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Vilazodone

Vilazodone is a prescription antidepressant used to treat major depressive disorder (MDD) in adults.

Brand name Viibryd
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 13 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 7, 2026
Vilazodone at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Vilazodone (Viibryd) is an antidepressant for major depressive disorder in adults that boosts serotonin two ways, keeping nerve cells from soaking it back up and partly activating the 5-HT1A serotonin receptor; on the market since about 2009 and available as a generic, it is usually tried after better-known antidepressants. Most people tolerate it reasonably well, though diarrhea and nausea are common early, one reason the dose starts low and climbs in steps. It carries a boxed warning for suicidal thoughts and behaviors in children, teens and young adults, so call your prescriber quickly if mood worsens or suicidal thoughts appear, especially early on or after a dose change.

Clinical pearls

  • Take it with a meal, since on an empty stomach your body absorbs less and it may work less well.
  • Never combine it with MAOI antidepressants, linezolid or IV methylene blue; remind hospital teams you take it.
  • Migraine triptans and St. John's Wort raise serotonin syndrome risk, while ibuprofen, aspirin and warfarin raise bleeding risk.
  • Do not stop it suddenly, even when you feel better; your prescriber will lower the dose gradually to avoid withdrawal-type symptoms.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Antidepressants like vilazodone raise the risk of suicidal thoughts and behaviors in children, teens and young adults. This was seen in short-term studies. Everyone taking an antidepressant should be watched closely, especially early on or after a dose change.

Watch for worsening depression, new suicidal thoughts, or unusual changes in behavior. Contact your doctor right away if you notice any of these. Vilazodone is not approved for use in children.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asTablet
Earliest FDA record2009
Companies listing it with the FDA13
FDA label last updatedOct 1, 2023
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Vilazodone, written from its FDA label.

What Vilazodone is used for

▾

Vilazodone is approved for one condition across the supported products.

  • Major depressive disorder (MDD) in adults: Viibryd and vilazodone hydrochloride tablets (oral).

How Vilazodone works

▾

Vilazodone is thought to ease depression by increasing serotonin activity in the brain. It blocks the reuptake (reabsorption) of serotonin, leaving more available. It also partly activates the 5-HT1A serotonin receptor, but the effect of that action is not known.

Vilazodone dosage

▾

Vilazodone tablets are taken by mouth once daily with food. Your prescriber usually starts low and increases the dose gradually.

  • Take it with food, since taking it without food can reduce how well it works.
  • Missed dose: take it when you remember, unless it's almost time for the next one. Never double up.
  • If you vomit within 7 hours of a dose, absorption is reduced, but no replacement dose is needed.
  • When stopping, your prescriber will lower the dose gradually.

