Midazolam Hydrochloride Injection shortage
Midazolam Hydrochloride Injection is currently listed in shortage by the FDA. The FDA lists 27 affected products. The reported reason: Demand increase for the drug; Other; Delay in shipping of the drug. This page was last refreshed from FDA data on Oct 2, 2026.
Midazolam hydrochloride injection is currently in shortage, driven by higher demand and shipping delays, and has been ongoing for over a year. Several strengths are still listed by makers not reporting a shortage, including Hikma, Hospira, and Sagent Pharmaceuticals.
Don’t stop or change your therapy on your own — ask your pharmacist about other manufacturers (see options) and your prescriber about a long-term plan.
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Midazolam Hydrochloride Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Oct 1, 2026Currently in shortage27 of 27 products affected.
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Sep 22, 2026FDA refreshed this shortage record8 products updated.
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Sep 18, 2026FDA refreshed this shortage record5 products updated.
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Sep 15, 2026FDA refreshed this shortage record7 products updated.
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Sep 1, 2026FDA refreshed this shortage record3 products updated.
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Jul 22, 2026FDA refreshed this shortage record2 products updated.
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Apr 2, 2020First reported to the FDA27 products first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Avet Pharmaceuticals, Inc. 📞 855-228-9470 3 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 23155-600-41) | — | Limited Availability | Estimated recovery: 9/25/2026 | Demand increase for the drug |
| Current | Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 23155-601-41) | — | Available | — | — |
| Current | Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 23155-601-42) | — | Available | — | — |
Manufacturer: Fresenius Kabi USA, LLC 📞 888-386-1300 7 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Midazolam Hydrochloride Preservative Free, Injection, 2 mg/2 mL (NDC 76045-211-20) | — | Unavailable | Next release October 2026. Check wholesalers for inventory. | Demand increase for the drug |
| Current | Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 63323-411-25) | — | Available | Check wholesalers for inventory | — |
| Current | Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 63323-412-02) | — | Available | Check wholesalers for inventory | — |
| Current | Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 63323-411-12) | — | Available | Check wholesalers for inventory | — |
| Current | Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 63323-412-25) | — | Unavailable | Next release October 2026. Check wholesalers for inventory. | Demand increase for the drug |
| Current | Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 63323-412-10) | — | Unavailable | Estimated recovery: TBD | Demand increase for the drug |
| Current | Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 63323-411-10) | — | Unavailable | Estimated recovery: TBD | Delay in shipping of the drug |
Manufacturer: Gland Pharma Limited 📞 Avet Pharmaceuticals, Inc.: 855-228-9470; Sagent Pharmaceuticals: 866-625-1618 2 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 25021-661-10) | — | Unavailable | Estimated recovery: TBD; Distributed by Sagent Pharmaceuticals | Other |
| Current | Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 25021-655-02) | — | Unavailable | Estimated recovery: TBD; Distributed by Sagent Pharmaceuticals | Other |
Manufacturer: Hikma Pharmaceuticals USA, Inc. 📞 800-631-2174 5 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 0641-6061-25) | — | Available | Additional lots are scheduled to be manufactured. Product will be made available as it is released. | — |
| Current | Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 0641-6057-25) | — | Available | Additional lots are scheduled to be manufactured. Product will be made available as it is released. | — |
| Current | Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 0641-6059-01) | — | Available | Additional lots are scheduled to be manufactured. Product will be made available as it is released. | — |
