Sodium Bicarbonate
Sodium bicarbonate is an antacid and skin-soothing ingredient used across many products to relieve heartburn, acid indigestion, upset stomach, minor skin irritation from insect bites and stings, and minor mouth and gum irritation.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 46 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
📖 Sodium Bicarbonate: Patient Information Guide
A plain-language walkthrough of Sodium Bicarbonate — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
🎯What it's used for▾
Sodium bicarbonate is used in many different products across several routes of administration. Here is the full range of supported uses:
- Relieves heartburn, sour stomach, acid indigestion, and upset stomach — oral powders (Adrian Bicarbonato, Arm and Hammer Baking Soda, D-d Sudium Bicarbonate U.s.p., De La Cruz Sodium Bicarbonate Antacid, Dr. Sana Bicarbonato De Sodio), oral solutions (Anti-Empacho, De La Cruz Desempacho), and oral tablets (Sodium Bicarbonate Antacid, Sodium Bicarbonate 5 gr, Sodium Bicarbonate 10 gr. (650 mg))
- Temporarily cleanses minor wounds and soothes minor gum inflammation from dental procedures, dentures, orthodontic appliances, or accidental injury — EcoDent Ultimate Essential Mouthcare oral solution
- Temporarily relieves minor skin irritation and itching from insect bites, stings, and contact with poison ivy, oak, or sumac — After Bite Kids cream, After Bite Advanced liquid, After Bite X Tech liquid, Itch Eraser Sensitive cream, AHHH Bite Relief gel, Insect sting relief latex lotion, Insect sting relief pad, Dermfree Insect Bite Relief liquid, and Arm and Hammer Baking Soda (used as a topical paste, compress, or bath soak)
- AHHH Bite Relief gel also provides rapid relief from deer flies, horse flies, black flies, mosquitoes, bees, wasps, and chiggers, as well as rashes and eczema
- IV sodium bicarbonate injection is used in clinical settings to treat metabolic acidosis (excess acid in the blood)
⚙️How it works▾
Sodium bicarbonate is a base — it neutralizes acid directly. When taken by mouth, it reacts with stomach acid to reduce acidity and relieve symptoms like heartburn and indigestion. Given intravenously, it raises the level of bicarbonate in the blood, buffers excess hydrogen ions (the particles that make blood too acidic), and brings blood pH back toward normal. The body can also convert excess bicarbonate into carbon dioxide, which is simply exhaled through the lungs. The kidneys help regulate bicarbonate levels by adjusting how much is kept or released in the urine.
💊How it's taken▾
The right way to take sodium bicarbonate depends on the specific product. Oral antacid powders must always be fully dissolved in water before swallowing — never taken dry. Tablets can be swallowed whole or dissolved in water first. Oral solutions should be measured carefully. Topical products go directly on the skin; Arm and Hammer Baking Soda can be mixed with water as a paste, compress, or bath soak. EcoDent oral solution is swished in the mouth and spit out — not swallowed.
- Do not exceed the daily dose limit for your age group on oral antacid products
- Adults 60 and older generally have a lower maximum daily dose than younger adults
- Do not use the maximum dose for more than 2 weeks without a doctor's guidance
- IV sodium bicarbonate is given only by healthcare professionals in a clinical setting
🤒Side effects — in detail▾
Side effects depend on how sodium bicarbonate is used. Most OTC products are well tolerated when used as directed, but the IV form carries more significant risks.
- Metabolic alkalosis — blood becomes too alkaline, causing muscle twitching and irritability (IV use)
- Tetany — involuntary muscle spasms (IV use with excessive dosing)
- Hypernatremia — too much sodium in the blood (IV use)
- Tissue damage, ulceration, or skin sloughing if IV solution leaks outside the vein (extravasation)
If you experience muscle twitching, spasms, or irritability after using sodium bicarbonate, seek medical attention right away. For OTC topical or oral products, stop use and contact a doctor or pharmacist if you notice any unexpected reactions.
⚠️Warnings & precautions▾
- Do not exceed daily dose limits on oral antacid products — limits are lower for adults 60 and older. Do not use the maximum dose for more than 2 weeks unless a doctor directs you to.
- If heartburn or stomach symptoms persist beyond 2 weeks, stop use and see a doctor — ongoing symptoms may need further evaluation.
- The IV form can cause metabolic alkalosis (blood becomes too alkaline) if given too aggressively — watch for muscle twitching, irritability, or tetany.