Dosing details from the FDA-approved label

From the Vilazodone prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Major Depressive Disorder (recommended target dosage)
    • 20 mg to 40 mg orally once daily with food
    • Titrate: start with 10 mg once daily with food for 7 days, then increase to 20 mg once daily with food
    • The dose may be increased up to 40 mg once daily with food after a minimum of 7 days between dosage increases
    • Maximum: 40 mg once daily
    • Take with food. If a dose is missed, take it as soon as remembered; if almost time for the next dose, skip it; do not take two doses at the same time.
  • Patients receiving concomitant strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, voriconazole)
    • Dose should not exceed 20 mg once daily during concomitant use
    • The original dose level can be resumed when the CYP3A4 inhibitor is discontinued
    • Maximum: 20 mg once daily
  • Patients receiving concomitant strong CYP3A4 inducers (e.g., carbamazepine, phenytoin, rifampin) for greater than 14 days
    • Based on clinical response, consider increasing the dosage by 2-fold over 1 to 2 weeks
    • If the inducer is discontinued, gradually reduce to the original level over 1 to 2 weeks
    • Maximum: 80 mg once daily
  • Discontinuing treatment from 40 mg once daily
    • Taper to 20 mg once daily for 4 days, followed by 10 mg once daily for 3 days
    • Gradual reduction rather than abrupt cessation is recommended whenever possible.
  • Discontinuing treatment from 20 mg once daily
    • Taper to 10 mg once daily for 7 days
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Recommended target dosage: 20 mg to 40 mg once daily with food. ( 2.1 , 12.3 ) To titrate: start with initial dosage of 10 mg once daily for 7 days, followed by 20 mg once daily. The dose may be increased up to 40 mg once daily after a minimum of 7 days between dosage increases. ( 2.1 ) Prior to initiating vilazodone hydrochloride tablets, screen for bipolar disorder. ( 2.2 , 5.4 ) When discontinuing vilazodone hydrochloride tablets, reduce dosage gradually. ( 2.4 , 5.5 ) 2.1 Dosage for Treatment of Major Depressive Disorder The recommended target dosage for vilazodone hydrochloride tablets is 20 mg to 40 mg orally once daily with food [see Clinical Pharmacology ( 12.3 ), Clinical Studies ( 14 )] . To achieve the target dosage, titrate vilazodone hydrochloride tablets as follows: Start with an initial dosage of 10 mg once daily with food for 7 days, Then increase to 20 mg once daily with food. The dose may be increased up to 40 mg once daily with food after a minimum of 7 days between dosage increases. If a dose is missed, it should be taken as soon as the patient remembers. If it is almost time for the next dose, the patient should skip the missed dose and take the next dose at the regular time. Two doses should not be taken at the same time. 2.2 Screen for Bipolar Disorder Prior to Starting Vilazodone Hydrochloride Tablets Prior to initiating treatment with vilazodone hydrochloride tablets or another antidepressant, screen patients for a personal or family history of bipolar disorder, mania, or hypomania [see Warnings and Precautions ( 5.4 )] . 2.3 Switching to or from a Monoamine Oxidase Inhibitor Antidepressant At least 14 days must elapse between discontinuation of a monoamine oxidase inhibitor (MAOI) antidepressant and initiation of vilazodone hydrochloride tablets. In addition, at least 14 days must elapse after stopping vilazodone hydrochloride tablets before starting an MAOI antidepressant [see Contraindications ( 4 ), Warnings and Precautions ( 5.2 )] . 2.4 Dosage Adjustments with CYP3A4 Inhibitors or Inducers Patients receiving concomitant CYP3A4 inhibitors : During concomitant use of a strong CYP3A4 inhibitor (e.g., itraconazole, clarithromycin, voriconazole), the vilazodone hydrochloride tablets dose should not exceed 20 mg once daily.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Vilazodone side effects

▾

The most common side effects are stomach-related and sleep-related.

Common side effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Trouble sleeping (insomnia)
  • Dry mouth
  • Headache
  • Dizziness
  • Sleepiness

When to get medical help

  • Call your doctor right away if you have new or worsening depression, suicidal thoughts, or unusual changes in behavior.
  • Get help for signs of serotonin syndrome, a dangerous reaction from too much serotonin activity. Overdose reports included restlessness, hallucinations and disorientation.
  • Tell your doctor about unusual bleeding or bruising, especially if you take aspirin, NSAIDs or blood thinners.
  • Report symptoms of mania or hypomania, such as unusually high energy or elevated mood.
  • Seek help for a seizure.
  • Report sudden eye pain or vision problems, since antidepressants can trigger angle closure glaucoma in people with narrow eye angles.
  • Tell your doctor about sexual side effects, which can occur.
  • Contact your doctor if you have symptoms after stopping the medicine (discontinuation syndrome) or signs of low sodium (hyponatremia).

Vilazodone warnings and precautions

▾
  • Suicidal thoughts and behaviors: highest risk in people age 24 and younger. Monitor for worsening mood.
  • Serotonin syndrome: possible alone or with other serotonergic drugs.
  • Bleeding: risk is higher with aspirin, NSAIDs, antiplatelets and anticoagulants.
  • Mania or hypomania: screen for bipolar disorder first.
  • Seizures: use caution if you have a seizure disorder.
  • Angle closure glaucoma: avoid with untreated narrow eye angles.
  • Sexual dysfunction and low sodium: can occur.
  • Stopping: adverse reactions can occur if stopped suddenly.

