Drug-induced nutrient depletion

Medications That May Deplete CHROMIUM

See which medications carry a reported association, how strong the evidence is, and what to discuss with your pharmacist.

58Medications
58Depletion records
About CHROMIUM

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, but results are mixed and the effect on weight loss is small and uncertain. For most healthy people who eat a varied diet, supplements are not needed; check with your pharmacist or doctor before starting.

Commonly used for: Blood sugar support in type 2 diabetes, Weight loss and appetite control, Insulin sensitivity, Cholesterol and lipid support, General nutritional supplement.

HelloPharmacist pharmacist-reviewed education. The medication records below are licensed clinical data, shown as published.

Deep dive: Chromium — uses, safety & drug interactions

The evidence

Medications associated with CHROMIUM depletion

Each record is shown as published in our licensed clinical database. Open a medication for its full nutrient report.

Brand names include Dymista

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Azelastine Hydrochloride, Fluticasone Propionate? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Fluticasone is a corticosteroid, and one thing corticosteroids are known to do is cause the kidneys to flush more chromium out through urine than they normally would. Chromium is a mineral your body uses to help insulin work properly and keep blood sugar steady, so losing more of it over time is worth paying attention to. Because this is rated as moderate depletion, long-term users of this medication have a reasonable reason to bring it up with their pharmacist or doctor, especially if blood sugar changes are a concern.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Azelastine Hydrochloride, Fluticasone Propionate →

Beclometasone dipropionate

Moderate Depletion

Brand names include Becotide

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Beclometasone dipropionate? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Beclometasone dipropionate is a corticosteroid, and corticosteroids can cause the kidneys to flush more chromium out in the urine than normal, which over time may nudge levels lower. The rating here is moderate, so this is a real enough concern that some long-term users may need a supplement. If you use this medication regularly, it is worth asking your pharmacist or doctor whether your chromium status should be checked.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Beclometasone dipropionate →

Beclomethasone

Moderate Depletion

Brand names include Beclovent, Vanceril

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Beclomethasone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Beclomethasone is a corticosteroid, and corticosteroids can cause your kidneys to flush more chromium out in the urine than usual, which may gradually lower your levels over time. Because this is rated as moderate depletion, long-term users have a realistic reason to bring it up with their doctor or pharmacist, since some people do end up needing a supplement.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Beclomethasone →

Beclomethasone dipropionate

Moderate Depletion

Brand names include Qvar, QNASL

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Beclomethasone dipropionate? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Beclomethasone dipropionate is a corticosteroid, and corticosteroids appear to cause the kidneys to flush more chromium out in the urine than usual, which over time can chip away at your body's chromium stores. Because this is rated as moderate depletion, long-term users may genuinely be at risk, especially if blood sugar changes are noticed. It is worth bringing up with your pharmacist or doctor, who can decide whether monitoring or a supplement makes sense for you.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Beclomethasone dipropionate →

Betamethasone

Moderate Depletion

Brand names include Celestone, Diprolene AF, Diprosone

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Betamethasone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin properly and keep blood sugar steady. Betamethasone and other corticosteroids appear to make the kidneys flush out more chromium than usual through the urine, and over time that extra loss can add up. With a moderate depletion rating, this is a real enough concern that some long-term users may benefit from monitoring or a supplement, though not everyone will. If you are taking betamethasone regularly, it is worth asking your pharmacist or doctor whether your chromium status should be checked.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Betamethasone →

Betamethasone Dipropionate

Moderate Depletion

Brand names include Sernivo

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Betamethasone Dipropionate? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Betamethasone dipropionate is a corticosteroid, and corticosteroids appear to cause the kidneys to flush more chromium out through the urine than normal. Over time, that extra loss can lower your chromium levels, and some research suggests this may make blood sugar harder to control. Because the evidence is rated moderate, long-term users of this medication are worth a conversation with their pharmacist or doctor about whether monitoring or a supplement makes sense for them.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Betamethasone Dipropionate →

