Drug & supplement interaction

Ambrette + Ivacaftor, Lumacaftor

Ivacaftor, Lumacaftor brand name: Orkambi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Ambrette and Ivacaftor, Lumacaftor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ambrette and Ivacaftor, Lumacaftor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ivacaftor, Lumacaftor and Ambrette in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ambrette safety at a glance

Ambrette overall Use caution Limited human safety data exist, so use cautiously and mainly as a fragrance or flavoring.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Possibly Unsafe When used orally or topically. Ambrette passes into mother's milk, but the effect is unknown. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ivacaftor, Lumacaftor and Ambrette? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ivacaftor, Lumacaftor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ivacaftor, Lumacaftor is filed under 3 classifications — cytochrome p450 3a4 (cyp3a4) inducers, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Ambrette has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Ivacaftor, Lumacaftor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ambrette Does Interact With Other Medications

Ambrette has 86 moderate known drug interactions in our database — Ivacaftor, Lumacaftor isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Ivacaftor, Lumacaftor)
Taking anything else?

Check Another of Your Medications Against Ambrette

Covers the 2,830 medications we’ve checked against Ambrette. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Ambrette and Ivacaftor, Lumacaftor May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Ambrette

    “Topically, ambrette has been reported to cause contact dermatitis and photosensitivity (6,31100).”

    Ambrette · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 31100. Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675. PubMed

    Ivacaftor, Lumacaftor

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivacaftor, Lumacaftor. Read the label on DailyMed ›

Reported for Ambrette but not commonly for Ivacaftor, Lumacaftor: sun sensitivity.

Effects for Ivacaftor, Lumacaftor come from the ADVERSE REACTIONS section of its FDA label; effects for Ambrette come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 8,520 voluntary FDA FAERS reports for Ivacaftor, Lumacaftor that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Ambrette in Pregnancy & Breastfeeding

Lactation Possibly Unsafe

When used orally or topically. Ambrette passes into mother's milk, but the effect is unknown.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Ivacaftor, Lumacaftor

This page covers Ambrette only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ivacaftor, Lumacaftor page lists 153 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 110 moderate · 40 minor.

From our pharmacist’s overview on the Ivacaftor, Lumacaftor page

“Ivacaftor with lumacaftor (Orkambi) only works against cystic fibrosis if its blood level stays steady, and most of the supplements on this page can tug that level up or down through a shared liver pathway called CYP3A4. Grapefruit can push the level higher, St.”

Reviewed by 2 · Jul 18, 2026

Open the Ivacaftor, Lumacaftor interaction page

How much people look this up

Where Ambrette and Ivacaftor, Lumacaftor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ambrette
Steady interest

#948 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ivacaftor, Lumacaftor
Top 5%

#110 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ambrette reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Ambrette and Ivacaftor, Lumacaftor records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ambrette

What is Ambrette?

Ambrette
  • Fragrance and aromatherapy
  • Digestive complaints
  • Respiratory complaints
  • Skin irritation
  • Insect repellent (traditional)

Ambrette (Abelmoschus moschatus) is a fragrant plant best known for its musky seed oil used in perfumes and food flavoring. It has a long history in traditional medicine for digestion, breathing problems, and skin issues, but solid human studies supporting these uses are lacking. If you want to try it, talk with your pharmacist or doctor first, and avoid use during pregnancy and breastfeeding.

Abelmoschus moschatus · Malvaceae · Seeds and seed essential oil · Essential oil, seed extracts, perfume/fragrance products, food flavoring

An interaction check asks whether these two react with each other — it does not ask whether Ambrette is a good idea for someone in your situation. Here is what our Ambrette record says about it on its own.

Ambrette: dosing

There is no established standardized dose for ambrette as a supplement or medicine. Amounts used in foods and fragrances are small, and these uses have not been studied as treatments.If you choose to use an ambrette product, follow the directions on the label and do not exceed the recommended amount.

From our Ambrette monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ambrette monograph & all interactions
Medication

About Lumacaftor and Ivacaftor

What Is Lumacaftor and Ivacaftor Used For?

Brand name: Orkambi

Lumacaftor and ivacaftor (Orkambi) treats cystic fibrosis (CF) in people aged 1 year and older who are homozygous for the F508del mutation in the CFTR gene. Homozygous means you inherited the mutation from both parents.

If your genetic makeup is unknown, an FDA-cleared CF mutation test is used to check for the mutation on both copies of the gene. Orkambi has not been shown to be safe or effective in people with CF who do not have two copies of F508del.

See full Lumacaftor and Ivacaftor drug information
Keep checking

Other Drugs & Ambrette

Browse every other medication we’ve checked against Ambrette — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Ambrette page.

No interaction 2,743 drugs checked — show the list

We also checked Ambrette against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Ambrette list.

See the full Ambrette interactions page
See every supplement checked against Ivacaftor, Lumacaftor, ranked by severity
Evidence & sources

Ambrette References

The 6 references that drive our Ambrette monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Liu, I. M., Liou, S. S., Lan, T. W., Hsu, F. L., and Cheng, J. T. Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 2005;71(7):617-621.
  3. Liu, I. M., Liou, S. S., and Cheng, J. T. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J.Ethnopharmacol. 3-8-2006;104(1-2):199-206.
  4. Liu, I. M., Tzeng, T. F., Liou, S. S., and Lan, T. W. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. 2007;73(10):1054-1060.
  5. Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675. PubMed
  6. Liu IM, Tzeng TF, Liou SS. Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity. Phytother Res 2010;24(2):233-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ambrette and Ivacaftor, Lumacaftor Together: Common Questions

Is it safe to take Ambrette with Ivacaftor, Lumacaftor?
We do not list a known interaction between Ambrette and Ivacaftor, Lumacaftor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ambrette and Ivacaftor, Lumacaftor have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Ambrette and Ivacaftor, Lumacaftor combination checked?
Interactions in our licensed database are recorded against drug classes. Ivacaftor, Lumacaftor is filed under 3 classifications, and Ambrette has documented interactions with 1 drug class — none of Ivacaftor, Lumacaftor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ambrette interact with any other medications?
Yes. Ambrette has 86 documented drug interactions in our database — Ivacaftor, Lumacaftor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ivacaftor, Lumacaftor interact with any supplements?
Yes. Ivacaftor, Lumacaftor has documented interactions with 153 supplements in our database — Ambrette is not one of them. The Ivacaftor, Lumacaftor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ambrette monograph Uses, safety profile, and every drug interaction in one place Lumacaftor and Ivacaftor drug information The full plain-English guide to this medication Ivacaftor, Lumacaftor supplement interactions Every supplement checked against Ivacaftor, Lumacaftor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ivacaftor, Lumacaftor and Ambrette?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.