Vilazodone interactions

▾

Several medicines can interact with vilazodone.

  • MAOIs (including linezolid and IV methylene blue): contraindicated because of serotonin syndrome risk.
  • Other serotonergic drugs (SSRIs, SNRIs, triptans, tricyclics, opioids, lithium, buspirone, amphetamines, tryptophan, St. John's Wort): raise serotonin syndrome risk.
  • Aspirin, NSAIDs, antiplatelets, warfarin, anticoagulants: may increase bleeding.
  • Strong CYP3A4 inhibitors: raise vilazodone levels, so the dose is limited.
  • Strong CYP3A4 inducers: lower vilazodone levels, so a dose increase may be considered.
  • Digoxin: levels may rise and need monitoring.

Interactions listed in the FDA-approved label

From the Vilazodone prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Monoamine Oxidase Inhibitors (MAOIs), including linezolid or intravenous methylene blue: Concomitant use of MAOIs and serotonergic drugs including vilazodone increases the risk of serotonin syndrome. Contraindicated in patients taking MAOIs. At least 14 days must elapse between stopping an MAOI antidepressant and starting vilazodone, and at least 14 days after stopping vilazodone before starting an MAOI antidepressant.
  • Other serotonergic drugs (other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, St. John's Wort): Concomitant use increases the risk of serotonin syndrome. Monitor patients for signs and symptoms of serotonin syndrome, particularly during initiation. If it occurs, consider discontinuing vilazodone and/or the concomitant serotonergic drugs.
  • Antiplatelet agents and anticoagulants: Concurrent use may potentiate the risk of bleeding. Inform patients of the increased bleeding risk. For patients taking warfarin, carefully monitor the INR when initiating, titrating, or discontinuing vilazodone.
  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, voriconazole): Concomitant use increased the exposure of vilazodone compared to vilazodone alone. The vilazodone dose should not exceed 20 mg once daily with concomitant use of a strong CYP3A4 inhibitor.
  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin, rifampin): Concomitant use decreased the exposure of vilazodone compared to vilazodone alone. Based on clinical response, consider increasing the vilazodone dosage over 1 to 2 weeks in patients taking strong CYP3A4 inducers for greater than 14 days.
  • Digoxin: Digoxin is a narrow therapeutic index drug; concomitant use of vilazodone increased digoxin concentrations. Measure serum digoxin concentrations before initiating concomitant use. Continue monitoring and reduce digoxin dose as necessary.
  • Substrates of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and/or P-glycoprotein (except narrow therapeutic index drugs, e.g., digoxin): No clinically important interactions based on pharmacokinetic studies. No dosage adjustment is required.
Read the label’s full interactions text

7 DRUG INTERACTIONS • CYP3A4 Inhibitors: The vilazodone hydrochloride tablet dose should not exceed 20 mg once daily when co-administered with strong CYP3A4 inhibitors (2.4, 7) • CYP3A4 Inducers: Consider increasing vilazodone hydrochloride tablets dosage by 2-fold, up to 80 mg once-daily over 1 to 2 weeks when used concomitantly with strong CYP3A4 inducers for greater than 14 days (2.4, 7) 7.1 Drugs Having Clinically Important Interactions With Vilazodone Hydrochloride Tablets Table 4: Clinically Important Drug Interactions with Vilazodone Hydrochloride Tablets Concomitant Drug Name or Drug Class Clinical Rationale Clinical Recommendation Monoamine Oxidase Inhibitors (MAOIs) The concomitant use of MAOIs and serotonergic drugs including vilazodone hydrochloride tablets increases the risk of serotonin syndrome. Vilazodone hydrochloride tablets are contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Contraindications (4), Dosage and Administration (2.3), and Warnings and Precautions (5.2)]. Other Serotonergic Drugs Concomitant use of vilazodone hydrochloride tablets with other serotonergic drugs (including other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St. John's Wort) increases the risk of serotonin syndrome. Monitor patients for signs and symptoms of serotonin syndrome, particularly during vilazodone hydrochloride tablets initiation. If serotonin syndrome occurs, consider discontinuation of vilazodone hydrochloride tablets and/or concomitant serotonergic drugs [see Warnings and Precautions (5.2)]. Antiplatelet Agents and Anticoagulants Serotonin release by platelets plays an important role in hemostasis. The concurrent use of an antiplatelet agent or anticoagulant with vilazodone hydrochloride tablets may potentiate the risk of bleeding.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿176 supplements and herbs with documented Vilazodone interactions, ranked by severity Check Vilazodone against a supplement or herb →