Brand names include Enstilar, Wynzora

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Betamethasone Dipropionate, Calcipotriene? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. This combination product contains a corticosteroid, and corticosteroids are known to cause the kidneys to flush out more chromium in the urine than usual. Over time, that extra loss can lower chromium levels and may make blood sugar harder to control. Because this is rated as a moderate concern, it is worth bringing up with your pharmacist or doctor, especially if you use this medication regularly or for extended periods.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Betamethasone Dipropionate, Calcipotriene →

Betamethasone valerate

Moderate Depletion

Brand names include Luxiq

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Betamethasone valerate? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Betamethasone valerate is a corticosteroid, and corticosteroids can cause the kidneys to flush more chromium out through urine than usual, which over time may bring chromium levels down. Because this is rated as moderate depletion, long-term users have a real reason to bring it up with their doctor or pharmacist, since low chromium has been linked to blood sugar changes in people on corticosteroids. Most people will not need to act on this right away, but it is worth a conversation if you use this medication regularly.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Betamethasone valerate →

Budesonide

Moderate Depletion

Brand names include Entocort EC, Pulmicort, Uceris

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Budesonide? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps the body use insulin properly and keep blood sugar steady. Budesonide, like other corticosteroids, appears to cause the kidneys to flush out more chromium than usual through urine, which over time can chip away at your levels. This is rated as a moderate concern, meaning some people on long-term budesonide may genuinely need to address it. It is worth bringing up with your pharmacist or doctor, especially if you have any blood sugar issues.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Budesonide →

Clobetasol

Moderate Depletion

Brand names include Temovate, Clobex

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Clobetasol? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Clobetasol is a corticosteroid, and corticosteroids are known to push the kidneys to flush more chromium out through the urine than usual, which can gradually lower your body's chromium stores. Because this is rated a moderate depletion, long-term users of clobetasol have a real reason to keep this on their radar, especially if blood sugar control becomes a concern. It is worth bringing up with your pharmacist or doctor so they can decide whether any monitoring or support makes sense for you.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Clobetasol →

Cortisone Acetate

Moderate Depletion

Brand names include Cortone, Cortisone Tablets

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Cortisone Acetate? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Cortisone acetate, like other corticosteroids, appears to cause the kidneys to flush out more chromium than usual in the urine, which can gradually bring levels down over time. This is rated as a moderate concern, meaning it is worth paying attention to, especially for long-term users, since lower chromium levels could make blood sugar harder to control. If you have been on cortisone acetate for a while, it is worth asking your pharmacist or doctor whether your chromium status should be checked.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Cortisone Acetate →

Dexamethasone

Moderate Depletion

Brand names include Decadron, Hexadrol, Dexone

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Dexamethasone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Dexamethasone, like other corticosteroids, appears to push the kidneys to flush more chromium out through the urine than usual, which can gradually lower your body's supply. This is rated as moderate depletion, meaning it is a real enough concern that some long-term users do end up needing a supplement, particularly because low chromium may make blood sugar harder to control while on a steroid. If you take dexamethasone regularly, it is worth bringing this up with your pharmacist or doctor to decide whether monitoring or supplementation makes sense for you.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Dexamethasone →

Fludrocortisone

Moderate Depletion

Brand names include Florinef Acetate

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Fludrocortisone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Fludrocortisone is a corticosteroid, and corticosteroids can cause the kidneys to flush chromium out through the urine at a higher rate than normal, which over time may bring levels down. Because this is rated as moderate depletion, long-term users have a real reason to bring it up with their doctor or pharmacist, since some people do need to address it.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Fludrocortisone →

Fluticasone

Moderate Depletion

Brand names include Flovent, Flonase, Flixotide

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Fluticasone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Fluticasone is a corticosteroid, and corticosteroids can cause the kidneys to flush more chromium out through the urine than usual, which over time may lower your body's chromium levels. This is rated as a moderate concern, so long-term users of fluticasone are worth watching, since lower chromium may make blood sugar harder to manage. If you use fluticasone regularly, it's worth asking your pharmacist or doctor whether your chromium levels or blood sugar should be checked.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Fluticasone →