| Current | Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 0641-6060-10) | — | Available | Additional lots are scheduled to be manufactured. Product will be made available as it is released. | — |
| Current | Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 0641-6056-10) | — | Available | Additional lots are scheduled to be manufactured. Product will be made available as it is released. | — |
Manufacturer: Hospira, Inc., a Pfizer Company 📞 844-646-4398 8 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Midazolam Hydrochloride Preservative Free, Injection, 2 mg/2mL (1 mg/mL) (NDC 0409-0001-25) | — | Limited Availability | Limited Supply Available. Next Delivery and Estimated Recovery: December 2026 | Demand increase for the drug |
| Current | Midazolam Hydrochloride, Injection, 10 mg/10 mL (1 mg/mL) (NDC 0409-2587-05) | — | Unavailable | Next Delivery and Estimated Recovery: December 2026 | Demand increase for the drug |
| Current | Midazolam Hydrochloride Preservative Free, Injection, 2 mg/2mL (1 mg/mL) (NDC 0409-2305-17) | — | Limited Availability | Next Estimated Delivery and Estimated Recovery: December 2026 | Demand increase for the drug |
| Current | Midazolam Hydrochloride, Injection, 25 mg/5 mL (5 mg/mL) (NDC 0409-2596-03) | — | Available | — | — |
| Current | Midazolam Hydrochloride Preservative Free, Injection, 5 mg/mL (5 mg/mL) (NDC 0409-2308-01) | — | Unavailable | Next Delivery and Estimated Recovery: December 2026 | Demand increase for the drug |
| Current | Midazolam Hydrochloride Preservative Free, Injection, 5 mg/5 mL (1 mg/mL) (NDC 0409-2305-05) | — | Unavailable | Next Delivery: October 2026; Estimated Recovery: December 2026 | Demand increase for the drug |
| Current | Midazolam Hydrochloride, Injection, 50 mg/10 mL (5 mg/mL) (NDC 0409-2596-05) | — | Available | — | — |
| Current | Midazolam Hydrochloride Preservative Free, Injection, 10 mg/2 mL (5 mg/mL) (NDC 0409-2308-02) | — | Unavailable | Next Delivery and Estimated Recovery: September 2026 | Demand increase for the drug |
Manufacturer: WG Critical Care 📞 888-493-0861 2 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Midazolam In 0.9% Sodium Chloride, Injection, 1 mg/1 mL (NDC 44567-611-10) | — | Available | Please check wholesalers and distributors for inventory. | — |
| Current | Midazolam In 0.9% Sodium Chloride, Injection, 1 mg/1 mL (NDC 44567-610-10) | — | Available | Please check wholesalers and distributors for inventory. | — |
These rows are manufacturer reports to the FDA for Midazolam Hydrochloride Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Midazolam Hydrochloride Injection? options further down this page.
Why is Midazolam Hydrochloride Injection in shortage?
The main reason midazolam injection is in short supply right now is simply that more people need it than the manufacturers can keep up with — demand has outpaced production across several companies. On top of that, at least one packaging size from Fresenius Kabi is also being held up by a shipping delay. Gland Pharma (distributed by Sagent Pharmaceuticals) hasn't shared a specific public reason for their two unavailable sizes.
Here's a quick look at what's affected and when supply is expected to improve:
- Avet Pharmaceuticals — their 1 mg/1 mL vials are limited right now, with recovery estimated around September 25, 2026; their 5 mg/1 mL sizes are still available.
- Fresenius Kabi — several sizes (5 mg/1 mL and the preservative-free 2 mg/2 mL) are currently out, with the next release expected October 2026; some of their 1 mg/1 mL and 5 mg/1 mL packages are still available.
- Hospira (Pfizer) — multiple preservative-free sizes are out or limited, with next deliveries expected between September and December 2026; their 25 mg/5 mL and 50 mg/10 mL sizes remain available.
- Gland Pharma — both their 1 mg/1 mL and 5 mg/1 mL vials are unavailable with no recovery date set yet.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Midazolam Hydrochloride Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Midazolam Hydrochloride Injection?
Midazolam Hydrochloride Injection is currently on the FDA shortage list. This is a hospital- and clinic-administered injectable, and supply has been tight for over a year, so I want to walk you through where things stand.
