FDA-filed SPL labeling · retrieved through openFDA

Midazolam

Midazolam is a fast-acting benzodiazepine sedative used across multiple formulations for procedural sedation, anesthesia, critical care sedation in ventilated patients, and — as Nayzilam nasal spray — the acute treatment of seizure clusters in people with epilepsy.

Brand names VersedNayzilamMidazolam in Sodium ChlorideMidazolam In 0.8% Sodium ChlorideSeizalam
Drug class ⓘ Benzodiazepines
Rx Schedule CIV Forms 3 Routes Intramuscular, Intravenous · Intramuscular; Intravenous · Oral · Intravenous +2
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 40 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveJan 1, 2024
Clinical labels in scope ⓘ40
AvailabilityRx
Earliest approval/marketing year ⓘ1985
FDA-listed product records ⓘ224
Boxed warningYes
How we combine label and product data →
Other forms & routes:
Injection Nasal
⭐ Midazolam at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Midazolam is a powerful, fast-acting sedative used in carefully controlled medical settings for procedural sedation, anesthesia, critical care, and — as Nayzilam nasal spray — for stopping seizure clusters in people with epilepsy. It should only ever be used exactly as prescribed, with qualified personnel nearby, because serious breathing problems and risks of dependence are real. Never combine it with opioids, alcohol, or other sedatives without direct medical supervision.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Midazolam carries three serious boxed warnings from the FDA — the highest level of warning on any drug label.

1. Combined use with opioids can be fatal. Taking midazolam together with opioid pain medicines (like oxycodone, morphine, or fentanyl) can cause extreme sedation, stopped breathing, coma, and death. This combination should only be used when there is no alternative, at the lowest possible doses, for the shortest time — and with close monitoring for slowed or stopped breathing.

2. Risk of abuse, misuse, and addiction. Benzodiazepines like midazolam can be misused, leading to overdose or death. The risk goes up significantly when combined with other drugs, alcohol, or illicit substances. Your prescriber should assess your personal risk before and during treatment.

3. Physical dependence and dangerous withdrawal. Even though Nayzilam is intended for intermittent use only, using it more often than prescribed can lead to physical dependence. If that happens, stopping suddenly — or reducing the dose too quickly — can trigger severe, life-threatening withdrawal reactions including seizures. A gradual, supervised taper is required in that situation.

Read the full warning on DailyMed →

📖 Midazolam: Patient Information Guide

A plain-language walkthrough of Midazolam — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Midazolam is a benzodiazepine available in multiple products, each approved for specific uses:

  • Injectable midazolam (IV or IM): Sedation, anxiety relief, and memory prevention before or during procedures such as endoscopy, bronchoscopy, cardiac catheterization, cystoscopy, oncology procedures, and suturing of lacerations
  • Injectable midazolam (IV): Induction of general anesthesia before other anesthetic agents; may also be used as a component of balanced anesthesia with nitrous oxide and oxygen
  • Injectable midazolam (continuous IV infusion): Sedation of intubated and mechanically ventilated adult, pediatric, and neonatal patients as part of anesthesia or critical care treatment — this applies to midazolam in sodium chloride injection products specifically
  • Midazolam HCl oral syrup: Sedation, anxiety relief, and amnesia before diagnostic, therapeutic, or endoscopic procedures or before anesthesia induction in pediatric patients only; for use in monitored settings only, not for home or chronic use
  • Nayzilam (midazolam nasal spray): Acute treatment of intermittent seizure clusters (also called acute repetitive seizures) in patients with epilepsy aged 12 and older, when the cluster is distinct from the person's usual seizure pattern; intended for intermittent use only
⚙️How it works▾

Midazolam's exact mechanism isn't completely understood, but it is believed to work by binding to the benzodiazepine site on the GABA-A receptor — a key receptor in the brain and nervous system. This enhances the effect of GABA, the brain's primary inhibitory (calming) chemical messenger, resulting in sedation, reduced anxiety, muscle relaxation, and impaired formation of new memories around the time of the dose.

