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Ambrette Drug Interactions, Uses, Effectiveness, Safety & More

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Ambrette Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Ambrette drug interaction appears low for most people. None of the reported interactions are rated major, and the concern that does exist rests on animal research rather than studies in people.

Interactions deserving the most attention

The one area worth watching is diabetes medications. A compound in ambrette, myricetin, lowered blood glucose in animal studies, so in theory combining ambrette with these drugs could push blood sugar too low. Because blood sugar is closely monitored and matters day to day, people using insulin or other glucose-lowering treatments should pay attention to how they feel and to their readings. This effect has not been confirmed in humans.

What the rest of the list means

Although ambrette is listed alongside a fairly long list of medications, nearly all of that comes from this single blood sugar concern applied across many diabetes drugs. The interaction is theoretical, based on lab and animal findings, and has not been shown to cause meaningful changes in people. A long list here reflects caution, not proven harm.

Check your medications against Ambrette

Based on HelloPharmacist’s Ambrette interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Ambrette

86 medications have a known interaction with Ambrette, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose› AcetohexamideDymelor› AlbiglutideTanzeum› AlogliptinNesina› Alogliptin, MetforminKazano› Alogliptin, PioglitazoneOseni› Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi› CanagliflozinInvokana› Canagliflozin, MetforminInvokamet› Canagliflozin, Metformin HydrochlorideInvokamet XR› ChlorpropamideChlorpropam, Diabinese› DapagliflozinFarxiga› Dapagliflozin Propanediol, MetforminXigduo XR› Dapagliflozin Propanediol, Saxagliptin HydrochlorideQtern› Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR› Dasiglucagon HydrochlorideZegalogue› DulaglutideTrulicity› EmpagliflozinJardiance› Empagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR› Empagliflozin, MetforminSynjardy› Empagliflozin, Metformin HydrochlorideSynjardy XR› ErtugliflozinSteglatro› Ertugliflozin, Metformin HydrochlorideSegluromet› ExenatideBydureon, Byetta› Exenatide SyntheticBydureon BCISE› GliclazideDiamicron› GlimepirideAmaryl› GlipizideGlucotrol, Glucotrol XL› Glipizide, MetforminMetaglip› GlucagonBaqsimi, Glucagon›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Ambrette combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Ambrette affects

Every type of medication (drug category) Ambrette is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Ambrette interacts with
Antidiabetes Drugs
Antidiabetes Drugs

Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that myricetin, a constituent of ambrette, can lower blood glucose levels.

Likelihood Possible Evidence D
Monograph

Ambrette: Uses, Safety & Side Effects

The bottom line

Ambrette (Abelmoschus moschatus) is a fragrant plant best known for its musky seed oil used in perfumes and food flavoring. It has a long history in traditional medicine for digestion, breathing problems, and skin issues, but solid human studies supporting these uses are lacking. If you want to try it, talk with your pharmacist or doctor first, and avoid use during pregnancy and breastfeeding.

Ambrette
Scientific name
Abelmoschus moschatus
Family
Malvaceae
Part used
Seeds and seed essential oil
Common forms
Essential oil, seed extracts, perfume/fragrance products, food flavoring
People commonly use it for
  • Fragrance and aromatherapy
  • Digestive complaints
  • Respiratory complaints
  • Skin irritation
  • Insect repellent (traditional)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Limited human safety data exist, so use cautiously and mainly as a fragrance or flavoring.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

When used orally or topically. Ambrette passes into mother's milk, but the effect is unknown.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Ambrette comes from Abelmoschus moschatus, a flowering plant in the mallow family. It is native to India and grows in other warm, tropical parts of the world. The plant is closely related to hibiscus and okra.

The plant is most valued for its seeds, which have a distinctive musky, floral scent. An oil pressed or distilled from these seeds (often called ambrette seed oil) is widely used in perfumes, colognes, and as a natural flavoring in foods and drinks.

In traditional medicine systems, especially in India, ambrette seeds have been used for a range of complaints such as upset stomach, breathing problems, and skin irritation. Today most people encounter it as a fragrance ingredient rather than a medicine.

How it works

Ambrette seeds and oil contain a mix of plant compounds, including aromatic substances responsible for its musky scent (such as ambrettolide and certain fatty acid esters), along with other oils and plant chemicals.

Laboratory and animal studies suggest ambrette extracts may have antioxidant, antimicrobial, and anti-inflammatory activity. Some early research has also looked at effects on blood sugar and muscle relaxation. These findings are preliminary and were not done in well-designed human trials.

