Drug & supplement interaction

Lion's Mane Mushroom + Ibuprofen, Oxycodone

Ibuprofen, Oxycodone brand name: Combunox.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Lion's Mane Mushroom has a moderate interaction with Ibuprofen, Oxycodone. Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lion's Mane Mushroom and Ibuprofen, Oxycodone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Ibuprofen, Oxycodone

Ibuprofen, Oxycodone falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Lion's Mane Mushroom interacts with.

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the angle that matters for Combunox: the ibuprofen half is an NSAID, and NSAIDs already nudge up bleeding risk by making platelets less sticky and by irritating the stomach lining. Lab studies hint that lion's mane may also make platelets clump together a bit less. Stack those two together and, in theory, you could see things like easier bruising, nosebleeds, or stomach upset and irritation.

To be fair, this is a theoretical concern based mostly on test-tube research, not real-world cases, so I wouldn't lose sleep over it. Still, if you take Combunox regularly, are on blood thinners, or have a history of ulcers or GI bleeds, it's worth a quick chat with your pharmacist or doctor before adding lion's mane.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lion's Mane Mushroom Also Interacts With Other Medications

Lion's Mane Mushroom has 326 moderate known drug interactions in our database — the Ibuprofen, Oxycodone one above is one of them. If you take anything else, check it against the full list below.

Moderate 326 No known interaction 2,504 (incl. Ibuprofen, Oxycodone)
Taking anything else?

Check Another of Your Medications Against Lion's Mane Mushroom

Covers the 2,830 medications we’ve checked against Lion's Mane Mushroom. Pick one to open its full report.

From our Q&A

Questions About Lion's Mane Mushroom or Ibuprofen, Oxycodone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lion's Mane Mushroom or Ibuprofen, Oxycodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ibuprofen, Oxycodone

This page covers Lion's Mane Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen, Oxycodone page lists 356 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 13 major · 303 moderate · 40 minor.

From our pharmacist’s overview on the Ibuprofen, Oxycodone page

“Combunox puts oxycodone, an opioid, together with the NSAID ibuprofen, and I want you to read this page carefully rather than skim it. Of the 356 supplements and herbs on file, 202 can raise your bleeding risk on top of what ibuprofen already does, and 78 can deepen the drowsiness and slowed breathing that come with oxycodone.”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen, Oxycodone interaction page

One more smart check

Taking Lion's Mane Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,338 real supplement products containing Lion's Mane Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lion's Mane Mushroom. Your product may carry other ingredients that interact with Ibuprofen, Oxycodone too, on top of Lion's Mane Mushroom — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lion's Mane Mushroom and Ibuprofen, Oxycodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lion's Mane Mushroom
Top 25%

#151 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen, Oxycodone
Steady interest

#1,736 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lion's Mane Mushroom

What is Lion's Mane Mushroom?

Lion's Mane Mushroom
  • Memory and cognitive support
  • Nerve health
  • Mood and anxiety
  • Immune support
  • General wellness/antioxidant

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as a food and supplement, but talk with your pharmacist or doctor before starting it, especially if you are pregnant, breastfeeding, or have allergies.

Read the full Lion's Mane Mushroom monograph & all interactions
Keep checking

Other Drugs & Lion's Mane Mushroom

Browse every other medication we’ve checked against Lion's Mane Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
326Moderate
0Minor
2,503No known interaction
326 Moderate 2,503 No interaction
Moderate

326 interactions

Showing 60 of 326 moderate interactions — see all 326 on the Lion's Mane Mushroom page.

No interaction 2,503 drugs checked — show the list

We also checked Lion's Mane Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,503 medications checked with no known interaction — see the full Lion's Mane Mushroom list.

See the full Lion's Mane Mushroom interactions page
See every supplement checked against Ibuprofen, Oxycodone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lion's Mane Mushroom monograph › Uses, safety, and every drug interaction in one place Ibuprofen, Oxycodone supplement interactions › Every supplement checked against Ibuprofen, Oxycodone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lion's Mane Mushroom and Ibuprofen, Oxycodone Together: Common Questions

Can you take Lion's Mane Mushroom with Ibuprofen, Oxycodone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lion's Mane Mushroom and Ibuprofen, Oxycodone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ibuprofen, Oxycodone and Lion's Mane Mushroom?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.