Drug & supplement interaction

Ambrette + Vilazodone

Vilazodone brand name: Viibryd.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ambrette and Vilazodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Vilazodone states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Ambrette and Vilazodone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Vilazodone and Ambrette in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ambrette safety at a glance

Ambrette overall Use caution Limited human safety data exist, so use cautiously and mainly as a fragrance or flavoring.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Possibly Unsafe When used orally or topically. Ambrette passes into mother's milk, but the effect is unknown. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Vilazodone and Ambrette? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Vilazodone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Vilazodone is filed under 8 classifications — including antidepressant drugs, cytochrome p450 2c19 (cyp2c19) substrates, serotonergic drugs. Ambrette has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Vilazodone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ambrette Does Interact With Other Medications

Ambrette has 86 moderate known drug interactions in our database — Vilazodone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Vilazodone)
Taking anything else?

Check Another of Your Medications Against Ambrette

Covers the 2,830 medications we’ve checked against Ambrette. Pick one to open its full report.

What to actually watch for

What Ambrette Itself Has Been Linked To

This is not an interaction — nothing below involves Vilazodone. It is the side-effect record for Ambrette on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ambrette, this list is the first place to look.

  • Sun sensitivity / A skin rash Additional detail

    “Topically, ambrette has been reported to cause contact dermatitis and photosensitivity (6,31100).”

    Ambrette · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 31100. Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Ambrette — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Vilazodone’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Vilazodone column appears here.

Special populations

Ambrette in Pregnancy & Breastfeeding

Lactation Possibly Unsafe

When used orally or topically. Ambrette passes into mother's milk, but the effect is unknown.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Vilazodone Products Have a Food Rule — Ambrette Should Not Break It

At least one FDA label for a product containing Vilazodone says to take it with food. If you take Ambrette on an empty stomach out of habit, keep them separate — and take Vilazodone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Vilazodone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended target dosage: 20 mg to 40 mg once daily with food ( 2.1 , 12.3 ) To titrate: start with initial dosage of 10 mg once daily for 7 days, followed by 20 mg once daily.

From the Dosage and Administration section of the FDA label we read for Vilazodone — where that label names a specific product, the instruction is that product's. See the Vilazodone drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Vilazodone Is Prescribed For, and What Ambrette Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Vilazodone is a prescription medicine with approved uses on its FDA label. Ambrette is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Vilazodone is prescribed for: Vilazodone hydrochloride tablets — sold as the brand Viibryd and as generic vilazodone hydrochloride — are approved to treat major depressive disorder (MDD) in adults. MDD is more than just feeling sad; it's a clinical condition involving persistent low mood, loss of interest, and other symptoms that significantly affect daily life. Vilazodone is not approved for use in children or teenagers. Its safety and effectiveness have not been established in pediatric patients.

Ambrette has been studied for:

  • Depression studied, not established Ambrette has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Ambrette for depression

    Although there has been interest in using oral ambrette for depression, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Vilazodone on your own; if you are taking Ambrette for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Vilazodone

This page covers Ambrette only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Vilazodone page lists 176 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 131 moderate · 41 minor.

Open the Vilazodone interaction page

How much people look this up

Where Ambrette and Vilazodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ambrette
Top half

#607 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Vilazodone
Top half

#1,063 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ambrette reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ambrette and Vilazodone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ambrette

What is Ambrette?

Ambrette
  • Fragrance and aromatherapy
  • Digestive complaints
  • Respiratory complaints
  • Skin irritation
  • Insect repellent (traditional)

Ambrette (Abelmoschus moschatus) is a fragrant plant best known for its musky seed oil used in perfumes and food flavoring. It has a long history in traditional medicine for digestion, breathing problems, and skin issues, but solid human studies supporting these uses are lacking. If you want to try it, talk with your pharmacist or doctor first, and avoid use during pregnancy and breastfeeding.

Abelmoschus moschatus · Malvaceae · Seeds and seed essential oil · Essential oil, seed extracts, perfume/fragrance products, food flavoring

An interaction check asks whether these two react with each other — it does not ask whether Ambrette is a good idea for someone in your situation. Here is what our Ambrette record says about it on its own.

Ambrette: dosing

There is no established standardized dose for ambrette as a supplement or medicine. Amounts used in foods and fragrances are small, and these uses have not been studied as treatments.If you choose to use an ambrette product, follow the directions on the label and do not exceed the recommended amount.

From our Ambrette monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ambrette monograph & all interactions
Medication

About Vilazodone

What Is Vilazodone Used For?

Brand name: Viibryd

Vilazodone hydrochloride tablets — sold as the brand Viibryd and as generic vilazodone hydrochloride — are approved to treat major depressive disorder (MDD) in adults. MDD is more than just feeling sad; it's a clinical condition involving persistent low mood, loss of interest, and other symptoms that significantly affect daily life.

Vilazodone is not approved for use in children or teenagers. Its safety and effectiveness have not been established in pediatric patients.

See full Vilazodone drug information
Keep checking

Other Drugs & Ambrette

Browse every other medication we’ve checked against Ambrette — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Ambrette page.

No interaction 2,743 drugs checked — show the list

We also checked Ambrette against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Ambrette list.

See the full Ambrette interactions page
See every supplement checked against Vilazodone, ranked by severity
Evidence & sources

Ambrette References

The 6 references that drive our Ambrette monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Liu, I. M., Liou, S. S., Lan, T. W., Hsu, F. L., and Cheng, J. T. Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 2005;71(7):617-621.
  3. Liu, I. M., Liou, S. S., and Cheng, J. T. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J.Ethnopharmacol. 3-8-2006;104(1-2):199-206.
  4. Liu, I. M., Tzeng, T. F., Liou, S. S., and Lan, T. W. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. 2007;73(10):1054-1060.
  5. Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675. PubMed
  6. Liu IM, Tzeng TF, Liou SS. Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity. Phytother Res 2010;24(2):233-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ambrette and Vilazodone Together: Common Questions

Is it safe to take Ambrette with Vilazodone?
We do not list a known interaction between Ambrette and Vilazodone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Ambrette and Vilazodone at the same time of day?
At least one FDA label for a product containing Vilazodone says to take it with food. If you take Ambrette on an empty stomach out of habit, keep them separate and take Vilazodone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Vilazodone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Ambrette and Vilazodone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ambrette in each. That is a conversation for your prescriber, especially if Vilazodone is being adjusted to a target.
How was the Ambrette and Vilazodone combination checked?
Interactions in our licensed database are recorded against drug classes. Vilazodone is filed under 8 classifications, and Ambrette has documented interactions with 1 drug class — none of Vilazodone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ambrette interact with any other medications?
Yes. Ambrette has 86 documented drug interactions in our database — Vilazodone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Vilazodone interact with any supplements?
Yes. Vilazodone has documented interactions with 176 supplements in our database — Ambrette is not one of them. The Vilazodone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ambrette monograph Uses, safety profile, and every drug interaction in one place Vilazodone drug information The full plain-English guide to this medication Vilazodone supplement interactions Every supplement checked against Vilazodone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Vilazodone and Ambrette?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.