Because it is a short-acting CNS (central nervous system) depressant, its effects are dose-dependent and also influenced by how it is given and what other medications are on board. Higher doses or faster administration increase both the depth of sedation and the risk of breathing suppression.

💊How it's taken▾

Midazolam is never self-administered from a pharmacy bottle in most settings — it is given by trained healthcare professionals in hospitals, procedure suites, or clinics, with monitoring equipment on hand. The specific form and timing depend on the product and purpose:

  • Injectable forms (IV/IM): Given by a healthcare professional; dose is carefully individualized based on age, health status, and other medications. IV doses are given slowly.
  • Midazolam in sodium chloride IV infusion: Administered as a continuous drip in a critical care setting; dosing is titrated to response.
  • Midazolam HCl oral syrup (pediatric): Given as a single dose by mouth before a procedure in a monitored setting; not for repeated or home use.
  • Nayzilam nasal spray: One spray (5 mg) into one nostril at the start of a seizure cluster; a second spray into the opposite nostril may be given after 10 minutes if needed. Do not use more than 2 sprays per episode, no more than one episode every 3 days, and no more than 5 episodes per month.
🤒Side effects — in detail▾

The most commonly reported side effects with midazolam include:

  • Nausea and vomiting (most common overall, often occurring after other anesthetic agents are also given)
  • Drowsiness and prolonged sleepiness after the dose
  • Partial or complete memory loss for the hours surrounding the dose (this is expected and often intentional)
  • Slowed or shallow breathing (respiratory depression)
  • Low blood pressure, particularly in patients who also received opioid premedication
  • Slight increase in heart rate
  • Agitation, involuntary muscle movements, hyperactivity, or combativeness — rare, may indicate paradoxical reaction or improper dosing

Serious breathing problems — including airway obstruction, stopped breathing, and cardiac arrest — have been reported and can be life-threatening. These require immediate emergency response. Do not drive or operate machinery until the full effects of the drug have worn off, which can take up to 6 hours or longer in some people.

⚠️Warnings & precautions▾
  • Breathing emergencies: Respiratory depression, airway obstruction, stopped breathing, and cardiac arrest have occurred — sometimes resulting in death. Every setting where midazolam is used must have resuscitation equipment and trained staff immediately available.
  • Combining with opioids is dangerous: This combination can cause profound sedation, coma, and death. It should be avoided unless absolutely necessary, and requires extremely close monitoring.
  • Abuse, addiction, and misuse: Midazolam, like all benzodiazepines, can be misused. The risk is highest when combined with other substances. Prescribers should assess risk before starting treatment.
  • Dependence and withdrawal: Especially if Nayzilam is used more often than recommended, sudden stopping can trigger life-threatening withdrawal seizures. A gradual taper is required in that situation.
  • Suicidal thoughts: As an antiepileptic drug, midazolam slightly increases the risk of suicidal thinking or behavior. Monitor for mood changes, depression, or unusual behavior.
  • Memory impairment: Midazolam reliably impairs memory for several hours. Do not drive or make important decisions until fully recovered.
  • Glaucoma: Contraindicated in narrow-angle glaucoma. Patients with open-angle glaucoma may need eye pressure monitoring if treated with Nayzilam.
  • Neonatal risks: Use late in pregnancy can cause sedation or withdrawal symptoms in newborns; neonates should be monitored closely.
🔀What it interacts with▾

Midazolam interacts with a number of commonly used drugs — some combinations are potentially life-threatening:

  • Opioids (morphine, fentanyl, meperidine, oxycodone): Together these dramatically increase the risk of severe breathing depression, coma, and death — this is the most dangerous combination
  • Alcohol: Increases CNS depression and the risk of respiratory depression significantly
  • Other CNS depressants (barbiturates like secobarbital, droperidol, sleep aids, muscle relaxants): Additive sedation and breathing risk
  • CYP3A4 inhibitors (erythromycin, ketoconazole, itraconazole, diltiazem, verapamil, cimetidine, saquinavir): These slow the liver's breakdown of midazolam, causing much higher drug levels and prolonged sedation
  • Thiopental and halothane (anesthetic agents): Midazolam reduces the amount of these drugs needed, which must be accounted for in dosing
  • Fentanyl in neonates: Rapid injection of either drug when the other is already being infused has caused severe low blood pressure in newborns