Before taking Vilazodone

▾
  • Do not use with an MAOI or within 14 days of stopping one.
  • Tell your prescriber about any personal or family history of bipolar disorder, mania or hypomania.
  • Use caution with a seizure disorder or narrow eye angles.
  • Not approved for children; efficacy was not shown in ages 7 to 17.
  • Pregnancy: use in the third trimester may raise risk of newborn problems, including persistent pulmonary hypertension and withdrawal. Late use may also raise postpartum bleeding risk.
  • Breastfeeding: no human data; weigh benefits against possible risks.
  • Older adults: may have a higher risk of low sodium; dosing is generally started conservatively.
  • The label notes no change in how the body handles vilazodone with kidney or liver impairment.

Vilazodone overdose

▾

Overdose experience is limited. In trials, doses of 5 to 7 times the recommended dosage caused serotonin syndrome, lethargy, restlessness, hallucinations and disorientation. There is no known antidote. Call Poison Control at 1-800-222-1222.

What Vilazodone does in the body

▾

Vilazodone binds strongly to the serotonin reuptake site and blocks serotonin reuptake, with much less effect on norepinephrine or dopamine. It also binds to 5-HT1A receptors and acts as a partial agonist. At twice the recommended dosage, it did not prolong the QTc interval (a heart rhythm measure) to a clinically relevant extent.

How your body processes Vilazodone

▾

Vilazodone levels peak about 4 to 5 hours after a dose, and the half-life is about 25 hours. Steady levels are reached in about 3 days. Taking it without food can cut absorption by roughly half, so take it with food. The body breaks it down mostly in the liver, mainly through CYP3A4, and only small amounts leave unchanged. Kidney or liver impairment, age and sex did not change how the body clears it.

How to store Vilazodone

▾

Store tablets at 25 o C (77°F).

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

176

Supplements & herbs that interact with Vilazodone

176 supplements and herbal products have documented interactions with Vilazodone in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 4
  • Moderate · 131
  • Minor · 41
ACTIVATED CHARCOAL Major GRAPEFRUIT Major LITHIUM Major ST. JOHN'S WORT Major 1,3-DMAA Moderate 5-HTP Moderate ACACIA RIGIDULA Moderate ACETYL-L-CARNITINE Moderate +168 more
Every supplement checked against Vilazodone — ranked by severity The full interaction hub: 4 major · 131 moderate · 41 minor · every one linked to its full report. Check Vilazodone against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Vilazodone has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

SODIUM Moderate Depletion
See the full Vilazodone nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Vilazodone: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Vilazodone — the kind of thing our pharmacy team would talk through with you at the counter.

What is vilazodone for?

▾
It's prescribed for major depressive disorder in adults. It's not approved for children or teens.

Do I really need to take it with food?

▾
Yes. Without food, your body absorbs much less of the medicine, and it may not work as well. Take it once a day with a meal or snack, as your prescriber directs.

What side effects should I expect?

▾
The most common are diarrhea, nausea, vomiting and trouble sleeping. Dry mouth, headache, dizziness and sleepiness also occur. Let your prescriber know if they're bothersome or don't ease up.

What should I do if I miss a dose?

▾
Take it when you remember. If it's almost time for your next dose, skip the missed one. Never take two doses together.

Can I stop it if I feel better?

▾
Please don't stop suddenly. Stopping abruptly can cause unwanted symptoms, so your prescriber will usually lower the dose gradually.

