Medications That May Deplete CHROMIUM
See which medications carry a reported association, how strong the evidence is, and what to discuss with your pharmacist.
Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, but results are mixed and the effect on weight loss is small and uncertain. For most healthy people who eat a varied diet, supplements are not needed; check with your pharmacist or doctor before starting.
Commonly used for: Blood sugar support in type 2 diabetes, Weight loss and appetite control, Insulin sensitivity, Cholesterol and lipid support, General nutritional supplement.
HelloPharmacist pharmacist-reviewed education. The medication records below are licensed clinical data, shown as published.
Deep dive: Chromium — uses, safety & drug interactions
Medications associated with CHROMIUM depletion
Each record is shown as published in our licensed clinical database. Open a medication for its full nutrient report.
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Azelastine Hydrochloride, Fluticasone Propionate
Moderate DepletionBrand names include Dymista
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Fluticasone is a corticosteroid, and one thing corticosteroids are known to do is cause the kidneys to flush more chromium out through urine than they normally would. Chromium is a mineral your body uses to help insulin work properly and keep blood sugar steady, so losing more of it over time is worth paying attention to. Because this is rated as moderate depletion, long-term users of this medication have a reasonable reason to bring it up with their pharmacist or doctor, especially if blood sugar changes are a concern.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Full nutrient report for Azelastine Hydrochloride, Fluticasone Propionate →
Beclometasone dipropionate
Moderate DepletionBrand names include Becotide
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Beclometasone dipropionate is a corticosteroid, and corticosteroids can cause the kidneys to flush more chromium out in the urine than normal, which over time may nudge levels lower. The rating here is moderate, so this is a real enough concern that some long-term users may need a supplement. If you use this medication regularly, it is worth asking your pharmacist or doctor whether your chromium status should be checked.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Beclomethasone
Moderate DepletionBrand names include Beclovent, Vanceril
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Beclomethasone is a corticosteroid, and corticosteroids can cause your kidneys to flush more chromium out in the urine than usual, which may gradually lower your levels over time. Because this is rated as moderate depletion, long-term users have a realistic reason to bring it up with their doctor or pharmacist, since some people do end up needing a supplement.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Beclomethasone dipropionate
Moderate DepletionBrand names include Qvar, QNASL
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Beclomethasone dipropionate is a corticosteroid, and corticosteroids appear to cause the kidneys to flush more chromium out in the urine than usual, which over time can chip away at your body's chromium stores. Because this is rated as moderate depletion, long-term users may genuinely be at risk, especially if blood sugar changes are noticed. It is worth bringing up with your pharmacist or doctor, who can decide whether monitoring or a supplement makes sense for you.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Betamethasone
Moderate DepletionBrand names include Celestone, Diprolene AF, Diprosone
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral that helps your body use insulin properly and keep blood sugar steady. Betamethasone and other corticosteroids appear to make the kidneys flush out more chromium than usual through the urine, and over time that extra loss can add up. With a moderate depletion rating, this is a real enough concern that some long-term users may benefit from monitoring or a supplement, though not everyone will. If you are taking betamethasone regularly, it is worth asking your pharmacist or doctor whether your chromium status should be checked.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Betamethasone Dipropionate
Moderate DepletionBrand names include Sernivo
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Betamethasone dipropionate is a corticosteroid, and corticosteroids appear to cause the kidneys to flush more chromium out through the urine than normal. Over time, that extra loss can lower your chromium levels, and some research suggests this may make blood sugar harder to control. Because the evidence is rated moderate, long-term users of this medication are worth a conversation with their pharmacist or doctor about whether monitoring or a supplement makes sense for them.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Betamethasone Dipropionate, Calcipotriene
Moderate DepletionBrand names include Enstilar, Wynzora
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. This combination product contains a corticosteroid, and corticosteroids are known to cause the kidneys to flush out more chromium in the urine than usual. Over time, that extra loss can lower chromium levels and may make blood sugar harder to control. Because this is rated as a moderate concern, it is worth bringing up with your pharmacist or doctor, especially if you use this medication regularly or for extended periods.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Full nutrient report for Betamethasone Dipropionate, Calcipotriene →