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Narrow-angle glaucoma: Midazolam is contraindicated — do not use
  • Allergy to midazolam or other benzodiazepines: Injectable form is contraindicated if you have a known hypersensitivity
  • Premature infants: Injectable formulations containing benzyl alcohol (a preservative) are contraindicated in premature infants
  • COPD or chronic lung disease: You are highly sensitive to breathing suppression from midazolam — extra caution and monitoring required
  • Congestive heart failure or kidney disease: Midazolam clears more slowly in these conditions, increasing the risk of prolonged sedation
  • Older adults (especially over 70): More sensitive to effects; longer half-life; close monitoring is recommended; rare deaths with IM administration have been reported, usually when opioids were also given
  • Pregnancy: Benzodiazepines cross the placenta; use late in pregnancy can cause newborn sedation and withdrawal — discuss risks with your doctor; a pregnancy registry exists for those taking antiepileptic drugs during pregnancy
  • Breastfeeding: Midazolam passes into breast milk; watch breastfed infants for sedation, poor feeding, and poor weight gain
  • Shock, coma, or acute alcohol intoxication with depressed vital signs: Injectable midazolam should not be used in these situations
  • History of substance use disorder: Higher risk of misuse and addiction with benzodiazepines
🚑If you take too much▾

Too much midazolam causes progressively deeper central nervous system depression — starting with extreme drowsiness, confusion, slurred speech, and poor coordination, and potentially progressing to stopped breathing and coma. Combining midazolam with opioids or alcohol makes overdose far more dangerous and potentially fatal. If overdose is suspected, call 911 immediately — emergency supportive care, airway management, and IV fluids are the priorities. Flumazenil (a benzodiazepine reversal agent) may be used by medical personnel, but it must be used cautiously because it can trigger severe withdrawal seizures, especially in people with epilepsy or long-term benzodiazepine use. You can also contact Poison Control at 1-800-222-1222.

📡Pharmacodynamics — effects in the body▾

Midazolam is a short-acting CNS depressant. After IM injection in adults, sedation begins within about 15 minutes and peaks at 30–60 minutes. After IV injection, sedation sets in within 3–5 minutes. It reliably impairs the ability to form new memories: studies show that the majority of patients have little or no recall of events occurring in the hours following a dose. After IV anesthesia induction, recovery of basic function (orientation, ability to stand) usually occurs within 2 hours, but may take up to 6 hours. Midazolam can suppress the breathing response to carbon dioxide — this effect is more pronounced in patients with COPD and is worsened by opioids.

🔬Pharmacokinetics — how your body processes it▾

Midazolam is rapidly absorbed when given orally, though it undergoes substantial first-pass metabolism in the gut and liver, meaning only a fraction of the oral dose reaches the bloodstream unchanged. It is broken down primarily in the liver into active metabolites, with the main one being alpha-hydroxymidazolam. Older adults and patients with kidney impairment, liver disease, or congestive heart failure clear midazolam more slowly, which extends how long its effects last and increases the risk of prolonged sedation. Midazolam passes into breast milk and crosses the placenta.

📦How to store it▾

Store at 20° to 25°C (68° to 77°F). Protect from light.

📄 Written from Midazolam’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

202

Supplements & herbs that interact with Midazolam

202 supplements and herbal products have documented interactions with Midazolam in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 11
  • Moderate · 153
  • Minor · 38
1,4-BUTANEDIOL Major ACTIVATED CHARCOAL Major BEER Major BITTER ORANGE Major FEVER BARK Major GAMMA-HYDROXYBUTYRATE (GHB) Major GRAPEFRUIT Major KAVA Major +194 more
Every supplement checked against Midazolam — ranked by severity The full interaction hub: 11 major · 153 moderate · 38 minor · every one linked to its full report. Check Midazolam against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Midazolam — the kind of thing our pharmacy team would talk through with you at the counter.

