Medication interaction hub

What Supplements Interact with Amiodarone?

Amiodarone brand names: Pacerone, Cordarone. Every interaction below applies to the brands too.

210 Interactions 11 Major 163 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Amiodarone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Amiodarone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Amiodarone (Pacerone, Cordarone) treats dangerous heart rhythms, and this is one supplement list I would genuinely be careful with. Of the 210 ingredients on file, 11 carry a major rating, and the everyday one is grapefruit, which blocks the liver enzyme that clears amiodarone and can push the drug's level higher than intended. St. John's wort does the opposite, speeding the drug's breakdown so it may protect the heart less.

The patterns repeat further down the list. Thirty-eight entries, alcohol among them, add to the liver strain amiodarone can cause on its own, 13 can stretch the heart's electrical timing even further, and about 20 raise sun sensitivity, already a familiar amiodarone side effect. The 163 moderate and 36 minor entries mostly run along these same tracks. Read the major-rated names first; that small group is where the danger concentrates.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 163 Minor 36 No known interaction 1,242

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Amiodarone: Top Interactions at a Glance

The Amiodarone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 210 interacting ingredients — plus 1,242 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Amiodarone Combinations Today

The Amiodarone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Iodine + Amiodaronei

Combining iodine with amiodarone might cause excessively high iodine levels.

Read the full interaction Minor Likelihood Possible Caffeine + Amiodaronei

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Vitamin B6 + Amiodaronei

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.

Read the full interaction Minor Likelihood Possible Valerian + Amiodaronei

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Grapefruit + Amiodaronei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Red Yeast Rice + Amiodaronei

Theoretically, concomitant use might increase the risk of liver damage.

Read the full interaction
The complete list

Every Supplement Checked Against Amiodarone

All 1,452 ingredients in our database, ranked by severity — 210 with a Amiodarone interaction on file and 1,242 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Amiodarone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Iodine with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining iodine with amiodarone might cause excessively high iodine levels.

Full Iodine + Amiodarone answer

Can you take Caffeine with Amiodarone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Caffeine + Amiodarone answer

Can you take Vitamin B6 with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.

Full Vitamin B6 + Amiodarone answer

Can you take Valerian with Amiodarone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Amiodarone answer

Can you take Grapefruit with Amiodarone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Amiodarone answer

Can you take Echinacea with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Amiodarone answer

Can you take English Ivy with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.

Full English Ivy + Amiodarone answer

Can you take Epistane with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Amiodarone answer

Can you take Ergot with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ergotamine, a constituent of ergot, is a substrate of cytochrome P450 3A4 (CYP3A4).

Full Ergot + Amiodarone answer

Can you take Eucalyptus with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Amiodarone answer

Can you take European Barberry with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Amiodarone answer

Can you take Evodia with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of evodia.

Full Evodia + Amiodarone answer

Can you take False Unicorn with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Amiodarone answer

Can you take Fennel with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Amiodarone answer

Can you take Fever Bark with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of yohimbine, a constituent of fever bark.

Full Fever Bark + Amiodarone answer

Can you take Feverfew with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Amiodarone answer

Can you take Fig with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.

Full Fig + Amiodarone answer

Can you take Fo-ti with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Fo-ti + Amiodarone answer

Can you take Garcinia with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Garcinia + Amiodarone answer

Can you take Garlic with Amiodarone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Amiodarone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amiodarone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amiodarone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amiodarone sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Amiodarone through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Amiodarone through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Amiodarone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Amiodarone through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Amiodarone through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Amiodarone through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Amiodarone through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Amiodarone through this category.

Amiodarone (Cordarone) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Amiodarone through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Amiodarone through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Amiodarone through this category.

Amiodarine (Cordarone) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Amiodarone through this category.

About Amiodarone

Amiodarone is an antiarrhythmic medication used to treat serious, life-threatening abnormal heart rhythms when other medications haven't worked.

Generic name: Amiodarone  ·  Brand names: Pacerone, Cordarone.

See the full Amiodarone drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Amiodarone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amiodarone.

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Pharmacist Counseling Corner

Amiodarone & Supplements: Common Questions

What supplements interact with Amiodarone?
In our interaction database, 210 supplement and herbal ingredients have an interaction with Amiodarone on file — 11 rated major, 163 moderate, and 36 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Amiodarone supplement interactions are the most serious?
The 11 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Arsenic and Beer — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Amiodarone?
That depends entirely on which supplement. The honest answer for Amiodarone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Pacerone have the same supplement interactions as Amiodarone?
Yes — Pacerone, Cordarone all contain Amiodarone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Amiodarone and my other medications?
This page covers Amiodarone against supplements and herbal ingredients. Checking Amiodarone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Amiodarone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.