Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Smart PS Phosphatide Softgels Ingredients & Drug Interactions

by Nootropics Depot

Smart PS Phosphatide Softgels label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Smart PS Phosphatide Softgels against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Smart PS Phosphatide Softgels is a dietary supplement by Nootropics Depot with 5 active ingredients. Its ingredients are commonly taken for liver health, memory and brain support, ulcerative colitis.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Smart PS Phosphatide Softgels by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Smart PS Phosphatide Softgels by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Smart PS Phosphatide Softgels by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Unsaturated Fat” is listed as a grouped ingredient — the label gives one combined amount (390 mg) without saying how much of each component you get.

Smart PS Phosphatidylserine Softgels contains 5 active ingredients, all of which are lipids (fatty compounds) found naturally in cell membranes. Phosphatidylserine and phosphatidylcholine are the main players here—they're both phospholipids that support brain cell structure and function.

The product also includes monounsaturated fat, polyunsaturated fat, and phosphatidylethanolamine. Each softgel is filled with inactive ingredients like gelatin (the capsule itself), glycerin, MCT oil, and polyglycitol syrup, which help deliver and stabilize the active lipids.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Memory, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Dementia, Alzheimer disease — and 3 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Memory, Dementia.

The evidence for phosphatidylserine leans toward possibly effective for age-related cognitive decline and Alzheimer disease. For other uses listed—athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia—the evidence isn't established enough to rate it either way.

Phosphatidylcholine shows possibly effective evidence only for ulcerative colitis (inflammation in the colon and rectum); for other conditions like Alzheimer disease, nonalcoholic fatty liver disease, and anxiety, the evidence is too limited to say whether it helps.

The evidence, ingredient by ingredient Phosphatidylcholine Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety data is incomplete. The most common side effects when taken by mouth are flatulence, stomach upset, headache, trouble sleeping (especially at higher doses around 600 mg), and nausea.

Phosphatidylcholine is also generally well tolerated, but high doses can cause bloating, diarrhea, nausea, altered taste, and vomiting. Both ingredients show side effects at smaller doses too, so start low if you're new to them.

For pregnancy: phosphatidylserine safety data is not sufficient, so it's best to avoid it during pregnancy. We don't have enough information to recommend phosphatidylcholine supplements during pregnancy either, though choline itself is needed—talk with your doctor before using supplements.

Neither ingredient has adequate safety data for breastfeeding, so discuss it with your healthcare provider first.

Side effects, ingredient by ingredient Phosphatidylcholine Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check if you're on anticholinergic drugs (used for bladder control or certain movement conditions)—phosphatidylserine may reduce their effectiveness. Also check for cholinergic medications, such as certain glaucoma drops or treatments for myasthenia gravis, where this supplement could add unwanted effects.

Use the search tool on this page to run through your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with age-related thinking problems or Alzheimer disease if the research holds up in your situation, but the evidence is still limited. If you take anticholinergic or cholinergic medications, check your exact prescriptions with our tool before starting—the interactions are real and worth verifying.

Pregnant or breastfeeding? Talk to your pharmacist or doctor first.

For everyone else, start with a low dose and watch for digestive upset or sleep problems.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Smart PS Phosphatide Softgels, straight from the product label.

Brand Nootropics Depot
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232633
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Smart PS Phosphatide Softgels by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
120
IngredientAmount% DV
Total Fat500 mg1%
Monounsaturated Fat75 mg--
Total Calories5.36 Calorie(s)--
Phosphatidylcholine25 mg--
Unsaturated Fat390 mg--
Polyunsaturated Fat315 mg--
Phosphatidylethanolamine2.5 mg--
Phosphatidylserine100 mg--

Other ingredients: Phosphatidylserine, Gelatin, Glycerin, Polyglycitol Syrup, MCT Oil, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Precautions

Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.

Allergens: Contains soy allergens.

Warning: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 softgel daily.

Brand IP Statement(s)

Smart PS is a trademark of Soft Gel Technologies, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Smart PS Phosphatide Softgels by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Smart PS Phosphatide Softgels label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Smart PS Phosphatide Softgels by Nootropics Depot

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Calories

5.36 Calorie(s) per serving

Phosphatidylcholine

No known
interactions
25 mg per serving

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...

Phosphatidylcholine monograph & interactions

Unsaturated Fat

390 mg per serving

Phosphatidylethanolamine

2.5 mg per serving

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Soy

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Phosphatidylserine, Gelatin, Glycerin, Polyglycitol Syrup, MCT Oil, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Smart PS Phosphatide Softgels by Nootropics Depot Drug Interactions

Want to check YOUR meds against Smart PS Phosphatide Softgels?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Smart PS Phosphatide Softgels interact with 219 drugs. Click any drug to see the details.

1 of the 5 ingredients in Smart PS Phosphatide Softgels interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Smart PS Phosphatide Softgels with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Smart PS Phosphatide Softgels, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Web Address
nootropicsdepot.com
Pharmacist Counseling Corner

Smart PS Phosphatide Softgels by Nootropics Depot: Common Questions

Does Smart PS Phosphatide Softgels by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Smart PS Phosphatide Softgels has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Smart PS Phosphatide Softgels contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
Phosphatidylserine is not recommended during pregnancy because we don't have enough safety data. Phosphatidylcholine safety in pregnancy beyond food sources isn't well studied either. For breastfeeding, safety data is not available for either ingredient. Talk with your doctor or pharmacist before using this product in either situation.
What are the most common side effects?
Phosphatidylserine may cause flatulence, stomach upset, headache, nausea, or trouble sleeping—especially at higher doses. Phosphatidylcholine can lead to bloating, diarrhea, nausea, altered taste, and vomiting, particularly at large doses. Most people tolerate these ingredients, but start with a lower dose to see how you respond.
Does this really help with memory or thinking?
Phosphatidylserine has some evidence it may help with age-related thinking decline and Alzheimer disease, but the data is limited. For other brain-related uses—ADHD, general memory, dementia—we don't have enough reliable evidence to say whether it works. Phosphatidylcholine shows evidence only for ulcerative colitis, not cognitive issues.
What is phosphatidylserine and why is it in here?
Phosphatidylserine is a fatty compound found in cell membranes, especially in your brain. It's included here because some research suggests it may support brain cells and possibly improve thinking in older adults or those with Alzheimer disease, though the evidence is still emerging.
Is this safe to take long-term?
Phosphatidylserine is generally well tolerated, but we don't have complete long-term safety data. If you plan to use it regularly, talk with your pharmacist about monitoring for side effects like sleep problems or digestive issues over time.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Smart PS Phosphatide Softgels label
Go deeper

The Full Monographs Behind Smart PS Phosphatide Softgels’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Smart PS Phosphatide Softgels's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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