well it works or how safe it is in people. Talk with your pharmacist or doctor before using any CBC product, and avoid it during pregnancy and breastfeeding.

Family: Cannabaceae
Part used: Flowers and resin of the cannabis plant (where the cannabinoid is concentrated)
Common forms: Oils and tinctures, capsules, edibles, full-spectrum hemp extracts, vape products

People commonly use it for

Pain relief
Inflammation
Mood and anxiety
Skin and acne concerns
Brain and nerve health

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallLimited data

Human safety data are very limited, so its long-term safety is not established.

PregnancyBest avoided

Not enough safety data; cannabinoids are best avoided during pregnancy.

BreastfeedingBest avoided

Cannabinoids can pass into breast milk, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Cannabichromene, usually shortened to CBC, is one of the many natural compounds called cannabinoids that are found in the cannabis (hemp and marijuana) plant. It is considered one of the more abundant cannabinoids in the plant, along with better-known compounds like THC and CBD.

Unlike THC, CBC is non-intoxicating, meaning it does not cause the "high" linked to marijuana. Because of this, it has drawn interest as a possible wellness ingredient.

CBC is most often sold as part of "full-spectrum" hemp products, where it appears alongside CBD and other cannabinoids. Stand-alone CBC products are less common. You may see it in oils, tinctures, capsules, edibles, and topical creams.

Uses & effectiveness

People are interested in CBC for a range of reasons, but it is important to understand that the science is still very early. Most of what we know comes from laboratory (test tube) and animal studies, not from well-designed human trials.

Common reasons people try CBC include:

Pain — early animal research suggests possible pain-relieving effects, but this has not been confirmed in people.
Inflammation — lab studies hint at anti-inflammatory activity.
Mood and anxiety — some animal research has explored effects on mood, but evidence is weak.
Skin and acne — test-tube studies have looked at effects on skin oil glands.
Brain and nerve health — early lab work has explored effects on nerve cells.

Overall, there is not enough reliable human evidence to say that CBC works for any of these conditions. Treat product marketing claims with caution.

How it works

CBC interacts with the body's endocannabinoid system, a network of receptors that helps regulate things like pain, mood, and inflammation. Unlike THC, CBC does not bind strongly to the CB1 receptors in the brain, which is why it does not cause a high.

Laboratory research suggests CBC may act on CB2 receptors (involved in immune and inflammatory responses) and on certain sensory channels called TRPV1 and TRPA1, which are involved in how the body senses pain and temperature.

Some scientists believe CBC may work better when combined with other cannabinoids, an idea called the "entourage effect." It is important to remember that these mechanisms are mostly based on cell and animal studies, and may not translate the same way in the human body.

Safety & precautions

The safety of CBC in humans is not well understood because there are few human studies. Because it is non-intoxicating, it is generally thought to be reasonably well tolerated, but this is not a guarantee of safety.

People who should be especially cautious include those with liver problems, those taking multiple medications, older adults, and anyone with a serious medical condition. Quality is also a concern: CBC products are not tightly regulated, so the actual contents may differ from the label, and some products may contain trace amounts of THC.

Pregnancy and breastfeeding: Avoid CBC if you are pregnant or breastfeeding. There is not enough safety information, and cannabinoids may affect a developing baby or pass into breast milk.

Always talk with your pharmacist or doctor before starting CBC, especially if you take prescription medicines or have a chronic health condition.

Side effects

Because CBC has not been widely studied in people, its full side-effect profile is unknown. Based on experience with related cannabinoids, possible side effects may include tiredness, dizziness, dry mouth, changes in appetite, or digestive upset.

Some hemp-derived products may contain small amounts of THC, which could cause unexpected effects or show up on a drug test. If you notice any unusual or troubling symptoms, stop using the product and contact a healthcare provider.

Dosing

There is no established or standardized dose for CBC. Because human research is so limited, experts cannot recommend a specific amount that is known to be safe or effective.

If you choose to try a CBC product, follow the directions on the product label and consider starting low. Look for products that have been tested by an independent lab and provide a certificate of analysis. Because supplement quality varies a lot, it is best to check with your pharmacist or doctor before using CBC.

References & further reading

The 1 references that drive our Cannabichromene (cbc) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Hatoum NS, Davis WM, Waters IW, Elsohly MA, Turner CE. Synergism of cannabichromene and CNS depressants in mice. Gen Pharmacol. 1981;12(5):351-6. PubMed

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Pharmacist Counseling Corner

Cannabichromene (cbc): Common Questions

Does Cannabichromene (cbc) interact with prescription medications?

Yes. We list 248 medications with a known interaction with Cannabichromene (cbc). Use the checker above to see how Cannabichromene (cbc) interacts with a specific drug.

How are Cannabichromene (cbc) interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take Cannabichromene (cbc) with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this Cannabichromene (cbc) interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

Will CBC get me high?

No. CBC is non-intoxicating and does not strongly activate the brain receptors responsible for the marijuana "high." However, some products may contain trace THC.

Is CBC the same as CBD?

No. CBC and CBD are different cannabinoids found in the cannabis plant. They have similar non-intoxicating profiles but act on the body in different ways, and CBD has been studied much more than CBC.

Is CBC proven to relieve pain?

Not yet. Some early animal and lab studies suggest possible pain and anti-inflammatory effects, but there is not enough human evidence to confirm that CBC works for pain.

Can I take CBC while pregnant or breastfeeding?

No. Because there is not enough safety data and cannabinoids may affect a baby, CBC should be avoided during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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