Why will I not remember what happened during my procedure? ▾
That's actually one of the intentional effects of midazolam — it reliably blocks the brain's ability to form new memories for several hours after a dose. So even if you're awake and responding during a procedure, you likely won't remember it afterward. Most people find this reassuring rather than alarming. The effect wears off as the drug clears your system.
Is it safe to go home right after receiving midazolam? ▾
You should not drive or operate any machinery until the full effects have worn off — and that can take up to 6 hours or sometimes longer. Plan to have someone drive you home. Even if you feel alert, your reaction time and judgment may still be impaired. Your medical team will tell you when it's safe to leave the facility.
Can I take my usual medications with midazolam? ▾
Some medications are a serious concern. Opioid pain medicines — like oxycodone or fentanyl — combined with midazolam can cause dangerously slowed breathing or worse. Certain antibiotics (like erythromycin), antifungals (like ketoconazole), and heart medications (like diltiazem or verapamil) can make midazolam stay in your body much longer, deepening sedation. Always tell your doctor and the procedure team about every medication, supplement, and over-the-counter drug you take.
My family member uses Nayzilam for seizure clusters — what should I know about giving it? ▾
Nayzilam is sprayed into one nostril at the first sign of a seizure cluster. If the seizures haven't stopped after 10 minutes, a second spray goes into the opposite nostril. You should use it no more than once every three days, and no more than five times in a month. Your healthcare provider should train you on what a seizure cluster looks like for your family member and exactly how to use the device before you ever need it urgently. Always call for emergency help if breathing problems occur after giving the dose.
Can midazolam be habit-forming? ▾
It can be, especially if used more often than prescribed. Midazolam is a benzodiazepine, and all benzodiazepines carry a real risk of physical dependence if used too frequently. Nayzilam, for example, is specifically designed for intermittent use only. If someone uses it more than recommended and then stops suddenly, serious withdrawal reactions — including dangerous seizures — can occur. Follow the prescribed frequency closely and talk to your doctor before making any changes.
Is midazolam safe during pregnancy or while breastfeeding? ▾
This is an important conversation to have with your doctor. Midazolam crosses the placenta, and babies born to mothers who used it late in pregnancy may show signs of sedation or withdrawal after birth — things like tremors, trouble feeding, or irritability. It also passes into breast milk and can cause drowsiness or poor feeding in a nursing infant. If you're pregnant or breastfeeding, your doctor will carefully weigh the benefits of treatment against these risks. A pregnancy registry also exists for people taking antiepileptic drugs during pregnancy — your doctor can give you more details.
Is Midazolam available over the counter? ▾
Midazolam is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
Is Midazolam a controlled substance? ▾
Yes — Midazolam is a federally controlled substance (Schedule IV) in the United States, so how it is prescribed, refilled and dispensed is regulated by the DEA.
When was Midazolam first available? ▾
Midazolam has been available in the United States since at least 1985, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Midazolam? ▾
Midazolam is supplied by 49 manufacturers listed in the FDA NDC Directory, including Hikma Pharmaceuticals USA Inc., Hospira, Inc., Fresenius Kabi USA, LLC.

💬 Answers drafted from Midazolam’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Midazolam supplement interactions202 checked — ranked by severity 🌿Drug & Supplement CheckerMidazolam vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Midazolam NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Midazolam comes

Midazolam is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

Into a muscle · Into a vein
Brands Midazolam In 0.8% Sodium Chloride Midazolam in Sodium Chloride Seizalam
Available strengths 5 strengths
1 mg/mL 2 mg/2 mL 5 mg/5 mL 5 mg/mL 10 mg/2 mL
183 FDA-listed product records ⓘ

