Medication interaction hub

What Supplements Interact with Ibuprofen, Oxycodone?

Ibuprofen, Oxycodone brand name: Combunox. Every interaction below applies to the brands too.

356 Interactions 13 Major 303 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ibuprofen, Oxycodone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ibuprofen, Oxycodone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Combunox puts oxycodone, an opioid, together with the NSAID ibuprofen, and I want you to read this page carefully rather than skim it. Of the 356 supplements and herbs on file, 202 can raise your bleeding risk on top of what ibuprofen already does, and 78 can deepen the drowsiness and slowed breathing that come with oxycodone. Alcohol, whether beer or wine, is the clearest major-rated example of that second group, and the evidence behind it is solid.

Another 121 entries can change how your body clears oxycodone; grapefruit is the everyday one, since it can push drug levels higher. Charcoal products and bulky fibers can block any pill from absorbing, so space them well apart from your doses. Start with the 13 entries rated major. The remaining 303 moderate and 40 minor ones mostly call for watching yourself for extra sleepiness or easy bruising.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 303 Minor 40 No known interaction 1,096

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ibuprofen, Oxycodone: Top Interactions at a Glance

The Ibuprofen, Oxycodone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 356 interacting ingredients — plus 1,096 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ibuprofen, Oxycodone Combinations Today

The Ibuprofen, Oxycodone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Melatonin + Ibuprofen, Oxycodonei

Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Unlikely Fenugreek + Ibuprofen, Oxycodonei

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Nattokinase + Ibuprofen, Oxycodonei

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Read the full interaction Major Likelihood Likely Wine + Ibuprofen, Oxycodonei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Moderate Likelihood Possible Caffeine + Ibuprofen, Oxycodonei

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible German Chamomile + Ibuprofen, Oxycodonei

Theoretically, German chamomile might have additive effects when used with CNS depressants.

Read the full interaction
The complete list

Every Supplement Checked Against Ibuprofen, Oxycodone

All 1,452 ingredients in our database, ranked by severity — 356 with a Ibuprofen, Oxycodone interaction on file and 1,096 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ibuprofen, Oxycodone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Melatonin with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Full Melatonin + Ibuprofen, Oxycodone answer

Can you take Fenugreek with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.

Full Fenugreek + Ibuprofen, Oxycodone answer

Can you take Nattokinase with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Nattokinase + Ibuprofen, Oxycodone answer

Can you take Wine with Ibuprofen, Oxycodone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Wine + Ibuprofen, Oxycodone answer

Can you take Caffeine with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Caffeine + Ibuprofen, Oxycodone answer

Can you take Dandelion with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.

Full Dandelion + Ibuprofen, Oxycodone answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Ibuprofen, Oxycodone answer

Can you take Dendrobium with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Ibuprofen, Oxycodone answer

Can you take Devil's Claw with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Ibuprofen, Oxycodone answer

Can you take Dhea with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Ibuprofen, Oxycodone answer

Can you take Dimethylsulfoxide (dmso) with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DMSO might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Dimethylsulfoxide (dmso) + Ibuprofen, Oxycodone answer

Can you take Diosmin with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Ibuprofen, Oxycodone answer

Can you take Dong Quai with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflict...

Full Dong Quai + Ibuprofen, Oxycodone answer

Can you take Echinacea with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Ibuprofen, Oxycodone answer

Can you take Eicosapentaenoic Acid (epa) with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, EPA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Eicosapentaenoic Acid (epa) + Ibuprofen, Oxycodone answer

Can you take Elecampane with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Ibuprofen, Oxycodone answer

Can you take Eleuthero with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drug...

Full Eleuthero + Ibuprofen, Oxycodone answer

Can you take English Ivy with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Full English Ivy + Ibuprofen, Oxycodone answer

Can you take Eucalyptus with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Ibuprofen, Oxycodone answer

Can you take European Barberry with Ibuprofen, Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Ibuprofen, Oxycodone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ibuprofen, Oxycodone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ibuprofen, Oxycodone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ibuprofen, Oxycodone sits in 12 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Ibuprofen (Advil, Others) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ibuprofen, Oxycodone through this category.

Related: does Ibuprofen, Oxycodone deplete any nutrients?

Ibuprofen, Oxycodone has 1 reported nutrient association in the research literature — see the Ibuprofen, Oxycodone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ibuprofen, Oxycodone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ibuprofen, Oxycodone.

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Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Pharmacist Counseling Corner

Ibuprofen, Oxycodone & Supplements: Common Questions

What supplements interact with Ibuprofen, Oxycodone?
Our database currently documents 356 ingredients with a known Ibuprofen, Oxycodone interaction (13 major, 303 moderate, 40 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 356. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Ibuprofen, Oxycodone supplement interactions are the most serious?
The 13 major-rated combinations — led by Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ibuprofen, Oxycodone?
Plenty of supplements coexist fine with Ibuprofen, Oxycodone; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Combunox have the same supplement interactions as Ibuprofen, Oxycodone?
Yes — Combunox all contain Ibuprofen, Oxycodone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ibuprofen, Oxycodone deplete any vitamins or nutrients?
It might — Ibuprofen, Oxycodone has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ibuprofen, Oxycodone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ibuprofen, Oxycodone and my other medications?
This page covers Ibuprofen, Oxycodone against supplements and herbal ingredients. Checking Ibuprofen, Oxycodone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.