Phosphatidylcholine With Plavix Question
In our latest question and answer, the pharmacist discusses the lack of an interaction between Plavix and phosphatidylcholine.

Question
Hi, would taking a PC Phosphatidylcholine supplement interact with clopidogrel?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 11, 2025
Key points
- There is no known interaction between phosphatidylcholine and clopidogrel.
Answer
Thank you for contacting us!
According to our database, there is no known interaction between phosphatidylcholine and Plavix (clopidogrel).
What Is PC?
Phosphatidylcholine (PC) is a phospholipid that plays a vital role in cell membranes, maintaining their structure and function.
PC is a popular dietary supplement used for various purposes, with its most common use being as a memory supplement. Phosphatidylcholine is the body's primary source of choline, a precursor to acetylcholine, a neurotransmitter crucial for memory and cognitive function.
Some studies suggest that PC supplementation may help improve memory and cognitive function, particularly in conditions like dementia where acetylcholine levels are low. However, the effects of oral PC supplementation on acetylcholine levels are still unclear and may vary depending on the individual's cholinergic activity.
Interactions
Our database lists no interactions between phosphatidylcholine and prescription or over-the-counter medication.
In fact, clinical studies show that phosphatidylcholine (PC) is generally well-tolerated. When taken orally, mild side effects such as bloating, diarrhea, altered taste, nausea, vomiting, sweating, and itching have been reported, especially with larger doses around 30 grams daily. There does not appear to be any issues with phosphatidylcholine affecting blood coagulation or platelets.
Nevertheless, the lack of documented interactions may simply be due to a paucity of research on the subject, so, as always where dietary supplements are concerned, it's important to be cautious when starting new ones.
Final Words
Thank you again for reaching out to us.
Be sure to talk to your doctor before starting any new supplements with your medication so you can be monitored appropriately.
-
Dr. Brian Staiger, PharmD
- 316 views