Phosphatidylcholine + Amiodarone
Amiodarone brand names: Pacerone, Cordarone.
We found no known interaction between Phosphatidylcholine and Amiodarone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Amiodarone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Phosphatidylcholine and Amiodarone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Amiodarone and Phosphatidylcholine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Phosphatidylcholine at all — not against Amiodarone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Phosphatidylcholine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Amiodarone Products Have a Food Rule — Phosphatidylcholine Should Not Break It
At least one FDA label for a product containing Amiodarone says to take it with food. If you take Phosphatidylcholine on an empty stomach out of habit, keep them separate — and take Amiodarone with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Amiodarone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Administration of amiodarone hydrochloride tablets in divided doses with meals is suggested for total daily doses of 1000 mg or higher, or when gastrointestinal intolerance occurs.
From the Dosage and Administration section of the FDA label we read for Amiodarone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Phosphatidylcholine or Amiodarone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Phosphatidylcholine or Amiodarone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Phosphatidylcholine With Plavix Question ›
- Hemp Supplement Concerns With Amiodarone ›
- How Long Does Prednisone Stay In Your System? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Amiodarone
This page covers Phosphatidylcholine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amiodarone page lists 210 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).
By severity: 11 major · 163 moderate · 36 minor.
From our pharmacist’s overview on the Amiodarone page
“Amiodarone (Pacerone, Cordarone) treats dangerous heart rhythms, and this is one supplement list I would genuinely be careful with. Of the 210 ingredients on file, 11 carry a major rating, and the everyday one is grapefruit, which blocks the liver enzyme that clears amiodarone and can push the drug's level higher than intended.”
Reviewed by 2 · Jul 18, 2026
Taking Phosphatidylcholine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,521 real supplement products containing Phosphatidylcholine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phosphatidylcholine. Even though Phosphatidylcholine itself has no known interaction with Amiodarone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Phosphatidylcholine and Amiodarone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#223 of 1,452 supplements looked up here in the last 7 days
#566 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phosphatidylcholine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phosphatidylcholine and Amiodarone records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Phosphatidylcholine
What is Phosphatidylcholine?
- Liver health
- Memory and brain support
- Ulcerative colitis
- Source of choline
- High cholesterol
Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for most uses. It is generally well tolerated, but talk to your pharmacist or doctor before starting it.
Phospholipid derived from sources such as soybeans, sunflower, and egg yolk · Capsules, softgels, tablets, granules, liquid, and powder (sometimes as part of lecithin)
An interaction check asks whether these two react with each other — it does not ask whether Phosphatidylcholine is a good idea for someone in your situation. Here is what our Phosphatidylcholine record says about it on its own.
Phosphatidylcholine: dosing
There is no single official or standardized dose of phosphatidylcholine for supplement use. The amount in products varies widely depending on the source and form, and the studied amounts differ from one condition to another.The best approach is to follow the dosing directions on your specific product's label. Higher doses are more likely to cause stomach upset and other side effects.
From our Phosphatidylcholine monograph — the full record covers uses, side effects and every documented interaction.
About Amiodarone
What Is Amiodarone Used For?
Brand names: Pacerone, Cordarone
Amiodarone is prescribed for adults with serious, life-threatening heart-rhythm problems that haven't responded to other medications. Specifically, it's used for two dangerous arrhythmias (abnormal heartbeats): recurrent ventricular fibrillation (a chaotic, potentially fatal heart rhythm) and recurrent ventricular tachycardia (a dangerously fast heart rhythm that causes unstable blood pressure).
Because amiodarone comes with significant risks, doctors reserve it for situations where other options haven't worked or can't be tolerated. It is not a first-choice medication — it's a last-resort tool for serious, life-threatening conditions.
Other Drugs & Phosphatidylcholine
Browse every other medication we’ve checked against Phosphatidylcholine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Phosphatidylcholine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Phosphatidylcholine list.
Phosphatidylcholine References
The 15 references that drive our Phosphatidylcholine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
- Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
- Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
- Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
- Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
- Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
- Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
- Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
- Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
- Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
- Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
- Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
- Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Phosphatidylcholine and Amiodarone Together: Common Questions
Is it safe to take Phosphatidylcholine with Amiodarone?
Do Phosphatidylcholine and Amiodarone have any of the same side effects?
Should I take Phosphatidylcholine and Amiodarone at the same time of day?
Does Amiodarone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Amiodarone and Phosphatidylcholine?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.