Betamethasone valerate
Moderate DepletionBrand names include Luxiq
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Betamethasone valerate is a corticosteroid, and corticosteroids can cause the kidneys to flush more chromium out through urine than usual, which over time may bring chromium levels down. Because this is rated as moderate depletion, long-term users have a real reason to bring it up with their doctor or pharmacist, since low chromium has been linked to blood sugar changes in people on corticosteroids. Most people will not need to act on this right away, but it is worth a conversation if you use this medication regularly.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Budesonide
Moderate DepletionBrand names include Entocort EC, Pulmicort, Uceris
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral that helps the body use insulin properly and keep blood sugar steady. Budesonide, like other corticosteroids, appears to cause the kidneys to flush out more chromium than usual through urine, which over time can chip away at your levels. This is rated as a moderate concern, meaning some people on long-term budesonide may genuinely need to address it. It is worth bringing up with your pharmacist or doctor, especially if you have any blood sugar issues.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Clobetasol
Moderate DepletionBrand names include Temovate, Clobex
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Clobetasol is a corticosteroid, and corticosteroids are known to push the kidneys to flush more chromium out through the urine than usual, which can gradually lower your body's chromium stores. Because this is rated a moderate depletion, long-term users of clobetasol have a real reason to keep this on their radar, especially if blood sugar control becomes a concern. It is worth bringing up with your pharmacist or doctor so they can decide whether any monitoring or support makes sense for you.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Cortisone Acetate
Moderate DepletionBrand names include Cortone, Cortisone Tablets
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Cortisone acetate, like other corticosteroids, appears to cause the kidneys to flush out more chromium than usual in the urine, which can gradually bring levels down over time. This is rated as a moderate concern, meaning it is worth paying attention to, especially for long-term users, since lower chromium levels could make blood sugar harder to control. If you have been on cortisone acetate for a while, it is worth asking your pharmacist or doctor whether your chromium status should be checked.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Dexamethasone
Moderate DepletionBrand names include Decadron, Hexadrol, Dexone
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Dexamethasone, like other corticosteroids, appears to push the kidneys to flush more chromium out through the urine than usual, which can gradually lower your body's supply. This is rated as moderate depletion, meaning it is a real enough concern that some long-term users do end up needing a supplement, particularly because low chromium may make blood sugar harder to control while on a steroid. If you take dexamethasone regularly, it is worth bringing this up with your pharmacist or doctor to decide whether monitoring or supplementation makes sense for you.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Fludrocortisone
Moderate DepletionBrand names include Florinef Acetate
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Fludrocortisone is a corticosteroid, and corticosteroids can cause the kidneys to flush chromium out through the urine at a higher rate than normal, which over time may bring levels down. Because this is rated as moderate depletion, long-term users have a real reason to bring it up with their doctor or pharmacist, since some people do need to address it.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Fluticasone
Moderate DepletionBrand names include Flovent, Flonase, Flixotide
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Fluticasone is a corticosteroid, and corticosteroids can cause the kidneys to flush more chromium out through the urine than usual, which over time may lower your body's chromium levels. This is rated as a moderate concern, so long-term users of fluticasone are worth watching, since lower chromium may make blood sugar harder to manage. If you use fluticasone regularly, it's worth asking your pharmacist or doctor whether your chromium levels or blood sugar should be checked.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Fluticasone Furoate, Umeclidinium, Vilanterol
Moderate DepletionBrand names include Trelegy Ellipta
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
The fluticasone furoate in this inhaler is a corticosteroid, and corticosteroids can cause the kidneys to flush more chromium out through the urine than they normally would. Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Because this loss happens gradually, long-term users are the ones most likely to notice an effect, and some may need a supplement. It is worth bringing up with your pharmacist or doctor, especially if you have any concerns about your blood sugar.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Full nutrient report for Fluticasone Furoate, Umeclidinium, Vilanterol →
Fluticasone Furoate, Vilanterol Trifenatate