Brand names include Trelegy Ellipta

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Fluticasone Furoate, Umeclidinium, Vilanterol? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

The fluticasone furoate in this inhaler is a corticosteroid, and corticosteroids can cause the kidneys to flush more chromium out through the urine than they normally would. Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Because this loss happens gradually, long-term users are the ones most likely to notice an effect, and some may need a supplement. It is worth bringing up with your pharmacist or doctor, especially if you have any concerns about your blood sugar.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Fluticasone Furoate, Umeclidinium, Vilanterol →

Brand names include Breo Ellipta

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Fluticasone Furoate, Vilanterol Trifenatate? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin properly and keep blood sugar in a healthy range. The corticosteroid in this inhaler, fluticasone furoate, can cause your kidneys to flush out more chromium than usual through the urine, and over time that extra loss may lower your levels. This is rated moderate, meaning it is a real enough concern that some long-term users do need to address it, particularly if blood sugar control becomes an issue. If you have been using this inhaler regularly, it is worth bringing up with your pharmacist or doctor to see whether monitoring or a supplement makes sense for you.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Fluticasone Furoate, Vilanterol Trifenatate →

Hydrocortisone

Moderate Depletion

Brand names include Cortef, Hydrocortone, Carmol HC cream

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Hydrocortisone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Hydrocortisone, like other corticosteroids, appears to cause the kidneys to flush extra chromium out through the urine rather than holding onto it. Over time, this loss can be meaningful enough that some long-term users end up with lower chromium levels, which may make blood sugar control harder. If you take hydrocortisone regularly, it is worth asking your pharmacist or doctor whether your chromium levels should be checked.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Hydrocortisone →

Methylprednisolone

Moderate Depletion

Brand names include Medrol, Medrol Dosepak

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Methylprednisolone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Methylprednisolone and other corticosteroids can cause your kidneys to flush out more chromium than usual through the urine, which over time may nudge levels lower. Because this is rated as moderate depletion, long-term users are worth monitoring, and some people do end up needing a supplement. It is worth bringing up with your pharmacist or doctor, especially if you take methylprednisolone regularly.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Methylprednisolone →

Brand names include Ryaltris

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Olopatadine Hydrochloride, Mometasone Furoate? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Mometasone is a corticosteroid, and one thing corticosteroids are known to do is cause the kidneys to flush out more chromium in the urine than normal. Chromium is a mineral your body uses to help insulin work properly and keep blood sugar steady, so losing more of it over time is worth paying attention to. This combination product contains mometasone, so long-term users may have a real reason to ask their pharmacist or doctor whether their chromium levels or blood sugar should be checked.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Olopatadine Hydrochloride, Mometasone Furoate →

Prednisolone

Moderate Depletion

Brand names include Sterane, Delta Cortef, Cortalone

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Prednisolone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Prednisolone and other corticosteroids can cause the kidneys to flush out more chromium than usual in the urine, and over time that loss can add up. This is rated as a moderate concern, meaning some long-term users may actually need to address it, especially because low chromium could make blood sugar harder to control. If you have been on prednisolone for a while, it is worth asking your pharmacist or doctor whether your chromium status is something to keep an eye on.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Prednisolone →

Prednisone

Moderate Depletion

Brand names include Deltasone, Cortan, Orasone

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Prednisone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body respond to insulin and keep blood sugar in a normal range. Prednisone can cause your kidneys to flush more chromium out through the urine than usual, which over time may nudge chromium levels lower. This matters enough with long-term steroid use that some patients do end up needing a supplement, so if you take prednisone regularly, it is worth bringing this up with your pharmacist or doctor to see whether monitoring or extra chromium makes sense for you.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Prednisone →

Triamcinolone

Moderate Depletion

Brand names include Aristocort, Kenacort, Adcortyl Intra-articular / Intradermal

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Triamcinolone? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Triamcinolone, like other corticosteroids, appears to cause the kidneys to flush out more chromium than usual through urine, which over time can chip away at your body's supply. Because this is rated a moderate depletion, long-term users have a real reason to bring it up with their doctor or pharmacist, since some people do end up needing a supplement.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Triamcinolone →

Triamcinolone Acetonide

Moderate Depletion

Brand names include Zilretta, Xipere

Corticosteroids increase chromium excretion and can lower chromium levels.

Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Taking Triamcinolone Acetonide? Monitor for depletion; a supplement is needed for some patients. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Triamcinolone acetonide, like other corticosteroids, appears to cause the kidneys to flush out more chromium than usual in the urine, which can gradually lower your levels over time. Because this is rated as a moderate depletion, long-term users have a real reason to bring it up with their doctor or pharmacist, since some people do end up needing a supplement, especially if blood sugar control becomes a concern.

References (2)
  1. Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
  2. Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI

Full nutrient report for Triamcinolone Acetonide →

Alginic Acid, Aluminum Hydroxide

Insufficient Evidence

Brand names include Rafton

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Alginic Acid, Aluminum Hydroxide? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. This antacid combination raises the pH inside your stomach, and there is some thought that a less acidic environment could make chromium harder to absorb through the gut wall. That said, the evidence for this interaction is really thin, and right now nobody knows whether it matters in a real-world sense. If you have concerns, a quick conversation with your pharmacist or doctor can help you sort out whether anything further is worth looking into.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Alginic Acid, Aluminum Hydroxide →

Aluminum Hydroxide

Insufficient Evidence

Brand names include Amphojel, Gaviscon, Alu-Cap

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aluminum Hydroxide? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and process blood sugar properly. Aluminum hydroxide works as an antacid by raising the pH inside your stomach, and there is some thought that this change in acidity could cause chromium from food to form compounds that your gut absorbs less easily. That said, the evidence here is really thin, and no one knows whether this matters at all in real life. If you take aluminum hydroxide regularly and have concerns, it is worth mentioning to your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aluminum Hydroxide →

Brand names include Ascriptin Codeine #2

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. The antacid ingredients in this combination (aluminum hydroxide and magnesium hydroxide) raise the pH inside your stomach, and a less acidic environment may cause chromium from food to form compounds that are harder to absorb. That said, the evidence here is quite thin, and nobody really knows whether this translates into a meaningful drop in chromium levels for real patients. If you take this product regularly over the long term, it is worth mentioning at your next pharmacy or doctor visit, but there is no need to worry right now.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide →

Brand names include Ascriptin

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aluminum Hydroxide, Aspirin, Magnesium Hydroxide? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and manage blood sugar. The antacids in this combination (aluminum hydroxide and magnesium hydroxide) raise the pH inside your stomach, and researchers think that change may cause chromium to form salts that are harder for your gut to absorb. That said, the evidence here is quite thin, and nobody has clearly shown this causes a real problem in people. If you take antacids regularly and have questions about your nutrient levels, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aluminum Hydroxide, Aspirin, Magnesium Hydroxide →

Brand names include Maalox, Mucogel

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aluminum Hydroxide, Magnesium Hydroxide (OTC drug)? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. This antacid combination neutralizes stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb since it forms less soluble compounds at higher pH levels. That said, the evidence here is really limited, and no one knows yet whether this matters in a real-world way for most people. If you use these antacids regularly and are curious, it is worth mentioning to your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aluminum Hydroxide, Magnesium Hydroxide (OTC drug) →

Brand names include Mylanta

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and manage blood sugar. This antacid combination works by neutralizing stomach acid, and that shift to a less acidic environment may cause chromium from food to form a poorly soluble compound that your gut has a harder time absorbing. That said, the research here is very thin, and nobody really knows whether this matters in practice for people taking an occasional antacid. If you use this product regularly and have concerns, it is worth mentioning to your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) →

Aluminum, Magnesium (OTC drug)

