SODIUM BICARBONATE 84 mg/mL Injection, Solution
Other active recalls for Sodium Bicarbonate (different manufacturers) — 5 · tap to view
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Salt solutions class.
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
Sodium bicarbonate is used to treat metabolic acidosis (when too much acid builds up in your body fluids). Sodium bicarbonate is in a class of medications called alkalinizing agents. It works by providing bicarbonate to balance the effects of acidosis in the body.
Read the full MedlinePlus article ↗- Sodium bicarbonate antacids work fast for occasional heartburn, but they're not meant for daily long-term use on your own. Most labels say not to use the maximum dose for more than...
- Can I use this for my heartburn every day?
- The active ingredient is the same — sodium bicarbonate. Products like Arm and Hammer Baking Soda are actually FDA-labeled for both antacid use and skin soaks or compresses for irri...
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Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Sodium Bicarbonate (OTC Drug) — tap one for details:
Sodium Bicarbonate (OTC Drug) may be associated with lower levels of 4 nutrients — worth a chat with your pharmacist, not a cause for alarm.
Where does this data come from?
Ask a licensed pharmacist directly — free, answered by our team.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII 142M471B3J
Carbon dioxide is a colorless gas used in medicines as a propellant in pressurized inhalers and aerosol sprays to help deliver the active medication to where it's needed.
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UNII N762921K75
A colorless, odorless gas that makes up most of the air we breathe. In medicines, it's used as a packaging gas or propellant to protect products from oxidation and maintain freshness.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
3 inactive ingredients listed in the exact product block matched to this NDC.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
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Can inactive ingredients matter?
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.154 | $192.50 / 1250 ml |
| Medicaid paysCMS SDUD · 12 mo | $0.2632 | $329.00 / 1250 ml |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Sodium Bicarbonate 84 mg/mL 72572-0740-20 | Civica | 20 vials | $0.154 | AP | Availability likely | +0% |
| Sodium Bicarbonate 84 mg/mL 81298-7620-03 | Long | 20 vials | $0.154 | AP | Availability likely | +0% |
| Sodium Bicarbonate 84 mg/mL 81665-0200-05 | OMNIVIUM | 20 vials | $0.154 | AP | Availability likely | +0% |
| Sodium Bicarbonate 84 mg/mL 00409-6625-14 | Hospira, | 25 vials | $0.154 | AP | Availability likely | — |
| Sodium Bicarbonate 84 mg/mL 51754-5001-04 | Exela | 25 vials | $0.154 | AP | Availability likely | — |
| Sodium Bicarbonate 84 mg/mL 51754-8888-04 | Exela | 25 vials | $0.154 | AP | Availability likely | — |
| Sodium Bicarbonate 84 mg/mL 63323-0089-50 | Fresenius | 25 vials | $0.154 | AP | Availability likely | — |
| Sodium Bicarbonate 84 mg/mLthis 68462-0951-65 | Glenmark | 25 vials | $0.154 | AP | Availability likely | — |
| Sodium Bicarbonate 84 mg/mL 70095-0050-03 | Sun | 25 vials | $0.154 | AP | Availability likely | — |
| Sodium Bicarbonate 84 mg/mL 72603-0209-25 | NORTHSTAR | 25 vials | $0.154 | AP | Discontinued | — |
| Sodium Bicarbonate 84 mg/mL 00404-9980-50 | Henry | 1 vial | — | — | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 50090-0530-00 | A-S | 50 ml | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 50090-6813-00 | A-S | 1 vial | — | AP | FDA listed | — |
| 8.4% Sodium Bicarbonate 84 mg/mL 51662-1256-01 | HF | 50 ml | — | — | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 51662-1573-01 | HF | 50 ml | — | — | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 71872-7247-01 | Medical | 1 vial | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 71872-7310-01 | Medical | 1 vial | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 71872-7371-01 | Medical | 1 vial | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 71872-7376-01 | Medical | 1 vial | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 72162-2314-02 | Bryant | 20 vials | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 80830-2305-02 | Amneal | 25 vials | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 82449-0000-05 | Steriscience | 20 vials | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 83854-0001-20 | Anthea | 20 vials | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 84549-0050-03 | ProPharma | 50 ml | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 51754-5011-04 | Exela | 25 vials | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 76329-3352-01 | International | 1 syringe | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 71872-7097-01 | Medical | 1 syringe | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 71872-7266-01 | Medical | 1 syringe | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 84549-0352-01 | ProPharma | 50 ml | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 70518-4158-00 | REMEDYREPACK | 1 syringe | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 51662-1383-01 | HF | 1 syringe | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 51662-1255-01 | HF | 1 syringe | — | — | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 00409-6637-14 | Hospira, | 1 syringe | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 71357-0004-10 | Milla | 10 vials | — | AP | FDA listed | — |
| Sodium Bicarbonate 84 mg/mL 51754-8020-04 | Exela | 25 vials | — | AP | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
🗺️ Medicaid utilization & spend
📊 Medicare Part D spend CMS · PART D · 2026 (Q1)
🔬 Reported adverse events (FAERS)
Top reported reactions
Age at onset
Reporter sex
Serious outcomes
Where does this data come from?
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 68462-0951-65 You're viewing this | 25 VIAL in 1 CARTON (68462-951-65) / 50 mL in 1 VIAL (68462-951-50) | 2025-08-07 | Active |
📄 Full prescribing information FDA SPL
🎯 Indications and Usage ▾
CONTRAINDICATIONS Sodium bicarbonate injection is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction, and in patients receiving diuretics known to produce a hypochloremic alkalosis.
⛔ Contraindications ▾
WARNINGS Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention. In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention. The intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema.