In simple terms, we do not have a clear, proven explanation of how ambrette might help people, because the human research needed to confirm any mechanism is missing.

Effectiveness

Does Ambrette work?

Evidence overview · 16 uses evaluated
16 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Ambrette, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 16 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Abdominal pain
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for abdominal pain, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Anorexia nervosa
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for anorexia nervosa, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Anxiety
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for anxiety, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for cancer, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Congestive heart failure (CHF)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for CHF, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Constipation
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for constipation, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Depression
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for depression, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Diabetic nephropathy
Rating & evidence shown verbatim from Natural Medicines

Oral ambrette has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for dyspepsia, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Gonorrhea
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for gonorrhea, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Headache
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for headache, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for hypertension, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Nausea and vomiting
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for nausea and vomiting, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for osteoarthritis, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Sexual dysfunction
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for sexual dysfunction, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Insufficient Reliable Evidence To Rate Urinary incontinence
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ambrette for urinary incontinence, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

When used in small amounts as a food flavoring or fragrance, ambrette is generally considered acceptable. However, there is little reliable information about the safety of taking concentrated ambrette extracts or oil as a supplement.

Essential oils can be irritating, and ambrette oil should not be swallowed unless a product is specifically labeled as safe for that use. Applying the oil to skin can sometimes cause irritation or allergic reactions, so do a small patch test first.

Pregnancy and breastfeeding: Because safety data are lacking, ambrette should be avoided by people who are pregnant or breastfeeding. Children and people with serious medical conditions should also avoid medicinal use unless cleared by a healthcare provider. Always check with your pharmacist or doctor before starting any new supplement.

Side effects

Reliable information on ambrette's side effects is limited. Possible problems include skin irritation or allergic reactions when the oil is applied to the skin, and stomach upset if seed extracts are swallowed.

As with any plant or essential oil, an allergic reaction is possible. Stop using it and seek medical care if you notice a rash, swelling, trouble breathing, or other signs of a serious reaction.

Ambrette: Reported Adverse Effects

Documented safety reports on Ambrette from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Dermatitis Dermatologic

Topically, ambrette has been reported to cause contact dermatitis and photosensitivity.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established standardized dose for ambrette as a supplement or medicine. Amounts used in foods and fragrances are small, and these uses have not been studied as treatments.

If you choose to use an ambrette product, follow the directions on the label and do not exceed the recommended amount. Because doses and product quality vary widely, it is best to check with a pharmacist or doctor before using it, especially in concentrated or essential-oil form.

Pregnancy & Breastfeeding

Ambrette & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Ambrette & Breastfeeding

Possibly Unsafe

When used orally or topically. Ambrette passes into mother's milk, but the effect is unknown.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 6 references that drive our Ambrette monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Liu, I. M., Liou, S. S., Lan, T. W., Hsu, F. L., and Cheng, J. T. Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 2005;71(7):617-621.
  3. Liu, I. M., Liou, S. S., and Cheng, J. T. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J.Ethnopharmacol. 3-8-2006;104(1-2):199-206.
  4. Liu, I. M., Tzeng, T. F., Liou, S. S., and Lan, T. W. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. 2007;73(10):1054-1060.
  5. Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675. PubMed
  6. Liu IM, Tzeng TF, Liou SS. Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity. Phytother Res 2010;24(2):233-9.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Ambrette: Common Questions

What is Ambrette used for, and does it work?
People use Ambrette for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Ambrette interact with prescription medications?
Yes. We list 86 medications with a known interaction with Ambrette. Use the checker above to see how Ambrette interacts with a specific drug.
How are Ambrette interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Ambrette with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Ambrette interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Ambrette used for?
Ambrette is mainly used as a musky fragrance in perfumes and as a natural flavoring in foods. In traditional medicine it has been used for digestive complaints, breathing problems, and skin irritation, but these uses are not well proven.
Is Ambrette safe to take?
Used in small amounts as a flavoring or fragrance, Ambrette is generally considered acceptable, but there is little safety data for taking concentrated extracts or oils. Talk with your pharmacist or doctor before using it as a supplement.
Can I use Ambrette during pregnancy or breastfeeding?
No. Because there is not enough safety information, it is best to avoid Ambrette if you are pregnant or breastfeeding.
Can Ambrette oil be put on the skin?
Ambrette essential oil is sometimes used on the skin in diluted form, but it can cause irritation or allergic reactions. Always dilute it properly and do a small patch test first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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