Drug & supplement interaction

Phosphatidylcholine + Amitriptyline

Amitriptyline brand name: Elavil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Phosphatidylcholine and Amitriptyline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Phosphatidylcholine and Amitriptyline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amitriptyline and Phosphatidylcholine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Phosphatidylcholine at all — not against Amitriptyline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phosphatidylcholine safety at a glance

Phosphatidylcholin... overall Use caution Generally well tolerated in food and supplement amounts, but high doses may cause digestive upset.
Pregnancy Use caution Choline is needed in pregnancy, but supplement safety beyond food sources is not well studied; check with your doctor.
Breastfeeding Use caution Not enough reliable data on supplement use while breastfeeding; speak with your healthcare provider first.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amitriptyline and Phosphatidylcholine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Phosphatidylcholine and Amitriptyline May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on Additional detail

    Phosphatidylcholine

    “When taken orally, phosphatidylcholine may increase sweating and itching. When given subcutaneously, phosphatidylcholine can cause pain, burning, itching, tenderness to touch, bruising, edema, and erythema at the injection site. The pain, itching and erythema usually resolve within 2 days of treatment; however localized tenderness can last longer. Edema and bruising usually resolve within 10 days of treatment.”

    Phosphatidylcholine · Natural Medicines adverse-effect record, reported in erythema.

    6 sources cited
    1. 5229. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
    2. 63244. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
    3. 15623. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
    4. 15624. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
    5. 15626. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
    6. 15627. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed

    Amitriptyline

    Listed in the ADVERSE REACTIONS section of the FDA label for Amitriptyline. Read the label on DailyMed ›

  • A change in taste / Diarrhea / Nausea / Vomiting reported in 8.8% of FDA reports for Amitriptyline Additional detail

    Phosphatidylcholine

    “Ingesting large amounts of phosphatidylcholine (30 grams per day) can cause gastrointestinal upset and diarrhea. However, bloating, diarrhea, altered taste, nausea, and vomiting have been reported with smaller doses. Although moderate subcutaneous doses do not usually cause systemic side effects, high doses exceeding 1.2 grams of phosphatidylcholine can cause nausea and abdominal pain in some people.”

    Phosphatidylcholine · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 5223. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
    2. 63244. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
    3. 68843. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
    4. 93389. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
    5. 93390. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
    6. 105728. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

    Amitriptyline

    Listed in the ADVERSE REACTIONS section of the FDA label for Amitriptyline, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Sweating / Swelling Additional detail

    Phosphatidylcholine

    Recorded for Phosphatidylcholine in the same Natural Medicines adverse-effect record shown under Bleeding or bruising above.

    Amitriptyline

    Listed in the ADVERSE REACTIONS section of the FDA label for Amitriptyline. Read the label on DailyMed ›

Reported for Phosphatidylcholine but not commonly for Amitriptyline: stomach upset, stomach pain, bloating or gas and itching.

Effects for Amitriptyline come from the ADVERSE REACTIONS section of its FDA label; effects for Phosphatidylcholine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 17,459 voluntary FDA FAERS reports for Amitriptyline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Phosphatidylcholine or Amitriptyline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Phosphatidylcholine or Amitriptyline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amitriptyline

This page covers Phosphatidylcholine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amitriptyline page lists 296 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 17 major · 228 moderate · 51 minor.

From our pharmacist’s overview on the Amitriptyline page

“Amitriptyline (Elavil), an older antidepressant now often prescribed for nerve pain, migraines, and sleep, is one of the drugs I genuinely want patients to be careful with, and 17 of the 296 supplement and herbal ingredients on this list carry a major rating. Most of the serious ones deepen the drowsiness amitriptyline already causes,…”

Reviewed by 2 · Jul 18, 2026

Open the Amitriptyline interaction page

One more smart check

Taking Phosphatidylcholine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,521 real supplement products containing Phosphatidylcholine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phosphatidylcholine. Even though Phosphatidylcholine itself has no known interaction with Amitriptyline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phosphatidylcholine and Amitriptyline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phosphatidylcholine
Top 25%

#209 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amitriptyline
Top 5%

#52 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phosphatidylcholine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Phosphatidylcholine and Amitriptyline records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phosphatidylcholine

What is Phosphatidylcholine?

Phosphatidylcholine
  • Liver health
  • Memory and brain support
  • Ulcerative colitis
  • Source of choline
  • High cholesterol

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for most uses. It is generally well tolerated, but talk to your pharmacist or doctor before starting it.

Phospholipid derived from sources such as soybeans, sunflower, and egg yolk · Capsules, softgels, tablets, granules, liquid, and powder (sometimes as part of lecithin)

An interaction check asks whether these two react with each other — it does not ask whether Phosphatidylcholine is a good idea for someone in your situation. Here is what our Phosphatidylcholine record says about it on its own.

Phosphatidylcholine: dosing

There is no single official or standardized dose of phosphatidylcholine for supplement use. The amount in products varies widely depending on the source and form, and the studied amounts differ from one condition to another.The best approach is to follow the dosing directions on your specific product's label. Higher doses are more likely to cause stomach upset and other side effects.

From our Phosphatidylcholine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phosphatidylcholine monograph & all interactions
Medication

About Amitriptyline

What Is Amitriptyline Used For?

Brand name: Elavil

Amitriptyline HCL and Amitriptyline Hydrochloride tablets are used to relieve symptoms of depression. Depression that originates from within the body (called endogenous depression) tends to respond better than other types of depression.

Most-Reported Side Effects for Amitriptyline

From FAERS, the FDA’s public side-effect reporting system (17,459 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 1,535 reports
Headache 1,476 reports
Fatigue 1,448 reports
Dyspnea 1,442 reports
Dizziness 1,227 reports
See full Amitriptyline drug information
Keep checking

Other Drugs & Phosphatidylcholine

Browse every other medication we’ve checked against Phosphatidylcholine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Phosphatidylcholine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Phosphatidylcholine list.

See the full Phosphatidylcholine interactions page
See every supplement checked against Amitriptyline, ranked by severity
Evidence & sources

Phosphatidylcholine References

The 15 references that drive our Phosphatidylcholine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phosphatidylcholine and Amitriptyline Together: Common Questions

Is it safe to take Phosphatidylcholine with Amitriptyline?
We do not list a known interaction between Phosphatidylcholine and Amitriptyline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Phosphatidylcholine and Amitriptyline have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Amitriptyline interact with any supplements?
Yes. Amitriptyline has documented interactions with 296 supplements in our database — Phosphatidylcholine is not one of them. The Amitriptyline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phosphatidylcholine monograph Uses, safety profile, and every drug interaction in one place Amitriptyline drug information The full plain-English guide to this medication Amitriptyline supplement interactions Every supplement checked against Amitriptyline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amitriptyline and Phosphatidylcholine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.