Moderate DepletionBrand names include Breo Ellipta
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral that helps your body use insulin properly and keep blood sugar in a healthy range. The corticosteroid in this inhaler, fluticasone furoate, can cause your kidneys to flush out more chromium than usual through the urine, and over time that extra loss may lower your levels. This is rated moderate, meaning it is a real enough concern that some long-term users do need to address it, particularly if blood sugar control becomes an issue. If you have been using this inhaler regularly, it is worth bringing up with your pharmacist or doctor to see whether monitoring or a supplement makes sense for you.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Full nutrient report for Fluticasone Furoate, Vilanterol Trifenatate →
Hydrocortisone
Moderate DepletionBrand names include Cortef, Hydrocortone, Carmol HC cream
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Hydrocortisone, like other corticosteroids, appears to cause the kidneys to flush extra chromium out through the urine rather than holding onto it. Over time, this loss can be meaningful enough that some long-term users end up with lower chromium levels, which may make blood sugar control harder. If you take hydrocortisone regularly, it is worth asking your pharmacist or doctor whether your chromium levels should be checked.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Methylprednisolone
Moderate DepletionBrand names include Medrol, Medrol Dosepak
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Methylprednisolone and other corticosteroids can cause your kidneys to flush out more chromium than usual through the urine, which over time may nudge levels lower. Because this is rated as moderate depletion, long-term users are worth monitoring, and some people do end up needing a supplement. It is worth bringing up with your pharmacist or doctor, especially if you take methylprednisolone regularly.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Olopatadine Hydrochloride, Mometasone Furoate
Moderate DepletionBrand names include Ryaltris
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Mometasone is a corticosteroid, and one thing corticosteroids are known to do is cause the kidneys to flush out more chromium in the urine than normal. Chromium is a mineral your body uses to help insulin work properly and keep blood sugar steady, so losing more of it over time is worth paying attention to. This combination product contains mometasone, so long-term users may have a real reason to ask their pharmacist or doctor whether their chromium levels or blood sugar should be checked.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Full nutrient report for Olopatadine Hydrochloride, Mometasone Furoate →
Prednisolone
Moderate DepletionBrand names include Sterane, Delta Cortef, Cortalone
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Prednisolone and other corticosteroids can cause the kidneys to flush out more chromium than usual in the urine, and over time that loss can add up. This is rated as a moderate concern, meaning some long-term users may actually need to address it, especially because low chromium could make blood sugar harder to control. If you have been on prednisolone for a while, it is worth asking your pharmacist or doctor whether your chromium status is something to keep an eye on.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Prednisone
Moderate DepletionBrand names include Deltasone, Cortan, Orasone
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral that helps your body respond to insulin and keep blood sugar in a normal range. Prednisone can cause your kidneys to flush more chromium out through the urine than usual, which over time may nudge chromium levels lower. This matters enough with long-term steroid use that some patients do end up needing a supplement, so if you take prednisone regularly, it is worth bringing this up with your pharmacist or doctor to see whether monitoring or extra chromium makes sense for you.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Triamcinolone
Moderate DepletionBrand names include Aristocort, Kenacort, Adcortyl Intra-articular / Intradermal
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Triamcinolone, like other corticosteroids, appears to cause the kidneys to flush out more chromium than usual through urine, which over time can chip away at your body's supply. Because this is rated a moderate depletion, long-term users have a real reason to bring it up with their doctor or pharmacist, since some people do end up needing a supplement.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Triamcinolone Acetonide
Moderate DepletionBrand names include Zilretta, Xipere
Use of corticosteroids can increase urinary chromium excretion, which might lead to chromium deficiency and/or corticosteroid-induced hyperglycemia.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar stable. Triamcinolone acetonide, like other corticosteroids, appears to cause the kidneys to flush out more chromium than usual in the urine, which can gradually lower your levels over time. Because this is rated as a moderate depletion, long-term users have a real reason to bring it up with their doctor or pharmacist, since some people do end up needing a supplement, especially if blood sugar control becomes a concern.
References (2)
- Ravina A, Slezak L, Mirsky N, et al. Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet Med 1999;16:164-7.
- Ravina A, Slezak L, Mirsky N, and et al. Control of steroid-induced diabetes with supplemental chromium. J Trace Elem Exper Med 1999;12(4):375-378. DOI
Alginic Acid, Aluminum Hydroxide
Insufficient EvidenceBrand names include Rafton
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. This antacid combination raises the pH inside your stomach, and there is some thought that a less acidic environment could make chromium harder to absorb through the gut wall. That said, the evidence for this interaction is really thin, and right now nobody knows whether it matters in a real-world sense. If you have concerns, a quick conversation with your pharmacist or doctor can help you sort out whether anything further is worth looking into.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Aluminum Hydroxide
Insufficient EvidenceBrand names include Amphojel, Gaviscon, Alu-Cap
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and process blood sugar properly. Aluminum hydroxide works as an antacid by raising the pH inside your stomach, and there is some thought that this change in acidity could cause chromium from food to form compounds that your gut absorbs less easily. That said, the evidence here is really thin, and no one knows whether this matters at all in real life. If you take aluminum hydroxide regularly and have concerns, it is worth mentioning to your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide
Insufficient EvidenceBrand names include Ascriptin Codeine #2
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. The antacid ingredients in this combination (aluminum hydroxide and magnesium hydroxide) raise the pH inside your stomach, and a less acidic environment may cause chromium from food to form compounds that are harder to absorb. That said, the evidence here is quite thin, and nobody really knows whether this translates into a meaningful drop in chromium levels for real patients. If you take this product regularly over the long term, it is worth mentioning at your next pharmacy or doctor visit, but there is no need to worry right now.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide →
Aluminum Hydroxide, Aspirin, Magnesium Hydroxide
Insufficient EvidenceBrand names include Ascriptin
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and manage blood sugar. The antacids in this combination (aluminum hydroxide and magnesium hydroxide) raise the pH inside your stomach, and researchers think that change may cause chromium to form salts that are harder for your gut to absorb. That said, the evidence here is quite thin, and nobody has clearly shown this causes a real problem in people. If you take antacids regularly and have questions about your nutrient levels, it is worth a quick conversation with your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Aluminum Hydroxide, Aspirin, Magnesium Hydroxide →
Aluminum Hydroxide, Magnesium Hydroxide (OTC drug)
Insufficient EvidenceBrand names include Maalox, Mucogel
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. This antacid combination neutralizes stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb since it forms less soluble compounds at higher pH levels. That said, the evidence here is really limited, and no one knows yet whether this matters in a real-world way for most people. If you use these antacids regularly and are curious, it is worth mentioning to your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Aluminum Hydroxide, Magnesium Hydroxide (OTC drug) →
Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug)
Insufficient EvidenceBrand names include Mylanta
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and manage blood sugar. This antacid combination works by neutralizing stomach acid, and that shift to a less acidic environment may cause chromium from food to form a poorly soluble compound that your gut has a harder time absorbing. That said, the research here is very thin, and nobody really knows whether this matters in practice for people taking an occasional antacid. If you use this product regularly and have concerns, it is worth mentioning to your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (OTC drug) →
Aluminum, Magnesium (OTC drug)
Insufficient EvidenceBrand names include Almagel
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Antacids like aluminum-magnesium products raise the pH inside your stomach, and that higher pH may cause chromium from food to form compounds that your gut has a harder time absorbing. That said, the research on this is quite limited, so nobody knows yet whether it causes any real-world problem for most people. If you take antacids regularly and have questions about chromium, it is worth a quick conversation with your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Amoxicillin, Omeprazole Magnesium, Rifabutin
Insufficient EvidenceBrand names include Talicia
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Omeprazole (the PPI in this combination therapy) works by reducing acid in your stomach, and that shift in acidity may make chromium, a mineral that helps your body use insulin and regulate blood sugar, harder to absorb properly. The thinking is that chromium needs a more acidic environment to stay dissolved and ready for absorption; raise the pH and it may form compounds that pass through without being taken up. That said, evidence for this interaction is currently too thin to know whether it matters clinically, so most people on this regimen do not need to worry about it. If you are curious or take omeprazole long-term, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Full nutrient report for Amoxicillin, Omeprazole Magnesium, Rifabutin →
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide
Insufficient EvidenceBrand names include Ascriptin Codeine #3
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar balanced. The antacids in this combination (aluminum hydroxide and magnesium hydroxide) raise the pH inside your stomach, and at a higher pH chromium can form less soluble compounds that your gut has a harder time absorbing. That said, the evidence here is really thin, and no one has clearly shown this causes a real problem in people. If you take antacids regularly and have concerns, it is worth a quick conversation with your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide →
Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide
Insufficient EvidenceBrand names include Bufferin
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Antacids like calcium carbonate and magnesium oxide raise the pH inside your stomach, and some research suggests that a less acidic environment may make chromium harder to absorb. That said, the evidence here is quite limited, and whether this actually causes a meaningful drop in chromium levels for real patients is simply not known. If you take antacids regularly and have concerns, it is worth a quick conversation with your pharmacist.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide →
Aspirin, Citric Acid, Sodium Bicarbonate
Insufficient EvidenceBrand names include Alka-Seltzer Pain Reliever and Antacid
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help regulate blood sugar and support normal metabolism. The sodium bicarbonate in this effervescent aspirin formula acts as an antacid, and antacids raise the pH inside your stomach. That higher pH can cause chromium from food to form compounds that are harder for your gut to absorb. That said, the research here is quite thin, and right now nobody knows whether this matters in a real-world, practical sense. If you use this product regularly and have questions about your chromium levels, it is worth a quick conversation with your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Aspirin, Citric Acid, Sodium Bicarbonate →
Bismuth Subcarbonate, Calcium Carbonate, Opium
Insufficient EvidenceBrand names include Diabismul
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help regulate blood sugar and support normal metabolism. This combination product contains calcium carbonate, which acts as an antacid and raises the pH level in your stomach. That shift in acidity may cause chromium from food or supplements to form compounds that are harder for the gut to absorb. That said, evidence for this interaction is quite limited, so most people taking this product short-term likely have nothing to worry about. If you use it regularly, it is worth a quick conversation with your pharmacist.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Bismuth Subcarbonate, Calcium Carbonate, Opium →
Calcium Carbonate
Insufficient EvidenceBrand names include Tums, Os-Cal, Adcal
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Calcium carbonate is an antacid that neutralizes stomach acid, and there is some thinking that a less acidic stomach environment could make chromium harder to absorb. That said, the evidence here is really preliminary, and right now we simply do not know whether this has any meaningful effect in real patients. If you take calcium carbonate regularly and have questions about your nutrition, it is worth mentioning to your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Cimetidine
Insufficient EvidenceBrand names include Tagamet HB, Tagamet, Cimetidine Injection
H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a normal range. Cimetidine reduces stomach acid, and there is some thought that less acid in the stomach could make chromium harder to absorb, since chromium seems to dissolve better in a more acidic environment. That said, the evidence here is quite thin, and right now it is not clear whether this matters at all in real patients. If you have been on cimetidine for a long time and are curious, it is worth mentioning to your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Dexlansoprazole
Insufficient EvidenceBrand names include Dexilant Solutab
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and manage blood sugar. Dexlansoprazole, like other proton pump inhibitors, reduces stomach acid, and the thinking is that a less acidic stomach environment may make chromium harder to absorb because it forms salts that dissolve poorly. That said, the evidence here is thin, and right now researchers simply do not know whether this matters in real life. If you have concerns about chromium or blood sugar regulation, it is worth bringing up with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Dihydroxyaluminum Sodium Carbonate
Insufficient EvidenceBrand names include Rolaids
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin properly and regulate blood sugar. Dihydroxyaluminum sodium carbonate is an antacid, and antacids work by raising the pH inside your stomach. That shift in acidity may cause chromium from food to form compounds that your gut has a harder time absorbing. That said, the evidence here is very thin, and real-world significance is simply not known, so most people taking this antacid do not need to worry. If you use antacids frequently and have concerns about chromium, it is worth a quick conversation with your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Dihydroxyaluminum Sodium Carbonate →
Esomeprazole
Insufficient EvidenceBrand names include Nexium
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a normal range. Esomeprazole reduces stomach acid, and there is some thought that a less acidic stomach environment might cause chromium to form compounds that are harder to absorb. That said, the evidence here is quite thin, and right now no one can say whether this actually matters for people taking the medication. If you have been on esomeprazole for a long time and are curious, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Esomeprazole Magnesium
Insufficient EvidenceBrand names include Nexium 24hr
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Esomeprazole works by reducing acid in the stomach, and that lower-acid environment may make chromium harder to absorb because chromium can form compounds that dissolve poorly at higher stomach pH levels. That said, the evidence here is quite thin, so this is more of a theoretical concern than a proven problem for most people taking this medication. If you have been on a PPI long-term and are curious whether this applies to you, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Esomeprazole Strontium
Insufficient EvidencePPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help regulate blood sugar and support normal metabolism. Esomeprazole strontium, like other proton pump inhibitors, reduces stomach acid, and there is some thought that a less acidic stomach environment may make chromium harder to absorb. That said, the evidence here is quite thin, and right now researchers simply do not know whether this matters clinically. If you have been on this medication long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Esomeprazole, Naproxen
Insufficient EvidenceBrand names include Vimovo
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help regulate blood sugar and support normal metabolism. The esomeprazole component of this combination medication reduces stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb, since the mineral needs acid to stay in a form the gut can take up. That said, the evidence here is really preliminary, so this is more of an open question than a proven concern. Most people on this medication do not need to act on this, but if you are curious whether it applies to you, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Famotidine
Insufficient EvidenceBrand names include Pepcid, Pepcid AC, Famotidine Injection
H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar steady. Famotidine reduces stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb, since chromium apparently dissolves better in more acidic conditions. That said, the evidence here is quite limited, and no one really knows whether this matters in everyday practice. If you have been on famotidine long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Famotidine, Ibuprofen
Insufficient EvidenceBrand names include Duexis
H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in a healthy range. Famotidine reduces stomach acid, and there is some thinking that less acid in the stomach could make chromium harder to absorb. That said, the evidence here is really thin, and right now researchers simply do not know whether this matters in practice. If you take famotidine regularly and have concerns, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Lansoprazole
Insufficient EvidenceBrand names include Prevacid
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Lansoprazole works by reducing acid in the stomach, and that less-acidic environment may cause chromium from food to form compounds that are harder for the gut to absorb. That said, the evidence here is really preliminary, and researchers simply do not know yet whether this matters in real life. If you have been on lansoprazole long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Lansoprazole, Amoxicillin, Clarithromycin
Insufficient EvidenceBrand names include Prevpac
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. The lansoprazole in this triple therapy reduces acid in your stomach, and there is some thought that a less acidic environment may make chromium harder to absorb since it can form compounds that do not dissolve as easily. That said, the evidence here is genuinely thin, and nobody really knows whether this matters in practice. If you have any concerns, it is worth bringing up with your pharmacist or doctor rather than acting on your own.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Full nutrient report for Lansoprazole, Amoxicillin, Clarithromycin →
Magaldrate
Insufficient EvidenceBrand names include Riopan
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar balanced. Magaldrate, like other antacids, neutralizes stomach acid, and there is some thought that a less acidic stomach environment could cause chromium from food to form compounds that are harder for the gut to absorb. That said, the evidence here is really thin, and right now it is not known whether this translates into any real-world problem for people taking magaldrate. If you use this antacid regularly and have questions about your nutrition, it is worth a quick conversation with your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Magnesium Sulfate (prescription drug)
Insufficient EvidenceBrand names include Bilagog, Magnesium Sulfate
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in check. The concern here is that magnesium sulfate, like antacids, can raise the pH inside your stomach, and a less acidic environment may cause chromium from food to form compounds that are harder to absorb. That said, the evidence for this interaction is quite thin, and nobody really knows if it matters in practice. If you have questions about your nutrient levels, it is worth a quick conversation with your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
Full nutrient report for Magnesium Sulfate (prescription drug) →
Nizatidine
Insufficient EvidenceBrand names include Axid, Axid Injection
H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Nizatidine works by reducing stomach acid, and there is some theoretical concern that a less acidic stomach environment could make chromium harder to absorb. That said, the evidence here is really thin, and most people taking nizatidine do not need to worry about this. If you have questions about your nutrient levels, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Omeprazole
Insufficient EvidenceBrand names include Prilosec, Zegerid, Losec
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and manage blood sugar. Omeprazole works by reducing stomach acid, and there is some thought that a less acidic stomach might make chromium harder to absorb, since it can form compounds that don't dissolve as well at higher pH. That said, the evidence here is really thin, and no one has shown this causes a real problem in people taking omeprazole. Most users don't need to worry, but if you have questions about your chromium intake, your pharmacist or doctor is a good place to start.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Omeprazole, Sodium Bicarbonate
Insufficient EvidenceBrand names include Konvomep
