Medication interaction hub

What Supplements Interact with Ivacaftor, Lumacaftor?

Ivacaftor, Lumacaftor brand name: Orkambi. Every interaction below applies to the brands too.

153 Interactions 3 Major 110 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ivacaftor, Lumacaftor? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ivacaftor, Lumacaftor against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ivacaftor with lumacaftor (Orkambi) only works against cystic fibrosis if its blood level stays steady, and most of the supplements on this page can tug that level up or down through a shared liver pathway called CYP3A4. Grapefruit can push the level higher, St. John's wort can pull it down, and activated charcoal can keep the dose from being absorbed at all. Those three carry the major ratings and warrant genuine caution.

With a CF medicine, the level-lowering entries worry me as much as the level-raising ones, since a drug that quietly fades looks fine until lung function slips. A smaller group interferes with absorption of anything taken by mouth, so space those well apart from your dose. Behind the three majors sit 110 moderate entries and 40 minor ones, a wide middle worth running past your pharmacist one item at a time.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 110 Minor 40 No known interaction 1,299

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ivacaftor, Lumacaftor: Top Interactions at a Glance

The Ivacaftor, Lumacaftor supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 153 interacting ingredients — plus 1,299 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ivacaftor, Lumacaftor Combinations Today

The Ivacaftor, Lumacaftor + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Golden Ragwort + Ivacaftor, Lumacaftori

Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in golden ragwort.

Read the full interaction Moderate Likelihood Possible Acacia Rigidula + Ivacaftor, Lumacaftori

Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Tansy Ragwort + Ivacaftor, Lumacaftori

Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in tansy ragwort.

Read the full interaction Moderate Likelihood Possible Rooibos + Ivacaftor, Lumacaftori

Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Ivacaftor, Lumacaftori

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ivacaftor, Lumacaftori

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Ivacaftor, Lumacaftor

All 1,452 ingredients in our database, ranked by severity — 153 with a Ivacaftor, Lumacaftor interaction on file and 1,299 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ivacaftor, Lumacaftor?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Golden Ragwort with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in golden ragwor...

Full Golden Ragwort + Ivacaftor, Lumacaftor answer

Can you take Acacia Rigidula with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Ivacaftor, Lumacaftor answer

Can you take Tansy Ragwort with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in tansy ragwort...

Full Tansy Ragwort + Ivacaftor, Lumacaftor answer

Can you take Rooibos with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Full Rooibos + Ivacaftor, Lumacaftor answer

Can you take Evodia with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Ivacaftor, Lumacaftor answer

Can you take False Unicorn with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Ivacaftor, Lumacaftor answer

Can you take Fennel with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Ivacaftor, Lumacaftor answer

Can you take Feverfew with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Ivacaftor, Lumacaftor answer

Can you take Fo-ti with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Ivacaftor, Lumacaftor answer

Can you take Garlic with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Ivacaftor, Lumacaftor answer

Can you take German Chamomile with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Ivacaftor, Lumacaftor answer

Can you take Ginger with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Ivacaftor, Lumacaftor answer

Can you take Ginkgo with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Ivacaftor, Lumacaftor answer

Can you take Goji with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Ivacaftor, Lumacaftor answer

Can you take Goldenseal with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Ivacaftor, Lumacaftor answer

Can you take Goldthread with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Ivacaftor, Lumacaftor answer

Can you take Grape with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Ivacaftor, Lumacaftor answer

Can you take Gravel Root with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Ivacaftor, Lumacaftor answer

Can you take Groundsel with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers with groundsel might increase the risk of pyrrolizidine alkaloid toxicity, such as hepatotoxicity.

Full Groundsel + Ivacaftor, Lumacaftor answer

Can you take Guar Gum with Ivacaftor, Lumacaftor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Ivacaftor, Lumacaftor answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ivacaftor, Lumacaftor is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ivacaftor, Lumacaftor, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ivacaftor, Lumacaftor sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ivacaftor, Lumacaftor through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Ivacaftor, Lumacaftor through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ivacaftor, Lumacaftor through this category.

About Ivacaftor, Lumacaftor

Lumacaftor and ivacaftor (Orkambi) is a combination medicine used to treat cystic fibrosis in patients aged 1 year and older who carry two copies of a specific CFTR gene mutation called F508del.

Generic name: Ivacaftor, Lumacaftor  ·  Brand name: Orkambi.

See the full Lumacaftor and Ivacaftor drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ivacaftor, Lumacaftor

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ivacaftor, Lumacaftor.

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Pharmacist Counseling Corner

Ivacaftor, Lumacaftor & Supplements: Common Questions

What supplements interact with Ivacaftor, Lumacaftor?
In our interaction database, 153 supplement and herbal ingredients have an interaction with Ivacaftor, Lumacaftor on file — 3 rated major, 110 moderate, and 40 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Ivacaftor, Lumacaftor supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ivacaftor, Lumacaftor?
That depends entirely on which supplement. The honest answer for Ivacaftor, Lumacaftor is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Orkambi have the same supplement interactions as Ivacaftor, Lumacaftor?
Yes — Orkambi all contain Ivacaftor, Lumacaftor, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ivacaftor, Lumacaftor and my other medications?
This page covers Ivacaftor, Lumacaftor against supplements and herbal ingredients. Checking Ivacaftor, Lumacaftor against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lumacaftor and Ivacaftor drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.