- IV solution leaking outside the vein (extravasation) can cause chemical burns, tissue damage, and skin ulceration — report any IV site pain or swelling immediately.
- Keep all sodium bicarbonate products out of reach of children. In case of overdose, call Poison Control at 1-800-222-1222.
🔀What it interacts with▾
Sodium bicarbonate can interact with several medications and IV additives depending on the route used.
- Prescription medications (oral use): antacids can affect how some prescription drugs are absorbed or work — always ask your pharmacist before combining
- Norepinephrine and dobutamine (IV use): these drugs are chemically incompatible with sodium bicarbonate injection and must not be mixed
- Calcium-containing IV solutions: mixing sodium bicarbonate with calcium can cause a dangerous precipitate (clumping) to form in the solution
- Any IV additive: all additives should be checked for compatibility with a pharmacist before mixing
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
📋Before taking it▾
- Tell your doctor if you are on a sodium-restricted diet — sodium bicarbonate adds sodium to your intake
- Ask your pharmacist if you take any prescription medications before using oral antacid products
- If you are pregnant or breastfeeding, check with a health professional before use
- Children under 12 years old should not take oral antacid forms unless a doctor recommends it
- Children under 2 years should only use topical or bath forms under a doctor's direction
- Adults 60 and older must follow the lower maximum daily dose limits on oral antacid products
- IV sodium bicarbonate must not be used in patients who are losing chloride through vomiting, continuous stomach suctioning, or use of diuretics (water pills) that cause hypochloremic alkalosis
🚑If you take too much▾
Taking too much sodium bicarbonate — especially by IV — can push the blood too far toward alkaline, causing a condition called metabolic alkalosis. Signs include muscle hyperirritability or tetany (involuntary muscle spasms). If alkalosis occurs with IV use, the infusion is stopped and treatments such as IV sodium chloride, potassium chloride, calcium gluconate, or an acidifying agent may be used depending on severity. For any suspected overdose with an OTC product, call Poison Control immediately at 1-800-222-1222.
📡Pharmacodynamics — effects in the body▾
Sodium bicarbonate directly raises the bicarbonate concentration in the blood, which buffers (neutralizes) excess hydrogen ions and increases blood pH — moving it away from acidic and back toward normal. When the blood is too acidic (metabolic acidosis), symptoms like confusion, rapid breathing, and muscle weakness can develop; sodium bicarbonate reverses these effects. The kidneys normally maintain bicarbonate balance by adjusting how much is reabsorbed or excreted in the urine, and the lungs help by exhaling any extra carbon dioxide produced in the buffering process.
📦How to store it▾
store at room temperature 15 ° - 30 ° C (59 ° - 86 ° F).
📄 Written from Sodium Bicarbonate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
Supplements & herbs that interact with Sodium Bicarbonate
30 supplements and herbal products have documented interactions with Sodium Bicarbonate in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 1
- Moderate · 10
- Minor · 19
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Sodium Bicarbonate has been associated with lower levels of 4 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
- Higher significance · 2
- Moderate · 1
- Unrated · 1
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
🩺 Pharmacist Counseling Corner
Quick, plain-English answers to the questions patients ask most about Sodium Bicarbonate — the kind of thing our pharmacy team would talk through with you at the counter.