Insufficient Evidence

Brand names include Almagel

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aluminum, Magnesium (OTC drug)? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Antacids like aluminum-magnesium products raise the pH inside your stomach, and that higher pH may cause chromium from food to form compounds that your gut has a harder time absorbing. That said, the research on this is quite limited, so nobody knows yet whether it causes any real-world problem for most people. If you take antacids regularly and have questions about chromium, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aluminum, Magnesium (OTC drug) →

Brand names include Talicia

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Amoxicillin, Omeprazole Magnesium, Rifabutin? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Omeprazole (the PPI in this combination therapy) works by reducing acid in your stomach, and that shift in acidity may make chromium, a mineral that helps your body use insulin and regulate blood sugar, harder to absorb properly. The thinking is that chromium needs a more acidic environment to stay dissolved and ready for absorption; raise the pH and it may form compounds that pass through without being taken up. That said, evidence for this interaction is currently too thin to know whether it matters clinically, so most people on this regimen do not need to worry about it. If you are curious or take omeprazole long-term, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Amoxicillin, Omeprazole Magnesium, Rifabutin →

Brand names include Ascriptin Codeine #3

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar balanced. The antacids in this combination (aluminum hydroxide and magnesium hydroxide) raise the pH inside your stomach, and at a higher pH chromium can form less soluble compounds that your gut has a harder time absorbing. That said, the evidence here is really thin, and no one has clearly shown this causes a real problem in people. If you take antacids regularly and have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide →

Brand names include Bufferin

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Antacids like calcium carbonate and magnesium oxide raise the pH inside your stomach, and some research suggests that a less acidic environment may make chromium harder to absorb. That said, the evidence here is quite limited, and whether this actually causes a meaningful drop in chromium levels for real patients is simply not known. If you take antacids regularly and have concerns, it is worth a quick conversation with your pharmacist.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide →

Brand names include Alka-Seltzer Pain Reliever and Antacid

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Aspirin, Citric Acid, Sodium Bicarbonate? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help regulate blood sugar and support normal metabolism. The sodium bicarbonate in this effervescent aspirin formula acts as an antacid, and antacids raise the pH inside your stomach. That higher pH can cause chromium from food to form compounds that are harder for your gut to absorb. That said, the research here is quite thin, and right now nobody knows whether this matters in a real-world, practical sense. If you use this product regularly and have questions about your chromium levels, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Aspirin, Citric Acid, Sodium Bicarbonate →

Brand names include Diabismul

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Bismuth Subcarbonate, Calcium Carbonate, Opium? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help regulate blood sugar and support normal metabolism. This combination product contains calcium carbonate, which acts as an antacid and raises the pH level in your stomach. That shift in acidity may cause chromium from food or supplements to form compounds that are harder for the gut to absorb. That said, evidence for this interaction is quite limited, so most people taking this product short-term likely have nothing to worry about. If you use it regularly, it is worth a quick conversation with your pharmacist.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Bismuth Subcarbonate, Calcium Carbonate, Opium →

Calcium Carbonate

Insufficient Evidence

Brand names include Tums, Os-Cal, Adcal

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Calcium Carbonate? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Calcium carbonate is an antacid that neutralizes stomach acid, and there is some thinking that a less acidic stomach environment could make chromium harder to absorb. That said, the evidence here is really preliminary, and right now we simply do not know whether this has any meaningful effect in real patients. If you take calcium carbonate regularly and have questions about your nutrition, it is worth mentioning to your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Calcium Carbonate →

Cimetidine

Insufficient Evidence

Brand names include Tagamet HB, Tagamet, Cimetidine Injection

H2-blockers might decrease chromium levels by inhibiting the absorption of chromium.