What other medicines should I watch out for?

▾
Never combine it with an MAOI, including linezolid or IV methylene blue. Tell me about other antidepressants, triptans, opioids, St. John's Wort, aspirin, NSAIDs, blood thinners, digoxin, or certain antifungals and antibiotics. These can raise risks like serotonin syndrome or bleeding.

Is Vilazodone available over the counter?

▾
No. Vilazodone is a prescription medicine: every Vilazodone product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Vilazodone first available?

▾
The earliest FDA record we hold for Vilazodone is from 2009: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Vilazodone was first used.

Who makes Vilazodone?

▾
13 companies currently list Vilazodone products in the FDA's NDC Directory, including Accord Healthcare Inc., Alembic Pharmaceuticals Inc., Alembic Pharmaceuticals Limited. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Vilazodone on HelloPharmacist

📊Vilazodone supplement interactions176 checked — ranked by severity 🌿Drug & Supplement CheckerVilazodone vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Vilazodone NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Vilazodone Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Vilazodone forms and strengths (how it comes)

Vilazodone is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Vilazodone inactive ingredients by manufacturer.

Tablet

By mouth
Brands Viibryd
How this form is used
What it may be used for
  • Viibryd is used to treat major depressive disorder (MDD) in adults.
  • Vilazodone Hydrochloride tablets are used to treat major depressive disorder (MDD) in adults.
Important instructions
  • Viibryd is taken by mouth once daily with food.
  • Vilazodone Hydrochloride tablets are taken by mouth once daily with food.
  • Viibryd label: stopping is done by gradually lowering the dose rather than abruptly.
Available strengths 3 strengths
10 mg 20 mg 40 mg
72 FDA-listed product records ⓘ

Vilazodone on the U.S. market: products, makers and brands

How Vilazodone appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

13 companies list 36 Vilazodone product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 2009. Brand names on the directory include Viibryd; the rest are generics.

1
Dose forms ⓘ
13
Labelers (makers, repackagers, distributors)
2
Brand names
36
FDA-listed product records ⓘ
2009
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (6) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Accord Healthcare Inc.8%
Alembic Pharmaceuticals Inc.8%
Alembic Pharmaceuticals Limited8%
Allergan, Inc.8%
Apotex Corp.8%
Cipla USA Inc.8%
Other makers50%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Vilazodone is used (Medicaid data)

A general measure of how commonly Vilazodone is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Vilazodone is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

285,554
Medicaid prescriptions filled (Q1–Q4 2025)
$18.5M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Vilazodone prescribed? Of the 1,601 medications we measure, Vilazodone ranks #335 by Medicaid prescriptions — more than 79% of them.

Where Vilazodone ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #335 of 1,601
#330 Mycophenolate Mofetil 292,779 Rx #331 Valproic Acid 292,052 Rx #332 Bumetanide 291,494 Rx #333 Sodium Bicarbonate 289,349 Rx #334 Midazolam Injection 286,843 Rx #335 Vilazodone 285,554 Rx #336 Ipratropium Nasal Spra... 285,523 Rx #337 Fluocinolone Topical 284,022 Rx #338 Colchicine 278,344 Rx #339 Beclomethasone Oral In... 276,319 Rx #340 Umeclidinium and Vilan... 275,927 Rx

Utilization by Vilazodone product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 40 mg oral tablet is the most-dispensed Vilazodone product — about 44% of these Medicaid prescriptions.

vilazodone hydrochloride 40 MG Oral Tablet Most dispensed

125,037 Medicaid prescriptions (Q1–Q4 2025) 44% of Vilazodone prescriptions shown $8.8M gross reimbursement (before rebates) ≈ $71 per prescription (gross)

Summed across the 7 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1086784

vilazodone hydrochloride 20 MG Oral Tablet

100,740 Medicaid prescriptions (Q1–Q4 2025) 35% of Vilazodone prescriptions shown $6.2M gross reimbursement (before rebates) ≈ $61 per prescription (gross)

Summed across the 8 of 26 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1086778

vilazodone hydrochloride 10 MG Oral Tablet

59,777 Medicaid prescriptions (Q1–Q4 2025) 21% of Vilazodone prescriptions shown $3.5M gross reimbursement (before rebates) ≈ $58 per prescription (gross)

Summed across the 7 of 24 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1086772

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Vilazodone, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 22 of 77 listed Vilazodone NDCs with Medicaid activity.