Extravascular infiltration should be avoided, see ADVERSE REACTIONS .
⚠️ Warnings ▾
PRECAUTIONS General Do not use unless solution is clear and the container or seal is intact. Discard unused portion. The potentially large loads of sodium given with bicarbonate require that caution be exercised in the use of sodium bicarbonate in patients with congestive heart failure or other edematous or sodium-retaining states, as well as in patients with oliguria or anuria.
See table in HOW SUPPLIED section for amount of sodium present in the solution. Caution must be exercised in the administration of parenteral fluids, especially those containing sodium ions, to patients receiving corticosteroids or corticotropin. Potassium depletion may predispose to metabolic alkalosis and coexistent hypocalcemia may be associated with carpopedal spasm as the plasma pH rises.
These dangers can be minimized if such electrolyte imbalances are appropriately treated prior to or concomitantly with bicarbonate infusion. Laboratory Tests The aim of all bicarbonate therapy is to produce a substantial correction of the low total CO 2 content and blood pH, but the risks of overdosage and alkalosis should be avoided. Hence, repeated fractional doses and periodic monitoring by appropriate laboratory tests are recommended to minimize the possibility of overdosage.
Drug Interactions Additives may be incompatible; norepinephrine and dobutamine are incompatible with sodium bicarbonate solution. The addition of sodium bicarbonate to parenteral solutions containing calcium should be avoided, except where compatibility has been previously established. Precipitation or haze may result from sodium bicarbonate-calcium admixtures.
NOTE: Do not use the injection if it contains precipitate. Additives may be incompatible. Consult with pharmacist, if available.
When introducing additives, consult with pharmacist, if available. When introducing additives, use aseptic technique, mix thoroughly and do not store. Pregnancy: Teratogenic Effects.
Animal reproduction studies have not been conducted with sodium bicarbonate. It is also not known whether sodium bicarbonate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sodium bicarbonate should be given to a pregnant woman only if clearly needed.
Pediatric Rapid injection (10 mL/min) of hypertonic sodium bicarbonate injection solutions into neonates and children under two years of age may produce hypernatremia, a decrease in cerebrospinal fluid pressure and possible intracranial hemorrhage. The rate of administration in such patients should therefore be limited to no more than 8 mEq/kg/day. A 4.2% solution may be preferred for such slow administration.
In emergencies such as cardiac arrest, the risk of rapid infusion must be weighed against the potential for fatality due to acidosis. Geriatric Clinical studies of sodium bicarbonate injection did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.
🤒 Adverse Reactions ▾
OVERDOSAGE Should alkalosis result, the bicarbonate should be stopped and the patient managed according to the degree of alkalosis present. 0.9% sodium chloride injection intravenous may be given; potassium chloride also may be indicated if there is hypokalemia. Severe alkalosis may be accompanied by hyperirritability or tetany and these symptoms may be controlled by calcium gluconate.
An acidifying agent such as ammonium chloride may also be indicated in severe alkalosis. See WARNINGS and PRECAUTIONS .
🆘 Overdosage ▾
HOW SUPPLIED Sodium bicarbonate injection, USP is supplied in the following dosage form: NDC Code: Conc % mg/mL (NaHC3) mEq/mL (Na+) mEq/mL (HCO3) mEq/ Container size (mL) mOsmol 68462-951-50 (vial) 68462-951-65 (25 vials per carton) 8.4 84 1 1 50/50 2/mL The 50 mL sodium bicarbonate injection vials are supplied as 25 vials per carton, with a single package insert. Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat.
Protect from freezing. Store at 20°C to 25°C (68°F to 77°F). [See USP Controlled Room Temperature.] Distributed by: Glenmark Pharmaceuticals Inc., USA Elmwood Park, NJ 07407 Questions? 1 (888) 721-7115 www.glenmarkpharma-us.com Manufactured by: Anthea Pharma Private Limited Hyderabad, 502307, INDIA August 2025 logo
🧬 Clinical Pharmacology ▾
INDICATIONS AND USAGE Sodium bicarbonate injection is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of hemoglobin and its breakdown products.
Sodium bicarbonate also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Treatment of metabolic acidosis should, if possible, be superimposed on measures designed to control the basic cause of the acidosis - e.g., insulin in uncomplicated diabetes, blood volume restoration in shock. But since an appreciable time interval may elapse before all of the ancillary effects are brought about, bicarbonate therapy is indicated to minimize risks inherent to the acidosis itself.
Vigorous bicarbonate therapy is required in any form of metabolic acidosis where a rapid increase in plasma total CO 2 content is crucial - e.g., cardiac arrest, circulatory insufficiency due to shock or severe dehydration, and in severe primary lactic acidosis or severe diabetic acidosis.
📋 Description ▾
CLINICAL PHARMACOLOGY Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis. Sodium bicarbonate in water dissociates to provide sodium (Na + ) and bicarbonate (HCO 3 - ) ions. Sodium (Na + ) is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances.
Bicarbonate (HCO 3 - ) is a normal constituent of body fluids and the normal plasma level ranges from 24 to 31 mEq/liter. Plasma concentration is regulated by the kidney through acidification of the urine when there is a deficit or by alkalinization of the urine when there is an excess. Bicarbonate anion is considered "labile" since at a proper concentration of hydrogen ion (H+) it may be converted to carbonic acid (H 2 CO 3 ) and thence to its volatile form, carbon dioxide (CO 2 ) excreted by the lung.
Normally a ratio of 1:20 (carbonic acid: bicarbonate) is present in the extracellular fluid. In a healthy adult with normal kidney function, practically all the glomerular filtered bicarbonate ion is reabsorbed; less than 1% is excreted in the urine.