H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Cimetidine? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a normal range. Cimetidine reduces stomach acid, and there is some thought that less acid in the stomach could make chromium harder to absorb, since chromium seems to dissolve better in a more acidic environment. That said, the evidence here is quite thin, and right now it is not clear whether this matters at all in real patients. If you have been on cimetidine for a long time and are curious, it is worth mentioning to your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Cimetidine →

Dexlansoprazole

Insufficient Evidence

Brand names include Dexilant Solutab

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Dexlansoprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and manage blood sugar. Dexlansoprazole, like other proton pump inhibitors, reduces stomach acid, and the thinking is that a less acidic stomach environment may make chromium harder to absorb because it forms salts that dissolve poorly. That said, the evidence here is thin, and right now researchers simply do not know whether this matters in real life. If you have concerns about chromium or blood sugar regulation, it is worth bringing up with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Dexlansoprazole →

Dihydroxyaluminum Sodium Carbonate

Insufficient Evidence

Brand names include Rolaids

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Dihydroxyaluminum Sodium Carbonate? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin properly and regulate blood sugar. Dihydroxyaluminum sodium carbonate is an antacid, and antacids work by raising the pH inside your stomach. That shift in acidity may cause chromium from food to form compounds that your gut has a harder time absorbing. That said, the evidence here is very thin, and real-world significance is simply not known, so most people taking this antacid do not need to worry. If you use antacids frequently and have concerns about chromium, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Dihydroxyaluminum Sodium Carbonate →

Esomeprazole

Insufficient Evidence

Brand names include Nexium

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Esomeprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a normal range. Esomeprazole reduces stomach acid, and there is some thought that a less acidic stomach environment might cause chromium to form compounds that are harder to absorb. That said, the evidence here is quite thin, and right now no one can say whether this actually matters for people taking the medication. If you have been on esomeprazole for a long time and are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Esomeprazole →

Esomeprazole Magnesium

Insufficient Evidence

Brand names include Nexium 24hr

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Esomeprazole Magnesium? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Esomeprazole works by reducing acid in the stomach, and that lower-acid environment may make chromium harder to absorb because chromium can form compounds that dissolve poorly at higher stomach pH levels. That said, the evidence here is quite thin, so this is more of a theoretical concern than a proven problem for most people taking this medication. If you have been on a PPI long-term and are curious whether this applies to you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Esomeprazole Magnesium →

Esomeprazole Strontium

Insufficient Evidence
PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Esomeprazole Strontium? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help regulate blood sugar and support normal metabolism. Esomeprazole strontium, like other proton pump inhibitors, reduces stomach acid, and there is some thought that a less acidic stomach environment may make chromium harder to absorb. That said, the evidence here is quite thin, and right now researchers simply do not know whether this matters clinically. If you have been on this medication long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Esomeprazole Strontium →

Esomeprazole, Naproxen

Insufficient Evidence

Brand names include Vimovo

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Esomeprazole, Naproxen? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help regulate blood sugar and support normal metabolism. The esomeprazole component of this combination medication reduces stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb, since the mineral needs acid to stay in a form the gut can take up. That said, the evidence here is really preliminary, so this is more of an open question than a proven concern. Most people on this medication do not need to act on this, but if you are curious whether it applies to you, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Esomeprazole, Naproxen →

Famotidine

Insufficient Evidence

Brand names include Pepcid, Pepcid AC, Famotidine Injection

H2-blockers might decrease chromium levels by inhibiting the absorption of chromium.

H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Famotidine? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Famotidine reduces stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb, since chromium apparently dissolves better in more acidic conditions. That said, the evidence here is quite limited, and no one really knows whether this matters in everyday practice. If you have been on famotidine long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Famotidine →

Famotidine, Ibuprofen

Insufficient Evidence

Brand names include Duexis

H2-blockers might decrease chromium levels by inhibiting the absorption of chromium.

H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Famotidine, Ibuprofen? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Famotidine reduces stomach acid, and there is some thinking that less acid in the stomach could make chromium harder to absorb. That said, the evidence here is really thin, and right now researchers simply do not know whether this matters in practice. If you take famotidine regularly and have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Famotidine, Ibuprofen →

Lansoprazole

Insufficient Evidence

Brand names include Prevacid

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Lansoprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Lansoprazole works by reducing acid in the stomach, and that less-acidic environment may cause chromium from food to form compounds that are harder for the gut to absorb. That said, the evidence here is really preliminary, and researchers simply do not know yet whether this matters in real life. If you have been on lansoprazole long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Lansoprazole →

Brand names include Prevpac

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Lansoprazole, Amoxicillin, Clarithromycin? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. The lansoprazole in this triple therapy reduces acid in your stomach, and there is some thought that a less acidic environment may make chromium harder to absorb since it can form compounds that do not dissolve as easily. That said, the evidence here is genuinely thin, and nobody really knows whether this matters in practice. If you have any concerns, it is worth bringing up with your pharmacist or doctor rather than acting on your own.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Lansoprazole, Amoxicillin, Clarithromycin →

Magaldrate

Insufficient Evidence

Brand names include Riopan

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Magaldrate? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar balanced. Magaldrate, like other antacids, neutralizes stomach acid, and there is some thought that a less acidic stomach environment could cause chromium from food to form compounds that are harder for the gut to absorb. That said, the evidence here is really thin, and right now it is not known whether this translates into any real-world problem for people taking magaldrate. If you use this antacid regularly and have questions about your nutrition, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Magaldrate →

Brand names include Bilagog, Magnesium Sulfate

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Magnesium Sulfate (prescription drug)? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in check. The concern here is that magnesium sulfate, like antacids, can raise the pH inside your stomach, and a less acidic environment may cause chromium from food to form compounds that are harder to absorb. That said, the evidence for this interaction is quite thin, and nobody really knows if it matters in practice. If you have questions about your nutrient levels, it is worth a quick conversation with your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Magnesium Sulfate (prescription drug) →

Nizatidine

Insufficient Evidence

Brand names include Axid, Axid Injection

H2-blockers might decrease chromium levels by inhibiting the absorption of chromium.

H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Nizatidine? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Nizatidine works by reducing stomach acid, and there is some theoretical concern that a less acidic stomach environment could make chromium harder to absorb. That said, the evidence here is really thin, and most people taking nizatidine do not need to worry about this. If you have questions about your nutrient levels, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Nizatidine →

Omeprazole

Insufficient Evidence

Brand names include Prilosec, Zegerid, Losec

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Omeprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and manage blood sugar. Omeprazole works by reducing stomach acid, and there is some thought that a less acidic stomach might make chromium harder to absorb, since it can form compounds that don't dissolve as well at higher pH. That said, the evidence here is really thin, and no one has shown this causes a real problem in people taking omeprazole. Most users don't need to worry, but if you have questions about your chromium intake, your pharmacist or doctor is a good place to start.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Omeprazole →

Omeprazole, Sodium Bicarbonate

Insufficient Evidence

Brand names include Konvomep

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Omeprazole, Sodium Bicarbonate? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Omeprazole works by raising the acid level in your stomach, and there is some thought that a less acidic stomach might make chromium harder to absorb, since it can form compounds that are more difficult for the gut to take up. That said, the evidence here is really thin, and the clinical significance is simply not known yet. Most people taking this medication do not need to act on this, but if you have questions about your chromium levels, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Omeprazole, Sodium Bicarbonate →

Pantoprazole

Insufficient Evidence

Brand names include Protonix, Pantoloc, Protonix IV

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Pantoprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in balance. Pantoprazole reduces stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb, since the mineral may become less soluble at higher pH levels. That said, the evidence here is quite thin, and right now it is not known whether this matters in any practical way for people taking pantoprazole. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Pantoprazole →

Rabeprazole

Insufficient Evidence

Brand names include Pariet

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Rabeprazole? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar balanced. Rabeprazole, like other proton pump inhibitors, reduces acid in the stomach, and there is some thought that a less acidic environment might make chromium harder to absorb because it forms compounds that do not dissolve as well. That said, the evidence here is really thin, so this is more of a 'we are not sure yet' situation than a proven concern. Most people taking rabeprazole do not need to worry about this, but if you have questions, your pharmacist or doctor is a good person to ask.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Rabeprazole →

Rabeprazole Sodium

Insufficient Evidence

Brand names include Aciphex, Aciphex Sprinkle

PPIs might decrease chromium levels by inhibiting chromium absorption.

PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Rabeprazole Sodium? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral that helps your body use insulin and process blood sugar properly. Rabeprazole belongs to a drug class that reduces stomach acid, and because stomach acid helps dissolve chromium into a form the body can absorb, less acid could mean slightly less chromium gets taken up in the gut. That said, the evidence here is really preliminary, and there is no clear proof this causes any real problem for people taking this medication. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Rabeprazole Sodium →

Ranitidine

Insufficient Evidence

Brand names include Zantac 150 EFFER, Zantac 150 GEL, Zantac 150

H2-blockers might decrease chromium levels by inhibiting the absorption of chromium.

H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Ranitidine? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in check. Ranitidine reduces stomach acid, and there is some thought that a less acidic stomach environment may make chromium harder to absorb, since it can form compounds that dissolve poorly at higher pH levels. That said, the evidence here is quite thin, and no one really knows whether this makes a meaningful difference in practice. Most people taking ranitidine do not need to worry about this, but if you have questions, your pharmacist or doctor is a good place to start.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Ranitidine →

Ranitidine Bismuth Citrate

Insufficient Evidence

Brand names include Tritec

H2-blockers might decrease chromium levels by inhibiting the absorption of chromium.

H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Ranitidine Bismuth Citrate? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in balance. Ranitidine bismuth citrate reduces stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb, since chromium dissolves better in more acidic conditions. That said, the evidence here is quite thin, and right now nobody really knows whether this matters in practice. If you have been on this medication long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.

References (1)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

Full nutrient report for Ranitidine Bismuth Citrate →

Sodium Bicarbonate (OTC Drug)

Insufficient Evidence

Brand names include Sodium Bicarbonate

Antacids might decrease chromium levels by inhibiting the absorption of chromium.

Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Taking Sodium Bicarbonate (OTC Drug)? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in check. Sodium bicarbonate is an antacid that neutralizes stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb from food. That said, the evidence here is really preliminary, so most people taking an occasional antacid tablet have nothing to worry about. If you use sodium bicarbonate frequently and have questions about your nutrition, it is worth a quick chat with your pharmacist or doctor.

References (3)
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  3. Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI

Full nutrient report for Sodium Bicarbonate (OTC Drug) →

Important

This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.

Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.

© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
Understand the basics

What drug-induced nutrient depletion means

Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.

Association is not deficiency

An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.

Evidence varies by pair

Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.

When to ask about labs

If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.

Don't self-supplement blindly

Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.

Never stop a medication over this

These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.

Food first, usually

For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.

Common questions

CHROMIUM & medications: FAQs

Which medications can lower CHROMIUM?
In our licensed clinical database, 58 medications have been associated with CHROMIUM depletion, including Azelastine Hydrochloride, Fluticasone Propionate, Beclometasone dipropionate, Beclomethasone and Beclomethasone dipropionate. Each entry above shows the evidence rating and the published details. An association is not a guarantee — dose, duration, diet, and your own health all matter.
I take one of these medications — am I deficient in CHROMIUM?
Not necessarily. These entries describe reported associations, not certainties. Many people take these medications without developing a meaningful CHROMIUM problem. If you take one long-term, the reasonable step is to ask your healthcare provider whether checking your CHROMIUM status is appropriate for you.
Should I start a CHROMIUM supplement?
Not without checking first. Supplements are not risk-free — some interact with medications, and for certain nutrients (like potassium or magnesium) supplementation can be genuinely risky with kidney disease or particular drug combinations. Food-first strategies and clinician-guided testing usually come before a supplement.
Where does this information come from?
The depletion records come from the Natural Medicines (Therapeutic Research Center) database — an evidence-graded clinical reference — and are displayed as published, with their citations. The plain-English education is written and reviewed by licensed HelloPharmacist pharmacists.

Wondering about your CHROMIUM levels?

Ask a licensed pharmacist — free, no appointment needed.

Ask a pharmacist
Sources

Sources & How We Checked

Medication associations with CHROMIUM are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.