Can I use this for my heartburn every day? ▾
Is baking soda from the kitchen the same as these antacid products? ▾
Can I put these topical products on my child's insect bite? ▾
What should I watch for that means I've taken too much? ▾
I take prescription medications. Is it safe to use this antacid? ▾
Can I use the EcoDent mouthwash to treat a toothache or infection? ▾
Is Sodium Bicarbonate available over the counter? ▾
When was Sodium Bicarbonate first available? ▾
Who makes Sodium Bicarbonate? ▾
💬 Answers drafted from Sodium Bicarbonate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 Keep exploring
💊 How Sodium Bicarbonate comes
Sodium Bicarbonate is available in 8 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Injection
How this form is used
- Sodium bicarbonate injection is used intravenously to treat metabolic acidosis (excess acid in the blood) and to reverse its symptoms by raising blood pH
- Administered intravenously (by IV) by a healthcare professional in a clinical setting only
- Do not use the injection if it contains any particles or cloudiness — discard the vial
- Do not mix with norepinephrine, dobutamine, or calcium-containing solutions
- Any additives should be mixed only by a pharmacist using sterile technique
Tablet
How this form is used
- Sodium Bicarbonate Antacid tablets relieve acid indigestion, heartburn, sour stomach, and upset stomach
- Sodium Bicarbonate 5 gr tablets relieve acid indigestion, heartburn, sour stomach, and upset stomach
- Sodium Bicarbonate 10 gr. (650 mg) tablets relieve acid indigestion, heartburn, sour stomach, and upset stomach
- Sodium Bicarbonate Antacid and Sodium Bicarbonate 10 gr. (650 mg): tablets may be swallowed whole or dissolved in water before use; adults 60 and older have a lower maximum daily dose than younger adults
- Sodium Bicarbonate 5 gr: dissolve each tablet in a full glass of water before drinking; not recommended for children
- Do not use the maximum daily dose for more than 2 weeks unless directed by a doctor
- Stop use and ask a doctor if symptoms continue beyond 2 weeks
Oral powder
How this form is used
- Arm and Hammer Baking Soda relieves heartburn, sour stomach, acid indigestion, and upset stomach
- Arm and Hammer Baking Soda also temporarily soothes minor skin irritation and itching from poison ivy, oak, sumac, and insect bites when used as a paste, soak, or compress
- Adrian Bicarbonato and D-d Sudium Bicarbonate U.s.p. relieve heartburn, sour stomach, acid indigestion, and upset stomach
- De La Cruz Sodium Bicarbonate Antacid and Dr. Sana Bicarbonato De Sodio relieve heartburn, sour stomach, acid indigestion, and upset stomach
- Arm and Hammer Baking Soda (oral antacid use): dissolve completely in water before drinking; do not swallow dry powder
- Arm and Hammer Baking Soda (skin use): mix with water to form a paste, a compress, or a bath soak; pat skin dry gently after a bath soak
- De La Cruz Sodium Bicarbonate Antacid: dissolve completely in water before drinking; adults under 12 should not use this product
- Follow your product's label for the correct dose for your age group and do not exceed the maximum daily amount
Show 1 more strength Show fewer strengths
Oral solution
How this form is used
- Anti-Empacho relieves heartburn, acid indigestion, sour stomach, and upset stomach
- De La Cruz Desempacho relieves heartburn, sour stomach, acid indigestion, and upset stomach
- EcoDent Ultimate Essential Mouthcare temporarily cleanses minor mouth wounds and soothes minor gum inflammation from dental procedures, dentures, orthodontic appliances, or accidental injury
- De La Cruz Desempacho: shake well before using; adults and children 12 and older take one tablespoon (15 mL) every four hours as needed; consult a doctor for children under 12
- EcoDent Ultimate Essential Mouthcare: swish 2–3 capfuls around the affected area for at least 1 minute, then spit out — do not swallow; use up to 4 times daily
- EcoDent Ultimate Essential Mouthcare: children under 12 should be supervised; consult a dentist or doctor for children under 2
- Do not exceed the recommended daily dose for any oral solution; stop use and see a doctor if symptoms last more than 2 weeks
Topical solution
How this form is used
- After Bite Advanced and After Bite X Tech liquids temporarily relieve minor skin irritation and itching from insect bites and poison ivy, oak, or sumac
- Dermfree Insect Bite Relief liquid temporarily relieves minor skin irritation and itching from insect bites and poison ivy, oak, or sumac
- Apply directly to the affected skin area according to the directions on the product label
- For external use only — do not apply to broken or severely damaged skin without consulting a doctor
Topical cream, ointment or gel
How this form is used
- After Bite Kids cream temporarily relieves minor skin irritation and itching from insect bites and poison ivy, oak, or sumac
- AHHH Bite Relief gel provides rapid relief from bites and stings of deer flies, horse flies, black flies, mosquitoes, bees, wasps, and chiggers, and soothes irritation from rashes and eczema
- Itch Eraser Sensitive cream temporarily relieves minor skin irritation and itching from insect bites and poison ivy, oak, or sumac
- Insect sting relief latex lotion and Insect sting relief pad temporarily relieve irritation and itching from insect bites, stings, and poison ivy, oak, or sumac
- Apply directly to the affected skin area as directed on the product label
- After Bite Kids: for children under 2 years, ask a doctor before use
- Arm and Hammer Baking Soda paste (oral powder used topically): add enough water to form a paste and apply to the affected skin area as needed
Ear drops
Orally disintegrating tablet
📊 Sodium Bicarbonate across the U.S. market
How Sodium Bicarbonate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (16) · Crystal (2) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
📈 How widely Sodium Bicarbonate is used
A general measure of how commonly Sodium Bicarbonate is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Sodium Bicarbonate is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Sodium Bicarbonate prescribed? Of the 1,596 medications we measure, Sodium Bicarbonate ranks #333 by Medicaid prescriptions — more than 79% of them.
