Medication interaction hub

What Supplements Interact with Erdafitinib?

Erdafitinib brand name: Balversa. Every interaction below applies to the brands too.

169 Interactions 4 Major 127 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Erdafitinib? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Erdafitinib against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Erdafitinib (Balversa) treats bladder cancers driven by FGFR gene changes, and its benefit depends on holding a steady drug level, so this is a list to be genuinely careful with. Four entries are rated major. Grapefruit can push erdafitinib levels up, St. John's wort can drain them until treatment quietly loses ground, activated charcoal can soak up a dose before it absorbs, and phosphate supplements matter because erdafitinib already raises phosphate on its own.

That phosphate point is easy to overlook; patients on this drug are usually asked to hold phosphate intake to roughly 600 to 800 mg a day, so read labels on multivitamins and bone formulas. Almost everything else works through the liver enzymes that clear erdafitinib, mostly CYP3A4, nudging its level up or down, or slows how any pill absorbs. Those quieter effects account for the other 127 moderate and 38 minor entries among the 169 total.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 127 Minor 38 No known interaction 1,283

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Erdafitinib: Top Interactions at a Glance

The most significant Erdafitinib supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 169 interacting ingredients — plus 1,283 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Erdafitinib + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Erdafitinibi

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Erdafitinibi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Phosphate Salts + Erdafitinibi

Taking erdafitinib with phosphate salts increases the risk of hyperphosphatemia.

Read the full interaction Major Likelihood Probable St. John's Wort + Erdafitinibi

St.

Read the full interaction
The complete list

Every Supplement Checked Against Erdafitinib

All 1,452 ingredients in our database, ranked by severity — 169 with a Erdafitinib interaction on file and 1,283 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Erdafitinib?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ginger with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Erdafitinib answer

Can you take Grapefruit with Erdafitinib?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Erdafitinib answer

Can you take Butterbur with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.

Full Butterbur + Erdafitinib answer

Can you take Glucomannan with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Erdafitinib answer

Can you take Guggul with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Erdafitinib answer

Can you take Schisandra with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Erdafitinib answer

Can you take Tree Turmeric with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Erdafitinib answer

Can you take Acacia Rigidula with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Erdafitinib answer

Can you take Adrafinil with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit CYP3A4 might increase the levels and clinical effects of adrafinil.

Full Adrafinil + Erdafitinib answer

Can you take African Wild Potato with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits cytochrome P450 2C9 (CYP2C9).

Full African Wild Potato + Erdafitinib answer

Can you take Alkanna with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PAs) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Alkanna + Erdafitinib answer

Can you take Alpine Ragwort with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in alpine ragwor...

Full Alpine Ragwort + Erdafitinib answer

Can you take American Elder with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Erdafitinib answer

Can you take Astaxanthin with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Erdafitinib answer

Can you take Ayahuasca with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Erdafitinib answer

Can you take Bacopa with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.

Full Bacopa + Erdafitinib answer

Can you take Beet with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Erdafitinib answer

Can you take Berberine with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.

Full Berberine + Erdafitinib answer

Can you take Beta-methylphenethylamine (bmpea) with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Erdafitinib answer

Can you take Bishop's Weed with Erdafitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Erdafitinib answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Erdafitinib is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Erdafitinib, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Erdafitinib sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Erdafitinib through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Erdafitinib through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Erdafitinib through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Erdafitinib through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Erdafitinib through this category.

Erdafitinib (Balversa) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Erdafitinib through this category.

About Erdafitinib

Erdafitinib is a targeted cancer therapy used to treat locally advanced or metastatic urothelial carcinoma (bladder and urinary tract cancer) with specific FGFR3 gene changes.

Generic name: Erdafitinib  ·  Brand name: Balversa.

See the full Erdafitinib drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Erdafitinib

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Erdafitinib.

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Pharmacist Counseling Corner

Erdafitinib & Supplements: Common Questions

What supplements interact with Erdafitinib?
In our interaction database, 169 supplement and herbal ingredients have an interaction with Erdafitinib on file — 4 rated major, 127 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, Phosphate Salts.
Which Erdafitinib supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Phosphate Salts and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Erdafitinib?
That depends entirely on which supplement. The honest answer for Erdafitinib is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Balversa have the same supplement interactions as Erdafitinib?
Yes — Balversa all contain Erdafitinib, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Erdafitinib and my other medications?
This page covers Erdafitinib against supplements and herbal ingredients. Checking Erdafitinib against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Erdafitinib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.