Drug & supplement interaction

Cannabichromene (cbc) + Ibuprofen, Oxycodone

Ibuprofen, Oxycodone brand name: Combunox.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cannabichromene (cbc) has a moderate interaction with Ibuprofen, Oxycodone. Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cannabichromene (cbc) and Ibuprofen, Oxycodone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Ibuprofen, Oxycodone

Ibuprofen, Oxycodone falls under CNS DEPRESSANTS — the group Cannabichromene (cbc) interacts with.

Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.
Animal research shows that cannabichromene, given as a single dose intraperitoneally, increases the sedative response to the drugs hexobarbital, barbital, and zoxazolamine. However, this effect was not maintained when cannabichromene was given continuously. After receiving cannabichromene daily for 7 days, the sedative effect of these drugs was reduced when compared with a control group or a single dose of cannabichromene.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Combunox combines ibuprofen with oxycodone, and it's the oxycodone half that matters here. Oxycodone is an opioid that slows down the brain and body, so it can already make you sleepy, foggy, or short of breath, and it can lower your blood pressure. The concern is simply that piling CBC on top of a sedating medicine might add to that drowsiness.

Honestly, this caution comes only from animal studies using a single dose of CBC, so we can't say how strongly (or even whether) it applies to people. Interestingly, the same research showed less sedation after several days of CBC. Because the evidence is so thin and oxycodone is potent on its own, please run any CBC product by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hatoum NS, Davis WM, Waters IW, Elsohly MA, Turner CE. Synergism of cannabichromene and CNS depressants in mice. Gen Pharmacol. 1981;12(5):351-6. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cannabichromene (cbc) Also Interacts With Other Medications

Cannabichromene (cbc) has 247 moderate known drug interactions in our database — the Ibuprofen, Oxycodone one above is one of them. If you take anything else, check it against the full list below.

Moderate 247 No known interaction 2,583 (incl. Ibuprofen, Oxycodone)
Taking anything else?

Check Another of Your Medications Against Cannabichromene (cbc)

Covers the 2,830 medications we’ve checked against Cannabichromene (cbc). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ibuprofen, Oxycodone

This page covers Cannabichromene (cbc) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen, Oxycodone page lists 356 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 13 major · 303 moderate · 40 minor.

From our pharmacist’s overview on the Ibuprofen, Oxycodone page

“Combunox puts oxycodone, an opioid, together with the NSAID ibuprofen, and I want you to read this page carefully rather than skim it. Of the 356 supplements and herbs on file, 202 can raise your bleeding risk on top of what ibuprofen already does, and 78 can deepen the drowsiness and slowed breathing that come with oxycodone.”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen, Oxycodone interaction page

How much people look this up

Where Cannabichromene (cbc) and Ibuprofen, Oxycodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabichromene (cbc)
Steady interest

#1,121 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen, Oxycodone
Steady interest

#1,926 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cannabichromene (cbc)

What is Cannabichromene (cbc)?

Cannabichromene (cbc)
  • Pain relief
  • Inflammation
  • Mood and anxiety
  • Skin and acne concerns
  • Brain and nerve health

Cannabichromene (CBC) is a non-intoxicating cannabinoid found in the cannabis plant that is being studied for possible pain, anti-inflammatory, and nervous-system effects. Almost all current evidence comes from laboratory and animal research, so we do not yet know how well it works or how safe it is in people. Talk with your pharmacist or doctor before using any CBC product, and avoid it during pregnancy and breastfeeding.

Read the full Cannabichromene (cbc) monograph & all interactions
Keep checking

Other Drugs & Cannabichromene (cbc)

Browse every other medication we’ve checked against Cannabichromene (cbc) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
247Moderate
0Minor
2,582No known interaction
247 Moderate 2,582 No interaction
Moderate

247 interactions

Showing 60 of 247 moderate interactions — see all 247 on the Cannabichromene (cbc) page.

No interaction 2,582 drugs checked — show the list

We also checked Cannabichromene (cbc) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,582 medications checked with no known interaction — see the full Cannabichromene (cbc) list.

See the full Cannabichromene (cbc) interactions page
See every supplement checked against Ibuprofen, Oxycodone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cannabichromene (cbc) monograph › Uses, safety, and every drug interaction in one place Ibuprofen, Oxycodone supplement interactions › Every supplement checked against Ibuprofen, Oxycodone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cannabichromene (cbc) and Ibuprofen, Oxycodone Together: Common Questions

Can you take Cannabichromene (cbc) with Ibuprofen, Oxycodone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cannabichromene (cbc) and Ibuprofen, Oxycodone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ibuprofen, Oxycodone and Cannabichromene (cbc)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.