Utilization by Sodium Bicarbonate product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
sodium bicarbonate 650 MG Oral Tablet Most dispensed
Summed across the 5 of 63 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198861
50 ML sodium bicarbonate 84 MG/ML Injection
Summed across the 10 of 48 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1868486
sodium bicarbonate 325 MG Oral Tablet
Summed across the 1 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198859
50 ML sodium bicarbonate 84 MG/ML Prefilled Syringe
Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 792582
5 ML sodium bicarbonate 42 MG/ML Injection
Summed across the 2 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1868469
10 ML sodium bicarbonate 84 MG/ML Injection
Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1923484
10 ML sodium bicarbonate 42 MG/ML Injection
Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2198792
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Sodium Bicarbonate, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 22 of 151 listed Sodium Bicarbonate NDCs with Medicaid activity.
🔍 Compare Sodium Bicarbonate products
A representative set of FDA-listed product records for Sodium Bicarbonate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Ear drops | ||||
| 5 g/100 mL | Auricular (otic) | Marie's Original Formulas LLC | OTC MONOGRAPH DRUG | View NDC → |
| 💊Injection | ||||
| 84 mg/mL | Intravenous | A-S Medication Solutions × 2 listings | ANDA | View NDC → |
| 84 mg/mL | Intravenous | A-S Medication Solutions | UNAPPROVED DRUG OTHER | View NDC → |
| 12.6 mg/mL | Intravenous | Amneal Pharmaceuticals Private Limited | NDA | View NDC → |
| 84 mg/mL | Intravenous | Amneal Pharmaceuticals Private Limited | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Anthea Pharma Private Limited | ANDA | View NDC → |
| 12.6 mg/mL | Intravenous | Baxter Healthcare Corporation | NDA | View NDC → |
| 84 mg/mL | Intravenous | Bryant Ranch Prepack | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Civica × 3 listings | ANDA | View NDC → |
| 25 kg/25 kg | — | Emnar Pharma Private Limited | BULK INGREDIENT | View NDC → |
| 42 mg/mL | Intravenous | Exela Pharma Sciences, LLC | ANDA | View NDC → |
| 75 mg/mL | Intravenous | Exela Pharma Sciences, LLC | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Exela Pharma Sciences, LLC × 4 listings | ANDA | View NDC → |
| 42 mg/mL | Intravenous | Fresenius Kabi USA, LLC | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Fresenius Kabi USA, LLC | ANDA | View NDC → |
| 42 mg/mL | Intravenous | Fresensius Kabi USA, LLC | UNAPPROVED DRUG OTHER | View NDC → |
| 84 mg/mL | Intravenous | Fresensius Kabi USA, LLC | UNAPPROVED DRUG OTHER | View NDC → |
| 42 mg/mL | Intravenous | General Injectables & Vaccines, Inc | UNAPPROVED DRUG OTHER | Find on DailyMed ↗ |
| 84 mg/mL | Intravenous | General Injectables & Vaccines, Inc | UNAPPROVED DRUG OTHER | Find on DailyMed ↗ |
| 42 mg/mL | Intravenous | General Injectables & Vaccines, Inc. × 2 listings | ANDA | View NDC → |
| 75 mg/mL | Intravenous | General Injectables & Vaccines, Inc. | UNAPPROVED DRUG OTHER | Find on DailyMed ↗ |
| 84 mg/mL | Intravenous | General Injectables and Vaccines, Inc. × 2 listings | UNAPPROVED DRUG OTHER | View NDC → |
| 84 mg/mL | Intravenous | Glenmark Pharmaceuticals Inc., USA | ANDA | View NDC → |
| 42 mg/mL | Intravenous | Henry Schein, Inc. × 4 listings | ANDA | View NDC → |
| 42 mg/mL | Intravenous | Henry Schein, Inc. | UNAPPROVED DRUG OTHER | View NDC → |
| 75 mg/mL | Intravenous | Henry Schein, Inc. | UNAPPROVED DRUG OTHER | View NDC → |
| 75 mg/mL | Intravenous | Henry Schein, Inc. | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Henry Schein, Inc. × 3 listings | UNAPPROVED DRUG OTHER | View NDC → |
| 84 mg/mL | Intravenous | Henry Schein, Inc. | ANDA | View NDC → |
| 42 mg/mL | Intravenous | HF Acquisition Co LLC, DBA HealthFirst × 3 listings | ANDA | View NDC → |
| 42 mg/mL | Intravenous | HF Acquisition Co LLC, DBA HealthFirst × 2 listings | UNAPPROVED DRUG OTHER | View NDC → |
| 84 mg/mL | Intravenous | HF Acquisition Co LLC, DBA HealthFirst × 3 listings | ANDA | View NDC → |
| 84 mg/mL | Intravenous | HF Acquisition Co LLC, DBA HealthFirst × 5 listings | UNAPPROVED DRUG OTHER | View NDC → |
| 42 mg/mL | Intravenous | Hospira, Inc. × 8 listings | ANDA | View NDC → |
| 75 mg/mL | Intravenous | Hospira, Inc. | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Hospira, Inc. × 7 listings | ANDA | View NDC → |
| 84 mg/mL | Intravenous | International Medication Systems, Limited | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Medical Purchasing Solutions, LLC × 7 listings | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Medical Purchasing Solutions, LLC × 2 listings | UNAPPROVED DRUG OTHER | View NDC → |
| 84 mg/mL | Intravenous | Medical Purchasing Solutions, LLC. | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Milla Pharmaceuticals Inc. | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Northstar Rx Llc | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Omnivium Pharmaceuticals Llc. | ANDA | View NDC → |
| 84 mg/mL | Intravenous | ProPharma Distribution × 2 listings | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Remedyrepack Inc. × 2 listings | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Steriscience Specialties Private Limited × 2 listings | ANDA | View NDC → |
| 84 mg/mL | Intravenous | Sun Pharmaceutical Industries Limited | ANDA | View NDC → |
| 💊Oral powder | ||||
| 1 g/g | Oral | Church & Dwight Co., Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 2.6 g/2.6 g | Oral | DLC Laboratories, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 2.6 g/2.6 g | Oral | DLC Laboratories, Inc. × 2 listings | OTC MONOGRAPH FINAL | View NDC → |
| 315 mg/g | Oral | Evi Labs × 3 listings | OTC MONOGRAPH DRUG | View NDC → |
| 616 mg/g | Oral | Evi Labs | OTC MONOGRAPH DRUG | View NDC → |
| 1000 mg/g | Oral | Humco Holding Group, Inc | OTC MONOGRAPH DRUG | View NDC → |
| 1000 mg/g | Oral | Humco Holding Group, Inc | OTC MONOGRAPH FINAL | View NDC → |
| 1000 mg/g | Oral | Humco Holding Group, Inc. × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 1000 mg/g | Oral | Humco Holding Group, Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 2.616 g/2.616 g | Oral | Menper Distributors Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 1.02 g/5 g | Oral | Neobourne Pharma Lp | OTC MONOGRAPH FINAL | View NDC → |
| 2.6 g/2.6 g | Oral | Pharmadel LLC | OTC MONOGRAPH DRUG | View NDC → |
| 2.6 g/2.6 g | Oral | Pharmadel LLC | OTC MONOGRAPH FINAL | View NDC → |
| 1000 mg/g | Oral | Pharma Nobis, LLC | OTC MONOGRAPH DRUG | View NDC → |
| 1000 mg/g | Oral | Pharma Nobis, LLC | OTC MONOGRAPH FINAL | View NDC → |
| 2.6 g/2.6 g | Oral | Vitamex USA, Corp | OTC MONOGRAPH DRUG | View NDC → |
| 2.6 g/2.6 g | Oral | World Perfumes Inc | OTC MONOGRAPH DRUG | View NDC → |
| 2.6 g/2.6 g | Oral | World Perfumes Inc × 2 listings | OTC MONOGRAPH FINAL | View NDC → |
| 💊Oral solution | ||||
| 1 g/g | Oral | Church & Dwight Co., Inc. × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 1 g/g | Oral | Church & Dwight Co., Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 525 mg/15 mL | Oral | Dlc Laboratories, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 525 mg/15 mL | Oral | Dlc Laboratories, Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 25 mg/mL | Oral | Lotus Brands, Inc. × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 25 mg/mL | Oral | Lotus Brands, Inc. × 2 listings | OTC MONOGRAPH NOT FINAL | View NDC → |
| 525 mg/15 mL | Oral | Menper Distributors, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 525 mg/15 mL | Oral | Menper Distributors, Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 💊Tablet | ||||
| 650 mg | Oral | Advanced Rx LLC | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | Aphena Pharma Solutions - Tennessee, LLC | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | Aphena Pharma Solutions - Tennessee, LLC × 3 listings | OTC MONOGRAPH FINAL | View NDC → |
| 650 mg | Oral | Aphena Pharma Solutions - Tennessee, LLC | OTC MONOGRAPH NOT FINAL | Find on DailyMed ↗ |
| 650 mg | Oral | Apnar Pharma Lp | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | Apnar Pharma Lp | OTC MONOGRAPH FINAL | View NDC → |
| 6 [hp_X]/60 mg | Oral | BM Private Limited | UNAPPROVED HOMEOPATHIC | View NDC → |
| 650 mg | Oral | Bryant Ranch Prepack | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | Bryant Ranch Prepack × 2 listings | OTC MONOGRAPH FINAL | View NDC → |
| 650 mg | Oral | Cardinal Health | UNAPPROVED DRUG OTHER | View NDC → |
| 650 mg | Oral | Cardinal Health 107, LLC × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | Cardinal Health 107, LLC | UNAPPROVED DRUG OTHER | View NDC → |
| 325 mg | Oral | CitraGen Pharmaceuticals Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 325 mg | Oral | CitraGen Pharmaceuticals Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 650 mg | Oral | CitraGen Pharmaceuticals Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | CitraGen Pharmaceuticals Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 650 mg | Oral | Gendose Pharmaceuticals, LLC × 3 listings | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | Gendose Pharmaceuticals, LLC | OTC MONOGRAPH NOT FINAL | View NDC → |
| 650 mg | Oral | Geri-Care Pharmaceutical Corp | OTC MONOGRAPH FINAL | View NDC → |
| 325 mg | Oral | Graxcell Pharmaceutical, Llc × 2 listings | OTC MONOGRAPH NOT FINAL | View NDC → |
| 650 mg | Oral | Graxcell Pharmaceutical, Llc | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | Graxcell Pharmaceutical, Llc | OTC MONOGRAPH NOT FINAL | View NDC → |
| 650 mg | Oral | Ingenus Pharmaceuticals NJ, LLC × 2 listings | OTC MONOGRAPH FINAL | View NDC → |
| 650 mg | Oral | Major Pharmaceuticals | OTC MONOGRAPH DRUG | View NDC → |
| 650 mg | Oral | Major Pharmaceuticals | OTC MONOGRAPH FINAL | View NDC → |
| 325 mg | Oral | Marlex Pharmaceuticals Inc | OTC MONOGRAPH NOT FINAL | View NDC → |
| 650 mg | Oral | Marlex Pharmaceuticals Inc | OTC MONOGRAPH NOT FINAL | View NDC → |
| 650 mg | Oral | NCS HealthCare of KY, LLC dba Vangard Labs | OTC MONOGRAPH DRUG | View NDC → |
| 325 mg | Oral | Richmond Pharmaceuticals, Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 650 mg | Oral | Richmond Pharmaceuticals, Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 650 mg | Oral | Rising Pharmaceuticals, Inc. × 3 listings | OTC MONOGRAPH FINAL | View NDC → |
| 650 mg | Oral | Rising Pharma Holdings, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 💊Topical cream, ointment or gel | ||||
| 5 g/25 g | Topical | 78271 | OTC MONOGRAPH DRUG | View NDC → |
| 1 g/20 g | Topical | Adventure Ready Brands | OTC MONOGRAPH DRUG | View NDC → |
| 0.05 g | Topical | Cosmuses Cosmetics (Ningbo) Co., Ltd. | OTC MONOGRAPH DRUG | View NDC → |
| 5 g/100 g | Topical | Cosmuses Cosmetics (Ningbo) Co., Ltd. | OTC MONOGRAPH DRUG | View NDC → |
| 1.04 g/20 g | Topical | Tender Corporation d/b/a Adventure Ready Brands × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 💊Topical solution | ||||
| 50 mg/1000 mL | Topical | Adventure Ready Brands | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg/1000 mL | Topical | Adventure Ready Brands | OTC MONOGRAPH FINAL | View NDC → |
| 50 mg/mL | Topical | Adventure Ready Brands × 3 listings | OTC MONOGRAPH FINAL | View NDC → |
| 5 g/100 g | Topical | Tender Corporation | OTC MONOGRAPH FINAL | Find on DailyMed ↗ |
| 0.7 g/14 g | Topical | Tender Corporation d/b/a Adventure Ready Brands | OTC MONOGRAPH DRUG | View NDC → |
