Sodium Bicarbonate Injection shortage
Sodium Bicarbonate Injection is currently listed in shortage by the FDA. The FDA lists 15 affected products. The reported reason: Other; Demand increase for the drug. This page was last refreshed from FDA data on Oct 2, 2026.
Sodium bicarbonate injection has been in shortage for over a year, with the 75 mg/mL strength currently having no available source. Other strengths remain listed by several manufacturers not reporting a shortage.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Sodium Bicarbonate Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Oct 1, 2026Currently in shortage15 of 15 products affected.
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Sep 22, 2026FDA refreshed this shortage record4 products updated.
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Sep 16, 2026FDA refreshed this shortage record1 product updated.
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Sep 15, 2026FDA refreshed this shortage record2 products updated.
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Nov 7, 2025FDA refreshed this shortage record4 products updated.
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Nov 7, 2025More presentations reported4 more products added to the shortage.
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Jul 24, 2017More presentations reported5 more products added to the shortage.
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Mar 1, 2017First reported to the FDA6 products first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Amphastar Pharmaceuticals, Inc. 📞 800-423-4136 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Sodium Bicarbonate, Injection, 84 mg/1 mL (NDC 76329-3352-1) | — | Limited Availability | Available on allocation | Demand increase for the drug |
Manufacturer: Exela Pharma Sciences, LLC 📞 828-758-5474 ext. 154 3 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Sodium Bicarbonate, Injection, 42 mg/1 mL (NDC 51754-5012-4) | — | Available | — | — |
| Current | Sodium Bicarbonate, Injection, 84 mg/1 mL (NDC 51754-5011-4) | — | Available | — | — |
| Current | Sodium Bicarbonate, Injection, 84 mg/1 mL (NDC 51754-5001-5) | — | Available | — | — |
Manufacturer: Fresenius Kabi USA, LLC 📞 888-386-1300 2 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Sodium Bicarbonate, Injection, 84 mg/1 mL (NDC 63323-089-50) | — | Available | Check wholesalers for inventory | — |
| Current | Sodium Bicarbonate, Injection, 42 mg/1 mL (NDC 63323-083-05) | — | Available | Check wholesalers for inventory. | — |
Manufacturer: Hospira, Inc., a Pfizer Company 📞 844-646-4398 8 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Sodium Bicarbonate, Injection, 2.5 mEq/5 mL (4.2%, 0.5 mEq/mL) (NDC 0409-5555-02) | — | Limited Availability | Limited Supply Available. Next Delivery: October 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay | Other |
| Current | Sodium Bicarbonate, Injection, 50 mEq/50 mL (8.4%, 1 mEq/mL) (NDC 0409-6625-35) | — | Unavailable | Next Delivery: January 2027; Estimated Recovery: March 2027; Shortage per Manufacturer: Manufacturing Delay | Other |
| Current | Sodium Bicarbonate, Injection, 2.5 mEq/5 mL (4.2%, 0.5 mEq/mL) (NDC 0409-5555-01) | — | Limited Availability | Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay | Other |
| Current | Sodium Bicarbonate, Injection, 50 mEq/50 mL (8.4%, 1 mEq/mL) (NDC 0409-6625-14) | — | Available | — | — |
| To Be Discontinued | Sodium Bicarbonate, Injection, 84 mg/1 mL (NDC 0409-6637-14) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Sodium Bicarbonate, Injection, 84 mg/1 mL (NDC 0409-4900-14) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Sodium Bicarbonate, Injection, 42 mg/1 mL (NDC 0409-5534-14) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Sodium Bicarbonate, Injection, 75 mg/1 mL (NDC 0409-4916-14) | — | — | Discontinuation of the manufacture of the drug | — |
Manufacturer: Long Grove Pharmaceuticals LLC 📞 833-268-5559 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| Current | Sodium Bicarbonate, Injection, 84 mg/1 mL (NDC 81298-7620-3) | — | Available | — | — |
These rows are manufacturer reports to the FDA for Sodium Bicarbonate Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Sodium Bicarbonate Injection? options further down this page.
Why is Sodium Bicarbonate Injection in shortage?
Sodium Bicarbonate Injection is on the shortage list for a couple of reasons, depending on which manufacturer and product you're looking at. For Amphastar, their 84 mg/1 mL version has limited availability because more people need it than they can fully supply right now — it's being distributed on an allocation basis. For Hospira (a Pfizer company), the situation is more complex: they've permanently stopped making several of their specific package sizes — the 75 mg/1 mL, certain 84 mg/1 mL vials, and the 42 mg/1 mL. On top of that, two of their remaining products are being delayed at the factory. Their 50 mEq/50 mL (8.4%) large vial is currently unavailable, with the next delivery expected January 2027 and a recovery estimated by March 2027. Their 2.5 mEq/5 mL (4.2%) smaller vial has limited supply, with one package size expecting delivery by October 2026 (recovery December 2026) and another not until May 2027 (recovery June 2027). Notably, Hospira's 50 mEq/50 mL (8.4%) in a different package size is currently still available.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Sodium Bicarbonate Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Sodium Bicarbonate Injection?
Sodium Bicarbonate Injection is currently on the FDA shortage list. Because this is a hospital and clinic injection managed by your care team, I want to walk you through what the data shows so you know where things stand.