Compare Vilazodone products

A representative set of FDA-listed product records for Vilazodone — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 36 of 36 products — FDA National Drug Code Directory. See every product, package size and price: browse all 36 Vilazodone NDCs →

Vilazodone side effects reported to the FDA (FAERS)

After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Vilazodone — a signal of what to watch for, not proof the drug caused it.

The effects most often named in FDA reports that mention Vilazodone are diarrhoea, nausea, anxiety; about 39% of the reports were classed as serious. These are voluntary reports, so they show what people report, not how often it happens.

9,170
Reports mentioning it
39%
Reported as serious
12
Distinct effects shown
Most reported effects
Diarrhoea
781
Nausea
780
Anxiety
634
Insomnia
617
Headache
542
Depression
490
Dizziness
483
Fatigue
457
Suicidal Ideation
415
Feeling Abnormal
401
Age groups
Adult · 543Elderly · 129Adolescent · 12

Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Vilazodone in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.

Vilazodone FDA approval history

How Vilazodone went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.

Vilazodone was first approved by the FDA in 2009; the first generic version was approved in 2019. It remains available in U.S. pharmacies today.

2009
First FDA approval
2019
First generic approved
Lower-cost ANDA competition begins
2026
Available today
Active in U.S. pharmacies

Source: Drugs@FDA.

Vilazodone recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Vilazodone recalls since July 2021.

✅No Vilazodone recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Vilazodone RxCUI 1086769 1 dose form · 3 strengths

Look up RxCUI 1086769 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Vilazodone costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet · Oral 40 mg $12.19 per tablet NDC details & price history
Tablet · Oral 20 mg $12.18 per tablet NDC details & price history
Tablet · Oral 10 mg $12.17 per tablet NDC details & price history
Tablet, Film Coated · Oral 40 mg $0.840 per tablet NDC details & price history
Tablet, Film Coated · Oral 20 mg $0.706 per tablet NDC details & price history
Tablet, Film Coated · Oral 10 mg $0.732 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Vilazodone brand names

Vilazodone is sold under one brand name in the FDA directory — Viibryd. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Viibryd

Who makes Vilazodone: manufacturers and labelers

13 companies list Vilazodone products with the FDA. By number of product records, the largest are Accord Healthcare Inc., Alembic Pharmaceuticals Inc., Alembic Pharmaceuticals Limited. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Accord Healthcare Inc. 3 Alembic Pharmaceuticals Inc. 3 Alembic Pharmaceuticals Limited 3 Allergan, Inc. 3 Apotex Corp. 3 Cipla USA Inc. 3 Exelan Pharmaceuticals Inc. 3 Golden State Medical Supply, Inc. 3 Northstar Rx LLC 3 Novadoz Pharmaceuticals LLC 3 Teva Pharmaceuticals, Inc. 3 Preferred Pharmaceuticals Inc. 2 Proficient Rx LP 1

Vilazodone drug class (RxNorm)

Vilazodone belongs to the Other antidepressants class.

Drug family (ATC) Other antidepressants

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Vilazodone page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Oct 1, 2023
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Vilazodone.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Vilazodone after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
13
Finished products in the current FDA directory
36
Companies listing them (makers, repackagers, distributors)
13
FDA labeler codes behind them ⓘ
13
Linked representative label ⓘ
Allergan, Inc.
Linked label effective
Oct 1, 2023
Composite sections available
25
Linked SPL Set ID
4c55ccfb-c4cf-11df-851a-0800200c9a66
Linked SPL Document ID
7502bf82-6281-4d90-8471-1450580c4f3c
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Allergan, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →