Drug & supplement interaction

Ambrette + Methylnaltrexone

Methylnaltrexone brand name: Relistor.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Ambrette and Methylnaltrexone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Methylnaltrexone states a food rule worth keeping to.

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Interaction report

Ambrette and Methylnaltrexone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methylnaltrexone and Ambrette in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ambrette safety at a glance

Ambrette overall Use caution Limited human safety data exist, so use cautiously and mainly as a fragrance or flavoring.

Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.

Breastfeeding Possibly Unsafe When used orally or topically. Ambrette passes into mother's milk, but the effect is unknown. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methylnaltrexone and Ambrette? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Methylnaltrexone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methylnaltrexone is filed under a single classification — cytochrome p450 2d6 (cyp2d6) inhibitors. Ambrette has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Methylnaltrexone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ambrette Does Interact With Other Medications

Ambrette has 86 moderate known drug interactions in our database — Methylnaltrexone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Methylnaltrexone)

Taking anything else?

Check Another of Your Medications Against Ambrette

Covers the 2,830 medications we’ve checked against Ambrette. Pick one to open its full report.

What to actually watch for

What Ambrette Itself Has Been Linked To

This is not an interaction — nothing below involves Methylnaltrexone. It is the side-effect record for Ambrette on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ambrette, this list is the first place to look.

Sun sensitivity / A skin rash Additional detail
“Topically, ambrette has been reported to cause contact dermatitis and photosensitivity (6,31100).”

Ambrette · Natural Medicines adverse-effect record, reported in dermatitis.
2 sources cited

6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

31100. Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Ambrette — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Methylnaltrexone’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Methylnaltrexone column appears here.

Special populations

Ambrette in Pregnancy & Breastfeeding

Lactation Possibly Unsafe

When used orally or topically. Ambrette passes into mother's milk, but the effect is unknown.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Methylnaltrexone Products Have a Food Rule — Ambrette Should Not Break It

At least one FDA label for a product containing Methylnaltrexone says to take it on an empty stomach. Most supplements — Ambrette included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Methylnaltrexone on its own and move Ambrette to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Methylnaltrexone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

o In patients with chronic non-cancer pain and OIC, take RELISTOR tablets with water on an empty stomach at least 30 minutes before the first meal of the day.

From the Dosage and Administration section of the FDA label we read for Methylnaltrexone — where that label names a specific product, the instruction is that product's. See the Methylnaltrexone drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Methylnaltrexone Is Prescribed For, and What Ambrette Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Methylnaltrexone is a prescription medicine with approved uses on its FDA label. Ambrette is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Methylnaltrexone is prescribed for: Methylnaltrexone, sold as Relistor, treats opioid-induced constipation (OIC) — constipation caused by opioid pain medications. Both Relistor tablets and Relistor injection are approved for adults with chronic non-cancer pain, including those with pain related to a prior cancer or its treatment who do not need frequent opioid dose increases. Relistor injection is also approved for adults with advanced illness or active cancer pain who require increasing opioid doses as part of palliative care.

Ambrette has been studied for:

Constipation studied, not established Ambrette has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Ambrette for constipation

Although there has been interest in using oral ambrette for constipation, there is insufficient reliable information about the clinical effects of ambrette for this purpose.
Cancer studied, not established Ambrette has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Ambrette for cancer

Although there has been interest in using oral ambrette for cancer, there is insufficient reliable information about the clinical effects of ambrette for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Methylnaltrexone on your own; if you are taking Ambrette for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Methylnaltrexone

This page covers Ambrette only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methylnaltrexone page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (moderate), Iboga (moderate) and Yohimbe (moderate).

By severity: 3 moderate.

From our pharmacist’s overview on the Methylnaltrexone page

“If you take methylnaltrexone (Relistor) for opioid-induced constipation, the supplement list to know is short: three ingredients, all rated moderate, none major. Yohimbe, fever bark, and iboga are all cleared by the same liver enzyme, CYP2D6, and methylnaltrexone can slow that enzyme, letting their active compounds build up in your blood.”

Reviewed by 2 · Jul 18, 2026

Open the Methylnaltrexone interaction page

How much people look this up

Where Ambrette and Methylnaltrexone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ambrette

Top half

#598 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Methylnaltrexone

Steady interest

#2,793 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ambrette reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ambrette and Methylnaltrexone records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Ambrette

What is Ambrette?

Fragrance and aromatherapy
Digestive complaints
Respiratory complaints
Skin irritation
Insect repellent (traditional)

Ambrette (Abelmoschus moschatus) is a fragrant plant best known for its musky seed oil used in perfumes and food flavoring. It has a long history in traditional medicine for digestion, breathing problems, and skin issues, but solid human studies supporting these uses are lacking. If you want to try it, talk with your pharmacist or doctor first, and avoid use during pregnancy and breastfeeding.

Abelmoschus moschatus · Malvaceae · Seeds and seed essential oil · Essential oil, seed extracts, perfume/fragrance products, food flavoring

An interaction check asks whether these two react with each other — it does not ask whether Ambrette is a good idea for someone in your situation. Here is what our Ambrette record says about it on its own.

Ambrette: dosing

There is no established standardized dose for ambrette as a supplement or medicine. Amounts used in foods and fragrances are small, and these uses have not been studied as treatments.If you choose to use an ambrette product, follow the directions on the label and do not exceed the recommended amount.

From our Ambrette monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ambrette monograph & all interactions

Medication

About Methylnaltrexone

What Is Methylnaltrexone Used For?

Brand name: Relistor

Methylnaltrexone, sold as Relistor, treats opioid-induced constipation (OIC) — constipation caused by opioid pain medications. Both Relistor tablets and Relistor injection are approved for adults with chronic non-cancer pain, including those with pain related to a prior cancer or its treatment who do not need frequent opioid dose increases.

Relistor injection is also approved for adults with advanced illness or active cancer pain who require increasing opioid doses as part of palliative care.

See full Methylnaltrexone drug information

Keep checking

Other Drugs & Ambrette

Browse every other medication we’ve checked against Ambrette — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

86Moderate

0Minor

2,743No known interaction

86 Moderate 2,743 No interaction

Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Ambrette page.

No interaction 2,743 drugs checked — show the list

We also checked Ambrette against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Ambrette list.

See the full Ambrette interactions page

See every supplement checked against Methylnaltrexone, ranked by severity

Evidence & sources

Ambrette References

The 6 references that drive our Ambrette monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
Liu, I. M., Liou, S. S., Lan, T. W., Hsu, F. L., and Cheng, J. T. Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 2005;71(7):617-621.
Liu, I. M., Liou, S. S., and Cheng, J. T. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J.Ethnopharmacol. 3-8-2006;104(1-2):199-206.
Liu, I. M., Tzeng, T. F., Liou, S. S., and Lan, T. W. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. 2007;73(10):1054-1060.
Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675. PubMed
Liu IM, Tzeng TF, Liou SS. Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity. Phytother Res 2010;24(2):233-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ambrette and Methylnaltrexone Together: Common Questions

Is it safe to take Ambrette with Methylnaltrexone?

We do not list a known interaction between Ambrette and Methylnaltrexone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Ambrette and Methylnaltrexone at the same time of day?

At least one FDA label for a product containing Methylnaltrexone says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Methylnaltrexone on its own and move Ambrette to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

Are Ambrette and Methylnaltrexone used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ambrette in each. That is a conversation for your prescriber, especially if Methylnaltrexone is being adjusted to a target.

How was the Ambrette and Methylnaltrexone combination checked?

Interactions in our licensed database are recorded against drug classes. Methylnaltrexone is filed under 1 classification, and Ambrette has documented interactions with 1 drug class — none of Methylnaltrexone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Ambrette interact with any other medications?

Yes. Ambrette has 86 documented drug interactions in our database — Methylnaltrexone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Methylnaltrexone interact with any supplements?

Yes. Methylnaltrexone has documented interactions with 3 supplements in our database — Ambrette is not one of them. The Methylnaltrexone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ambrette monograph Uses, safety profile, and every drug interaction in one place Methylnaltrexone drug information The full plain-English guide to this medication Methylnaltrexone supplement interactions Every supplement checked against Methylnaltrexone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methylnaltrexone and Ambrette?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.