| 5 g/100 mL | Topical | Wenzhou Yuyuan Pharmaceutical Co., Ltd. | OTC MONOGRAPH DRUG | View NDC → |
| 💊Bulk drug substance | ||||
| 1 kg/kg | — | Alivus Life Sciences Limited | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Avantor Performance Materials, LLC | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Church & Dwight Co., Inc. × 9 listings | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Gulkas Pharma Private Limited | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Huber Soda, LLC (DBA Natrium Products) × 2 listings | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Maithri Drugs Private Limited | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Spectrum Laboratory Products, Inc. | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | WE Soda Alkali LLC × 2 listings | BULK INGREDIENT | View NDC → |
Showing 200 of 221 products — FDA National Drug Code Directory. See every product, package size and price: browse all 221 Sodium Bicarbonate NDCs →
📈 What people report — real-world data (FDA FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Sodium Bicarbonate — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Sodium Bicarbonate in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ The road to your pharmacy
How Sodium Bicarbonate went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 36676 10 dose forms · 30 strengths
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Dose form (SCDF) Cartridge RxCUI 1868481No current FDA listingClinical drug / strength (SCD) 0.1 ML sodium bicarbonate 84 MG/MLRxCUI 27137961.7 ML sodium bicarbonate 84 MG/MLRxCUI 18684822.7 ML sodium bicarbonate 84 MG/MLRxCUI 1868485 -
Dose form (SCDF) Injectable Solution RxCUI 373896In current FDA listingsClinical drug / strength (SCD) 0.15 MEQ/MLRxCUI 4134240.167 MEQ/MLRxCUI 10092350.326 MEQ/MLRxCUI 10092370.595 MEQ/MLRxCUI 1009241 -
Dose form (SCDF) Injection RxCUI 1868187In current FDA listingsClinical drug / strength (SCD) 5 ML sodium bicarbonate 40 MG/MLRxCUI 3129735 ML sodium bicarbonate 42 MG/MLRxCUI 186846910 ML sodium bicarbonate 42 MG/MLRxCUI 219879210 ML sodium bicarbonate 84 MG/MLRxCUI 192348450 ML sodium bicarbonate 75 MG/MLRxCUI 80728450 ML sodium bicarbonate 84 MG/MLRxCUI 1868486100 ML sodium bicarbonate 84 MG/MLRxCUI 22630781000 ML sodium bicarbonate 12.6 MG/MLRxCUI 2747138 -
Dose form (SCDF) Mouthwash RxCUI 1425558No current FDA listingClinical drug / strength (SCD) 0.298 MEQ/MLRxCUI 1425559 -
Dose form (SCDF) Oral Capsule RxCUI 379272No current FDA listingClinical drug / strength (SCD) 500 MGRxCUI 104021 -
Dose form (SCDF) Oral Solution RxCUI 373897In current FDA listings -
Dose form (SCDF) Oral Tablet RxCUI 373899In current FDA listings -
Dose form (SCDF) Powder for Oral Solution RxCUI 2105954In current FDA listingsClinical drug / strength (SCD) 2600 MGRxCUI 1488624 -
Dose form (SCDF) Prefilled Syringe RxCUI 727994No current FDA listingClinical drug / strength (SCD) 10 ML sodium bicarbonate 42 MG/MLRxCUI 186847310 ML sodium bicarbonate 84 MG/MLRxCUI 79257750 ML sodium bicarbonate 75 MG/MLRxCUI 72799550 ML sodium bicarbonate 84 MG/MLRxCUI 792582 -
Dose form (SCDF) Topical Solution RxCUI 1547233In current FDA listingsClinical drug / strength (SCD) 50 MG/MLRxCUI 1547234
Look up RxCUI 36676 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Supply & shortage status
Whether Sodium Bicarbonate is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏷️ Sold under these brand names
🏭 Manufacturers & labelers
…and 16 more on the FDA NDC directory.
RxNorm drug class
Sodium Bicarbonate belongs to the Salt solutions class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Where this comes from
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 46 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Cardinal Health 107, LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.