Several strengths still have an available source right now: 1 mg/1 mL, 5 mg/1 mL, 25 mg/5 mL (5 mg/mL), 2 mg/2 mL (1 mg/mL), and 50 mg/10 mL (5 mg/mL). The strengths that have no available source at this time are 2 mg/2 mL, 5 mg/mL, 5 mg/5 mL (1 mg/mL), 10 mg/10 mL (1 mg/mL), and 10 mg/2 mL (5 mg/mL). Some of these list a next delivery or estimated recovery in late 2026.
The reported causes are a rise in demand, a shipping delay, and "other" reasons. Reassuringly, 5 of the 6 manufacturers on this record are still reporting some supply, and additional lots are scheduled to be made and released as they become ready.
Here is what I suggest:
- Do not stop, skip, or change any dose on your own.
- If your strength still has supply, ask your pharmacy or care team to order it — they can check wholesalers and other manufacturers.
- The same medicine is made by several companies on the available list, so your pharmacy may be able to source one of those, though it may not be in local stock.
- If your exact strength cannot be found, ask your prescriber or pharmacist about options, such as a different strength or a clinician-chosen alternative.
- Manufacturer contact numbers are listed on this page for reference; pharmacies usually handle those calls.
This is general, national information and may not match your local pharmacy's actual stock.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
- This is a controlled substance. Transfers between pharmacies and switching strengths have extra federal/state rules — ask the pharmacy before you assume a transfer is possible.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Midazolam Hydrochloride Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Midazolam Hydrochloride Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Midazolam In Sodium Chloride | MIDAZOLAM HYDROCHLORIDE 1 mg/mL | Injection · Intravenous | Hikma Pharmaceuticals USA Inc. | 00143-9379-10 |
| Midazolam | MIDAZOLAM HYDROCHLORIDE 1 mg/mL | Injection, Solution · Intramuscular, Intravenous | Hospira, Inc. | 00409-2305-50 |
| Midazolam | MIDAZOLAM HYDROCHLORIDE 5 mg/mL | Injection, Solution · Intramuscular, Intravenous | Hospira, Inc. | 00409-2308-49 |
| Midazolam | MIDAZOLAM HYDROCHLORIDE 5 mg/mL | Injection · Intramuscular, Intravenous | Hikma Pharmaceuticals USA Inc. | 00641-6061-10 |
| Midazolam In Sodium Chloride | MIDAZOLAM HYDROCHLORIDE 1 mg/mL | Injection, Solution · Intravenous | Sagent Pharmaceuticals | 25021-0688-82 |
| Midazolam Hydrochloride | MIDAZOLAM HYDROCHLORIDE 5 mg/mL | Injection, Solution · Intramuscular, Intravenous | A-S Medication Solutions | 50090-5342-00 |
| Midazolam Hydrochloride | MIDAZOLAM HYDROCHLORIDE 1 mg/mL | Injection, Solution · Intramuscular, Intravenous | A-S Medication Solutions | 50090-5472-00 |
| Midazolam | MIDAZOLAM HYDROCHLORIDE 1 mg/mL | Injection, Solution · Intramuscular, Intravenous | Fresenius Kabi USA, LLC | 63323-0411-27 |
| Midazolam | MIDAZOLAM HYDROCHLORIDE 2 mg/2mL | Injection, Solution · Intramuscular, Intravenous | SOMERSET THERAPEUTICS, LLC | 70069-0816-10 |
| Midazolam | MIDAZOLAM HYDROCHLORIDE 5 mg/5mL | Injection, Solution · Intramuscular, Intravenous | SOMERSET THERAPEUTICS, LLC | 70069-0817-10 |
| Midazolam | MIDAZOLAM HYDROCHLORIDE 2 mg/2mL | Injection, Solution · Intramuscular, Intravenous | REMEDYREPACK INC. | 70518-4328-00 |