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and regulate blood sugar. Omeprazole works by raising the acid level in your stomach, and there is some thought that a less acidic stomach might make chromium harder to absorb, since it can form compounds that are more difficult for the gut to take up. That said, the evidence here is really thin, and the clinical significance is simply not known yet. Most people taking this medication do not need to act on this, but if you have questions about your chromium levels, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Pantoprazole
Insufficient EvidenceBrand names include Protonix, Pantoloc, Protonix IV
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in balance. Pantoprazole reduces stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb, since the mineral may become less soluble at higher pH levels. That said, the evidence here is quite thin, and right now it is not known whether this matters in any practical way for people taking pantoprazole. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Rabeprazole
Insufficient EvidenceBrand names include Pariet
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar balanced. Rabeprazole, like other proton pump inhibitors, reduces acid in the stomach, and there is some thought that a less acidic environment might make chromium harder to absorb because it forms compounds that do not dissolve as well. That said, the evidence here is really thin, so this is more of a 'we are not sure yet' situation than a proven concern. Most people taking rabeprazole do not need to worry about this, but if you have questions, your pharmacist or doctor is a good person to ask.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Rabeprazole Sodium
Insufficient EvidenceBrand names include Aciphex, Aciphex Sprinkle
PPIs increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral that helps your body use insulin and process blood sugar properly. Rabeprazole belongs to a drug class that reduces stomach acid, and because stomach acid helps dissolve chromium into a form the body can absorb, less acid could mean slightly less chromium gets taken up in the gut. That said, the evidence here is really preliminary, and there is no clear proof this causes any real problem for people taking this medication. If you have concerns, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Ranitidine
Insufficient EvidenceBrand names include Zantac 150 EFFER, Zantac 150 GEL, Zantac 150
H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in check. Ranitidine reduces stomach acid, and there is some thought that a less acidic stomach environment may make chromium harder to absorb, since it can form compounds that dissolve poorly at higher pH levels. That said, the evidence here is quite thin, and no one really knows whether this makes a meaningful difference in practice. Most people taking ranitidine do not need to worry about this, but if you have questions, your pharmacist or doctor is a good place to start.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Ranitidine Bismuth Citrate
Insufficient EvidenceBrand names include Tritec
H2-blockers increase the gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in balance. Ranitidine bismuth citrate reduces stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb, since chromium dissolves better in more acidic conditions. That said, the evidence here is quite thin, and right now nobody really knows whether this matters in practice. If you have been on this medication long-term and are curious, it is worth a quick conversation with your pharmacist or doctor.
References (1)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Sodium Bicarbonate (OTC Drug)
Insufficient EvidenceBrand names include Sodium Bicarbonate
Antacids increase gastric pH, which might decrease chromium absorption due to formation of less soluble chromium salts. However, the clinical significance of this is not clear.
Chromium is a trace mineral your body uses to help insulin work properly and keep blood sugar in check. Sodium bicarbonate is an antacid that neutralizes stomach acid, and there is some thought that a less acidic stomach environment could make chromium harder to absorb from food. That said, the evidence here is really preliminary, so most people taking an occasional antacid tablet have nothing to worry about. If you use sodium bicarbonate frequently and have questions about your nutrition, it is worth a quick chat with your pharmacist or doctor.
References (3)
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Seaborn CD and Stoecker BJ. Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research 1990;10:1401-1407. DOI
This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.
Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
What drug-induced nutrient depletion means
Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.
Association is not deficiency
An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.
Evidence varies by pair
Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.
When to ask about labs
If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.
Don't self-supplement blindly
Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.
Never stop a medication over this
These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.
Food first, usually
For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.
CHROMIUM & medications: FAQs
Which medications can lower CHROMIUM?
I take one of these medications — am I deficient in CHROMIUM?
Should I start a CHROMIUM supplement?
Where does this information come from?
Other commonly implicated nutrients
Wondering about your CHROMIUM levels?
Ask a licensed pharmacist — free, no appointment needed.
Sources & How We Checked
Medication associations with CHROMIUM are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for drug-induced nutrient depletions, supplements, and interactions — the basis for this page.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for medication overviews across the site.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.