Oral solution

By mouth
Available strengths 1 strength
2 mg/mL
23 FDA-listed product records ⓘ

Nasal spray

In the nose
Brands Nayzilam
Available strengths 1 strength
5 mg/0.1 mL
2 FDA-listed product records ⓘ

📊 Midazolam across the U.S. market

How Midazolam appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

3
Dose forms ⓘ
49
Manufacturers
6
Brand names
224
FDA-listed product records ⓘ
1985
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (16) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Hikma Pharmaceuticals USA Inc.18%
Hospira, Inc.11%
Fresenius Kabi USA, LLC9%
Henry Schein, Inc.6%
A-S Medication Solutions4%
WG Critical Care, LLC.4%
Other makers47%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Midazolam is used

A general measure of how commonly Midazolam is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Midazolam is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

401,717
Medicaid prescriptions filled (Q1–Q4 2025)
$127.1M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Midazolam prescribed? Of the 1,596 medications we measure, Midazolam ranks #290 by Medicaid prescriptions — more than 82% of them.

Where Midazolam ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #290 of 1,596
#285 Loperamide 409,237 Rx #286 Tacrolimus Topical 408,485 Rx #287 Cyclosporine 403,927 Rx #288 Betamethasone 403,381 Rx #289 Betamethasone Topical 402,754 Rx #290 Midazolam 401,717 Rx #291 Zonisamide 395,289 Rx #292 Methimazole 378,542 Rx #293 Cyclosporine Ophthalmi... 377,528 Rx #294 Finasteride 375,944 Rx #295 Neomycin, Polymyxin, a... 367,823 Rx

Utilization by Midazolam product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 1 mg/mL injectable solution is the most-dispensed Midazolam product — about 31% of these Medicaid prescriptions.

midazolam 1 MG/ML Injectable Solution Most dispensed

125,331 Medicaid prescriptions (Q1–Q4 2025) 31% of Midazolam prescriptions shown $14.3M gross reimbursement (before rebates) ≈ $114 per prescription (gross)

Summed across the 10 of 42 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311700

2 ML midazolam 1 MG/ML Injection

117,374 Medicaid prescriptions (Q1–Q4 2025) 29% of Midazolam prescriptions shown $14.7M gross reimbursement (before rebates) ≈ $125 per prescription (gross)

Summed across the 7 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1666798

midazolam 50 MG/ML Nasal Spray

109,459 Medicaid prescriptions (Q1–Q4 2025) 27% of Midazolam prescriptions shown $96M gross reimbursement (before rebates) ≈ $877 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2173494

5 ML midazolam 1 MG/ML Injection

15,057 Medicaid prescriptions (Q1–Q4 2025) 4% of Midazolam prescriptions shown $798,835 gross reimbursement (before rebates) ≈ $53 per prescription (gross)

Summed across the 3 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1666800

midazolam 5 MG/ML Injectable Solution

13,371 Medicaid prescriptions (Q1–Q4 2025) 3% of Midazolam prescriptions shown $560,693 gross reimbursement (before rebates) ≈ $42 per prescription (gross)

Summed across the 12 of 68 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311702

2 ML midazolam 5 MG/ML Injection

8,044 Medicaid prescriptions (Q1–Q4 2025) 2% of Midazolam prescriptions shown $72,381 gross reimbursement (before rebates) ≈ $9.00 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1666823

midazolam 2 MG/ML Oral Solution

5,415 Medicaid prescriptions (Q1–Q4 2025) 1% of Midazolam prescriptions shown $122,078 gross reimbursement (before rebates) ≈ $23 per prescription (gross)

Summed across the 6 of 22 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 422410

1 ML midazolam 5 MG/ML Injection

4,374 Medicaid prescriptions (Q1–Q4 2025) 1% of Midazolam prescriptions shown $114,722 gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1666814

2 ML midazolam 1 MG/ML Prefilled Syringe

3,189 Medicaid prescriptions (Q1–Q4 2025) <1% of Midazolam prescriptions shown $395,322 gross reimbursement (before rebates) ≈ $124 per prescription (gross)