Most strengths still have at least one manufacturer reporting available supply. The 42 mg/1 mL, 84 mg/1 mL, 1 mEq/mL, and 0.5 mEq/mL strengths each have an available source right now, though some are listed as limited or on allocation. The one strength with no available source at this time is 75 mg/1 mL, which a manufacturer has reported discontinuing.
The reported reasons are increased demand and other supply factors, and this situation has lasted more than a year. All five manufacturers on this record are still reporting supply for at least some strengths, and a few list expected recovery dates in late 2026 and 2027.
Here is what I suggest:
- Do not stop, skip, or change any dose on your own.
- If your strength still has supply, ask your pharmacy or care team to order it — they can check wholesalers and other manufacturers.
- The same medicine (84 mg/mL) is listed from several other makers; your pharmacy may be able to source one, though it may not be in local stock.
- If your exact strength is discontinued or cannot be found, ask your prescriber or pharmacist about options, such as a different strength or a clinician-chosen alternative.
Manufacturer contact numbers are listed on this page for reference; pharmacies usually handle those calls. This is national, manufacturer-reported data and may not match local stock.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Sodium Bicarbonate Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Sodium Bicarbonate Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Sodium Bicarbonate | SODIUM BICARBONATE 84 mg/mL | Injection, Solution · Intravenous | A-S Medication Solutions | 50090-0530-00 |
| Sodium Bicarbonate | SODIUM BICARBONATE 84 mg/mL | Injection, Solution · Intravenous | Exela Pharma Sciences, LLC | 51754-5001-04 |
| Sodium Bicarbonate | SODIUM BICARBONATE 84 mg/mL | Injection, Solution · Intravenous | Glenmark Pharmaceuticals Inc., USA | 68462-0951-65 |
| Sodium Bicarbonate | SODIUM BICARBONATE 84 mg/mL | Injection, Solution · Intravenous | Sun Pharmaceutical Industries Limited | 70095-0050-03 |
| Sodium Bicarbonate | SODIUM BICARBONATE 84 mg/mL | Injection · Intravenous | REMEDYREPACK INC. | 70518-4158-00 |
| Sodium Bicarbonate | SODIUM BICARBONATE 84 mg/mL | Injection, Solution · Intravenous | Bryant Ranch Prepack | 72162-2314-02 |
| Sodium Bicarbonate | SODIUM BICARBONATE 84 mg/mL | Injection, Solution · Intravenous | Civica | 72572-0740-20 |
| Sodium Bicarbonate | SODIUM BICARBONATE 84 mg/mL | Injection, Solution · Intravenous | OMNIVIUM PHARMACEUTICALS LLC. | 81665-0200-05 |
Alternative dosage forms of Sodium Bicarbonate
A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:
Therapeutic equivalents & pricing 30 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Sodium Bicarbonate 84 mg/mL | Exela | 25 vials | $0.154 | AP | Availability likely |
| Sodium Bicarbonate 84 mg/mL | Glenmark | 25 vials | $0.154 | AP | Availability likely |
| Sodium Bicarbonate 84 mg/mL | Hospira, | 25 vials | $0.154 | AP | Availability likely |
| Sodium Bicarbonate 84 mg/mL | Sun | 25 vials | $0.154 | AP | Availability likely |
| Sodium Bicarbonate 84 mg/mL | Exela | 25 vials | $0.154 | AP | Availability likely |
| Sodium Bicarbonate 84 mg/mL | NORTHSTAR | 25 vials | $0.154 | AP | Discontinued |
| Sodium Bicarbonate 84 mg/mL | Fresenius | 25 vials | $0.154 | AP | Availability likely |
| Sodium Bicarbonate 84 mg/mL | OMNIVIUM | 20 vials | $0.159 | AP | Availability likely |
| Sodium Bicarbonate 84 mg/mL | Civica | 20 vials | $0.159 | AP | Availability likely |
| Sodium Bicarbonate 84 mg/mL | Hospira, | 1 syringe | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | HF | 1 syringe | — | — | FDA listed |
| Sodium Bicarbonate 84 mg/mL | HF | 1 syringe | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | REMEDYREPACK | 1 syringe | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Medical | 1 syringe | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Medical | 1 syringe | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | International | 1 syringe | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | ProPharma | 50 ml | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Exela | 25 vials | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Medical | 1 vial | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | A-S | 50 ml | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | A-S | 1 vial | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Medical | 1 vial | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Anthea | 20 vials | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Henry | 1 vial | — | — | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Steriscience | 20 vials | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | ProPharma | 50 ml | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | HF | 50 ml | — | — | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Medical | 1 vial | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Medical | 1 vial | — | AP | FDA listed |
| Sodium Bicarbonate 84 mg/mL | Bryant | 20 vials | — | AP | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Sodium Bicarbonate Injection — that fall in the same broad treatment class (bicarbonate producing/containing agents) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other endocrinology/metabolism, gastroenterology, pediatric shortages
Sodium Bicarbonate Injection shortage FAQs
Is Sodium Bicarbonate Injection in shortage?
Why is Sodium Bicarbonate Injection in shortage?
Which products are affected?
When will Sodium Bicarbonate Injection be available again?
Can I still get Sodium Bicarbonate somewhere?
What should I do if I take Sodium Bicarbonate Injection?
Still have a question about the Sodium Bicarbonate Injection shortage?
Ask a pharmacist about this shortage →View Sodium Bicarbonate Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.