| Midazolam | MIDAZOLAM HYDROCHLORIDE 1 mg/mL | Injection · Intramuscular, Intravenous | Civica, Inc. | 72572-0430-25 |
Alternative dosage forms of Midazolam Hydrochloride
A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:
Therapeutic equivalents & pricing 30 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Midazolam 1 mg/mL | Hikma | 25 vials | $0.233 | AP | Availability likely |
| Midazolam hydrochloride 1 mg/mL | Heritage | 25 vials | $0.233 | AP | Availability likely |
| Midazolam 1 mg/mL | Civica, | 25 vials | $0.233 | AP | Availability likely |
| Midazolam 5 mg/mL | Hikma | 10 vials | $0.382 | AP | Availability likely |
| Midazolam 5 mg/mL | Hikma | 10 vials | $0.382 | AP | Availability likely |
| Midazolam 5 mg/mL | Hikma | 10 vials | $0.382 | AP | Availability likely |
| Midazolam hydrochloride 5 mg/mL | Heritage | 10 vials | $0.382 | AP | Availability likely |
| Midazolam 1 mg/mL | Hospira, | 25 vials | $0.420 | AP | FDA listed |
| midazolam 5 mg/mL | Sagent | 10 vials | $0.450 | AP | FDA listed |
| Midazolam 5 mg/mL | Hospira, | 10 vials | $1.226 | AP | Availability likely |
| Midazolam 1 mg/mL | Hospira, | 10 vials | — | AP | FDA listed |
| midazolam 1 mg/mL | Sagent | 10 vials | — | AP | FDA listed |
| Midazolam 1 mg/mL | Micro | 25 vials | — | AP | FDA listed |
| Midazolam 1 mg/mL | Cardinal | 5 vials | — | AP | FDA listed |
| Midazolam hydrochloride 1 mg/mL | Gland | 10 vials | — | AP | FDA listed |
| Midazolam 2 mg/2mL | SOMERSET | 10 vials | — | AP | FDA listed |
| Midazolam 2 mg/2mL | REMEDYREPACK | 10 vials | — | AP | FDA listed |
| Midazolam 1 mg/mL | Onesource | 10 vials | — | AP | FDA listed |
| Midazolam 1 mg/mL | Steriscience | 10 vials | — | AP | Discontinued |
| Midazolam 1 mg/mL | Steriscience | 10 vials | — | AP | Discontinued |
| Midazolam 1 mg/mL | Steriscience | 10 vials | — | AP | FDA listed |
| Midazolam Hydrochloride 1 mg/mL | A-S | 10 vials | — | AP | FDA listed |
| Midazolam 1 mg/mL | Fresenius | 10 vials | — | AP | FDA listed |
| Midazolam 1 mg/mL | Hospira, | 10 vials | — | AP | FDA listed |
| Midazolam 1 mg/mL | Onesource | 10 vials | — | AP | FDA listed |
| Midazolam 1 mg/mL | Onesource | 10 vials | — | AP | FDA listed |
| Midazolam 5 mg/mL | Henry | 1 vial | — | AP | FDA listed |
| Midazolam 5 mg/mL | Henry | 1 vial | — | AP | FDA listed |
| Midazolam 5 mg/mL | Hospira, | 10 vials | — | AP | FDA listed |
| Midazolam 5 mg/mL | Hikma | 10 vials | — | AP | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Midazolam Hydrochloride Injection — that fall in the same broad treatment class (general anesthetics,injectable-benzodiazepine type) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Midazolam Hydrochloride Injection shortage FAQs
Is Midazolam Hydrochloride Injection in shortage?
Why is Midazolam Hydrochloride Injection in shortage?
Which products are affected?
When will Midazolam Hydrochloride Injection be available again?
Can I still get Midazolam Hydrochloride somewhere?
What should I do if I take Midazolam Hydrochloride Injection?
Still have a question about the Midazolam Hydrochloride Injection shortage?
Ask a pharmacist about this shortage →View Midazolam Hydrochloride Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.