Summed across the 2 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 998211

1 ML midazolam 5 MG/ML Prefilled Syringe

65 Medicaid prescriptions (Q1–Q4 2025) <1% of Midazolam prescriptions shown $5,930 gross reimbursement (before rebates) ≈ $91 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1551395

100 ML midazolam 1 MG/ML Injection

38 Medicaid prescriptions (Q1–Q4 2025) <1% of Midazolam prescriptions shown $10,957 gross reimbursement (before rebates) ≈ $288 per prescription (gross)

Summed across the 1 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2541171

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Midazolam, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 47 of 213 listed Midazolam NDCs with Medicaid activity.

🔍 Compare Midazolam products

A representative set of FDA-listed product records for Midazolam — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 224 products — FDA National Drug Code Directory. See every product, package size and price: browse all 224 Midazolam NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Midazolam RxCUI 6960 8 dose forms · 18 strengths
  1. Dose form (SCDF) Auto-Injector RxCUI 2608697 In current FDA listings
    Clinical drug / strength (SCD) 0.7 ML midazolam 14.3 MG/ML RxCUI 2608698
  2. Dose form (SCDF) Cartridge RxCUI 1666776 No current FDA listing
    Clinical drug / strength (SCD) 1 ML midazolam 5 MG/ML RxCUI 1666821 2 ML midazolam 1 MG/ML RxCUI 1666777
  3. Dose form (SCDF) Injectable Solution RxCUI 379133 In current FDA listings
    Clinical drug / strength (SCD) 1 MG/ML RxCUI 311700 2 MG/ML RxCUI 106517 5 MG/ML RxCUI 311702
  5. Dose form (SCDF) Nasal Spray RxCUI 2173493 In current FDA listings
    Clinical drug / strength (SCD) 50 MG/ML RxCUI 2173494
  6. Dose form (SCDF) Oral Solution RxCUI 446503 In current FDA listings
    Clinical drug / strength (SCD) 2 MG/ML RxCUI 422410
  7. Dose form (SCDF) Oral Tablet RxCUI 372922 No current FDA listing
    Clinical drug / strength (SCD) 15 MG RxCUI 248630

Look up RxCUI 6960 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Versed Nayzilam Midazolam in Sodium Chloride Midazolam In 0.8% Sodium Chloride Seizalam

🏭 Manufacturers & labelers

Hikma Pharmaceuticals USA Inc. 39 Hospira, Inc. 24 Fresenius Kabi USA, LLC 20 Henry Schein, Inc. 13 A-S Medication Solutions 9 WG Critical Care, LLC. 8 Civica, Inc. 8 Steriscience Specialties Private Limited 7 Onesource Specialty Pharma Limited 7 Precision Dose Inc. 6 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 5 Gland Pharma Limited 5 American Health Packaging 4 General Injectables and Vaccines, Inc. 4 Almaject, Inc. 4 Akorn 4 Bryant Ranch Prepack 3 Major Pharmaceuticals 3 F.i.s. Fabbrica Italiana Sintetici S.p.a. 3 Somerset Therapeutics, Llc 3 Sagent Pharmaceuticals 3 Meridian Medical Technologies LLC 2 Micro Labs Limited 2 Padagis US LLC 2

…and 16 more on the FDA NDC directory.

RxNorm drug class

Midazolam belongs to the Benzodiazepine class.

Pharmacologic class Benzodiazepine
Drug family (ATC) Benzodiazepine derivatives

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jan 1, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Midazolam.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Midazolam after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
40
NDC products indexed
224
Distinct labelers/manufacturers represented
49
Linked representative label ⓘ
Fresenius Kabi USA, LLC
Linked label effective
Jan 1, 2024
Composite sections available
22
Linked SPL Set ID
1cc9ba6e-fa1b-405e-9de8-720c567b2a73
Linked SPL Document ID
ec9c9aee-b95f-4645-bf17-df7f1e3967d3
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 40 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Fresenius Kabi USA, LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.